Alfenta (BioDeep_00000839875)
代谢物信息卡片
Alfenta
化学式: C21H35ClN6O4 (470.24081800000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCN3C(=O)N(N=N3)CC)COC.O.Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark S Wallace. Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain.
Pain medicine (Malden, Mass.).
2021 Dec; 22(12):3072-3079. doi:
10.1093/pm/pnab222. [PMID: 34329455] - Jean Jung, Allan Kolodziej, Elise Pape, Michael Bisch, Lucie Javot, Valérie Gibaja, Jean-Yves Jouzeau, Julien Scala-Bertola, Nicolas Gambier. Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.
Forensic science international.
2020 Dec; 317(?):110437. doi:
10.1016/j.forsciint.2020.110437. [PMID: 33007729] - Robert J Brosnan, Bruno H Pypendop, Scott D Stanley. Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats.
Journal of veterinary pharmacology and therapeutics.
2020 Nov; 43(6):533-537. doi:
10.1111/jvp.12886. [PMID: 32557697] - Haruka Tsutsui, Motohiro Kato, Shino Kuramoto, Nobuo Sekiguchi, Hidetoshi Shindoh, Kazuhisa Ozeki. Quantitative evaluation of hepatic and intestinal induction of CYP3A in clinical practice.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Aug; 50(8):875-884. doi:
10.1080/00498254.2019.1710620. [PMID: 31885304] - Khaled Abduljalil, Xian Pan, Amita Pansari, Masoud Jamei, Trevor N Johnson. Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population.
Clinical pharmacokinetics.
2020 04; 59(4):501-518. doi:
10.1007/s40262-019-00827-4. [PMID: 31587145] - Jing-Yang Liou, Mei-Yung Tsou, Shinju Obara, Lu Yu, Chien-Kun Ting. Plasma concentration based response surface model predict better than effect-site concentration based model for wake-up time during gastrointestinal endoscopy sedation.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2019 Jan; 118(1 Pt 2):291-298. doi:
10.1016/j.jfma.2018.05.007. [PMID: 29803320] - Nina Hanke, Sebastian Frechen, Daniel Moj, Hannah Britz, Thomas Eissing, Thomas Wendl, Thorsten Lehr. PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin.
CPT: pharmacometrics & systems pharmacology.
2018 10; 7(10):647-659. doi:
10.1002/psp4.12343. [PMID: 30091221] - Carolyn Schifftner, Gery Schulteis, Mark S Wallace. Effect of Intravenous Alfentanil on Nonpainful Thermally Induced Hyperalgesia in Healthy Volunteers.
Journal of clinical pharmacology.
2017 09; 57(9):1207-1214. doi:
10.1002/jcph.911. [PMID: 28464270] - M Roozekrans, E Olofsen, R van der Schrier, M Boom, R Mooren, A Dahan. Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers.
Clinical pharmacology and therapeutics.
2017 07; 102(1):115-122. doi:
10.1002/cpt.601. [PMID: 28001306] - Mohammad H Abou-Arab, Morten Rostrup, Tom Heier. Dose requirements of alfentanil to eliminate autonomic responses during rapid-sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg.
Journal of clinical anesthesia.
2016 Dec; 35(?):465-474. doi:
10.1016/j.jclinane.2016.09.026. [PMID: 27871575] - Pegah Zahedi, Saied Saeed Hosseiny Davarani, Hamid Reza Moazami, Saeed Nojavan. Surfactant assisted pulsed two-phase electromembrane extraction followed by GC analysis for quantification of basic drugs in biological samples.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 117(?):485-91. doi:
10.1016/j.jpba.2015.10.002. [PMID: 26469297] - M H Abou-Arab, J R Feiner, O Spigset, T Heier. Alfentanil during rapid sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg: tracheal intubation conditions.
Acta anaesthesiologica Scandinavica.
