(6R,7R)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrogen sulfate (BioDeep_00000839840)
代谢物信息卡片
(6R,7R)-3-[[3-amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrogen sulfate
化学式: C23H32N12O12S3 (764.1424711999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(=O)O)ON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)O.OS(=O)(=O)[O-]
InChI: /m1./s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wei Gao, Julie Passarell, Yogesh T Patel, Zufei Zhang, Gina Lin, Jill Fiedler-Kelly, Christopher J Bruno, Elizabeth G Rhee, Carisa S De Anda, Hwa-Ping Feng. Exposure-Efficacy Analyses Support Optimal Dosing Regimens of Ceftolozane/Tazobactam in Participants with Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia in ASPECT-NP.
Antimicrobial agents and chemotherapy.
2022 05; 66(5):e0139921. doi:
10.1128/aac.01399-21. [PMID: 35471040] - Nezar M Bahabri, Maha Mahmoud Al-Alawi, Mohammed O Qutub, Wail A Tashkandi, Raha AlTurki, Safiah Saad Janah, Heidi Essam Ali, Albandari F Almutairi, Sherif Khalil. In-vitro activity of ceftolozane/tazobactam against recent clinical bacterial isolates from two Saudi Arabian hospitals.
Journal of infection and public health.
2022 Apr; 15(4):486-490. doi:
10.1016/j.jiph.2022.02.009. [PMID: 35221238] - Bence Mogyoródi, András B Csékó, Csaba Hermann, János Gál, Zsolt D Iványi. Ceftolozane/tazobactam versus colistin in the treatment of ventilator-associated pneumonia due to extensively drug-resistant Pseudomonas aeruginosa.
Scientific reports.
2022 03; 12(1):4455. doi:
10.1038/s41598-022-08307-9. [PMID: 35292686] - Thamer A Almangour, Ahmad Aljabri, Mohammed Al Musawa, Abdullah Almohaizeie, Sara Almuhisen, Nader Damfu, Awaly Alfozan, Basem M Alraddadi, Majda Alattas, Mohammed Qutub, Abrar F Alhameed, Malik Khuwaja, Ahlam Alghamdi, Khalifa M Binkhamis, Wafa Alfahad, Fatimah S AlShahrani. Ceftolozane-tazobactam vs. colistin for the treatment of infections due to multidrug-resistant Pseudomonas aeruginosa: a multicentre cohort study.
Journal of global antimicrobial resistance.
2022 03; 28(?):288-294. doi:
10.1016/j.jgar.2022.01.023. [PMID: 35121161] - Sunish Shah, Derek N Bremmer, Ellen G Kline, David P Nicolau, Ryan K Shields. Ceftolozane/tazobactam for refractory P. aeruginosa endocarditis: A case report and pharmacokinetic analysis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Jan; 28(1):87-90. doi:
10.1016/j.jiac.2021.08.013. [PMID: 34535403] - A Pinilla-Rello, R Huarte-Lacunza, A Magallón-Martínez, L Cazorla-Poderoso, O Pereira-Blanco, M Pérez-Moreno, I Larrodé-Leciñena, R M Martínez-Álvarez, A I López-Calleja. [Utilization study in real clinical practice of ceftolozane/tazobactam vs aminoglycosides and/or colistin in the treatment of multirresistant or extremely resistant Pseudomonas aeruginosa].
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia.
2021 Oct; 34(5):441-449. doi:
10.37201/req/006.2021. [PMID: 34154319] - V Al Jalali, M Wölfl-Duchek, M Taubert, P Matzneller, E Lackner, C Dorn, A Kratzer, B Wulkersdorfer, Z Österreicher, M Zeitlinger. Plasma and soft tissue pharmacokinetics of ceftolozane/tazobactam in healthy volunteers after single and multiple intravenous infusion: a microdialysis study.
The Journal of antimicrobial chemotherapy.
