(-)-1,2,3,4-tetrahydro-1-(3,4,5-Trimethoxybenzyl)isoquinoline-6,7-diol hydrochloride monohydrate (BioDeep_00000840093)
代谢物信息卡片
(-)-1,2,3,4-tetrahydro-1-(3,4,5-Trimethoxybenzyl)isoquinoline-6,7-diol hydrochloride monohydrate
化学式: C19H26ClNO6 (399.1448566)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C=C3CCN2)O)O.O.Cl
InChI: 1H
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
同义名列表
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
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文献列表
- Masato Okano, Asami Miyamoto, Mitsuhiko Sato, Shinji Kageyama. Analysis of tretoquinol and its metabolites in human urine by liquid chromatography-tandem mass spectrometry.
Drug testing and analysis.
2019 Nov; 11(11-12):1724-1730. doi:
10.1002/dta.2714. [PMID: 31664780] - Hideaki Oka, Taro Kamimura, Yuki Hiramatsu, Kento Fukumitsu, Rei Iwata, Mika Kondo, Yutaro Hirashima, Seishi Aihara, Atsumi Harada, Kazuhiko Tsuruya. Cholesterol Crystal Embolism Induced by Direct Factor Xa Inhibitor: A First Case Report.
Internal medicine (Tokyo, Japan).
2018 Jan; 57(1):71-74. doi:
10.2169/internalmedicine.8660-16. [PMID: 28943551] - F C Camargo, N E Robinson, L Dirikolu, C Berney, S Eberhart, F J Derksen, A F Lehner, J May, C Hughes, T Tobin. Plasma and urinary concentrations of trimetoquinol by LC-MS-MS following intravenous and intra-tracheal administration to horses with heaves.
Journal of veterinary pharmacology and therapeutics.
2008 Dec; 31(6):501-10. doi:
10.1111/j.1365-2885.2008.00984.x. [PMID: 19000271] - H Kawai, Y Makino, M Hirobe, S Ohta. Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism.
Journal of neurochemistry.
1998 Feb; 70(2):745-51. doi:
10.1046/j.1471-4159.1998.70020745.x. [PMID: 9453570] - K J Romstedt, Y Shin, G Shams, K Doyle, V Tantishaiyakul, M T Clark, A Adejare, A Hamada, D D Miller, D R Feller. Halogen-substituted trimetoquinol analogs as thromboxane A2 receptor antagonists in platelets and aorta.
Biochemical pharmacology.
1993 Dec; 46(11):2051-9. doi:
10.1016/0006-2952(93)90647-f. [PMID: 8267653] - M F Bureau, F De Clerck, J Lefort, C D Arreto, B B Vargaftig. Thromboxane A2 accounts for bronchoconstriction but not for platelet sequestration and microvascular albumin exchanges induced by fMLP in the guinea pig lung.
The Journal of pharmacology and experimental therapeutics.
1992 Feb; 260(2):832-40. doi:
NULL. [PMID: 1738127] - Y Shin, K J Romstedt, K Doyle, M W Harrold, M A Gerhardt, D D Miller, P N Patil, D R Feller. Pharmacologic antagonism of thromboxane A2 receptors by trimetoquinol analogs in vitro and in vivo.
Chirality.
1991; 3(2):112-7. doi:
10.1002/chir.530030206. [PMID: 1830752] - J Sugihara, S Furuuchi, K Nakano, S Harigaya. Studies on intestinal lymphatic absorption of drugs. I. Lymphatic absorption of alkyl ester derivatives and alpha-monoglyceride derivatives of drugs.
Journal of pharmacobio-dynamics.
1988 May; 11(5):369-76. doi:
10.1248/bpb1978.11.369. [PMID: 3171878] - M W Harrold, M A Gerhardt, K Romstedt, D R Feller, D D Miller. Synthesis and platelet antiaggregatory activity of trimetoquinol analogs as endoperoxide/thromboxane A2 antagonists.
Drug design and delivery.
1987 Feb; 1(3):193-207. doi:
". [PMID: 3509333] - E Brode, R Binder, W Breckwoldt. [Determination of trimethoquinol in plasma by electrochemical detection after HPLC separation].
Arzneimittel-Forschung.
1986 Mar; 36(3):437-42. doi:
NULL. [PMID: 3707662] - T Suzuki, K Tsuzurahara, T Murata, S Takeyama. Quantitative determination of trimetoquinol in plasma as its mixed pentafluoropropionyl-trimethylsilyl derivative by gas chromatography mass spectrometry.
Biomedical mass spectrometry.
1982 Mar; 9(3):94-8. doi:
10.1002/bms.1200090303. [PMID: 7066482] - D D Miller, J F Bossart, J R Mayo, D R Feller. Synthesis, beta-adrenergic activity, and platelet antiaggregatory activity of a positional isomer of trimetoquinol: 1-(2',4',5'-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4,-tetrahydroisoquinoline.
Journal of medicinal chemistry.
1980 Mar; 23(3):331-3. doi:
10.1021/jm00177a027. [PMID: 6102607] - M T Piascik, P Osei-Gyimah, D D Miller, D R Feller. beta-Adrenoceptor blocking activity of 1-substituted trimetoquinol analogs.
Biochemical pharmacology.
1979 Jun; 28(11):1807-10. doi:
10.1016/0006-2952(79)90546-x. [PMID: 38798] - P Osei-Gyimah, M T Piascik, J W Fowble, D R Feller, D D Miller. Synthesis and beta-adrenoceptor activity of the erythro and threo isomers of substituted alpha-hydroxytrimetoquinol.
Journal of medicinal chemistry.
1978 Nov; 21(11):1173-8. doi:
10.1021/jm00209a019. [PMID: 31479] - D Castello, T Bignante, F De Candussio, D Franchi, A Martini. [Comparative studies of the metabolic and cardiovascular effects of 3 current bronchodilator agents (trimethoquinol, terbutaline and Th 1165a)].
Minerva pediatrica.
1977 Dec; 29(38):2293-309. doi:
". [PMID: 342900] - D D Miller, P Osei-Gyimah, R V Raman, D R Feller. Synthesis of 1-substituted analogues of trimetoquinol possessing differential and selective beta-adrenergic properties.
Journal of medicinal chemistry.
1977 Nov; 20(11):1502-4. doi:
10.1021/jm00221a029. [PMID: 21293] - M T Piascik, D D Miller, D R Feller. Phosphodiesterase inhibition and lipolytic action of the stereoisomers of trimetoquinol.
Research communications in chemical pathology and pharmacology.
1976 Feb; 13(2):203-15. doi:
". [PMID: 176706] - A Kaneto, E Miki, K Kosaka. Effect of beta and beta2 adrenoreceptor stimulants infused intrapancreatically on glucagon and insulin secretion.
Endocrinology.
1975 Nov; 97(5):1166-73. doi:
10.1210/endo-97-5-1166. [PMID: 241626] - D D Miller, P Osei-Gyimah, J Bardin, D R Feller. Synthesis and biological evaluation of fragmented derivatives of tetrahydroisoquinolines. 2. Trimetoquinol studies.
Journal of medicinal chemistry.
1975 May; 18(5):454-7. doi:
10.1021/jm00239a002. [PMID: 239233]