Raclopride C 11 (BioDeep_00000839978)

   


代谢物信息卡片


Raclopride C 11

化学式: C15H20Cl2N2O3 (346.08509100000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN1CCCC1CNC(=O)C2=C(C(=CC(=C2OC)Cl)Cl)O
InChI: InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1/i2-1

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C1446 - Radiopharmaceutical Compound > C2124 - Radioconjugate

同义名列表

1 个代谢物同义名

Raclopride C 11



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xuenan Wang, Min Li, Jinlu Xie, Dadian Chen, Xiwen Geng, Shuang Sun, Bo Liu, Min Wang. Beta band modulation by dopamine D2 receptors in the primary motor cortex and pedunculopontine nucleus in a rat model of Parkinson's disease. Brain research bulletin. 2022 04; 181(?):121-128. doi: 10.1016/j.brainresbull.2022.01.012. [PMID: 35077843]
  • Peter Manza, Ehsan Shokri-Kojori, Corinde E Wiers, Danielle Kroll, Dana Feldman, Katherine McPherson, Erin Biesecker, Evan Dennis, Allison Johnson, Andrew Kelleher, Song Qu, Dardo Tomasi, Gene-Jack Wang, Nora D Volkow. Sex differences in methylphenidate-induced dopamine increases in ventral striatum. Molecular psychiatry. 2022 02; 27(2):939-946. doi: 10.1038/s41380-021-01294-9. [PMID: 34707237]
  • Katina C Calakos, Heather Liu, Yihuan Lu, Jon Mikael Anderson, David Matuskey, Nabeel Nabulsi, Yunpeng Ye, Patrick D Skosnik, Deepak Cyril D'Souza, Evan D Morris, Kelly P Cosgrove, Ansel T Hillmer. Assessment of transient dopamine responses to smoked cannabis. Drug and alcohol dependence. 2021 10; 227(?):108920. doi: 10.1016/j.drugalcdep.2021.108920. [PMID: 34399137]
  • Anna Schildt, Erik F J de Vries, Antoon T M Willemsen, Bruno Lima Giacobbo, Rodrigo Moraga-Amaro, Jürgen W A Sijbesma, Aren van Waarde, Vesna Sossi, Rudi A J O Dierckx, Janine Doorduin. Effect of Dopamine D2 Receptor Antagonists on [18F]-FEOBV Binding. Molecular pharmaceutics. 2020 03; 17(3):865-872. doi: 10.1021/acs.molpharmaceut.9b01129. [PMID: 32011892]
  • Esteban A Fridman, Joseph R Osborne, Paul D Mozley, Jonathan D Victor, Nicholas D Schiff. Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury. Brain : a journal of neurology. 2019 07; 142(7):1887-1893. doi: 10.1093/brain/awz118. [PMID: 31505542]
  • Courtney A Marshall, Zachary D Brodnik, Ole V Mortensen, Maarten E A Reith, Jed S Shumsky, Barry D Waterhouse, Rodrigo A España, Sandhya Kortagere. Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention. Neuropharmacology. 2019 04; 148(?):178-188. doi: 10.1016/j.neuropharm.2019.01.003. [PMID: 30633928]
  • Kimberly E Vanover, Robert E Davis, Yun Zhou, Weiguo Ye, James R Brašić, Lorena Gapasin, Jelena Saillard, Michal Weingart, Robert E Litman, Sharon Mates, Dean F Wong. Dopamine D2 receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019 02; 44(3):598-605. doi: 10.1038/s41386-018-0251-1. [PMID: 30449883]
  • Yin Cheong Wong, Trayana Ilkova, Rob C van Wijk, Robin Hartman, Elizabeth C M de Lange. Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Jan; 111(?):514-525. doi: 10.1016/j.ejps.2017.10.031. [PMID: 29106979]
  • Masahiro Mishina, Kenji Ishii, Yuichi Kimura, Masahiko Suzuki, Shin Kitamura, Kenji Ishibashi, Muneyuki Sakata, Keiichi Oda, Shiro Kobayashi, Kazumi Kimura, Kiichi Ishiwata. Adenosine A1 receptors measured with 11 C-MPDX PET in early Parkinson's disease. Synapse (New York, N.Y.). 2017 08; 71(8):. doi: 10.1002/syn.21979. [PMID: 28407307]
  • J R Petrulli, B Kalish, N B Nabulsi, Y Huang, J Hannestad, E D Morris. Systemic inflammation enhances stimulant-induced striatal dopamine elevation. Translational psychiatry. 2017 03; 7(3):e1076. doi: 10.1038/tp.2017.18. [PMID: 28350401]
  • Panayotis K Thanos, Ronald Kim, Foteini Delis, Mark J Rocco, Jacob Cho, Nora D Volkow. Effects of chronic methamphetamine on psychomotor and cognitive functions and dopamine signaling in the brain. Behavioural brain research. 2017 03; 320(?):282-290. doi: 10.1016/j.bbr.2016.12.010. [PMID: 27993694]
