Ornithine phenylacetate (BioDeep_00000839846)
代谢物信息卡片
化学式: C13H20N2O4 (268.14230000000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CC(=O)O.C(CC(C(=O)O)N)CN
InChI: 4-/m.0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Rifaat Safadi, Robert S Rahimi, Dominique Thabut, Jasmohan S Bajaj, Kalyan Ram Bhamidimarri, Nikolaos Pyrsopoulos, Amy Potthoff, Stan Bukofzer, Laurene Wang, Khurram Jamil, Krishna R Devarakonda. Pharmacokinetics/pharmacodynamics of L-ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes.
Clinical and translational science.
2022 06; 15(6):1449-1459. doi:
10.1111/cts.13257
. [PMID: 35238476] - R Todd Stravitz, Michelle Gottfried, Valerie Durkalski, Robert J Fontana, A James Hanje, David Koch, Bilal Hameed, Daniel Ganger, Ram M Subramanian, Stan Bukofzer, William R Ravis, Kristen Clasen, Averell Sherker, Lanna Little, William M Lee. Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia.
Hepatology (Baltimore, Md.).
2018 03; 67(3):1003-1013. doi:
10.1002/hep.29621
. [PMID: 29080224] - Rune Gangsoy Kristiansen. Current state of knowledge of hepatic encephalopathy (part I): newer treatment strategies for hyperammonemia in liver failure.
Metabolic brain disease.
2016 12; 31(6):1357-1358. doi:
10.1007/s11011-016-9908-9
. [PMID: 27651377] - Rajiv Jalan, Francesco De Chiara, Vairappan Balasubramaniyan, Fausto Andreola, Varun Khetan, Massimo Malago, Massimo Pinzani, Rajeshwar P Mookerjee, Krista Rombouts. Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension.
Journal of hepatology.
2016 Apr; 64(4):823-33. doi:
10.1016/j.jhep.2015.11.019
. [PMID: 26654994] - Rune Gangsøy Kristiansen, Christopher F Rose, Ole-Martin Fuskevåg, Hanne Mæhre, Arthur Revhaug, Rajiv Jalan, Lars Marius Ytrebø. L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway.
American journal of physiology. Gastrointestinal and liver physiology.
2014 Nov; 307(10):G1024-31. doi:
10.1152/ajpgi.00244.2014
. [PMID: 25258408] - M Jover-Cobos, L Noiret, K Lee, V Sharma, A Habtesion, M Romero-Gomez, N Davies, R Jalan. Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats.
Journal of hepatology.
2014 Mar; 60(3):545-53. doi:
10.1016/j.jhep.2013.10.012
. [PMID: 24512823] - Meritxell Ventura-Cots, José A Arranz, Macarena Simón-Talero, Maria Torrens, Albert Blanco, Encarnació Riudor, Inma Fuentes, Pilar Suñé, German Soriano, Juan Córdoba. Safety of ornithine phenylacetate in cirrhotic decompensated patients: an open-label, dose-escalating, single-cohort study.
Journal of clinical gastroenterology.
2013 Nov; 47(10):881-7. doi:
10.1097/mcg.0b013e318299c789
. [PMID: 23751856] - Maria Jover-Cobos, Lorette Noiret, Yalda Sharifi, Rajiv Jalan. Ornithine phenylacetate revisited.
Metabolic brain disease.
2013 Jun; 28(2):327-31. doi:
10.1007/s11011-013-9391-5
. [PMID: 23456516] - Sherry Dadsetan, Michael Sørensen, Lasse K Bak, Hendrik Vilstrup, Peter Ott, Arne Schousboe, Rajiv Jalan, Susanne Keiding, Helle S Waagepetersen. Interorgan metabolism of ornithine phenylacetate (OP)--a novel strategy for treatment of hyperammonemia.
Biochemical pharmacology.
2013 Jan; 85(1):115-23. doi:
10.1016/j.bcp.2012.10.015
. [PMID: 23103564] - Gavin Wright, Balasubramaniyan Vairappan, Vanessa Stadlbauer, Rajeshwar P Mookerjee, Nathan A Davies, Rajiv Jalan. Reduction in hyperammonaemia by ornithine phenylacetate prevents lipopolysaccharide-induced brain edema and coma in cirrhotic rats.
Liver international : official journal of the International Association for the Study of the Liver.
2012 Mar; 32(3):410-9. doi:
10.1111/j.1478-3231.2011.02698.x
. [PMID: 22151131] - Marc Oria, Jordi Romero-Giménez, José Antonio Arranz, Encarnació Riudor, Núria Raguer, Juan Córdoba. Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis.
Journal of hepatology.
2012 Jan; 56(1):109-14. doi:
10.1016/j.jhep.2011.06.026
. [PMID: 21835138]