2021 08; 76(9):2342-2351. doi:
10.1093/jac/dkab166. [PMID: 34050650] - Marianna Meschiari, Iacopo Franconi, Erica Bacca, Vincenzo Bianco, Gabriella Orlando, Gianluca Cuomo, Andrea Bedini, Cristina Mussini. Ceftazidime/avibactam and ceftolozane/tazobactam for the treatment of extensively drug-resistant Pseudomonas aeruginosa post-neurosurgical infections: three cases and a review of the literature.
Infection.
2021 Jun; 49(3):549-553. doi:
10.1007/s15010-020-01539-9. [PMID: 33074365] - Suzanne L Parker, Saurabh Pandey, Fekade B Sime, Janine Stuart, Jeffrey Lipman, Jason A Roberts, Steven C Wallis. A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane-tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies.
Clinical chemistry and laboratory medicine.
2021 04; 59(5):921-933. doi:
10.1515/cclm-2020-1196. [PMID: 33554515] - S Alexander Winans, Richelle L Guerrero-Wooley, Susie H Park, Garret Hino, Steven C Forland. Continuous infusion of ceftolozane-tazobactam resulted in high cerebrospinal fluid concentrations of ceftolozane in a patient with multidrug-resistant Pseudomonas aeruginosa meningitis.
Infection.
2021 Apr; 49(2):355-359. doi:
10.1007/s15010-020-01510-8. [PMID: 32862306] - Fekade B Sime, Melissa Lassig-Smith, Therese Starr, Janine Stuart, Saurabh Pandey, Suzanne L Parker, Steven C Wallis, Jeffrey Lipman, Jason A Roberts. Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain.
Antimicrobial agents and chemotherapy.
2020 12; 65(1):. doi:
10.1128/aac.01698-20. [PMID: 33077655] - William C Putnam, Raja Reddy Kallem, Vindhya Edpuganti, Indhu Subramaniyan, Ronald G Hall. Development and validation of a quantitative LC-MS/MS method for the simultaneous determination of ceftolozane and tazobactam in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Nov; 1159(?):122354. doi:
10.1016/j.jchromb.2020.122354. [PMID: 32905989] - Jennifer A Huntington, Brian Yu, Linping Li, Erin Jensen, Christopher Bruno, Mathew Boakye, Zufei Zhang, Wei Gao, Hwa-Ping Feng, Elizabeth Rhee. Outcomes in Participants with Renal Impairment from a Phase 3 Clinical Trial for Ceftolozane/Tazobactam Treatment of Nosocomial Pneumonia (ASPECT-NP).
Antimicrobial agents and chemotherapy.
2020 11; 64(12):. doi:
10.1128/aac.00731-20. [PMID: 32988827] - Irene Galani, Vassiliki Papoutsaki, Irene Karantani, Ilias Karaiskos, Lamprini Galani, Panagiota Adamou, Ioannis Deliolanis, Antigoni Kodonaki, Eleni Papadogeorgaki, Margarita Markopoulou, Sofia Maraki, Maria Damala, Eleni Prifti, Eleni Vagiakou, Efthimia Petinaki, Kimon Fountoulis, Sophia Tsiplakou, Helen Kirikou, Maria Souli, Anastasia Antoniadou, Helen Giamarellou. In vitro activity of ceftolozane/tazobactam alone and in combination with amikacin against MDR/XDR Pseudomonas aeruginosa isolates from Greece.
The Journal of antimicrobial chemotherapy.
2020 08; 75(8):2164-2172. doi:
10.1093/jac/dkaa160. [PMID: 32449909] - Jason M Pogue, Keith S Kaye, Michael P Veve, Twisha S Patel, Anthony T Gerlach, Susan L Davis, Laura A Puzniak, Tom M File, Shannon Olson, Sorabh Dhar, Robert A Bonomo, Federico Perez. Ceftolozane/Tazobactam vs Polymyxin or Aminoglycoside-based Regimens for the Treatment of Drug-resistant Pseudomonas aeruginosa.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 07; 71(2):304-310. doi:
10.1093/cid/ciz816. [PMID: 31545346] - Luzelena Caro, David P Nicolau, Jan J De Waele, Joseph L Kuti, Kajal B Larson, Elaine Gadzicki, Brian Yu, Zhen Zeng, Adedayo Adedoyin, Elizabeth G Rhee. Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia.
