Ranelic acid (BioDeep_00000839897)
代谢物信息卡片
Ranelic acid
化学式: C12H10N2O8S (342.01578600000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C1=C(SC(=C1C#N)N(CC(=O)O)CC(=O)O)C(=O)O)C(=O)O
InChI: InChI=1S/C12H10N2O8S/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yunfeng Li, Xudong Li, Guodong Song, Kan Chen, Guozhu Yin, Jing Hu. Effects of strontium ranelate on osseointegration of titanium implant in osteoporotic rats.
Clinical oral implants research.
2012 Sep; 23(9):1038-44. doi:
10.1111/j.1600-0501.2011.02252.x. [PMID: 22117625] - J Y Reginster, O Bruyere, J Collette. Strontium ranelate treatment increases osteoprotegerin serum levels in postmenopausal osteoporotic women.
Bone.
2012 May; 50(5):1201-2; author reply 1203. doi:
10.1016/j.bone.2011.12.024. [PMID: 22270053] - Jehoon Lee, Samuel Vasikaran. Current recommendations for laboratory testing and use of bone turnover markers in management of osteoporosis.
Annals of laboratory medicine.
2012 Mar; 32(2):105-12. doi:
10.3343/alm.2012.32.2.105. [PMID: 22389876] - Yunfeng Li, Jihua Li, Songsong Zhu, En Luo, Ge Feng, Qianming Chen, Jing Hu. Effects of strontium on proliferation and differentiation of rat bone marrow mesenchymal stem cells.
Biochemical and biophysical research communications.
2012 Feb; 418(4):725-30. doi:
10.1016/j.bbrc.2012.01.088. [PMID: 22306818] - C Fournier, A Perrier, M Thomas, N Laroche, V Dumas, A Rattner, L Vico, A Guignandon. Reduction by strontium of the bone marrow adiposity in mice and repression of the adipogenic commitment of multipotent C3H10T1/2 cells.
Bone.
2012 Feb; 50(2):499-509. doi:
10.1016/j.bone.2011.07.038. [PMID: 21839191] - Serap Yalin, Ozgun Sagír, Ulku Comelekoglu, Mehmet Berköz, Pelin Eroglu. Strontium ranelate treatment improves oxidative damage in osteoporotic rat model.
Pharmacological reports : PR.
2012; 64(2):396-402. doi:
10.1016/s1734-1140(12)70780-6. [PMID: 22661191] - R Rizzoli, R D Chapurlat, J-M Laroche, M A Krieg, T Thomas, I Frieling, S Boutroy, A Laib, O Bock, D Felsenberg. Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2012 Jan; 23(1):305-15. doi:
10.1007/s00198-011-1758-z. [PMID: 21909729] - Terry J Aspray, Roger M Francis. Treatment of osteoporosis in women intolerant of oral bisphosphonates.
Maturitas.
2012 Jan; 71(1):76-8. doi:
10.1016/j.maturitas.2011.10.005. [PMID: 22079368] - Zekeriya Ulger, Esin Ileri Gurel, Meltem Halil, Gulsen Oozen, Isilay Kalan, Nurten Seringec, Burcu Balam Yavuz, Yusuf Yesil, Mustafa Cankurtaran, Neslihan Dikmenoglu, Servet Ariogul. Hemorheological changes with strontium ranelate treatment do not seem to be related to its claimed prothrombotic effects.
Archives of gerontology and geriatrics.
2012 Jan; 54(1):218-21. doi:
10.1016/j.archger.2010.11.024. [PMID: 21167612] - Kristyna Brabnikova Maresova, Tomas Franek, Tomas Vondracek, Jan J Stepan. A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption.
Clinical chemistry and laboratory medicine.
2011 Nov; 50(2):333-5. doi:
10.1515/cclm.2011.781. [PMID: 22080821] - Bernhard Pemmer, Jochen G Hofstaetter, Florian Meirer, Stephan Smolek, Peter Wobrauschek, Rolf Simon, Robyn K Fuchs, Matthew R Allen, Keith W Condon, Susan Reinwald, Roger J Phipps, David B Burr, Eleftherios P Paschalis, Klaus Klaushofer, Christina Streli, Paul Roschger. Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride.
Journal of synchrotron radiation.
2011 Nov; 18(Pt 6):835-41. doi:
10.1107/s090904951103038x. [PMID: 21997907] - Wei Qi, Pu-jie Wang, Wen-jun Guo, Ya-bo Yan, Yang Zhang, Wei Lei. The mechanism of Cordyceps sinensis and strontium in prevention of osteoporosis in rats.
Biological trace element research.
2011 Oct; 143(1):302-9. doi:
10.1007/s12011-010-8829-4. [PMID: 20803174] - N N C Carvalho, L A Voss, M O P Almeida, C L Salgado, F Bandeira. Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide.
