Ceftobiprole medocaril (BioDeep_00000839879)
代谢物信息卡片
化学式: C26H25N8NaO11S2 (712.098186)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(OC(=O)O1)COC(=O)N2CCC(C2)N3CCC(=CC4=C(N5C(C(C5=O)NC(=O)C(=NO)C6=NSC(=N6)N)SC4)C(=O)[O-])C3=O.[Na+]
InChI: /q
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use
同义名列表
1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- J R Azanza Perea, B Sádaba Díaz de Rada. Ceftobiprole: pharmacokinetics and PK/PD profile.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia.
2019 Sep; 32 Suppl 3(?):11-16. doi:
NULL
. [PMID: 31364336] - Gary Eichenbaum, Jennifer Skibbe, Andrew Parkinson, Mark D Johnson, Dawn Baumgardner, Brian Ogilvie, Etsuko Usuki, Fred Tonelli, Jeff Holsapple, Anne Schmitt-Hoffmann. Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: a case study example with the prodrug ceftobiprole medocaril.
Journal of pharmaceutical sciences.
2012 Mar; 101(3):1242-52. doi:
10.1002/jps.22816
. [PMID: 22095741] - A Stucki, M Cottagnoud, F Acosta, U Egerman, J Läuffer, P Cottagnoud. Evaluation of ceftobiprole activity against a variety of gram-negative pathogens, including Escherichia coli, Haemophilus influenzae (β-lactamase positive and β-lactamase negative), and Klebsiella pneumoniae, in a rabbit meningitis model.
Antimicrobial agents and chemotherapy.
2012 Feb; 56(2):921-5. doi:
10.1128/aac.01537-10
. [PMID: 22064544] - Li-Yan Yin, Jason H Calhoun, Jacob K Thomas, Stuart Shapiro, Anne Schmitt-Hoffmann. Efficacies of ceftobiprole medocaril and comparators in a rabbit model of osteomyelitis due to methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy.
2008 May; 52(5):1618-22. doi:
10.1128/aac.00638-07
. [PMID: 18332175] - Bindu Murthy, Anne Schmitt-Hoffmann. Pharmacokinetics and pharmacodynamics of ceftobiprole, an anti-MRSA cephalosporin with broad-spectrum activity.
Clinical pharmacokinetics.
2008; 47(1):21-33. doi:
10.2165/00003088-200847010-00003
. [PMID: 18076216]