  • Shir Atzil, Alexandra Touroutoglou, Tali Rudy, Stephanie Salcedo, Ruth Feldman, Jacob M Hooker, Bradford C Dickerson, Ciprian Catana, Lisa Feldman Barrett. Dopamine in the medial amygdala network mediates human bonding. Proceedings of the National Academy of Sciences of the United States of America. 2017 02; 114(9):2361-2366. doi: 10.1073/pnas.1612233114. [PMID: 28193868]
  • Sotaro Momosaki, Miwa Ito, Hiroko Yamato, Hitoshi Iimori, Hirokazu Sumiyoshi, Kenji Morimoto, Natsumi Imamoto, Tadashi Watabe, Eku Shimosegawa, Jun Hatazawa, Kohji Abe. Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2017 Feb; 37(2):605-613. doi: 10.1177/0271678x16635183. [PMID: 26911894]
  • Y Kimura, J Maeda, M Yamada, K Takahata, K Yokokawa, Y Ikoma, C Seki, H Ito, M Higuchi, T Suhara. Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol. Psychopharmacology. 2017 Feb; 234(3):323-328. doi: 10.1007/s00213-016-4464-x. [PMID: 27766370]
  • Ruimin Wang, Baixuan Xu, Zhe Guo, Tong Chen, Jinming Zhang, Yingmao Chen, Haiyan Zhu. Suite PET/CT neuroimaging for the diagnosis of Parkinson's disease: statistical parametric mapping analysis. Nuclear medicine communications. 2017 Feb; 38(2):164-169. doi: 10.1097/mnm.0000000000000622. [PMID: 27893588]
  • Kayoko Kanamitsu, Ryosuke Arakawa, Yuichi Sugiyama, Tetsuya Suhara, Hiroyuki Kusuhara. Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments. Drug metabolism and pharmacokinetics. 2016 Dec; 31(6):395-404. doi: 10.1016/j.dmpk.2016.07.003. [PMID: 27745731]
  • Molly M McGinnis, Cody A Siciliano, Sara R Jones. Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. Journal of neurochemistry. 2016 09; 138(6):821-9. doi: 10.1111/jnc.13732. [PMID: 27393374]
  • Shinichiro Nakajima, Hiroyuki Uchida, Robert R Bies, Fernando Caravaggio, Takefumi Suzuki, Eric Plitman, Wanna Mar, Philip Gerretsen, Bruce G Pollock, Benoit H Mulsant, David C Mamo, Ariel Graff-Guerrero. Dopamine D2/3 Receptor Occupancy Following Dose Reduction Is Predictable With Minimal Plasma Antipsychotic Concentrations: An Open-Label Clinical Trial. Schizophrenia bulletin. 2016 Jan; 42(1):212-9. doi: 10.1093/schbul/sbv106. [PMID: 26221049]
  • Laurie P Sutton, Marc G Caron. Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine. Neuropharmacology. 2015 Dec; 99(?):610-9. doi: 10.1016/j.neuropharm.2015.08.024. [PMID: 26314207]
  • Obaidur Rahman, Akihiro Takano, Nahid Amini, Kenneth Dahl, Naoki Kanegawa, Bengt Långström, Lars Farde, Christer Halldin. Synthesis of ([(11)C]carbonyl)raclopride and a comparison with ([(11)C]methyl)raclopride in a monkey PET study. Nuclear medicine and biology. 2015 Nov; 42(11):893-8. doi: 10.1016/j.nucmedbio.2015.07.003. [PMID: 26272268]
  • Stefanie Geisler, Nicola Beindorff, Markus Cremer, Kerstin Hoffmann, Winfried Brenner, Paul Cumming, Philipp T Meyer, Karl-Josef Langen, Eberhard Fuchs, Ralph Buchert. Characterization of [123I]FP-CIT binding to the dopamine transporter in the striatum of tree shrews by quantitative in vitro autoradiography. Synapse (New York, N.Y.). 2015 Oct; 69(10):497-504. doi: 10.1002/syn.21838. [PMID: 26126942]
  • Kristoffer Sahlholm, Jurgen W A Sijbesma, Bram Maas, Chantal Kwizera, Daniel Marcellino, Nisha K Ramakrishnan, Rudi A J O Dierckx, Philip H Elsinga, Aren van Waarde. Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses. Psychopharmacology. 2015 Sep; 232(18):3443-53. doi: 10.1007/s00213-015-3997-8. [PMID: 26159455]
  • Ying-Shan Piao, Frank Scott Hall, Yuki Moriya, Miki Ito, Arihisa Ohara, Ruri Kikura-Hanajiri, Yukihiro Goda, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sora. Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Behavioural pharmacology. 2015 Jun; 26(4):345-52. doi: 10.1097/fbp.0000000000000135. [PMID: 25794333]
