Treprostinil diolamine (BioDeep_00000839843)
代谢物信息卡片
Treprostinil diolamine
化学式: C27H45NO7 (495.319586)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O.C(CO)NCCO
InChI: /m0./s1
描述信息
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
C78568 - Prostaglandin Analogue
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Felix Rafael De Bie, Christopher Gates Halline, Travis Kotzur, Kevin Hayes, Christopher Copeland Rouse, Jonathan Chang, Abby Christine Larson, Sameer Ahmad Khan, Ashley Spina, Samantha Tilden, Francesca Maria Russo, Holly Lee Hedrick, Jan Deprest, Emily Anne Partridge. Prenatal treprostinil reduces the pulmonary hypertension phenotype in the rat model of congenital diaphragmatic hernia.
EBioMedicine.
2022 Jul; 81(?):104106. doi:
10.1016/j.ebiom.2022.104106. [PMID: 35779494] - Xuemei Wu, Xiaohan Zhang, Ruichao Xu, Imam Hussain Shaik, Raman Venkataramanan. Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended-release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment.
British journal of clinical pharmacology.
2022 02; 88(2):587-599. doi:
10.1111/bcp.14966. [PMID: 34190364] - Joyce Hou, Evelyn Tolbert, Mark Birkenbach, Nisanne S Ghonem. Treprostinil alleviates hepatic mitochondrial injury during rat renal ischemia-reperfusion injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112172. doi:
10.1016/j.biopha.2021.112172. [PMID: 34560548] - Meiwen Ding, Evelyn Tolbert, Mark Birkenbach, Reginald Gohh, Fatemeh Akhlaghi, Nisanne S Ghonem. Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111912. doi:
10.1016/j.biopha.2021.111912. [PMID: 34328097] - Omar Abdulhameed Almazroo, Mohammad Kowser Miah, Venkateswaran C Pillai, Imam H Shaik, Ruichao Xu, Stalin Dharmayan, Heather J Johnson, Swaytha Ganesh, Raymond M Planinsic, Anthony J Demetris, Ali Al-Khafaji, Roberto Lopez, Michele Molinari, Amit D Tevar, Christopher Hughes, Abhinav Humar, Raman Venkataramanan. An evaluation of the safety and preliminary efficacy of peri- and post-operative treprostinil in preventing ischemia and reperfusion injury in adult orthotopic liver transplant recipients.
Clinical transplantation.
2021 06; 35(6):e14298. doi:
10.1111/ctr.14298. [PMID: 33764591] - Eric J Rubin, Lindsey R Baden, Jeffrey M Drazen, Darren B Taichman, Stephen Morrissey. Audio Interview: Vaccination in Nursing Homes and New Pulmonary/Critical Care Research.
The New England journal of medicine.
2021 May; 384(20):e89. doi:
10.1056/nejme2108598. [PMID: 34010537] - H James Ford, Wayne H Anderson, Blair Wendlandt, Thomas Bice, Agathe Ceppe, Joyce Lanier, Shannon S Carson. Randomized, Placebo-controlled Trial of Inhaled Treprostinil for Patients at Risk for Acute Respiratory Distress Syndrome.
Annals of the American Thoracic Society.
2021 04; 18(4):641-647. doi:
10.1513/annalsats.202004-374oc. [PMID: 33095030] - Richard W Chapman, Zhili Li, Donald Chun, Helena Gauani, Vladimir Malinin, Adam J Plaunt, David Cipolla, Walter R Perkins, Michel R Corboz. Treprostinil palmitil, an inhaled long-acting pulmonary vasodilator, does not show tachyphylaxis with daily dosing in rats.
Pulmonary pharmacology & therapeutics.
2021 02; 66(?):101983. doi:
10.1016/j.pupt.2020.101983. [PMID: 33346142] - Michel R Corboz, William Salvail, Sandra Gagnon, Daniel LaSala, Charles E Laurent, Dany Salvail, Kuan-Ju Chen, David Cipolla, Walter R Perkins, Richard W Chapman. Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts.
Prostaglandins & other lipid mediators.
2021 02; 152(?):106486. doi:
10.1016/j.prostaglandins.2020.106486. [PMID: 33011365] - Meiwen Ding, Evelyn Tolbert, Mark Birkenbach, Fatemeh Akhlaghi, Reginald Gohh, Nisanne S Ghonem. Treprostinil, a prostacyclin analog, ameliorates renal ischemia-reperfusion injury: preclinical studies in a rat model of acute kidney injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 01; 36(2):257-266. doi:
10.1093/ndt/gfaa236. [PMID: 33156922] - Richard W Chapman, Michel R Corboz, Vladimir S Malinin, Adam J Plaunt, Donna M Konicek, Zhili Li, Walter R Perkins. An overview of the biology of a long-acting inhaled treprostinil prodrug.