2015 Nov; 59(10):1278-86. doi:
10.1111/aas.12584. [PMID: 26176994] - M Barann, U M Stamer, M Lyutenska, F Stüber, H Bönisch, B Urban. Effects of opioids on human serotonin transporters.
Naunyn-Schmiedeberg's archives of pharmacology.
2015 Jan; 388(1):43-9. doi:
10.1007/s00210-014-1056-3. [PMID: 25332055] - T Schaaf, M Lyutenska, B W Urban, M Wittmann. Direct effects of morphine but not of fentanyl-type opioids on human 5-HT3A receptors in outside-out patch-clamp studies.
European journal of pain (London, England).
2014 Sep; 18(8):1165-72. doi:
10.1002/j.1532-2149.2014.00463.x. [PMID: 24590579] - Guillaume Baneyx, Neil Parrott, Christophe Meille, Athanassios Iliadis, Thierry Lavé. Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: influence of time between substrate and inducer administration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Jun; 56(?):1-15. doi:
10.1016/j.ejps.2014.02.002. [PMID: 24530864] - B H Pypendop, R J Brosnan, C R Majewski-Tiedeken, S D Stanley, J E Ilkiw. Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats.
Journal of veterinary pharmacology and therapeutics.
2014 Feb; 37(1):13-7. doi:
10.1111/jvp.12047. [PMID: 23895731] - Min-Hsien Chiang, Shao-Chun Wu, Chia-Hsun You, Keng-Liang Wu, Yi-Chun Chiu, Chao-Wei Ma, Chin-Wei Kao, Kun-Chen Lin, Kuan-Hung Chen, Peng-Chih Wang, An-Kuo Chou. Target-controlled infusion vs. manually controlled infusion of propofol with alfentanil for bidirectional endoscopy: a randomized controlled trial.
Endoscopy.
2013 Nov; 45(11):907-14. doi:
10.1055/s-0033-1344645. [PMID: 24165817] - N Sigmond, M Baechtold, P M Schumacher, V Hartwich, T W Schnider, M Luginbühl. Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems.
British journal of anaesthesia.
2013 Aug; 111(2):197-208. doi:
10.1093/bja/aet049. [PMID: 23512864] - Ali Reza Fakhari, Hadi Tabani, Saeed Nojavan. Miniaturized hollow fibre assisted liquid-phase microextraction and gas chromatography for determination of trace concentration of sufentanil and alfentanil in biological samples.
Drug testing and analysis.
2013 Jul; 5(7):589-95. doi:
10.1002/dta.1387. [PMID: 22786780] - James R Miner, Johanna C Moore, David Plummer, Richard O Gray, Sagar Patel, Jeffrey D Ho. Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
2013 Apr; 20(4):330-7. doi:
10.1111/acem.12110. [PMID: 23701339] - O Pérus, A Marsot, E Ramain, M Dahman, A Paci, M Raucoules-Aimé, N Simon. Performance of alfentanil target-controlled infusion in normal and morbidly obese female patients.
British journal of anaesthesia.
2012 Oct; 109(4):551-60. doi:
10.1093/bja/aes211. [PMID: 22732112] - Sabina Strano-Rossi, Iván Alvarez, María Jesús Tabernero, Pamela Cabarcos, Purificación Fernández, Ana María Bermejo. Determination of fentanyl, metabolite and analogs in urine by GC/MS.
Journal of applied toxicology : JAT.
2011 Oct; 31(7):649-54. doi:
10.1002/jat.1613. [PMID: 21132842] - E D Kharasch, A Francis, A London, K Frey, T Kim, J Blood. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
Clinical pharmacology and therapeutics.
2011 Jul; 90(1):100-8. doi:
10.1038/clpt.2011.59. [PMID: 21562488] - Thomas Kim, Amy London, Evan D Kharasch. Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2011 Jun; 55(3):487-93. doi:
10.1016/j.jpba.2011.01.040. [PMID: 21382685] - Mohammad Saraji, Malihe Khalili Boroujeni, Ali Akbar Hajialiakbari Bidgoli. Comparison of dispersive liquid-liquid microextraction and hollow fiber liquid-liquid-liquid microextraction for the determination of fentanyl, alfentanil, and sufentanil in water and biological fluids by high-performance liquid chromatography.