  • Fernando Caravaggio, Carol Borlido, Margaret Hahn, Zhe Feng, Gagan Fervaha, Philip Gerretsen, Shinichiro Nakajima, Eric Plitman, Jun Ku Chung, Yusuke Iwata, Alan Wilson, Gary Remington, Ariel Graff-Guerrero. Reduced insulin sensitivity is related to less endogenous dopamine at D2/3 receptors in the ventral striatum of healthy nonobese humans. The international journal of neuropsychopharmacology. 2015 Feb; 18(7):pyv014. doi: 10.1093/ijnp/pyv014. [PMID: 25716779]
  • Floris H P van Velden, Syahir M Mansor, Daniëlle M E van Assema, Bart N M van Berckel, Femke E Froklage, Shaonan Wang, Robert C Schuit, Marie-Claude Asselin, Adriaan A Lammertsma, Ronald Boellaard, Marc C Huisman. Comparison of HRRT and HR+ scanners for quantitative (R)-[11C]verapamil, [11C]raclopride and [11C]flumazenil brain studies. Molecular imaging and biology. 2015 Feb; 17(1):129-39. doi: 10.1007/s11307-014-0766-8. [PMID: 25028091]
  • Nelleke Tolboom, Henk W Berendse, Josee E Leysen, Maqsood Yaqub, Bart N M van Berckel, Robert C Schuit, Mirthe M Ponsen, Esther Bakker, Nikie J Hoetjes, Albert D Windhorst, Maria L Carlsson, Adriaan A Lammertsma, Arvid Carlsson. The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 Jan; 40(2):472-9. doi: 10.1038/npp.2014.195. [PMID: 25248987]
  • Takeshi Sakayori, Amane Tateno, Ryosuke Arakawa, Yumiko Ikeda, Hidenori Suzuki, Yoshiro Okubo. Effect of mazindol on extracellular dopamine concentration in human brain measured by PET. Psychopharmacology. 2014 Jun; 231(11):2321-5. doi: 10.1007/s00213-013-3392-2. [PMID: 24398821]
  • Duncan Casey, Kalypso Charalambous, Antony Gee, Robert V Law, Oscar Ces. Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature. Journal of the Royal Society, Interface. 2014 May; 11(94):20131062. doi: 10.1098/rsif.2013.1062. [PMID: 24621813]
  • J Sun, N J Cairns, J S Perlmutter, R H Mach, J Xu. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. 2013 Sep; 248(?):112-26. doi: 10.1016/j.neuroscience.2013.05.048. [PMID: 23732230]
  • Carl Björkholm, Kent Jardemark, Monica M Marcus, Anna Malmerfelt, Svante Nyberg, Björn Schilström, Torgny H Svensson. Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2013 Jul; 23(7):709-20. doi: 10.1016/j.euroneuro.2012.05.012. [PMID: 22732518]
  • Dasiel O Borroto-Escuela, Annalisa Ravani, Alexander O Tarakanov, Ismel Brito, Manuel Narvaez, Wilber Romero-Fernandez, Fidel Corrales, Luigi F Agnati, Sergio Tanganelli, Luca Ferraro, Kjell Fuxe. Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers. Biochemical and biophysical research communications. 2013 May; 435(1):140-6. doi: 10.1016/j.bbrc.2013.04.058. [PMID: 23624386]
  • Amane Tateno, Ryosuke Arakawa, Masaki Okumura, Hajime Fukuta, Kazuyoshi Honjo, Keiichi Ishihara, Hiroshi Nakamura, Shin-ichiro Kumita, Yoshiro Okubo. Striatal and extrastriatal dopamine D2 receptor occupancy by a novel antipsychotic, blonanserin: a PET study with [11C]raclopride and [11C]FLB 457 in schizophrenia. Journal of clinical psychopharmacology. 2013 Apr; 33(2):162-9. doi: 10.1097/jcp.0b013e3182825bce. [PMID: 23422369]
  • Ursula F Bailer, Guido K Frank, Julie C Price, Carolyn C Meltzer, Carl Becker, Chester A Mathis, Angela Wagner, Nicole C Barbarich-Marsteller, Cinnamon S Bloss, Karen Putnam, Nicholas J Schork, Anthony Gamst, Walter H Kaye. Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa. Psychiatry research. 2013 Feb; 211(2):160-8. doi: 10.1016/j.pscychresns.2012.06.010. [PMID: 23154100]
  • Edward F Domino, Lisong Ni, Joseph S Domino, Wendy Yang, Catherine Evans, Sally Guthrie, Heng Wang, Robert A Koeppe, Jon-Kar Zubieta. Denicotinized versus average nicotine tobacco cigarette smoking differentially releases striatal dopamine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2013 Jan; 15(1):11-21. doi: 10.1093/ntr/nts029. [PMID: 22491891]
  • Mark E Schmidt, Peter de Boer, Randolph Andrews, Martine Neyens, Stefaan Rossenu, Demiana William Falteos, Erik Mannaert. D₂-receptor occupancy measurement of JNJ-37822681, a novel fast off-rate D₂-receptor antagonist, in healthy subjects using positron emission tomography: single dose versus steady state and dose selection. Psychopharmacology. 2012 Dec; 224(4):549-57. doi: 10.1007/s00213-012-2782-1. [PMID: 22773165]