The Journal of antimicrobial chemotherapy.
2020 06; 75(6):1546-1553. doi:
10.1093/jac/dkaa049. [PMID: 32211756] - Jens Martens-Lobenhoffer, Matthias Hinderhofer, Uwe Tröger, Stefanie M Bode-Böger. Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage.
Journal of pharmacological and toxicological methods.
2020 May; 103(?):106692. doi:
10.1016/j.vascn.2020.106692. [PMID: 32171855] - Eduard Argudo, Jordi Riera, Sonia Luque, Ibai Los-Arcos, Manuel López-Meseguer, Alberto Sandiumenge, Xavier Nuvials, Santiago Grau, Ricard Ferrer. Effects of the extracorporeal membrane oxygenation circuit on plasma levels of ceftolozane.
Perfusion.
2020 04; 35(3):267-270. doi:
10.1177/0267659119864813. [PMID: 31387460] - Alina Karoline Nussbaumer-Pröll, Sabine Eberl, Birgit Reiter, Thomas Stimpfl, Christoph Dorn, Markus Zeitlinger. Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections.
The Journal of antimicrobial chemotherapy.
2020 03; 75(3):593-599. doi:
10.1093/jac/dkz488. [PMID: 31794023] - Sümeyye Akyüz, Mehmet Parlak, Hüseyin Güdücüoğlu. [In-vitro Activity of Ceftolozane-Tazobactam in Combination with Various Antibiotics Against Multidrug-resistant Acinetobacter baumannii Isolated from Intensive Care Patients].
Mikrobiyoloji bulteni.
2020 Jan; 54(1):154-162. doi:
10.5578/mb.68981. [PMID: 32050886] - Fekade B Sime, Melissa Lassig-Smith, Therese Starr, Janine Stuart, Saurabh Pandey, Suzanne L Parker, Steven C Wallis, Jeffrey Lipman, Jason A Roberts. Population Pharmacokinetics of Unbound Ceftolozane and Tazobactam in Critically Ill Patients without Renal Dysfunction.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.01265-19. [PMID: 31358583] - Kajal B Larson, Yogesh T Patel, Susan Willavize, John S Bradley, Elizabeth G Rhee, Luzelena Caro, Matthew L Rizk. Ceftolozane-Tazobactam Population Pharmacokinetics and Dose Selection for Further Clinical Evaluation in Pediatric Patients with Complicated Urinary Tract or Complicated Intra-abdominal Infections.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.02578-18. [PMID: 30962340] - Ana Motos, Joseph L Kuti, Gianluigi Li Bassi, Antoni Torres, David P Nicolau. Is One Sample Enough? β-Lactam Target Attainment and Penetration into Epithelial Lining Fluid Based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01922-18. [PMID: 30509937] - Alexander Kratzer, Selina Schießer, Peter Matzneller, Beatrix Wulkersdorfer, Markus Zeitlinger, Jens Schlossmann, Frieder Kees, Christoph Dorn. Determination of total and free ceftolozane and tazobactam in human plasma and interstitial fluid by HPLC-UV.
Journal of pharmaceutical and biomedical analysis.
2019 Jan; 163(?):34-38. doi:
10.1016/j.jpba.2018.09.044. [PMID: 30278324] - Olga Saran, Beata Sulik-Tyszka, Grzegorz W Basak, Marta M Wróblewska. Activity of Ceftolozane/Tazobactam Against Gram-Negative Rods of the Family Enterobacteriaceae and Pseudomonas Spp. Isolated from Onco-Hematological Patients Hospitalized in a Clinical Hospital in Poland.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Jan; 25(?):305-311. doi:
10.12659/msm.913352. [PMID: 30628586] - Carlos Ezquer-Garin, Rafael Ferriols-Lisart, Manuel Alós-Almiñana, Gerardo Aguilar-Aguilar, Javier F Belda-Nacher, Jose-Antonio Carbonell. Validated HPLC-UV detection method for the simultaneous determination of ceftolozane and tazobactam in human plasma.
