Unii-2Q6R3259KS (BioDeep_00000839970)

   


代谢物信息卡片


manganese(2+);(4R,9R,14R,19R)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(26),22,24-triene;dichloride

化学式: C21H35Cl2MnN5 (482.165)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC2C(C1)NCCNC3CCCCC3NCC4=CC=CC(=N4)CN2.[Cl-].[Cl-].[Mn+2]
InChI: InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20

描述信息

C26170 - Protective Agent > C275 - Antioxidant

同义名列表

12 个代谢物同义名

Unii-2Q6R3259KS; 2Q6R3259KS; imisopasem manganese; Imisopasem manganese (USAN/INN); IMISOPASEM MANGANESE [INN]; IMISOPASEM MANGANESE [MI]; Imisopasem manganese [USAN:INN]; IMISOPASEM MANGANESE [USAN]; IMISOPASEM MANGANESE [WHO-DD]; Imisopasem manganese dichloride; Manganese(2+) chloride--1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-icosahydro-7,11-(azeno)dibenzo[b,h][1,4,7,10]tetraazacycloheptadecine (1/2/1); Manganese(2+);(4R,9R,14R,19R)-3,10,13,20,26-pentazatetracyclo[20.3.1.04,9.014,19]hexacosa-1(26),22,24-triene;dichloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ana Stancic, Milos Filipovic, Ivana Ivanovic-Burmazovic, Sava Masovic, Aleksandra Jankovic, Vesna Otasevic, Aleksandra Korac, Biljana Buzadzic, Bato Korac. Early energy metabolism-related molecular events in skeletal muscle of diabetic rats: The effects of l-arginine and SOD mimic. Chemico-biological interactions. 2017 Jun; 272(?):188-196. doi: 10.1016/j.cbi.2017.05.003. [PMID: 28483572]
  • Muralidhar Kondapaneni, John R McGregor, Daniela Salvemini, Victor E Laubach, Wolfram E Samlowski. Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice. Journal of immunotherapy (Hagerstown, Md. : 1997). 2008 May; 31(4):325-33. doi: 10.1097/cji.0b013e31816112e8. [PMID: 18391763]
  • Rosanna Di Paola, Emanuela Mazzon, Federico Rotondo, Francesco Dattola, Domenico Britti, Massimo De Majo, Tiziana Genovese, Salvatore Cuzzocrea. Reduced development of experimental periodontitis by treatment with M40403, a superoxide dismutase mimetic. European journal of pharmacology. 2005 Jun; 516(2):151-7. doi: 10.1016/j.ejphar.2005.04.039. [PMID: 15921679]
  • Clara Di Filippo, Salvatore Cuzzocrea, Raffaele Marfella, Valentina Fabbroni, Giuseppe Scollo, Liberato Berrino, Dario Giugliano, Francesco Rossi, Michele D'Amico. M40403 prevents myocardial injury induced by acute hyperglycaemia in perfused rat heart. European journal of pharmacology. 2004 Aug; 497(1):65-74. doi: 10.1016/j.ejphar.2004.06.037. [PMID: 15321736]
  • Wolfram E Samlowski, Ryan Petersen, Salvatore Cuzzocrea, Heather Macarthur, Damali Burton, John R McGregor, Daniela Salvemini. A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects. Nature medicine. 2003 Jun; 9(6):750-5. doi: 10.1038/nm874. [PMID: 12730689]
  • Jeffrey A Sosman, James W Mier. Biological drug duo delivers one-two tumor punch. Nature medicine. 2003 Jun; 9(6):649-50. doi: 10.1038/nm0603-649. [PMID: 12778160]
  • Salvatore Cuzzocrea, Emanuela Mazzon, Laura Dugo, Ivana Serraino, Rosanna Di Paola, Domenico Britti, Angela De Sarro, Simone Pierpaoli, Achille Caputi, Emanuela Masini, Daniela Salvemini. A role for superoxide in gentamicin-mediated nephropathy in rats. European journal of pharmacology. 2002 Aug; 450(1):67-76. doi: 10.1016/s0014-2999(02)01749-1. [PMID: 12176111]
  • Emanuela Masini, Salvatore Cuzzocrea, Emanuela Mazzon, Cosimo Marzocca, Pier Francesco Mannaioni, Daniela Salvemini. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. British journal of pharmacology. 2002 Jul; 136(6):905-17. doi: 10.1038/sj.bjp.0704774. [PMID: 12110615]
  • Daniela Salvemini, Salvatore Cuzzocrea. Superoxide, superoxide dismutase and ischemic injury. Current opinion in investigational drugs (London, England : 2000). 2002 Jun; 3(6):886-95. doi: ". [PMID: 12137408]
  • Jeffrey J Lysiak, Quoc An T Nguyen, Terry T Turner. Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsion. Journal of andrology. 2002 May; 23(3):400-9. doi: ". [PMID: 12002442]
  • S Cuzzocrea, E Mazzon, L Dugo, A P Caputi, D P Riley, D Salvemini. Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis. European journal of pharmacology. 2001 Nov; 432(1):79-89. doi: 10.1016/s0014-2999(01)01427-3. [PMID: 11734191]
  • L J Coppey, J S Gellett, E P Davidson, J A Dunlap, D D Lund, D Salvemini, M A Yorek. Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. British journal of pharmacology. 2001 Sep; 134(1):21-9. doi: 10.1038/sj.bjp.0704216. [PMID: 11522593]
  • D Salvemini, E Mazzon, L Dugo, D P Riley, I Serraino, A P Caputi, S Cuzzocrea. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403. British journal of pharmacology. 2001 Feb; 132(4):815-27. doi: 10.1038/sj.bjp.0703841. [PMID: 11181422]
  • H Macarthur, T C Westfall, D P Riley, T P Misko, D Salvemini. Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proceedings of the National Academy of Sciences of the United States of America. 2000 Aug; 97(17):9753-8. doi: 10.1073/pnas.97.17.9753. [PMID: 10944234]