Analytical and bioanalytical chemistry.
2011 Jun; 400(7):2149-58. doi:
10.1007/s00216-011-4874-x. [PMID: 21442368] - E D Kharasch, S Vangveravong, N Buck, A London, T Kim, J Blood, R H Mach. Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.
Clinical pharmacology and therapeutics.
2011 Apr; 89(4):562-70. doi:
10.1038/clpt.2010.313. [PMID: 21346758] - Agnieszka Bienert, Paweł Wiczling, Czesław Zaba, Zbigniew Zaba, Anna Wolc, Ryszard Marciniak, Edmund Grześkowiak, Krzysztof Kusza. Influence of demographic factors, basic blood test parameters and opioid type on propofol pharmacokinetics and pharmacodynamics in ASA I-III patients.
Arzneimittel-Forschung.
2011; 61(10):545-52. doi:
10.1055/s-0031-1300552. [PMID: 22164962] - Kevin D Johnston. The potential for mu-opioid receptor agonists to be anti-emetic in humans: a review of clinical data.
Acta anaesthesiologica Scandinavica.
2010 Feb; 54(2):132-40. doi:
10.1111/j.1399-6576.2009.02115.x. [PMID: 19817719] - S M Lee, G H Kim, J J Lee, J A Kim, S J Choi, G S Kim, H H Jung. Does propofol and alfentanil-induced sedation cause periodic apnoea in chronic renal failure patients?.
International journal of clinical practice.
2010 Jan; 64(1):1-5. doi:
10.1111/j.1742-1241.2007.01443.x. [PMID: 18005040] - Y Ginosar, E M Davidson, Y Meroz, S Blotnick, M Shacham, Y Caraco. Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study.
British journal of anaesthesia.
2009 Sep; 103(3):420-7. doi:
10.1093/bja/aep192. [PMID: 19605407] - E D Kharasch, P S Bedynek, A Walker, D Whittington, C Hoffer. Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
Clinical pharmacology and therapeutics.
2008 Oct; 84(4):506-12. doi:
10.1038/clpt.2008.102. [PMID: 19238656] - B G Oertel, C Preibisch, T Wallenhorst, T Hummel, G Geisslinger, H Lanfermann, J Lötsch. Differential opioid action on sensory and affective cerebral pain processing.
Clinical pharmacology and therapeutics.
2008 Apr; 83(4):577-88. doi:
10.1038/sj.clpt.6100441. [PMID: 18030306] - Andrea N Edginton, Stefan Willmann. Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis.
Clinical pharmacokinetics.
2008; 47(11):743-52. doi:
10.2165/00003088-200847110-00005. [PMID: 18840029] - E D Kharasch, A Walker, N Isoherranen, C Hoffer, P Sheffels, K Thummel, D Whittington, D Ensign. Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam.
Clinical pharmacology and therapeutics.
2007 Oct; 82(4):410-26. doi:
10.1038/sj.clpt.6100237. [PMID: 17554244] - John Heijmans, Erik Fransen, Wim Buurman, Jos Maessen, Paul Roekaerts. Comparison of the modulatory effects of four different fast-track anesthetic techniques on the inflammatory response to cardiac surgery with cardiopulmonary bypass.
Journal of cardiothoracic and vascular anesthesia.
2007 Aug; 21(4):512-8. doi:
10.1053/j.jvca.2007.02.008. [PMID: 17678776] - J Cory Kalvass, Emily R Olson, Gary M Pollack. Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Mar; 35(3):455-9. doi:
10.1124/dmd.106.011445. [PMID: 17178769] - D J Duncan, P M Hopkins, S M Harrison. Negative inotropic effects of tumour necrosis factor-alpha and interleukin-1beta are ameliorated by alfentanil in rat ventricular myocytes.