  • Paul R Burghardt, Tiffany M Love, Christian S Stohler, Colin Hodgkinson, Pei-Hong Shen, Mary-Anne Enoch, David Goldman, Jon-Kar Zubieta. Leptin regulates dopamine responses to sustained stress in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Oct; 32(44):15369-76. doi: 10.1523/jneurosci.2521-12.2012. [PMID: 23115175]
  • Anders Borgkvist, Torun Malmlöf, Kristin Feltmann, Maria Lindskog, Björn Schilström. Dopamine in the hippocampus is cleared by the norepinephrine transporter. The international journal of neuropsychopharmacology. 2012 May; 15(4):531-40. doi: 10.1017/s1461145711000812. [PMID: 21669025]
  • Stelvio Sestini, Christer Halldin, Luigi Mansi, Antonio Castagnoli, Lars Farde. Pharmacokinetic analysis of plasma curves obtained after i.v. injection of the PET radioligand [11C] raclopride provides a likely explanation for rapid radioligand metabolism. Journal of cellular physiology. 2012 Apr; 227(4):1663-9. doi: 10.1002/jcp.22890. [PMID: 21678422]
  • W Anthony Owens, Jason M Williams, Christine Saunders, Malcolm J Avison, Aurelio Galli, Lynette C Daws. Rescue of dopamine transporter function in hypoinsulinemic rats by a D2 receptor-ERK-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Feb; 32(8):2637-47. doi: 10.1523/jneurosci.3759-11.2012. [PMID: 22357848]
  • Shu-Ling Liang, Jenn-Tser Pan. An endogenous dopaminergic tone acting on dopamine D3 receptors may be involved in diurnal changes of tuberoinfundibular dopaminergic neuron activity and prolactin secretion in estrogen-primed ovariectomized rats. Brain research bulletin. 2012 Feb; 87(2-3):334-9. doi: 10.1016/j.brainresbull.2011.11.018. [PMID: 22155687]
  • Richard J A Goodwin, C Logan Mackay, Anna Nilsson, David J Harrison, Lars Farde, Per E Andren, Suzanne L Iverson. Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method. Analytical chemistry. 2011 Dec; 83(24):9694-701. doi: 10.1021/ac202630t. [PMID: 22077717]
  • Magdalena Nord, Svante Nyberg, Jacob Brogren, Aurelija Jucaite, Christer Halldin, Lars Farde. Comparison of D₂ dopamine receptor occupancy after oral administration of quetiapine fumarate immediate-release and extended-release formulations in healthy subjects. The international journal of neuropsychopharmacology. 2011 Nov; 14(10):1357-66. doi: 10.1017/s1461145711000514. [PMID: 21477416]
  • N D Volkow, G-J Wang, J H Newcorn, S H Kollins, T L Wigal, F Telang, J S Fowler, R Z Goldstein, N Klein, J Logan, C Wong, J M Swanson. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular psychiatry. 2011 Nov; 16(11):1147-54. doi: 10.1038/mp.2010.97. [PMID: 20856250]
  • Euitae Kim, Oliver D Howes, Bo-Hyung Kim, Kyung-Sang Yu, Jae Min Jeong, Jae Sung Lee, Su Jin Kim, In-Jin Jang, Jung Shin Park, Yong Gil Kim, Sang-Goo Shin, Federico E Turkheimer, Shitij Kapur, Jun Soo Kwon. The use of healthy volunteers instead of patients to inform drug dosing studies: a [¹¹C]raclopride PET study. Psychopharmacology. 2011 Oct; 217(4):515-23. doi: 10.1007/s00213-011-2306-4. [PMID: 21503604]
  • P S Suresh, Ravindra Ramachandra Punde, Manish Gupta, Abhishek Dixit, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. A highly sensitive LC-MS/MS method for the determination of S-raclopride in rat plasma: application to a pharmacokinetic study in rats. Biomedical chromatography : BMC. 2011 Aug; 25(8):930-7. doi: 10.1002/bmc.1547. [PMID: 21154642]
  • Wei Sun, Kenji Sugiyama, Tetsuya Asakawa, Hiroshi Yamaguchi, Soichi Akamine, Yasuomi Ouchi, Yasuhiro Magata, Hiroki Namba. Dynamic changes of striatal dopamine D2 receptor binding at later stages after unilateral lesions of the medial forebrain bundle in Parkinsonian rat models. Neuroscience letters. 2011 Jun; 496(3):157-62. doi: 10.1016/j.neulet.2011.04.006. [PMID: 21514359]