The Journal of clinical endocrinology and metabolism.
2011 Sep; 96(9):2675-80. doi:
10.1210/jc.2011-0593. [PMID: 21752890] - Abdullah Foraih Al-Anazi, Viquar Fatima Qureshi, Khalida Javaid, Shoeb Qureshi. Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: An overview.
Journal of natural science, biology, and medicine.
2011 Jul; 2(2):154-63. doi:
10.4103/0976-9668.92322. [PMID: 22346228] - P Alexandersen, M A Karsdal, I Byrjalsen, C Christiansen. Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis.
Climacteric : the journal of the International Menopause Society.
2011 Apr; 14(2):236-43. doi:
10.3109/13697137.2010.507887. [PMID: 20726814] - Gilbert R Kaats, Harry G Preuss, Harry A Croft, Samuel C Keith, Patti L Keith. A comparative effectiveness study of bone density changes in women over 40 following three bone health plans containing variations of the same novel plant-sourced calcium.
International journal of medical sciences.
2011 Mar; 8(3):180-91. doi:
10.7150/ijms.8.180. [PMID: 21448303] - Annemarie Brüel, Jakob Olsen, Henrik Birkedal, Malene Risager, Troels Torp Andreassen, Anders Christer Raffalt, Jens Enevold Thaulov Andersen, Jesper Skovhus Thomsen. Strontium is incorporated into the fracture callus but does not influence the mechanical strength of healing rat fractures.
Calcified tissue international.
2011 Feb; 88(2):142-52. doi:
10.1007/s00223-010-9439-z. [PMID: 21153023] - V Geoffroy, D Chappard, C Marty, H Libouban, A Ostertag, A Lalande, M-C de Vernejoul. Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2011 Jan; 22(1):289-97. doi:
10.1007/s00198-010-1193-6. [PMID: 20204596] - Björn Jobke, Andrew J Burghardt, Burkhard Muche, Michael Hahn, Jutta Semler, Michael Amling, Sharmila Majumdar, Björn Busse. Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment.
PloS one.
2011; 6(8):e23638. doi:
10.1371/journal.pone.0023638. [PMID: 21858188] - Katarzyna Kupisiewicz, Patrice Boissy, Basem M Abdallah, Frederik Dagnaes Hansen, Reinhold G Erben, Jean-Francois Savouret, Kent Søe, Thomas L Andersen, Torben Plesner, Jean-Marie Delaisse. Potential of resveratrol analogues as antagonists of osteoclasts and promoters of osteoblasts.
Calcified tissue international.
2010 Nov; 87(5):437-49. doi:
10.1007/s00223-010-9399-3. [PMID: 20842496] - Zhaoping Li, Hannah Karp, Alona Zerlin, Tsz Ying Amy Lee, Catherine Carpenter, David Heber. Absorption of silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study.
Nutrition journal.
2010 Oct; 9(?):44. doi:
10.1186/1475-2891-9-44. [PMID: 20946656] - Enrico M Messalli, Cono Scaffa. Long-term safety and efficacy of raloxifene in the prevention and treatment of postmenopausal osteoporosis: an update.
International journal of women's health.
2010 Aug; 1(?):11-20. doi:
10.2147/ijwh.s3894. [PMID: 21072271] - Gustavo Duque, Jacqueline J Close, Julien P de Jager, Peter R Ebeling, Charles Inderjeeth, Stephen Lord, Andrew J McLachlan, Ian R Reid, Bruce R Troen, Philip N Sambrook. Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention.
The Medical journal of Australia.
2010 Aug; 193(3):173-9. doi:
10.5694/j.1326-5377.2010.tb03839.x. [PMID: 20678047] - S Takaoka, T Yamaguchi, S Yano, M Yamauchi, T Sugimoto. The Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2010 Aug; 42(9):627-31. doi:
10.1055/s-0030-1255091. [PMID: 20560105] - O Bruyère, J Collette, R Rizzoli, C Decock, S Ortolani, C Cormier, J Detilleux, J-Y Reginster. Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2010 Jun; 21(6):1031-6. doi:
10.1007/s00198-009-1078-8. [PMID: 19813043] - Rui Yang, Zhen Huang, De-hong Cai, Hua Zhang, A-na Lai, Zhen Zhang, Ping Sun, Hong Chen. [Preventive and therapeutic effect of strontium ranelate on osteoporosis in rats subjected to simulated weightlessness].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Apr; 30(4):834-7. doi:
NULL. [PMID: 20423860] - Isabel Oliveira de Sousa, Erik Trovão Diniz, Thyciara Fontenele Marques, Luiz Griz, Mário de Almeida Pereira Coutinho, Francisco Bandeira. Short-term bone marker responses to teriparatide and strontium ranelate in patients with osteoporosis previously treated with bisphosphonates.