Bioanalysis.
2018 Apr; 10(7):461-473. doi:
10.4155/bio-2017-0257. [PMID: 29633862] - Matthew Rawlins, Vesa Cheng, Edward Raby, John Dyer, Adrian Regli, Paul Ingram, Brett C McWhinney, Jacobus P J Ungerer, Jason A Roberts. Pharmacokinetics of Ceftolozane-Tazobactam during Prolonged Intermittent Renal Replacement Therapy.
Chemotherapy.
2018; 63(4):203-206. doi:
10.1159/000493196. [PMID: 30304718] - Anthony Aiudi, Benjamin Miller, Gopal Krishna, Adedayo Adedoyin, Alan Xiao. Pharmacokinetics, safety, and tolerability of ceftolozane/tazobactam in healthy Japanese, Chinese, and white subjects.
Fundamental & clinical pharmacology.
2016 Dec; 30(6):625-633. doi:
10.1111/fcp.12227. [PMID: 27473285] - Christina A Sutherland, David P Nicolau. Development of an HPLC Method for the Determination of Ceftolozane/Tazobactam in Biological and Aqueous Matrixes.
Journal of chromatographic science.
2016 Jul; 54(6):1037-40. doi:
10.1093/chromsci/bmw047. [PMID: 27048639] - Alan J Xiao, Benjamin W Miller, Jennifer A Huntington, David P Nicolau. Ceftolozane/tazobactam pharmacokinetic/pharmacodynamic-derived dose justification for phase 3 studies in patients with nosocomial pneumonia.
Journal of clinical pharmacology.
2016 Jan; 56(1):56-66. doi:
10.1002/jcph.566. [PMID: 26096377] - Gurudatt Chandorkar, Alan Xiao, Mohamad-Samer Mouksassi, Ellie Hershberger, Gopal Krishna. Population pharmacokinetics of ceftolozane/tazobactam in healthy volunteers, subjects with varying degrees of renal function and patients with bacterial infections.
Journal of clinical pharmacology.
2015 Feb; 55(2):230-9. doi:
10.1002/jcph.395. [PMID: 25196976] - M J Melchers, E Mavridou, S Seyedmousavi, A C van Mil, C Lagarde, J W Mouton. Plasma and epithelial lining fluid pharmacokinetics of ceftolozane and tazobactam alone and in combination in mice.
Antimicrobial agents and chemotherapy.
2015; 59(6):3373-6. doi:
10.1128/aac.04402-14. [PMID: 25824214] - George G Zhanel, Phillip Chung, Heather Adam, Sheryl Zelenitsky, Andrew Denisuik, Frank Schweizer, Philippe R S Lagacé-Wiens, Ethan Rubinstein, Alfred S Gin, Andrew Walkty, Daryl J Hoban, Joseph P Lynch, James A Karlowsky. Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli.
Drugs.
2014 Jan; 74(1):31-51. doi:
10.1007/s40265-013-0168-2. [PMID: 24352909] - Myra Wooley, Benjamin Miller, Gopal Krishna, Ellie Hershberger, Gurudatt Chandorkar. Impact of renal function on the pharmacokinetics and safety of ceftolozane-tazobactam.
Antimicrobial agents and chemotherapy.
2014; 58(4):2249-55. doi:
10.1128/aac.02151-13. [PMID: 24492369] - Yigong Ge, M J Whitehouse, Ian Friedland, George H Talbot. Pharmacokinetics and safety of CXA-101, a new antipseudomonal cephalosporin, in healthy adult male and female subjects receiving single- and multiple-dose intravenous infusions.
Antimicrobial agents and chemotherapy.
2010 Aug; 54(8):3427-31. doi:
10.1128/aac.01753-09. [PMID: 20457817]