  • Fumitoshi Kodaka, Hiroshi Ito, Harumasa Takano, Hidehiko Takahashi, Ryosuke Arakawa, Michie Miyoshi, Masaki Okumura, Tatsui Otsuka, Kazuhiko Nakayama, Christer Halldin, Lars Farde, Tetsuya Suhara. Effect of risperidone on high-affinity state of dopamine D2 receptors: a PET study with agonist ligand [11C](R)-2-CH3O-N-n-propylnorapomorphine. The international journal of neuropsychopharmacology. 2011 Feb; 14(1):83-9. doi: 10.1017/s1461145710001148. [PMID: 20860881]
  • Mark Slifstein, Raymond F Suckow, Jonathan A Javitch, Thomas Cooper, Jeffrey Lieberman, Anissa Abi-Dargham. Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2011 Jan; 31(1):293-304. doi: 10.1038/jcbfm.2010.91. [PMID: 20571519]
  • Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, Takeharu Kakiuchi. Differential effects of stress on [¹¹C]raclopride and [¹¹C]MNPA binding to striatal D₂/D₃ dopamine receptors: a PET study in conscious monkeys. Synapse (New York, N.Y.). 2011 Jan; 65(1):84-9. doi: 10.1002/syn.20845. [PMID: 20687105]
  • Thomas J Spencer, Bertha K Madras, Ali A Bonab, Darin D Dougherty, Allison Clarke, Tara Mirto, Jessica Martin, Alan J Fischman. A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride. Biological psychiatry. 2010 Nov; 68(10):964-70. doi: 10.1016/j.biopsych.2010.08.026. [PMID: 21035624]
  • J Park, B J Aragona, B M Kile, R M Carelli, R M Wightman. In vivo voltammetric monitoring of catecholamine release in subterritories of the nucleus accumbens shell. Neuroscience. 2010 Aug; 169(1):132-42. doi: 10.1016/j.neuroscience.2010.04.076. [PMID: 20451589]
  • Ryosuke Arakawa, Hiroshi Ito, Akihiro Takano, Masaki Okumura, Hidehiko Takahashi, Harumasa Takano, Yoshiro Okubo, Tetsuya Suhara. Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects. Psychopharmacology. 2010 May; 209(4):285-90. doi: 10.1007/s00213-010-1783-1. [PMID: 20349050]
  • Mark Slifstein, Lawrence S Kegeles, Xiaoyan Xu, Judy L Thompson, Nina Urban, John Castrillon, Elizabeth Hackett, S-A Bae, Marc Laruelle, Anissa Abi-Dargham. Striatal and extrastriatal dopamine release measured with PET and [(18)F] fallypride. Synapse (New York, N.Y.). 2010 May; 64(5):350-62. doi: 10.1002/syn.20734. [PMID: 20029833]
  • Rajesh Narendran, N Scott Mason, Charles M Laymon, Brian J Lopresti, Natalie D Velasquez, Maureen A May, Steve Kendro, Diana Martinez, Chester A Mathis, W Gordon Frankle. A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum. The Journal of pharmacology and experimental therapeutics. 2010 May; 333(2):533-9. doi: 10.1124/jpet.109.163501. [PMID: 20103586]
  • Fuat Balci, Elliot A Ludvig, Ron Abner, Xiaoxi Zhuang, Patrick Poon, Dani Brunner. Motivational effects on interval timing in dopamine transporter (DAT) knockdown mice. Brain research. 2010 Apr; 1325(?):89-99. doi: 10.1016/j.brainres.2010.02.034. [PMID: 20167208]
  • Anna Secher, Henriette Husum, Birgitte Holst, Kristoffer Lihme Egerod, Erling Mellerup. Risperidone treatment increases CB1 receptor binding in rat brain. Neuroendocrinology. 2010; 91(2):155-68. doi: 10.1159/000245220. [PMID: 19815998]
  • Nora D Volkow, Gene-Jack Wang, Scott H Kollins, Tim L Wigal, Jeffrey H Newcorn, Frank Telang, Joanna S Fowler, Wei Zhu, Jean Logan, Yeming Ma, Kith Pradhan, Christopher Wong, James M Swanson. Evaluating dopamine reward pathway in ADHD: clinical implications. JAMA. 2009 Sep; 302(10):1084-91. doi: 10.1001/jama.2009.1308. [PMID: 19738093]
  • Thomas J R Beveridge, Hilary R Smith, Michael A Nader, Linda J Porrino. Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 Apr; 34(5):1162-71. doi: 10.1038/npp.2008.135. [PMID: 18769473]
  • Kenji Ishibashi, Kenji Ishii, Keiichi Oda, Keiichi Kawasaki, Hidehiro Mizusawa, Kiichi Ishiwata. Regional analysis of age-related decline in dopamine transporters and dopamine D2-like receptors in human striatum. Synapse (New York, N.Y.). 2009 Apr; 63(4):282-90. doi: 10.1002/syn.20603. [PMID: 19116949]