British journal of pharmacology.
2007 Mar; 150(6):720-6. doi:
10.1038/sj.bjp.0707147. [PMID: 17279089] - Nariné Baririan, Luc Van Obbergh, Jean-Pierre Desager, Roger K Verbeeck, Pierre Wallemacq, Peter Starkel, Yves Horsmans. Alfentanil-induced miosis as a surrogate measure of alfentanil pharmacokinetics in patients with mild and moderate liver cirrhosis.
Clinical pharmacokinetics.
2007; 46(3):261-70. doi:
10.2165/00003088-200746030-00006. [PMID: 17328584] - Zbigniew Zaba, Agnieszka Bienert, Leon Drobnik, Stanislaw Dyderski, Krzysztof Kusza. Spectral frequency index monitoring during propofol-remifentanil and propofol-alfentanil total intravenous anaesthesia.
CNS drugs.
2007; 21(2):165-71. doi:
10.2165/00023210-200721020-00006. [PMID: 17284097] - Teijo I Saari, Kari Laine, Kari Leino, Mika Valtonen, Pertti J Neuvonen, Klaus T Olkkola. Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life.
Clinical pharmacology and therapeutics.
2006 Nov; 80(5):502-8. doi:
10.1016/j.clpt.2006.07.008. [PMID: 17112806] - Martin Luginbühl, Christian Bieniok, Daniel Leibundgut, Rolf Wymann, Andrea Gentilini, Thomas W Schnider. Closed-loop control of mean arterial blood pressure during surgery with alfentanil: clinical evaluation of a novel model-based predictive controller.
Anesthesiology.
2006 Sep; 105(3):462-70. doi:
10.1097/00000542-200609000-00008. [PMID: 16931977] - K Schmieder, F Möller, M Engelhardt, M Scholz, W Schregel, A Christmann, A Harders. Dynamic cerebral autoregulation in patients with ruptured and unruptured aneurysms after induction of general anesthesia.
Zentralblatt fur Neurochirurgie.
2006 May; 67(2):81-7. doi:
10.1055/s-2006-933374. [PMID: 16673240] - Sven Björkman. Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants and children : how accurate are available scaling methods?.
Clinical pharmacokinetics.
2006; 45(1):1-11. doi:
10.2165/00003088-200645010-00001. [PMID: 16430308] - Narine Baririan, Yves Horsmans, Jean-Pierre Desager, Roger Verbeeck, Roger Vanbinst, Pierre Wallemacq, Luc Van Obbergh. Alfentanil-induced miosis clearance as a liver CYP3A4 and 3A5 activity measure in healthy volunteers: improvement of experimental conditions.
Journal of clinical pharmacology.
2005 Dec; 45(12):1434-41. doi:
10.1177/0091270005282629. [PMID: 16291719] - Harshvardhan N Chaobal, Evan D Kharasch. Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.
Clinical pharmacology and therapeutics.
2005 Nov; 78(5):529-39. doi:
10.1016/j.clpt.2005.08.004. [PMID: 16321619] - Evan D Kharasch, Alysa Walker, Christine Hoffer, Pamela Sheffels. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.
Journal of clinical pharmacology.
2005 Oct; 45(10):1187-97. doi:
10.1177/0091270005280077. [PMID: 16172184] - M Cicek, A Koroglu, S Demirbilek, H Teksan, M O Ersoy. Comparison of propofol-alfentanil and propofol-remifentanil anaesthesia in percutaneous nephrolithotripsy.
European journal of anaesthesiology.
2005 Sep; 22(9):683-8. doi:
10.1017/s0265021505001134. [PMID: 16163915] - Theresa Mariero Klees, Pamela Sheffels, Ola Dale, Evan D Kharasch. Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Mar; 33(3):303-11. doi:
10.1124/dmd.104.002709. [PMID: 15557344] - Martin Luginbühl, Steen Petersen-Felix, Alex M Zbinden, Thomas W Schnider. Xenon does not reduce opioid requirement for orthopedic surgery.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2005 Jan; 52(1):38-44. doi:
10.1007/bf03018578. [PMID: 15625254] - Evan D Kharasch, Alysa Walker, Christine Hoffer, Pamela Sheffels. Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.
