Quinelorane hydrochloride (BioDeep_00000840037)
代谢物信息卡片
化学式: C14H24Cl2N4 (318.13779239999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1CCCC2C1CC3=CN=C(N=C3C2)N.Cl.Cl
InChI: /m1../s1
描述信息
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Bailey, A Metaxas, J H Yoo, T McGee, I Kitchen. Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm.
The European journal of neuroscience.
2008 Aug; 28(4):759-70. doi:
10.1111/j.1460-9568.2008.06369.x. [PMID: 18671743] - Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischman. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo.
The Journal of pharmacology and experimental therapeutics.
2006 Nov; 319(2):570-85. doi:
10.1124/jpet.106.105312. [PMID: 16885433] - Pedro Gomes, P Soares-Da-Silva. D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.
American journal of physiology. Renal physiology.
2002 Jul; 283(1):F114-23. doi:
10.1152/ajprenal.00244.2001. [PMID: 12060593] - R A Durham, J D Johnson, M J Eaton, K E Moore, K J Lookingland. Opposing roles for dopamine D1 and D2 receptors in the regulation of hypothalamic tuberoinfundibular dopamine neurons.
European journal of pharmacology.
1998 Aug; 355(2-3):141-7. doi:
10.1016/s0014-2999(98)00498-1. [PMID: 9760028] - M J Eaton, C Gopalan, E Kim, K J Lookingland, K E Moore. Comparison of the effects of the dopamine D2 agonist quinelorane on tuberoinfundibular dopaminergic neuronal activity in male and female rats.
Brain research.
1993 Nov; 629(1):53-8. doi:
10.1016/0006-8993(93)90480-b. [PMID: 7904532] - M J Eaton, K E Moore, K J Lookingland. Differential effects of the D2 receptor agonist quinelorane on the secretion of prolactin and alpha-melanocyte-stimulating hormone.
Life sciences.
1993; 53(2):107-12. doi:
10.1016/0024-3205(93)90657-o. [PMID: 8100041] - J L Cameron, S M Pomerantz, L M Layden, J A Amico. Dopaminergic stimulation of oxytocin concentrations in the plasma of male and female monkeys by apomorphine and a D2 receptor agonist.
The Journal of clinical endocrinology and metabolism.
1992 Sep; 75(3):855-60. doi:
10.1210/jcem.75.3.1355489. [PMID: 1355489] - B M Manzione, J R Bernstein, R B Franklin. Observations on the absorption, distribution, metabolism, and excretion of the dopamine (D2) agonist, quinelorane, in rats, mice, dogs, and monkeys.
Drug metabolism and disposition: the biological fate of chemicals.
1991 Jan; 19(1):54-60. doi:
NULL. [PMID: 1673422] - M M Foreman, R W Fuller, M D Hynes, J S Gidda, C L Nichols, J M Schaus, E C Kornfeld, J A Clemens. Preclinical studies on quinelorane, a potent and highly selective D2-dopaminergic agonist.
The Journal of pharmacology and experimental therapeutics.
1989 Jul; 250(1):227-35. doi:
NULL. [PMID: 2526214] - C M Gust, R W Fuller. Further characterization of tolerance to the corticosterone-elevating effect of pergolide in rats.
Neuroscience letters.
1988 Nov; 93(2-3):307-11. doi:
10.1016/0304-3940(88)90100-0. [PMID: 2907374] - B J Miller, J B Tenbarge, J R Bernstein, R B Franklin. High-performance liquid chromatographic assay of trans-(-)-5,5a,6,7,8,9,9a,10-octahydro-6-propylpyrimido[4,5-g] quinolin-2-amine dihydrochloride (LY163502), a potent D-2 agonist, in plasma.
Journal of chromatography.
1988 Apr; 426(2):438-43. doi:
10.1016/s0378-4347(00)81976-3. [PMID: 3392156] - L D Taber, J M Apathy, A F DeLong, J R Sportsman. Enzyme-linked immunosorbent assay for LY163502, a potent dopamine agonist.
Journal of pharmaceutical sciences.
1987 Jun; 76(6):492-5. doi:
10.1002/jps.2600760616. [PMID: 3625497]