  • Hiroyuki Uchida, Ariel Graff-Guerrero, Benoit H Mulsant, Bruce G Pollock, David C Mamo. Long-term stability of measuring D(2) receptors in schizophrenia patients treated with antipsychotics. Schizophrenia research. 2009 Apr; 109(1-3):130-3. doi: 10.1016/j.schres.2008.12.022. [PMID: 19179049]
  • Nora D Volkow, Joanna S Fowler, Jean Logan, David Alexoff, Wei Zhu, Frank Telang, Gene-Jack Wang, Millard Jayne, Jacob M Hooker, Christopher Wong, Barbara Hubbard, Pauline Carter, Donald Warner, Payton King, Colleen Shea, Youwen Xu, Lisa Muench, Karen Apelskog-Torres. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA. 2009 Mar; 301(11):1148-54. doi: 10.1001/jama.2009.351. [PMID: 19293415]
  • Hiroyuki Uchida, Shitij Kapur, Benoit H Mulsant, Ariel Graff-Guerrero, Bruce G Pollock, David C Mamo. Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2009 Mar; 17(3):255-63. doi: 10.1097/jgp.0b013e318198776d. [PMID: 19225277]
  • Yun Zhou, Weiguo Ye, James R Brasić, Andrew H Crabb, John Hilton, Dean F Wong. A consistent and efficient graphical analysis method to improve the quantification of reversible tracer binding in radioligand receptor dynamic PET studies. NeuroImage. 2009 Feb; 44(3):661-70. doi: 10.1016/j.neuroimage.2008.09.021. [PMID: 18930830]
  • Gwenn S Smith, Yilong Ma, Vijay Dhawan, Thomas Chaly, David Eidelberg. Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography. Synapse (New York, N.Y.). 2009 Jan; 63(1):1-6. doi: 10.1002/syn.20574. [PMID: 18925655]
  • Franklin R Schneier, Anissa Abi-Dargham, Diana Martinez, Mark Slifstein, Dah-Ren Hwang, Michael R Liebowitz, Marc Laruelle. Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder. Depression and anxiety. 2009; 26(5):411-8. doi: 10.1002/da.20543. [PMID: 19180583]
  • Ingo Vernaleken, Christine Fellows, Hildegard Janouschek, Anno Bröcheler, Tanja Veselinovic, Christian Landvogt, Christian Boy, Hans-Georg Buchholz, Katja Spreckelmeyer, Peter Bartenstein, Paul Cumming, Christoph Hiemke, Frank Rösch, Wolfgang Schäfer, Dean F Wong, Gerhard Gründer. Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone). Journal of clinical psychopharmacology. 2008 Dec; 28(6):608-17. doi: 10.1097/jcp.0b013e31818ba2f6. [PMID: 19011428]
  • Angelika Schedel, Patrick Schloss, Harald Klüter, Peter Bugert. The dopamine agonism on ADP-stimulated platelets is mediated through D2-like but not D1-like dopamine receptors. Naunyn-Schmiedeberg's archives of pharmacology. 2008 Oct; 378(4):431-9. doi: 10.1007/s00210-008-0320-9. [PMID: 18542926]
  • Rajkumar J Sevak, Wouter Koek, William Anthony Owens, Aurelio Galli, Lynette C Daws, Charles P France. Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats. European journal of pharmacology. 2008 Sep; 592(1-3):109-15. doi: 10.1016/j.ejphar.2008.07.002. [PMID: 18652823]
  • A Bailey, A Metaxas, J H Yoo, T McGee, I Kitchen. Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. The European journal of neuroscience. 2008 Aug; 28(4):759-70. doi: 10.1111/j.1460-9568.2008.06369.x. [PMID: 18671743]
  • Teresa Marie du Bois, Ching-Wen Hsu, Yulin Li, Yean Yeow Tan, Chao Deng, Xu-Feng Huang. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochemical research. 2008 Jul; 33(7):1224-31. doi: 10.1007/s11064-007-9571-y. [PMID: 18256931]
  • William P Melega, Matthew J Jorgensen, Goran Laćan, Baldwin M Way, Jamie Pham, Grenvill Morton, Arthur K Cho, Lynn A Fairbanks. Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008 May; 33(6):1441-52. doi: 10.1038/sj.npp.1301502. [PMID: 17625500]
  • Dean F Wong, James R Brasić, Harvey S Singer, David J Schretlen, Hiroto Kuwabara, Yun Zhou, Ayon Nandi, Marika A Maris, Mohab Alexander, Weiguo Ye, Olivier Rousset, Anil Kumar, Zsolt Szabo, Albert Gjedde, Anthony A Grace. Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: clues from an in vivo neurochemistry study with PET. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008 May; 33(6):1239-51. doi: 10.1038/sj.npp.1301528. [PMID: 17987065]