Journal of clinical pharmacology.
2005 Jan; 45(1):79-88. doi:
10.1177/0091270004269705. [PMID: 15601808] - E Guasch, M Ardoy, C Cuadrado, P González Gancedo, A González, F Gilsanz. [Comparison of 4 anesthetic techniques for in vitro fertilization].
Revista espanola de anestesiologia y reanimacion.
2005 Jan; 52(1):9-18. doi:
. [PMID: 15747701] - Mario Thevis, Hans Geyer, Daniel Bahr, Wilhelm Schänzer. Identification of fentanyl, alfentanil, sufentanil, remifentanil and their major metabolites in human urine by liquid chromatography/tandem mass spectrometry for doping control purposes.
European journal of mass spectrometry (Chichester, England).
2005; 11(4):419-27. doi:
10.1255/ejms.761. [PMID: 16204809] - Evan D Kharasch, Alysa Walker, Christine Hoffer, Pamela Sheffels. Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
Clinical pharmacology and therapeutics.
2004 Nov; 76(5):452-66. doi:
10.1016/j.clpt.2004.07.006. [PMID: 15536460] - Martin S Angst, Bhamini Ramaswamy, M Frances Davies, Mervyn Maze. Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans.
Anesthesiology.
2004 Sep; 101(3):744-52. doi:
10.1097/00000542-200409000-00024. [PMID: 15329600] - Semra Demirbilek, Süleyman Ganidağli, Nurten Aksoy, Cevdet Becerik, Zeynep Baysal. The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy.
Journal of clinical anesthesia.
2004 Aug; 16(5):358-63. doi:
10.1016/j.jclinane.2003.10.002. [PMID: 15374557] - Nadine F J Van Nimmen, Katrien L C Poels, Hendrik A F Veulemans. Highly sensitive gas chromatographic-mass spectrometric screening method for the determination of picogram levels of fentanyl, sufentanil and alfentanil and their major metabolites in urine of opioid exposed workers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 May; 804(2):375-87. doi:
10.1016/j.jchromb.2004.01.044. [PMID: 15081933] - Mark D Graham, Philip M Hopkins, Simon M Harrison. The effects of alfentanil on cytosolic Ca(2+) and contraction in rat ventricular myocytes.
Anesthesia and analgesia.
2004 Apr; 98(4):1013-1016. doi:
10.1213/01.ane.0000104481.20813.35. [PMID: 15041590] - Martijn J Mertens, Erik Olofsen, Anton G L Burm, James G Bovill, Jaap Vuyk. Mixed-effects modeling of the influence of alfentanil on propofol pharmacokinetics.
Anesthesiology.
2004 Apr; 100(4):795-805. doi:
10.1097/00000542-200404000-00008. [PMID: 15087613] - T Bouillon, G Garstka, D Stafforst, S Shafer, H Schwilden, A Hoeft. Piritramide and alfentanil display similar respiratory depressant potency.
Acta anaesthesiologica Scandinavica.
2003 Nov; 47(10):1231-41. doi:
10.1046/j.1399-6576.2003.00251.x. [PMID: 14616320] - H Schulte, T Graven-Nielsen, A Sollevi, Y Jansson, L Arendt-Nielsen, M Segerdahl. Pharmacological modulation of experimental phasic and tonic muscle pain by morphine, alfentanil and ketamine in healthy volunteers.
Acta anaesthesiologica Scandinavica.
2003 Sep; 47(8):1020-30. doi:
10.1034/j.1399-6576.2003.00204.x. [PMID: 12904196] - S Atici, A Aribogan. Comparison of the effects of sevoflurane and total intravenous anaesthesia in percutaneous nephrolithotomy.
European journal of anaesthesiology.
