Ipsapirone hydrochloride (BioDeep_00000839927)
代谢物信息卡片
Ipsapirone hydrochloride
化学式: C19H24ClN5O3S (437.1288304000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NC=CC=N4.Cl
InChI: 1H
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
同义名列表
1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Erik Sjögren, David Dahlgren, Carl Roos, Hans Lennernäs. Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data.
Molecular pharmaceutics.
2015 Jun; 12(6):2026-39. doi:
10.1021/mp500834v. [PMID: 25919764] - Marcela Almeida, Royce Lee, Emil F Coccaro. Cortisol responses to ipsapirone challenge correlate with aggression, while basal cortisol levels correlate with impulsivity, in personality disorder and healthy volunteer subjects.
Journal of psychiatric research.
2010 Oct; 44(14):874-80. doi:
10.1016/j.jpsychires.2010.02.012. [PMID: 20378126] - Michael J Minzenberg, Robert Grossman, Antonia S New, Vivian Mitropoulou, Rachel Yehuda, Marianne Goodman, Diedre A Reynolds, Jeremy M Silverman, Emil F Coccaro, Sue Marcus, Larry J Siever. Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2006 Jan; 31(1):197-203. doi:
10.1038/sj.npp.1300853. [PMID: 16123761] - Mary J Druse, Nuzhath F Tajuddin, Roberta A Gillespie, Elizabeth Dickson, Mohammed Atieh, Constance A Pietrzak, Phong T Le. The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons.
Brain research. Developmental brain research.
2004 Jun; 150(2):79-88. doi:
10.1016/j.devbrainres.2004.02.009. [PMID: 15158072] - Nicholas J Delva, Deborah L Brooks, Michael Franklin, Khalid al-Said, Emily R Hawken, Zul Merali, J Stuart Lawson, Arun V Ravindran. Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects.
Journal of psychiatry & neuroscience : JPN.
2002 Nov; 27(6):429-37. doi:
NULL. [PMID: 12491576] - A Broocks, B Bandelow, K Koch, U Bartmann, J Kinkelbur, U Schweiger, F Hohagen, G Hajak. Smoking modulates neuroendocrine responses to ipsapirone in patients with panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2002 Aug; 27(2):270-8. doi:
10.1016/s0893-133x(02)00298-1. [PMID: 12093600] - M A Lee, H Y Meltzer. 5-HT(1A) receptor dysfunction in female patients with schizophrenia.
Biological psychiatry.
2001 Nov; 50(10):758-66. doi:
10.1016/s0006-3223(01)01202-1. [PMID: 11720694] - A Broocks, T Meyer, C H Gleiter, U Hillmer-Vogel, A George, U Bartmann, B Bandelow. Effect of aerobic exercise on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine and to ipsapirone in untrained healthy subjects.
Psychopharmacology.
2001 May; 155(3):234-41. doi:
10.1007/s002130100706. [PMID: 11432685] - V Fabre, C Beaufour, A Evrard, A Rioux, N Hanoun, K P Lesch, D L Murphy, L Lanfumey, M Hamon, M P Martres. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter.
The European journal of neuroscience.
2000 Jul; 12(7):2299-310. doi:
10.1046/j.1460-9568.2000.00126.x. [PMID: 10947809] - V Fabre, B Boutrel, N Hanoun, L Lanfumey, C M Fattaccini, B Demeneix, J Adrien, M Hamon, M P Martres. Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2000 Jul; 20(13):5065-75. doi:
NULL. [PMID: 10864964] - A Broocks, B Bandelow, A George, C Jestrabeck, M Opitz, U Bartmann, C H Gleiter, I Meineke, I S Roed, E Rüther, G Hajak. Increased psychological responses and divergent neuroendocrine responses to m-CPP and ipsapirone in patients with panic disorder.
International clinical psychopharmacology.
2000 May; 15(3):153-61. doi:
10.1097/00004850-200015030-00004. [PMID: 10870873] - B Lerer, Y Gelfin, M Gorfine, B Allolio, K P Lesch, M E Newman. 5-HT1A receptor function in normal subjects on clinical doses of fluoxetine: blunted temperature and hormone responses to ipsapirone challenge.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
1999 Jun; 20(6):628-39. doi:
10.1016/s0893-133x(98)00106-7. [PMID: 10327431] - H Hildebrand, M Rinke, G Schlüter, E Bomhard, F W Falkenberg. Urinary antigens as markers of papillary toxicity. II: Application of monoclonal antibodies for the determination of papillary antigens in rat urine.