  • Abesh Kumar Bhattacharjee, Lisa Chang, Laura White, Richard P Bazinet, Stanley I Rapoport. Imaging apomorphine stimulation of brain arachidonic acid signaling via D2-like receptors in unanesthetized rats. Psychopharmacology. 2008 May; 197(4):557-66. doi: 10.1007/s00213-008-1073-3. [PMID: 18274730]
  • Christina Kurre Olsen, Lise Tøttrup Brennum, Mads Kreilgaard. Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics. European journal of pharmacology. 2008 Apr; 584(2-3):318-27. doi: 10.1016/j.ejphar.2008.02.005. [PMID: 18325493]
  • Ryosuke Arakawa, Hiroshi Ito, Akihiro Takano, Hidehiko Takahashi, Takuya Morimoto, Takeshi Sassa, Katsuya Ohta, Motoichiro Kato, Yoshiro Okubo, Tetsuya Suhara. Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia. Psychopharmacology. 2008 Apr; 197(2):229-35. doi: 10.1007/s00213-007-1029-z. [PMID: 18058087]
  • Hiroshi Ito, Hidehiko Takahashi, Ryosuke Arakawa, Harumasa Takano, Tetsuya Suhara. Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography. NeuroImage. 2008 Jan; 39(2):555-65. doi: 10.1016/j.neuroimage.2007.09.011. [PMID: 17962043]
  • Rachel Tomer, Rita Z Goldstein, Gene-Jack Wang, Christopher Wong, Nora D Volkow. Incentive motivation is associated with striatal dopamine asymmetry. Biological psychology. 2008 Jan; 77(1):98-101. doi: 10.1016/j.biopsycho.2007.08.001. [PMID: 17868972]
  • Patrick N McCormick, Shitij Kapur, Philip Seeman, Alan A Wilson. Dopamine D2 receptor radiotracers [(11)C](+)-PHNO and [(3)H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo. Nuclear medicine and biology. 2008 Jan; 35(1):11-7. doi: 10.1016/j.nucmedbio.2007.08.005. [PMID: 18158938]
  • David Mamo, Ariel Graff, Romina Mizrahi, C M Shammi, Françoise Romeyer, Shitij Kapur. Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study. The American journal of psychiatry. 2007 Sep; 164(9):1411-7. doi: 10.1176/appi.ajp.2007.06091479. [PMID: 17728427]
  • Nora D Volkow, Gene-Jack Wang, Jeffrey Newcorn, Frank Telang, Mary V Solanto, Joanna S Fowler, Jean Logan, Yeming Ma, Kurt Schulz, Kith Pradhan, Christopher Wong, James M Swanson. Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder. Archives of general psychiatry. 2007 Aug; 64(8):932-40. doi: 10.1001/archpsyc.64.8.932. [PMID: 17679638]
  • Rosanna Moore, Elena V Krstew, Jeppe Kirchhoff, Robin L Davisson, Andrew J Lawrence. Central overexpression of angiotensin AT(1A) receptors prevents dopamine D(2) receptor regulation of alcohol consumption in mice. Alcoholism, clinical and experimental research. 2007 Jul; 31(7):1128-37. doi: 10.1111/j.1530-0277.2007.00399.x. [PMID: 17451402]
  • Daniela Pellegrino, Francesca Cicchetti, Xukui Wang, Aijun Zhu, Mexiang Yu, Martine Saint-Pierre, Anna-Liisa Brownell. Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2007 Jul; 48(7):1147-53. doi: 10.2967/jnumed.106.037796. [PMID: 17574972]
  • Ofer Agid, David Mamo, Nathalie Ginovart, Irina Vitcu, Alan A Wilson, Robert B Zipursky, Shitij Kapur. Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007 Jun; 32(6):1209-15. doi: 10.1038/sj.npp.1301242. [PMID: 17077809]
  • Rajkumar J Sevak, W Anthony Owens, Wouter Koek, Aurelio Galli, Lynette C Daws, Charles P France. Evidence for D2 receptor mediation of amphetamine-induced normalization of locomotion and dopamine transporter function in hypoinsulinemic rats. Journal of neurochemistry. 2007 Apr; 101(1):151-9. doi: 10.1111/j.1471-4159.2006.04358.x. [PMID: 17217413]
  • Abesh K Bhattacharjee, Lisa Chang, Laura White, Richard P Bazinet, Stanley I Rapoport. D-Amphetamine stimulates D2 dopamine receptor-mediated brain signaling involving arachidonic acid in unanesthetized rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Nov; 26(11):1378-88. doi: 10.1038/sj.jcbfm.9600290. [PMID: 16511499]
  • Kaveh M Koochesfahani, Raúl de la Fuente-Fernández, Vesna Sossi, Michael Schulzer, Lakshmi N Yatham, Thomas J Ruth, Stephan Blinder, A Jon Stoessl. Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies. Movement disorders : official journal of the Movement Disorder Society. 2006 Jul; 21(7):970-5. doi: 10.1002/mds.20857. [PMID: 16570297]