Pulmonary pharmacology & therapeutics.
2020 12; 65(?):102002. doi:
10.1016/j.pupt.2021.102002. [PMID: 33596473] - Felix R De Bie, Karel Allegaert, Holly L Hedrick, Natalie E Rintoul, Alexander Davidson. Treprostinil Attains Clinically Therapeutic Concentrations in Neonates with Pulmonary Hypertension on Extracorporeal Membrane Oxygenation Support.
Pharmacotherapy.
2020 10; 40(10):1054-1060. doi:
10.1002/phar.2459. [PMID: 32866289] - Keeley Hall, Michelle Ogawa, Charlotte Sakarovitch, Rachel K Hopper, Gregory T Adamson, Brian Hanna, David D Ivy, Kathleen Miller-Reed, Delphine Yung, Elisa McCarthy, Stephanie L Siehr-Handler, Jeffrey A Feinstein. Subcutaneous and Intravenous Treprostinil Pharmacokinetics in Children With Pulmonary Vascular Disease.
Journal of cardiovascular pharmacology.
2019 06; 73(6):383-393. doi:
10.1097/fjc.0000000000000674. [PMID: 31162247] - Beatrice Drambarean, Paula Bielnicka, Ali Alobaidi. Midodrine treatment in a patient with treprostinil-induced hypotension receiving hemodialysis.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2019 Jan; 76(1):13-16. doi:
10.1093/ajhp/zxy001. [PMID: 31381098] - Franziska G Leifer, Donna M Konicek, Kuan-Ju Chen, Adam J Plaunt, Dany Salvail, Charles E Laurent, Michel R Corboz, Zhili Li, Richard W Chapman, Walter R Perkins, Vladimir S Malinin. Inhaled Treprostinil-Prodrug Lipid Nanoparticle Formulations Provide Long-Acting Pulmonary Vasodilation.
Drug research.
2018 Nov; 68(11):605-614. doi:
10.1055/s-0044-100374. [PMID: 29791923] - Kendall M Lawrence, Holly L Hedrick, Heather M Monk, Lisa Herkert, Lindsay N Waqar, Brian D Hanna, William H Peranteau, Natalie E Rintoul, Rachel K Hopper. Treprostinil Improves Persistent Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia.
The Journal of pediatrics.
2018 09; 200(?):44-49. doi:
10.1016/j.jpeds.2018.04.052. [PMID: 29784517] - Richard W Chapman, Zhili Li, Michel R Corboz, Helena Gauani, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Charles E Laurent, Han Yin, Dany Salvail, Chad Dziak, Walter R Perkins, Vladimir Malinin. Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil.
Pulmonary pharmacology & therapeutics.
2018 04; 49(?):104-111. doi:
10.1016/j.pupt.2018.02.002. [PMID: 29421665] - Michel R Corboz, Zhili Li, Vladimir Malinin, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Kuan-Ju Chen, Charles E Laurent, Han Yin, Marzena C Biernat, Dany Salvail, Jianguo Zhuang, Fadi Xu, Aidan Curran, Walter R Perkins, Richard W Chapman. Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
The Journal of pharmacology and experimental therapeutics.
2017 12; 363(3):348-357. doi:
10.1124/jpet.117.242099. [PMID: 28904003] - Takanori Watanabe, Kohtaro Abe, Koshin Horimoto, Kazuya Hosokawa, Kisho Ohtani, Hiroyuki Tsutsui. Subcutaneous treprostinil was effective and tolerable in a patient with severe pulmonary hypertension associated with chronic kidney disease on hemodialysis.
Heart & lung : the journal of critical care.
2017 Mar; 46(2):129-130. doi:
10.1016/j.hrtlng.2017.01.004. [PMID: 28189266] - Robert C Bourge, Aaron B Waxman, Mardi Gomberg-Maitland, Shelley M Shapiro, James H Tarver, Dianne L Zwicke, Jeremy P Feldman, Murali M Chakinala, Robert P Frantz, Fernando Torres, Jeffrey Cerkvenik, Marty Morris, Melissa Thalin, Leigh Peterson, Lewis J Rubin. Treprostinil Administered to Treat Pulmonary Arterial Hypertension Using a Fully Implantable Programmable Intravascular Delivery System: Results of the DelIVery for PAH Trial.
Chest.
2016 Jul; 150(1):27-34. doi:
10.1016/j.chest.2015.11.005. [PMID: 27396777] - David M Smadja, Marilyne Levy, Lan Huang, Elisa Rossi, Adeline Blandinières, Dominique Israel-Biet, Pascale Gaussem, Joyce Bischoff. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells.
Thrombosis and haemostasis.