Arquivos brasileiros de endocrinologia e metabologia.
2010 Mar; 54(2):244-9. doi:
10.1590/s0004-27302010000200023. [PMID: 20485916] - Deepa Iyer, Yvonne Buggy, Katherine O'Reilly, Martin Searle. Strontium ranelate as a cause of acute renal failure and dress syndrome.
Nephrology (Carlton, Vic.).
2009 Sep; 14(6):624. doi:
10.1111/j.1440-1797.2009.01125.x. [PMID: 19712264] - S D Bain, C Jerome, V Shen, I Dupin-Roger, P Ammann. Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2009 Aug; 20(8):1417-28. doi:
10.1007/s00198-008-0815-8. [PMID: 19096745] - Robert R Recker, Fernando Marin, Sophia Ish-Shalom, Rüdiger Möricke, Federico Hawkins, Georgios Kapetanos, María P de la Peña, Jörn Kekow, Jordi Farrerons, Beatriz Sanz, Heide Oertel, Jan Stepan. Comparative effects of teriparatide and strontium ranelate on bone biopsies and biochemical markers of bone turnover in postmenopausal women with osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2009 Aug; 24(8):1358-68. doi:
10.1359/jbmr.090315. [PMID: 19338452] - Athanasios D Anastasilakis, Dimirtios G Goulis, Stergios A Polyzos, Spiridon Gerou, Iris Ballaouri, Zoe Efstathiadou, Marina Kita, Avraam Avramidis. No difference between strontium ranelate (SR) and calcium/vitamin D on bone turnover markers in women with established osteoporosis previously treated with teriparatide: a randomized controlled trial.
Clinical endocrinology.
2009 Apr; 70(4):522-6. doi:
10.1111/j.1365-2265.2008.03342.x. [PMID: 18625000] - M Gutierrez, E Filippucci, L Bugatti, C Bertolazzi, W Grassi. [Severe drug hypersensitivity syndrome due to sulphasalazine in patient with rheumatoid arthritis].
Reumatismo.
2009 Jan; 61(1):65-8. doi:
10.4081/reumatismo.2009.65. [PMID: 19370190] - Ilhan Bayhan, Dilek Uygur, Nil Ugurlu, Gulnur Ozaksit. Strontium ranelate decreases plasma homocysteine levels in postmenopausal osteoporotic women.
Rheumatology international.
2009 Jan; 29(3):263-6. doi:
10.1007/s00296-008-0693-6. [PMID: 18818926] - Olivier Bruyère, Nansa Burlet, Pierre D Delmas, René Rizzoli, Cyrus Cooper, Jean-Yves Reginster. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
BMC musculoskeletal disorders.
2008 Dec; 9(?):165. doi:
10.1186/1471-2474-9-165. [PMID: 19087296] - Luigi Gennari, Daniela Merlotti, Vincenzo De Paola, Giuseppe Martini, Ranuccio Nuti. Bazedoxifene for the prevention of postmenopausal osteoporosis.
Therapeutics and clinical risk management.
2008 Dec; 4(6):1229-42. doi:
10.2147/tcrm.s3476. [PMID: 19337430] - M A Karsdal, I Byrjalsen, D J Leeming, C Christiansen. Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation.
BMC musculoskeletal disorders.
2008 Nov; 9(?):153. doi:
10.1186/1471-2474-9-153. [PMID: 19019210] - Ibrahim Gulhan, Sibel Bilgili, Rezzan Gunaydin, Sibel Gulhan, Cemal Posaci. The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study.
Archives of gynecology and obstetrics.
2008 Nov; 278(5):437-41. doi:
10.1007/s00404-008-0611-x. [PMID: 18322691] - J S Hwang, J F Chen, T S Yang, D J Wu, K S Tsai, C Ho, C H Wu, S L Su, C J Wang, S T Tu. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis.
Calcified tissue international.
2008 Nov; 83(5):308-14. doi:
10.1007/s00223-008-9180-z. [PMID: 18843436] - R K Fuchs, M R Allen, K W Condon, S Reinwald, L M Miller, D McClenathan, B Keck, R J Phipps, D B Burr. Strontium ranelate does not stimulate bone formation in ovariectomized rats.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2008 Sep; 19(9):1331-41. doi:
10.1007/s00198-008-0602-6. [PMID: 18385919] - Yair Yodfat. [What's new in postmenopausal osteoporosis].
Harefuah.
2007 Feb; 146(2):134-9, 164. doi:
NULL. [PMID: 17352284] - Meltem Halil, Mustafa Cankurtaran, Burcu Balam Yavuz, Zekeriya Ulger, Serhan Piskinpasa, Arzu Gedik, Ibrahim Celalettin Haznedaroglu, Serafettin Kirazli, Servet Ariogul. Short-term hemostatic safety of strontium ranelate treatment in elderly women with osteoporosis.