  • Cynthia A Munro, Mary E McCaul, Dean F Wong, Lynn M Oswald, Yun Zhou, James Brasic, Hiroto Kuwabara, Anil Kumar, Mohab Alexander, Weiguo Ye, Gary S Wand. Sex differences in striatal dopamine release in healthy adults. Biological psychiatry. 2006 May; 59(10):966-74. doi: 10.1016/j.biopsych.2006.01.008. [PMID: 16616726]
  • Stéphane Bastianetto, Marc Danik, Françoise Mennicken, Sylvain Williams, Rémi Quirion. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC neuroscience. 2006 Mar; 7(?):28. doi: 10.1186/1471-2202-7-28. [PMID: 16573831]
  • Luciano Minuzzi, Aage Kristian Olsen, Dirk Bender, Sidse Arnfred, Rebecca Grant, Erik H Danielsen, Paul Cumming. Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Göttingen minipig: comparison with results in vivo. Synapse (New York, N.Y.). 2006 Mar; 59(4):211-9. doi: 10.1002/syn.20234. [PMID: 16385509]
  • Gary Remington, David Mamo, Alain Labelle, Jeffrey Reiss, Chekkera Shammi, Erik Mannaert, Steve Mann, Shitij Kapur. A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone. The American journal of psychiatry. 2006 Mar; 163(3):396-401. doi: 10.1176/appi.ajp.163.3.396. [PMID: 16513859]
  • Hongxiang Lan, Curtiss J Durand, Martha M Teeter, Kim A Neve. Structural determinants of pharmacological specificity between D(1) and D(2) dopamine receptors. Molecular pharmacology. 2006 Jan; 69(1):185-94. doi: 10.1124/mol.105.017244. [PMID: 16236817]
  • Marc D Normandin, Evan D Morris. Temporal resolution of ntPET using either arterial or reference region-derived plasma input functions. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2006 ; 2006(?):2005-8. doi: 10.1109/iembs.2006.259716. [PMID: 17946491]
  • Maria-João Ribeiro, Marcel Ricard, Sandrine Bourgeois, Marie-Angele Lièvre, Michel Bottlaender, Philippe Gervais, Frédéric Dollé, André Syrota. Biodistribution and radiation dosimetry of [11C]raclopride in healthy volunteers. European journal of nuclear medicine and molecular imaging. 2005 Aug; 32(8):952-8. doi: 10.1007/s00259-005-1783-2. [PMID: 15841376]
  • Mohab Alexander, Richard B Rothman, Michael H Baumann, Christopher J Endres, James Robert Brasić, Dean F Wong. Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubis. Synapse (New York, N.Y.). 2005 May; 56(2):94-9. doi: 10.1002/syn.20126. [PMID: 15729739]
  • Shengwei Zou, Lei Li, Lin Pei, Brian Vukusic, Hubert H M Van Tol, Frank J S Lee, Qi Wan, Fang Liu. Protein-protein coupling/uncoupling enables dopamine D2 receptor regulation of AMPA receptor-mediated excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Apr; 25(17):4385-95. doi: 10.1523/jneurosci.5099-04.2005. [PMID: 15858065]
  • Lynn M Oswald, Dean F Wong, Mary McCaul, Yun Zhou, Hiroto Kuwabara, Leena Choi, James Brasic, Gary S Wand. Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005 Apr; 30(4):821-32. doi: 10.1038/sj.npp.1300667. [PMID: 15702139]
  • Nanna Marie Lind, Aage Kristian Olsen, Anette Moustgaard, Svend Borup Jensen, Steen Jakobsen, Axel Kornerup Hansen, Sidse Marie Arnfred, Ralf Peter Hemmingsen, Albert Gjedde, Paul Cumming. Mapping the amphetamine-evoked dopamine release in the brain of the Göttingen minipig. Brain research bulletin. 2005 Feb; 65(1):1-9. doi: 10.1016/j.brainresbull.2004.08.007. [PMID: 15680539]
  • Aurelija Jucaite, Elisabeth Fernell, Christer Halldin, Hans Forssberg, Lars Farde. Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity. Biological psychiatry. 2005 Feb; 57(3):229-38. doi: 10.1016/j.biopsych.2004.11.009. [PMID: 15691523]
  • Tiago M Alfaro, Emanuel Vigia, Catarina R Oliveira, Rodrigo A Cunha. Effect of free radicals on adenosine A(2A) and dopamine D2 receptors in the striatum of young adult and aged rats. Neurochemistry international. 2004 Oct; 45(5):733-8. doi: 10.1016/j.neuint.2004.02.003. [PMID: 15234116]