2003 Aug; 20(8):653-7. doi:
10.1017/s0265021503001054. [PMID: 12932068] - C G McDonnell, D Malkan, F D Van Pelt, G D Shorten. Elimination of alfentanil delivered by infusion is not altered by the chronic administration of atorvastatin.
European journal of anaesthesiology.
2003 Aug; 20(8):662-7. doi:
10.1017/s0265021503001078. [PMID: 12932070] - D W Blake, C F Royse, A G Royse, A R Bjorksten, P F Soeding, J Pang. Alfentanil infusion as a component of intravenous anaesthesia for coronary artery bypass surgery with 'fast-track' recovery.
Anaesthesia and intensive care.
2003 Apr; 31(2):181-3. doi:
10.1177/0310057x0303100207. [PMID: 12712782] - Andra E Ibrahim, Jennifer Feldman, Aziz Karim, Evan D Kharasch. Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
Anesthesiology.
2003 Apr; 98(4):853-61. doi:
10.1097/00000542-200304000-00011. [PMID: 12657846] - Evan D Kharasch, Christine Hoffer, Alysa Walker, Pamela Sheffels. Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.
Clinical pharmacology and therapeutics.
2003 Mar; 73(3):199-208. doi:
10.1067/mcp.2003.30. [PMID: 12621385] - T W Hahn, T Mogensen, C Lund, L S Jacobsen, N-C Hjortsoe, S N Rasmussen, M Rasmussen. Analgesic effect of i.v. paracetamol: possible ceiling effect of paracetamol in postoperative pain.
Acta anaesthesiologica Scandinavica.
2003 Feb; 47(2):138-45. doi:
10.1034/j.1399-6576.2003.00046.x. [PMID: 12631041] - Stephen R Edwards, Laurence E Mather. Alfentanil potentiates anaesthetic and electroencephalographic responses to ketamine in the rat.
European journal of pharmacology.
2003 Jan; 460(1):27-35. doi:
10.1016/s0014-2999(02)02827-3. [PMID: 12535856] - Mark S Wallace, Jennifer Braun, Gery Schulteis. Postdelivery of alfentanil and ketamine has no effect on intradermal capsaicin-induced pain and hyperalgesia.
The Clinical journal of pain.
2002 Nov; 18(6):373-9. doi:
10.1097/00002508-200211000-00005. [PMID: 12441831] - M Luginbühl, F Reichlin, G H Sigurdsson, A M Zbinden, S Petersen-Felix. Prediction of the haemodynamic response to tracheal intubation: comparison of laser-Doppler skin vasomotor reflex and pulse wave reflex.
British journal of anaesthesia.
2002 Sep; 89(3):389-97. doi:
10.1093/bja/89.3.389. [PMID: 12402716] - Nora Hagelberg, Jaana K Kajander, Kjell Någren, Susanna Hinkka, Jarmo Hietala, Harry Scheinin. Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man.
Synapse (New York, N.Y.).
2002 Jul; 45(1):25-30. doi:
10.1002/syn.10078. [PMID: 12112410] - M P Dockery, G B Drummond. Respiratory response to skin incision during anaesthesia with infusions of propofol and alfentanil.
British journal of anaesthesia.
2002 May; 88(5):649-52. doi:
10.1093/bja/88.5.649. [PMID: 12067001] - Andrea Gentilini, Christoph Schaniel, Manfred Morari, Christian Bieniok, Rolf Wymann, Thomas Schnider. A new paradigm for the closed-loop intraoperative administration of analgesics in humans.
IEEE transactions on bio-medical engineering.
2002 Apr; 49(4):289-99. doi:
10.1109/10.991156. [PMID: 11942720] - S R Edwards, C F Minto, L E Mather. Concurrent ketamine and alfentanil administration: pharmacokinetic considerations.
British journal of anaesthesia.
2002 Jan; 88(1):94-100. doi:
10.1093/bja/88.1.94. [PMID: 11881891] - Mark S Wallace, Beri Ridgeway, Albert Leung, Gery Schulteis, Tony L Yaksh. Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia.