The Annals of pharmacotherapy.
2007 Jan; 41(1):41-5. doi:
10.1345/aph.1h506. [PMID: 17179188] - Peter Alexandersen, M A Karsdal, Per Qvist, J-Y Reginster, Claus Christiansen. Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women.
Bone.
2007 Jan; 40(1):218-22. doi:
10.1016/j.bone.2006.07.028. [PMID: 17010685] - G Lehmann, G Hein, G Wolf. [The osteoporosis patient with renal insufficiency: what has to be taken into account in the selection and administration of antiosteoporosis medication?].
Zeitschrift fur Rheumatologie.
2006 Sep; 65(5):378, 380-2. doi:
10.1007/s00393-006-0085-9. [PMID: 16924452] - Albrecht W Popp, Juerg Isenegger, Elizabeth M Buergi, Ulrich Buergi, Kurt Lippuner. Glucocorticosteroid-induced spinal osteoporosis: scientific update on pathophysiology and treatment.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society.
2006 Jul; 15(7):1035-49. doi:
10.1007/s00586-005-0056-x. [PMID: 16474946] - Pierre J Marie. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation.
Current opinion in rheumatology.
2006 Jun; 18 Suppl 1(?):S11-5. doi:
10.1097/01.bor.0000229522.89546.7b. [PMID: 16735840] - Christian Fottner, Matthias M Weber. [The latest developments in endocrinology 2004/2005].
Medizinische Klinik (Munich, Germany : 1983).
2006 Jan; 101(1):29-36. doi:
10.1007/s00063-006-1005-0. [PMID: 16418812] - Serge Cremers, Patrick Garnero. Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls.
Drugs.
2006; 66(16):2031-58. doi:
10.2165/00003495-200666160-00001. [PMID: 17112299] - Hans Peter Dimai. [Strontium ranelate: a novel concept for the treatment of osteoporosis].
Wiener klinische Wochenschrift.
2005 Nov; 117(21-22):728-38. doi:
10.1007/s00508-005-0471-3. [PMID: 16416353] - Lee S Simon. Osteoporosis.
Clinics in geriatric medicine.
2005 Aug; 21(3):603-29, viii. doi:
10.1016/j.cger.2005.02.002. [PMID: 15911210] - P J Marie. Strontium ranelate: a novel mode of action optimizing bone formation and resorption.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2005 Jan; 16 Suppl 1(?):S7-10. doi:
10.1007/s00198-004-1753-8. [PMID: 15578159] - Patrick Ammann, Victor Shen, Bruno Robin, Yves Mauras, Jean-Philippe Bonjour, Rene Rizzoli. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2004 Dec; 19(12):2012-20. doi:
10.1359/jbmr.040906. [PMID: 15537445] - J Y Reginster, J P Devogelaer. [Treatment of postmenopausal osteoporosis in 2004].
Revue medicale de Liege.
2004 Nov; 59(11):633-47. doi:
NULL. [PMID: 15646737] - V Ringa. [Alternatives to hormone replacement therapy for menopause: an epidemiological evaluation].
Journal de gynecologie, obstetrique et biologie de la reproduction.
2004 May; 33(3):195-209. doi:
10.1016/s0368-2315(04)96440-x. [PMID: 15170434] - Stig Pors Nielsen, Olaf Bärenholdt, Christine Bärenholdt-Schiøler, Yves Mauras, Pierre Allain. Noninvasive measurement of bone strontium.
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.
2004; 7(3):262-8. doi:
10.1385/jcd:7:3:262. [PMID: 15319495] - P Delannoy, D Bazot, P J Marie. Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice.
Metabolism: clinical and experimental.
2002 Jul; 51(7):906-11. doi:
10.1053/meta.2002.33360. [PMID: 12077740] - P J Meunier, D O Slosman, P D Delmas, J L Sebert, M L Brandi, C Albanese, R Lorenc, S Pors-Nielsen, M C De Vernejoul, A Roces, J Y Reginster. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial.
The Journal of clinical endocrinology and metabolism.
2002 May; 87(5):2060-6. doi:
10.1210/jcem.87.5.8507. [PMID: 11994341] - J Buehler, P Chappuis, J L Saffar, Y Tsouderos, A Vignery. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis).
Bone.
2001 Aug; 29(2):176-9. doi:
10.1016/s8756-3282(01)00484-7. [PMID: 11502480] - S G Dahl, P Allain, P J Marie, Y Mauras, G Boivin, P Ammann, Y Tsouderos, P D Delmas, C Christiansen. Incorporation and distribution of strontium in bone.
Bone.
2001 Apr; 28(4):446-53. doi:
10.1016/s8756-3282(01)00419-7. [PMID: 11336927]