Archives of toxicology.
1999 Jun; 73(4-5):233-45. doi:
10.1007/s002040050612. [PMID: 10463389] - P J Schwartz, E H Turner, D Garcia-Borreguero, J Sedway, R G Vetticad, T A Wehr, D L Murphy, N E Rosenthal. Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects.
Psychiatry research.
1999 Apr; 86(1):9-28. doi:
10.1016/s0165-1781(99)00017-7. [PMID: 10359479] - A Broocks, T Meyer, A George, U Hillmer-Vogel, D Meyer, B Bandelow, G Hajak, U Bartmann, C H Gleiter, E Rüther. Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
1999 Feb; 20(2):150-61. doi:
10.1016/s0893-133x(98)00056-6. [PMID: 9885795] - I S Shiah, L N Yatham, R W Lam, A P Zis. Effects of lamotrigine on the 5-HT1A receptor function in healthy human males.
Journal of affective disorders.
1998 May; 49(2):157-62. doi:
10.1016/s0165-0327(98)00008-1. [PMID: 9609681] - I Berlin, D Warot, V Legout, S Guillemant, G Schöllnhammer, A J Puech. Blunted 5-HT1A-receptor agonist-induced corticotropin and cortisol responses after long-term ipsapirone and fluoxetine administration to healthy subjects.
Clinical pharmacology and therapeutics.
1998 Apr; 63(4):428-36. doi:
10.1016/s0009-9236(98)90038-8. [PMID: 9585797] - U E Busto, C A Naranjo, K E Bremner, J E Peachey, M Bologa. Safety of ipsapirone treatment compared with lorazepam: discontinuation effects.
Journal of psychiatry & neuroscience : JPN.
1998 Jan; 23(1):35-44. doi:
NULL. [PMID: 9505058] - M Rinke, E M Bomhard, H Hildebrand, K H Leser, I Loof, C Ruehl-Fehlert. Serotonin (5-HT1A-receptor) agonist-induced collecting duct vacuolation and renal papillary necrosis in the rat.
Toxicologic pathology.
1998 Jan; 26(1):152-9. doi:
10.1177/019262339802600118. [PMID: 9502398] - N Laaris, E Le Poul, M Hamon, L Lanfumey. Stress-induced alterations of somatodendritic 5-HT1A autoreceptor sensitivity in the rat dorsal raphe nucleus--in vitro electrophysiological evidence.
Fundamental & clinical pharmacology.
1997; 11(3):206-14. doi:
10.1111/j.1472-8206.1997.tb00187.x. [PMID: 9243251] - P J Nathan, T R Norman, G D Burrows. Nocturnal plasma melatonin concentrations in healthy volunteers: effect of single doses of d-fenfluramine, paroxetine, and ipsapirone.
Journal of pineal research.
1996 Sep; 21(2):55-8. doi:
10.1111/j.1600-079x.1996.tb00271.x. [PMID: 8912230] - G K Matheson, B U Raess, G Tunnicliff. Effects of repeated doses of azapirones on rat brain 5-HT1A receptors and plasma corticosterone levels.
General pharmacology.
1996 Mar; 27(2):355-61. doi:
10.1016/0306-3623(95)02027-6. [PMID: 8919656] - H Y Meltzer, M Maes. Effects of ipsapirone on plasma cortisol and body temperature in major depression.
Biological psychiatry.
1995 Oct; 38(7):450-7. doi:
10.1016/0006-3223(94)00370-i. [PMID: 8672605] - C Opper, J Hennig, C Clement, U Laschefski, D Dey, J Dieckwisch, P Netter, W Wesemann. Lowering of body temperature affects human platelet functions and norepinephrine release.
Pharmacology, biochemistry, and behavior.
1995 Jun; 51(2-3):217-21. doi:
10.1016/0091-3057(94)00432-i. [PMID: 7667331] - I Berlin, S Chalon, C Payan, G Schöllnhammer, F Cesselin, O Varoquaux, A J Puech. Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine.
British journal of clinical pharmacology.