2015 Oct; 114(4):735-47. doi:
10.1160/th14-11-0907. [PMID: 26062754] - Chabha Benyahia, Gulsev Ozen, Nelson Orie, Agatha Ledwozyw, Liliane Louedec, Fangfang Li, Amira M Senbel, Adam Silverstein, Claire Danel, Dan Longrois, Lucie H Clapp, Xavier Norel, Gökçe Topal. Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents.
Prostaglandins & other lipid mediators.
2015 Sep; 121(Pt A):46-52. doi:
10.1016/j.prostaglandins.2015.09.002. [PMID: 26362969] - Huan Liu, Erli Yang, Xiaolan Lu, Caojian Zuo, Yuhu He, Daile Jia, Qian Zhu, Ying Yu, Ankang Lv. Serum levels of tumor necrosis factor-related apoptosis-inducing ligand correlate with the severity of pulmonary hypertension.
Pulmonary pharmacology & therapeutics.
2015 Aug; 33(?):39-46. doi:
10.1016/j.pupt.2015.06.002. [PMID: 26086178] - M Roustit, F Gaillard-Bigot, S Blaise, F Stanke-Labesque, C Cracowski, C Seinturier, J-F Jourdil, B Imbert, P H Carpentier, J-L Cracowski. Cutaneous iontophoresis of treprostinil in systemic sclerosis: a proof-of-concept study.
Clinical pharmacology and therapeutics.
2014 Apr; 95(4):439-45. doi:
10.1038/clpt.2013.255. [PMID: 24458011] - Amanda Jones, Laurene Wang-Smith, Theresa Pham, Kevin Laliberte. Pharmacokinetics of 3 times a day dosing of oral treprostinil in healthy volunteers.
Journal of cardiovascular pharmacology.
2014 Mar; 63(3):227-32. doi:
10.1097/fjc.0000000000000039. [PMID: 24603117] - A Lim, L Wang-Smith, J Kates, A Laurent, P Kumar, K Laliberte. The effect of different meal compositions on the oral bioavailability of treprostinil diolamine in healthy volunteers.
Journal of clinical pharmacy and therapeutics.
2013 Dec; 38(6):450-5. doi:
10.1111/jcpt.12085. [PMID: 23927483] - Chabha Benyahia, Kamel Boukais, Ingrid Gomez, Adam Silverstein, Lucie Clapp, Aurélie Fabre, Claire Danel, Guy Leséche, Dan Longrois, Xavier Norel. A comparative study of PGI2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor.
Prostaglandins & other lipid mediators.
2013 Dec; 107(?):48-55. doi:
10.1016/j.prostaglandins.2013.07.001. [PMID: 23850788] - N N Orie, A Ledwozyw, D J Williams, B J Whittle, L H Clapp. Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins.
Prostaglandins & other lipid mediators.
2013 Oct; 106(?):1-7. doi:
10.1016/j.prostaglandins.2013.07.003. [PMID: 23872196] - R James White, Fernando Torres, Roblee Allen, Carlos Jerjes, Tomas Pulido, David Yehle, Meredith Howell, Kevin Laliberte, Jean-Francois Marier, Victor F Tapson. Pharmacokinetics of oral treprostinil sustained release tablets during chronic administration to patients with pulmonary arterial hypertension.
Journal of cardiovascular pharmacology.
2013 Jun; 61(6):474-81. doi:
10.1097/fjc.0b013e31828685da. [PMID: 23328389] - Ami A Shah, Elena Schiopu, Laura K Hummers, Michael Wade, Kristine Phillips, Cynthia Anderson, Robert Wise, Francesco Boin, James R Seibold, Fredrick Wigley, Kristan D Rollins. Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion.
Arthritis research & therapy.
2013 Apr; 15(2):R54. doi:
10.1186/ar4216. [PMID: 23597147] - Amanda Jenkins, Laurene Wang-Smith, Thomas Marbury, Kevin Laliberte. Pharmacokinetics of treprostinil diolamine in subjects with end-stage renal disease on or off dialysis.
Journal of cardiovascular pharmacology.
2013 Apr; 61(4):272-6. doi:
10.1097/fjc.0b013e31827e0fa9. [PMID: 23188123] - Zhi-Cheng Jing, Keyur Parikh, Tomas Pulido, Carlos Jerjes-Sanchez, R James White, Roblee Allen, Adam Torbicki, Kai-Feng Xu, David Yehle, Kevin Laliberte, Carl Arneson, Lewis J Rubin. Efficacy and safety of oral treprostinil monotherapy for the treatment of pulmonary arterial hypertension: a randomized, controlled trial.
Circulation.
2013 Feb; 127(5):624-33. doi:
10.1161/circulationaha.112.124388. [PMID: 23307827] - Barbara L LeVarge, Richard N Channick. Inhaled treprostinil for the treatment of pulmonary arterial hypertension.
