Nevanimibe hydrochloride (BioDeep_00000839827)

   


代谢物信息卡片


Nevanimibe hydrochloride

化学式: C27H40ClN3O (457.28597400000007)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)NC(=O)NCC2(CCCC2)C3=CC=C(C=C3)N(C)C.Cl
InChI: 1H

描述信息

C471 - Enzyme Inhibitor
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer[1].

同义名列表

3 个代谢物同义名

Nevanimibe hydrochloride; PD-132301 hydrochloride; ATR101 hydrochloride



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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文献列表

  • J F Reindel, M A Dominick, T M Bocan, A W Gough, E J McGuire. Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys. Toxicologic pathology. 1994 Sep; 22(5):510-8. doi: 10.1177/019262339402200505. [PMID: 7899779]
  • B K Trivedi, T S Purchase, A Holmes, C E Augelli-Szafran, A D Essenburg, K L Hamelehle, R L Stanfield, R F Bousley, B R Krause. Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity. Journal of medicinal chemistry. 1994 May; 37(11):1652-9. doi: 10.1021/jm00037a016. [PMID: 8201599]
  • B R Krause, A Black, R Bousley, A Essenburg, J Cornicelli, A Holmes, R Homan, K Kieft, C Sekerke, M K Shaw-Hes. Divergent pharmacologic activities of PD 132301-2 and CL 277,082, urea inhibitors of acyl-CoA:cholesterol acyltransferase. The Journal of pharmacology and experimental therapeutics. 1993 Nov; 267(2):734-43. doi: NULL. [PMID: 8246149]
  • R G Elkin, M Freed, B A Watkins, M Srebnik, K A Kieft, R S Newton. Evaluation of two novel biochemicals on plasma and egg yolk lipid composition and laying hen performance. Poultry science. 1993 Mar; 72(3):513-20. doi: 10.3382/ps.0720513. [PMID: 8464792]
  • M A Dominick, E J McGuire, J F Reindel, W F Bobrowski, T M Bocan, A W Gough. Subacute toxicity of a novel inhibitor of acyl-CoA: cholesterol acyltransferase in beagle dogs. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1993 Feb; 20(2):217-24. doi: 10.1006/faat.1993.1029. [PMID: 8383621]
  • M A Dominick, W A Bobrowski, J R MacDonald, A W Gough. Morphogenesis of a zone-specific adrenocortical cytotoxicity in guinea pigs administered PD 132301-2, an inhibitor of acyl-CoA:cholesterol acyltransferase. Toxicologic pathology. 1993; 21(1):54-62. doi: 10.1177/019262339302100107. [PMID: 8397438]
  • L A Vernetti, J R MacDonald, G H Wolfgang, M A Dominick, D G Pegg. ATP depletion is associated with cytotoxicity of a novel lipid regulator in guinea pig adrenocortical cells. Toxicology and applied pharmacology. 1993 Jan; 118(1):30-8. doi: 10.1006/taap.1993.1005. [PMID: 8381566]