1995 Mar; 39(3):243-9. doi:
10.1111/j.1365-2125.1995.tb04443.x. [PMID: 7619663] - Q Li, M S Brownfield, A D Levy, G Battaglia, T M Cabrera, L D Van de Kar. Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats.
Biological psychiatry.
1994 Sep; 36(5):300-8. doi:
10.1016/0006-3223(94)90627-0. [PMID: 7993956] - T W Gettys, T A Fields, J R Raymond. Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptor.
Biochemistry.
1994 Apr; 33(14):4283-90. doi:
10.1021/bi00180a024. [PMID: 8155646] - G Bagdy, G B Makara. Hypothalamic paraventricular nucleus lesions differentially affect serotonin-1A (5-HT1A) and 5-HT2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses.
Endocrinology.
1994 Mar; 134(3):1127-31. doi:
10.1210/endo.134.3.8119151. [PMID: 8119151] - H Y Meltzer, M Maes. Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects.
Biological psychiatry.
1994 Mar; 35(5):316-23. doi:
10.1016/0006-3223(94)90035-3. [PMID: 8011800] - G Bagdy, K T Kalogeras. Stimulation of 5-HT1A and 5-HT2/5-HT1C receptors induce oxytocin release in the male rat.
Brain research.
1993 May; 611(2):330-2. doi:
10.1016/0006-8993(93)90521-n. [PMID: 8334526] - V Baudrie, J De Vry, P Broqua, B Schmidt, F Chaouloff, T Glaser. Subchronic treatment with anxiolytic doses of the 5-HT1A receptor agonist ipsapirone does not affect 5-HT2 receptor sensitivity in the rat.
European journal of pharmacology.
1993 Feb; 231(3):395-406. doi:
10.1016/0014-2999(93)90116-y. [PMID: 8095465] - J E Welch, G E Farrar, A J Dunn, D Saphier. Central 5-HT1A receptors inhibit adrenocortical secretion.
Neuroendocrinology.
1993; 57(2):272-81. doi:
10.1159/000126369. [PMID: 8510803] - B H Schmidt, F Chaouloff. Chronic treatment with an anxiolytic dose of the 5-HT1A agonist ipsapirone does not alter ipsapirone acute neuroendocrine effects.
Psychoneuroendocrinology.
1993; 18(7):457-66. doi:
10.1016/0306-4530(93)90039-n. [PMID: 7903466] - Q Li, P A Rittenhouse, A D Levy, M C Alvarez Sanz, L D Van de Kar. Neuroendocrine responses to the serotonin2 agonist DOI are differentially modified by three 5-HT1A agonists.
Neuropharmacology.
1992 Oct; 31(10):983-9. doi:
10.1016/0028-3908(92)90098-a. [PMID: 1359439] - S M Korte, G A Bouws, J M Koolhaas, B Bohus. Neuroendocrine and behavioral responses during conditioned active and passive behavior in the defensive burying/probe avoidance paradigm: effects of ipsapirone.
Physiology & behavior.
1992 Aug; 52(2):355-61. doi:
10.1016/0031-9384(92)90284-9. [PMID: 1355919] - D Kelder, S B Ross. Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist.
Naunyn-Schmiedeberg's archives of pharmacology.
1992 Aug; 346(2):121-6. doi:
10.1007/bf00165292. [PMID: 1448177] - S M Korte, G A Bouws, B Bohus. Adrenal hormones in rats before and after stress-experience: effects of ipsapirone.
Physiology & behavior.
1992 Jun; 51(6):1129-33. doi:
10.1016/0031-9384(92)90298-g. [PMID: 1353629] - P A Rittenhouse, E A Bakkum, P A O'Connor, M Carnes, C L Bethea, L D van de Kar. Comparison of neuroendocrine and behavioral effects of ipsapirone, a 5-HT1A agonist, in three stress paradigms: immobilization, forced swim and conditioned fear.
Brain research.
1992 May; 580(1-2):205-14. doi:
10.1016/0006-8993(92)90946-7. [PMID: 1354556] - M Beneke, W Wingender, R Horstmann, I Konrad-Dalhoff, H Weber, J Kuhlmann, B H Schmidt. Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers.
European journal of clinical pharmacology.
