Loprazolam mesylate (BioDeep_00000839959)
代谢物信息卡片
化学式: C24H25ClN6O6S (560.1245)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(CC1)C=C2C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl.CS(=O)(=O)O
InChI: 1H3,(H,2,3,4)/b19-14-
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- M C Dorling, I Hindmarch. Pharmacokinetic profile of loprazolam in 12 young and 12 elderly healthy volunteers.
Drugs under experimental and clinical research.
2001; 27(4):151-9. doi:
NULL. [PMID: 11822225] - B Marc, F Baudry, P Vaquero, L Zerrouki, S Hassnaoui, H Douceron. Sexual assault under benzodiazepine submission in a Paris suburb.
Archives of gynecology and obstetrics.
2000 Apr; 263(4):193-7. doi:
10.1007/s004040050282. [PMID: 10834331] - S R Bareggi, R Pirola, G Truci, S Leva, S Smirne. Effect of after-dinner administration on the pharmacokinetics of oral flunitrazepam and loprazolam.
Journal of clinical pharmacology.
1988 Apr; 28(4):371-5. doi:
10.1002/j.1552-4604.1988.tb03161.x. [PMID: 3392235] - M Mamelak, P Bunting, H Galin, V Price, A Csima, T Young, D Klein, J R Pelchat. Serum and quantitative electroencephalographic pharmacokinetics of loprazolam in the elderly.
Journal of clinical pharmacology.
1988 Apr; 28(4):376-83. doi:
10.1002/j.1552-4604.1988.tb03162.x. [PMID: 3392236] - S Ford, S I Ankier, D Corless, C D Bevan, A W Pidgen, J D Robinson, D C Rangedara. Pharmacokinetics of loprazolam and its principal metabolite in young subjects and elderly hospital patients.
Xenobiotica; the fate of foreign compounds in biological systems.
1987 Aug; 17(8):1001-9. doi:
10.3109/00498258709044199. [PMID: 2890241] - R Jochemsen, P A van Rijn, T G Hazelzet, C J van Boxtel, D D Breimer. Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration.
Biopharmaceutics & drug disposition.
1986 Jan; 7(1):53-61. doi:
10.1002/bdd.2510070108. [PMID: 2869795] - F A Levasseur, G Caillé, R Elie, M Vézina, L Larivière. Electron-capture gas chromatographic determination of loprazolam in plasma and a pharmacokinetic application.
Biopharmaceutics & drug disposition.
1985 Oct; 6(4):381-7. doi:
10.1002/bdd.2510060404. [PMID: 2867794] - C G Swift, M R Swift, S I Ankier, A Pidgen, J Robinson. Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly.
British journal of clinical pharmacology.
1985 Aug; 20(2):119-28. doi:
10.1111/j.1365-2125.1985.tb05041.x. [PMID: 2864049] - L A Stevens, A W Pidgen, C D Bevan, R M Ings, J R Lawrence, J McEwen. Correlation of the clinical pharmacodynamics of loprazolam with serum concentration.
Xenobiotica; the fate of foreign compounds in biological systems.
1985 Jul; 15(7):623-31. doi:
10.3109/00498258509045892. [PMID: 4049902] - G T McInnes, E A Bunting, R M Ings, J Robinson, S I Ankier. Pharmacokinetics and pharmacodynamics following single and repeated nightly administrations of loprazolam, a new benzodiazepine hypnotic.
British journal of clinical pharmacology.
1985 May; 19(5):649-56. doi:
10.1111/j.1365-2125.1985.tb02692.x. [PMID: 2860916] - K Adam, I Oswald, C Shapiro. Effects of loprazolam and of triazolam on sleep and overnight urinary cortisol.
Psychopharmacology.
1984; 82(4):389-94. doi:
10.1007/bf00427692. [PMID: 6145179] - H P Illing, C D Bevan, J D Robinson, J Chamberlain, J M Fromson. Metabolism of loprazolam in rat, dog and man in vivo.
Xenobiotica; the fate of foreign compounds in biological systems.
1983 Sep; 13(9):539-53. doi:
10.3109/00498258309052294. [PMID: 6659550] - H P Illing, R M Ings, K I Johnson, J M Fromson. Disposition of 14C-loprazolam in animals and man.
Xenobiotica; the fate of foreign compounds in biological systems.
1983 Jul; 13(7):439-49. doi:
10.3109/00498258309052282. [PMID: 6140793] - A N Nicholson, B M Stone. Imidazobenzodiazepines: sleep and performance studies in humans.
Journal of clinical psychopharmacology.
1983 Apr; 3(2):72-5. doi:
NULL. [PMID: 6841664] - P Hunt, J M Husson, J P Raynaud. A radioreceptor assay for benzodiazepines.
The Journal of pharmacy and pharmacology.
1979 Jul; 31(7):448-51. doi:
10.1111/j.2042-7158.1979.tb13551.x. [PMID: 38313]
