Piroxantrone hydrochloride (BioDeep_00000839994)
代谢物信息卡片
化学式: C21H27Cl2N5O4 (483.144)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=NCCCN)C2=C(C3=C(C=CC(=O)C3=C4C2=C1N(N4)CCNCCO)O)O.Cl.Cl
InChI: 2*1H
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- E H Herman, J Zhang, B B Hasinoff, K T Tran, D P Chadwick, J R Clark, V J Ferrans. Comparison of the chronic toxicity of piroxantrone, losoxantrone and doxorubicin in spontaneously hypertensive rats.
Toxicology.
1998 Jun; 128(1):35-52. doi:
10.1016/s0300-483x(98)00049-3. [PMID: 9704904] - J N Ingle, S A Kuross, J A Mailliard, C L Loprinzi, S H Jung, R A Nelimark, J E Krook, H J Long. Evaluation of piroxantrone in women with metastatic breast cancer and failure on nonanthracycline chemotherapy.
Cancer.
1994 Sep; 74(6):1733-8. doi:
10.1002/1097-0142(19940915)74:6<1733::aid-cncr2820740615>3.0.co;2-d. [PMID: 8082075] - S L Berg, F M Balis, K S Godwin, D G Poplack. Pharmacokinetics, cerebrospinal fluid penetration, and metabolism of piroxantrone in the rhesus monkey.
Investigational new drugs.
1993 Nov; 11(4):255-61. doi:
10.1007/bf00874424. [PMID: 8157468] - J M Gallo, P Varkonyi, E E Hassan, D R Groothius. Targeting anticancer drugs to the brain: II. Physiological pharmacokinetic model of oxantrazole following intraarterial administration to rat glioma-2 (RG-2) bearing rats.
Journal of pharmacokinetics and biopharmaceutics.
1993 Oct; 21(5):575-92. doi:
10.1007/bf01059115. [PMID: 8145132] - S L Berg, D M Savarese, F M Balis, A M Denicoff, M Hillig, J A O'Shaughnessy, D G Poplack, K H Cowan. Pharmacokinetics of piroxantrone in a phase I trial of piroxantrone and granulocyte-colony stimulating factor.
Cancer research.
1993 Jun; 53(11):2587-90. doi:
NULL. [PMID: 7684320] - E E Hassan, J M Gallo. High-performance liquid chromatographic analysis of the anticancer drug oxantrazole in rat whole blood and tissues.
Journal of chromatography.
1992 Nov; 582(1-2):225-31. doi:
10.1016/0378-4347(92)80323-i. [PMID: 1491045] - A Allen, M Wolf, E D Crawford, M P Davis, R B Natale, M L Barnett. Phase II evaluation of piroxantrone in renal cell carcinoma. A Southwest Oncology Group Study.
Investigational new drugs.
1992 Jul; 10(2):129-32. doi:
10.1007/bf00873131. [PMID: 1500267] - M M Ames, C L Loprinzi, J M Collins, C van Haelst-Pisani, R L Richardson, J Rubin, C G Moertel. Phase I and clinical pharmacological evaluation of pirozantrone hydrochloride (oxantrazole).
Cancer research.
1990 Jul; 50(13):3905-9. doi:
NULL. [PMID: 2191768] - A Hantel, R C Donehower, E K Rowinsky, E Vance, B V Clarke, W P McGuire, D S Ettinger, D A Noe, L B Grochow. Phase I study and pharmacodynamics of piroxantrone (NSC 349174), a new anthrapyrazole.
Cancer research.
1990 Jun; 50(11):3284-8. doi:
NULL. [PMID: 2334921] - S K Frank, D A Mathiesen, M Szurszewski, M J Kuffel, M M Ames. Preclinical pharmacology of the anthrapyrazole analog oxantrazole (NSC-349174, piroxantrone).
Cancer chemotherapy and pharmacology.
1989; 23(4):213-8. doi:
10.1007/bf00451644. [PMID: 2924379] - S K Frank, D A Mathiesen, L R Whitfield, M M Ames. High-performance liquid chromatographic assay for the experimental anticancer agent oxantrazole.
Journal of chromatography.
1987 Aug; 419(?):225-32. doi:
10.1016/0378-4347(87)80280-3. [PMID: 3667780] - P Frank, R F Novak. Effects of anthrapyrazole antineoplastic agents on lipid peroxidation.
Biochemical and biophysical research communications.
1986 Nov; 140(3):797-807. doi:
10.1016/0006-291x(86)90704-7. [PMID: 3778486]