1992; 42(2):163-9. doi:
10.1007/bf00278478. [PMID: 1352246] - V Baudrie, F Chaouloff. Repeated treatment with the 5-HT1A receptor agonist, ipsapirone, does not affect 8-OH-DPAT- and stress-induced increases in plasma adrenaline levels in the rat.
European journal of pharmacology.
1991 Jun; 198(2-3):129-35. doi:
10.1016/0014-2999(91)90611-s. [PMID: 1830845] - E Przegaliński, B Budziszewska, A Grochmal. Oxaprotiline enantiomers stimulate ACTH and corticosterone secretion in the rat.
Journal of neural transmission. General section.
1991; 85(3):211-22. doi:
10.1007/bf01244946. [PMID: 1681823] - B Przewłocka, A Sumová, W Lasoń. The influence of conditioned fear-induced stress on the opioid systems in the rat.
Pharmacology, biochemistry, and behavior.
1990 Dec; 37(4):661-6. doi:
10.1016/0091-3057(90)90543-q. [PMID: 1982694] - S M Korte, J Smit, G A Bouws, J M Koolhaas, B Bohus. Behavioral and neuroendocrine response to psychosocial stress in male rats: the effects of the 5-HT 1A agonist ipsapirone.
Hormones and behavior.
1990 Dec; 24(4):554-67. doi:
10.1016/0018-506x(90)90041-u. [PMID: 1981046] - M J Owens, E Edwards, C B Nemeroff. Effects of 5-HT1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain.
European journal of pharmacology.
1990 Nov; 190(1-2):113-22. doi:
10.1016/0014-2999(90)94118-h. [PMID: 1963847] - A Di Sciullo, M T Bluet-Pajot, F Mounier, C Oliver, B Schmidt, C Kordon. Changes in anterior pituitary hormone levels after serotonin 1A receptor stimulation.
Endocrinology.
1990 Aug; 127(2):567-72. doi:
10.1210/endo-127-2-567. [PMID: 2164913] - P J Cowen, I M Anderson, D G Grahame-Smith. Neuroendocrine effects of azapirones.
Journal of clinical psychopharmacology.
1990 Jun; 10(3 Suppl):21S-25S. doi:
10.1097/00004714-199006001-00005. [PMID: 1973937] - K P Lesch, K Söhnle, B Poten, G Schoellnhammer, R Rupprecht, H M Schulte. Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists.
The Journal of clinical endocrinology and metabolism.
1990 Mar; 70(3):670-4. doi:
10.1210/jcem-70-3-670. [PMID: 1968468] - F Chaouloff, V Baudrie, D Laude. Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat.
European journal of pharmacology.
1990 Feb; 177(1-2):107-10. doi:
10.1016/0014-2999(90)90558-n. [PMID: 2340854] - J F Nash, H Y Meltzer. Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat.
The Journal of pharmacology and experimental therapeutics.
1989 Apr; 249(1):236-41. doi:
NULL. [PMID: 2565390] - G Bianchi, S Caccia. Simultaneous determination of buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)piperazine in rat plasma and brain by high-performance liquid chromatography.
Journal of chromatography.
1988 Oct; 431(2):477-80. doi:
10.1016/s0378-4347(00)83123-0. [PMID: 2907515] - G Bianchi, S Caccia, F Della Vedova, S Garattini. The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP).
European journal of pharmacology.
1988 Jul; 151(3):365-71. doi:
10.1016/0014-2999(88)90532-8. [PMID: 2905658] - J I Koenig, H Y Meltzer, G A Gudelsky. 5-Hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone.
Pharmacology, biochemistry, and behavior.
1988 Apr; 29(4):711-5. doi:
10.1016/0091-3057(88)90192-x. [PMID: 2901112] - F Gilbert, C Brazell, M D Tricklebank, S M Stahl. Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration.
European journal of pharmacology.
1988 Mar; 147(3):431-9. doi:
10.1016/0014-2999(88)90178-1. [PMID: 2897920] - F Gilbert, C T Dourish, C Brazell, S McClue, S M Stahl. Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats.
Psychoneuroendocrinology.
1988; 13(6):471-8. doi:
10.1016/0306-4530(88)90032-7. [PMID: 2907164] - S A Lorens, L D Van de Kar. Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion.
Neuroendocrinology.
1987 Apr; 45(4):305-10. doi:
10.1159/000124754. [PMID: 2952898]