Journal of clinical pharmacology.
2002 Jan; 42(1):70-80. doi:
10.1177/0091270002042001008. [PMID: 11808827] - J S Shieh, L W Chang, M S Wang, W Z Sun, Y P Wang, Y P Yang. Pain model and fuzzy logic patient-controlled analgesia in shock-wave lithotripsy.
Medical & biological engineering & computing.
2002 Jan; 40(1):128-36. doi:
10.1007/bf02347706. [PMID: 11954700] - J W Johansen. Esmolol promotes electroencephalographic burst suppression during propofol/alfentanil anesthesia.
Anesthesia and analgesia.
2001 Dec; 93(6):1526-31, table of contents. doi:
10.1097/00000539-200112000-00039. [PMID: 11726435] - S Phimmasone, E D Kharasch. A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.
Clinical pharmacology and therapeutics.
2001 Dec; 70(6):505-17. doi:
10.1067/mcp.2001.119994. [PMID: 11753266] - R Park, M S Wallace, G Schulteis. Relative sensitivity to alfentanil and reliability of current perception threshold vs von Frey tactile stimulation and thermal sensory testing.
Journal of the peripheral nervous system : JPNS.
2001 Dec; 6(4):232-40. doi:
10.1046/j.1529-8027.2001.01025.x. [PMID: 11800047] - C Dufresne, P Favetta, C Paradis, R Boulieu. Stability of sufentanil in human plasma samples.
Therapeutic drug monitoring.
2001 Oct; 23(5):550-2. doi:
10.1097/00007691-200110000-00009. [PMID: 11591902] - L H Mildh, H Scheinin, O A Kirvelä. The concentration-effect relationship of the respiratory depressant effects of alfentanil and fentanyl.
Anesthesia and analgesia.
2001 Oct; 93(4):939-46. doi:
10.1097/00000539-200110000-00028. [PMID: 11574361] - M Luginbühl, T W Schnider, S Petersen-Felix, L Arendt-Nielsen, A M Zbinden. Comparison of five experimental pain tests to measure analgesic effects of alfentanil.
Anesthesiology.
2001 Jul; 95(1):22-9. doi:
10.1097/00000542-200107000-00009. [PMID: 11465562] - M J Mertens, J Vuyk, E Olofsen, J G Bovill, A G Burm. Propofol alters the pharmacokinetics of alfentanil in healthy male volunteers.
Anesthesiology.
2001 Jun; 94(6):949-57. doi:
10.1097/00000542-200106000-00006. [PMID: 11465619] - G G Tailly, J B Marcelo, I A Schneider, G Byttebier, K Daems. Patient-controlled analgesia during SWL treatments.
Journal of endourology.
2001 Jun; 15(5):465-71. doi:
10.1089/089277901750299230. [PMID: 11465323] - I Kissin, C A Bright, E L Bradley. Can inflammatory pain prevent the development of acute tolerance to alfentanil?.
Anesthesia and analgesia.
2001 May; 92(5):1296-300. doi:
10.1097/00000539-200105000-00041. [PMID: 11323365] - A Maguire, J P Thompson, C Guest, P J Sadler, J W Strupish, K J West. Comparison of the effects of intravenous alfentanil and esmolol on the cardiovascular response to double-lumen endobronchial intubation.
Anaesthesia.
2001 Apr; 56(4):319-25. doi:
10.1046/j.1365-2044.2001.01917.x. [PMID: 11284817] - A Leung, M S Wallace, B Ridgeway, T Yaksh. Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain.
Pain.
2001 Mar; 91(1-2):177-87. doi:
10.1016/s0304-3959(00)00433-4. [PMID: 11240090] - I Kissin, C A Bright, E L Bradley. The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?.
Anesthesia and analgesia.