Expert review of respiratory medicine.
2012 Jun; 6(3):255-65. doi:
10.1586/ers.12.23. [PMID: 22788940] - N Ghonem, J Yoshida, D B Stolz, A Humar, T E Starzl, N Murase, R Venkataramanan. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2011 Nov; 11(11):2508-16. doi:
10.1111/j.1600-6143.2011.03568.x. [PMID: 21668631] - Jagdish Hiremath, Sadagopa Thanikachalam, Keyur Parikh, Somasundaram Shanmugasundaram, Sudhakar Bangera, Leland Shapiro, Gregory B Pott, Cindy L Vnencak-Jones, Carl Arneson, Michael Wade, R James White. Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: a placebo-controlled trial.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2010 Feb; 29(2):137-49. doi:
10.1016/j.healun.2009.09.005. [PMID: 20022264] - C Shane McSwain, Ray Benza, Shelley Shapiro, Nicholas Hill, Robert Schilz, C Gregory Elliott, Dianne L Zwicke, Ronald J Oudiz, James P Staszewski, Carl P Arneson, Michael Wade, David Zaccardelli, Vallerie McLaughlin. Dose proportionality of treprostinil sodium administered by continuous subcutaneous and intravenous infusion.
Journal of clinical pharmacology.
2008 Jan; 48(1):19-25. doi:
10.1177/0091270007309708. [PMID: 18094217] - M Morris, K Phares, D Zaccardelli, M R Ujhelyi. A novel catheter system for totally implantable intravenous drug therapy: assessment of catheter function and patency with trepostinil therapy.
The journal of vascular access.
2008 Jan; 9(1):20-7. doi:
10.1177/112972980800900104. [PMID: 18379976] - N Skoro-Sajer, D Bonderman, F Wiesbauer, E Harja, J Jakowitsch, W Klepetko, M P Kneussl, I M Lang. Treprostinil for severe inoperable chronic thromboembolic pulmonary hypertension.
Journal of thrombosis and haemostasis : JTH.
2007 Mar; 5(3):483-9. doi:
10.1111/j.1538-7836.2007.02394.x. [PMID: 17319903] - David M Aronoff, Camila M Peres, Carlos H Serezani, Megan N Ballinger, Jennifer K Carstens, Nicole Coleman, Bethany B Moore, R Stokes Peebles, Lucia H Faccioli, Marc Peters-Golden. Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities.
Journal of immunology (Baltimore, Md. : 1950).
2007 Feb; 178(3):1628-34. doi:
10.4049/jimmunol.178.3.1628. [PMID: 17237412] - Robert Voswinckel, Beate Enke, Frank Reichenberger, Markus Kohstall, Andree Kreckel, Stefanie Krick, Henning Gall, Tobias Gessler, Thomas Schmehl, Hossein A Ghofrani, Ralph Theo Schermuly, Friedrich Grimminger, Lewis J Rubin, Werner Seeger, Horst Olschewski. Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies.
Journal of the American College of Cardiology.
2006 Oct; 48(8):1672-81. doi:
10.1016/j.jacc.2006.06.062. [PMID: 17045906] - Michael Wade, F Jo Baker, Robert Roscigno, Wayne DellaMaestra, Carl P Arneson, Thomas L Hunt, Allen A Lai. Pharmacokinetics of treprostinil sodium administered by 28-day chronic continuous subcutaneous infusion.
Journal of clinical pharmacology.
2004 May; 44(5):503-9. doi:
10.1177/0091270004264638. [PMID: 15102871] - Michael Wade, F Jo Baker, Robert Roscigno, Wayne DellaMaestra, Thomas L Hunt, Allen A Lai. Absolute bioavailability and pharmacokinetics of treprostinil sodium administered by acute subcutaneous infusion.
Journal of clinical pharmacology.
2004 Jan; 44(1):83-8. doi:
10.1177/0091270003261343. [PMID: 14681345] - Michael Dandel, Roland Hetzer. Clinical value of prostacyclin and its analogs in the management of pulmonary arterial hypertension.
Current vascular pharmacology.
2003 Jun; 1(2):171-81. doi:
10.2174/1570161033476754. [PMID: 15320842] - Lucie H Clapp, Paul Finney, Sally Turcato, Sandy Tran, Lewis J Rubin, Andrew Tinker. Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery.
American journal of respiratory cell and molecular biology.
2002 Feb; 26(2):194-201. doi:
10.1165/ajrcmb.26.2.4695. [PMID: 11804870] - Shelly B Flagel, Delia M Vázquez, Stanley J Watson, Charles R Neal. Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response.
American journal of physiology. Regulatory, integrative and comparative physiology.
2002 Jan; 282(1):R55-63. doi:
10.1152/ajpregu.2002.282.1.r55. [PMID: 11742823]