2000 Dec; 91(6):1483-8. doi:
10.1097/00000539-200012000-00035. [PMID: 11094005] - J Ahonen, K T Olkkola, M Hynynen, T Seppälä, H Ikävalko, B Remmerie, M Salmenperä. Comparison of alfentanil, fentanyl and sufentanil for total intravenous anaesthesia with propofol in patients undergoing coronary artery bypass surgery.
British journal of anaesthesia.
2000 Oct; 85(4):533-40. doi:
10.1093/bja/85.4.533. [PMID: 11064610] - P O Talke, J E Caldwell, C A Richardson, T Heier. The effects of clonidine on human digital vasculature.
Anesthesia and analgesia.
2000 Oct; 91(4):793-7. doi:
10.1097/00000539-200010000-00006. [PMID: 11004028] - I Kissin, C A Bright, E L Bradley. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems.
Anesthesia and analgesia.
2000 Jul; 91(1):110-6. doi:
10.1097/00000539-200007000-00021. [PMID: 10866896] - C Metz, L Göbel, M Gruber, K H Hoerauf, K Taeger. Pharmacokinetics of human cerebral opioid extraction: a comparative study on sufentanil, fentanyl, and alfentanil in a patient after severe head injury.
Anesthesiology.
2000 Jun; 92(6):1559-67. doi:
10.1097/00000542-200006000-00012. [PMID: 10839904] - T Gin, W D Ngan-Kee, Y K Siu, J C Stuart, P E Tan, K K Lam. Alfentanil given immediately before the induction of anesthesia for elective cesarean delivery.
Anesthesia and analgesia.
2000 May; 90(5):1167-72. doi:
10.1097/00000539-200005000-00031. [PMID: 10781473] - C Negishi, J S Kim, R Lenhardt, D I Sessler, M Ozaki, K Vuong, H Bastanmehr, A R Bjorksten. Alfentanil reduces the febrile response to interleukin-2 in humans.
Critical care medicine.
2000 May; 28(5):1295-300. doi:
10.1097/00003246-200005000-00006. [PMID: 10834668] - W C Ummenhofer, R H Arends, D D Shen, C M Bernards. Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil.
Anesthesiology.
2000 Mar; 92(3):739-53. doi:
10.1097/00000542-200003000-00018. [PMID: 10719953] - J E Caldwell, T Heier, P M Wright, S Lin, G McCarthy, J Szenohradszky, M L Sharma, J P Hing, M Schroeder, D I Sessler. Temperature-dependent pharmacokinetics and pharmacodynamics of vecuronium.
Anesthesiology.
2000 Jan; 92(1):84-93. doi:
10.1097/00000542-200001000-00018. [PMID: 10638903] - S Langevin, M R Lessard, C A Trépanier, J P Baribault. Alfentanil causes less postoperative nausea and vomiting than equipotent doses of fentanyl or sufentanil in outpatients.
Anesthesiology.
1999 Dec; 91(6):1666-73. doi:
10.1097/00000542-199912000-00019. [PMID: 10598609] - S Albrecht, H Ihmsen, K Suchodolski, C Frenkel, J Schüttler. [Analgo-sedation in intensive care: a quantitative, EEG-based trial with propofol 1\% and 2\%].
Der Anaesthesist.
1999 Nov; 48(11):794-801. doi:
10.1007/s001010050787. [PMID: 10631438] - M J Mertens, J Vuyk, K Parivar, F H Engbers, A G Burm, J G Bovill. Pharmacodynamic interaction of eltanolone and alfentanil during lower abdominal surgery in female patients.
British journal of anaesthesia.
1999 Aug; 83(2):250-2. doi:
10.1093/bja/83.2.250. [PMID: 10618938] - J Persson, H Scheinin, G Hellström, S Björkman, E Götharson, L L Gustafsson. Ketamine antagonises alfentanil-induced hypoventilation in healthy male volunteers.
Acta anaesthesiologica Scandinavica.
1999 Aug; 43(7):744-52. doi:
10.1034/j.1399-6576.1999.430710.x. [PMID: 10456815]