Levotofisopam (BioDeep_00000839823)
代谢物信息卡片
化学式: C22H26N2O4 (382.18924760000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1C(=NN=C(C2=CC(=C(C=C12)OC)OC)C3=CC(=C(C=C3)OC)OC)C
InChI: InChI=1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3/t15-/m1/s1
描述信息
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Joana Erdmann, Bjoern Moosmann. Cross reactivity of the CEDIA and HEIA benzodiazepine kits for 29 designer benzodiazepines and tofisopam.
Drug testing and analysis.
2021 Sep; 13(9):1686-1688. doi:
10.1002/dta.3111. [PMID: 34139790] - Michael D Cameron, Jason Wright, Christopher B Black, Naidong Ye. In vitro prediction and in vivo verification of enantioselective human tofisopam metabolite profiles.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Oct; 35(10):1894-902. doi:
10.1124/dmd.107.015875. [PMID: 17646282] - N Bonnet, P Bernard, H Beaupied, J C Bizot, F Trovero, D Courteix, C L Benhamou. Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling.
Toxicology and applied pharmacology.
2007 May; 221(1):111-8. doi:
10.1016/j.taap.2007.02.005. [PMID: 17383703] - Maria Tóth, Andrea Bereczki, Sándor Drabant, Katalin Balogh Nemes, Bálint Varga, Gyula Grézal, Judit Tömlo, Géza Lakner, Imre Klebovich. Gas chromatography nitrogen phosphorous detection (GC-NPD) assay of tofisopam in human plasma for pharmacokinetic evaluation.
Journal of pharmaceutical and biomedical analysis.
2006 Jun; 41(4):1354-9. doi:
10.1016/j.jpba.2006.03.033. [PMID: 16682162] - K B Ovanesov. [The effect of tofisopam and tinctura leonuri on the color-discrimination function in young humans].
Eksperimental'naia i klinicheskaia farmakologiia.
2005 May; 68(3):56-9. doi:
". [PMID: 16047683] - E B Arushaian, O A Mastiagina, S S Mastiagin, A P Popova. [Fluctuations of the antianxiety effect of valerian and grandaxin during daytime wakefulness in humans with different chronotypes].
Fiziologiia cheloveka.
2005 Mar; 31(2):135-7. doi:
". [PMID: 15889832] - é B Arushanian, O A Mastiagina, A P Popova. [Peculiarities in the effect of tofisopam and valerian extract on short-term memory and anxiety states in healthy humans].
Eksperimental'naia i klinicheskaia farmakologiia.
2004 Nov; 67(6):23-5. doi:
". [PMID: 15707009] - Soo Kyoung Baek, Sung Jin Choi, Jeong Soo Kim, Eun Jeon Park, Dong Hwan Sohn, Hee-Yong Lee, Hye Suk Lee. Analysis of tofisopam in human serum by column-switching semi-micro high-performance liquid chromatography and evaluation of tofisopam bioequivalency.
Biomedical chromatography : BMC.
2002 Jun; 16(4):277-81. doi:
10.1002/bmc.142. [PMID: 11933029] - D E Bodrina, V S Galkina, S K Eremin, E M Salomatin. [The analysis of grandaksin in cadaveric material].
Sudebno-meditsinskaia ekspertiza.
1996 Oct; 39(4):45-7. doi:
NULL. [PMID: 9026971] - A Tracqui, P Kintz, B Ludes, C Rougé, H Douibi, P Mangin. High-performance liquid chromatography coupled to ion spray mass spectrometry for the determination of colchicine at ppb levels in human biofluids.
Journal of chromatography. B, Biomedical applications.
1996 Jan; 675(2):235-42. doi:
10.1016/0378-4347(95)00386-x. [PMID: 8852710] - I Klebovich, M Abermann. [Pharmacokinetics and metabolism of tofizopam (Grandaxin)].
Acta pharmaceutica Hungarica.
1993 Mar; 63(2):83-90. doi:
NULL. [PMID: 8100113] - E Tomori, I Elekes, T Láng, G Horváth. Investigation of metabolites of tofizopam in man and animals.
Polish journal of pharmacology and pharmacy.
1984 Jul; 36(4):423-30. doi:
NULL. [PMID: 6152052] - M Simonyi, I Fitos. Stereoselective binding of a 2,3-benzodiazepine to human serum albumin. Effect of conformation on tofizopam binding.
Biochemical pharmacology.
1983 Jun; 32(12):1917-20. doi:
10.1016/0006-2952(83)90058-8. [PMID: 6882467] - T Mennini, A Abbiati, S Caccia, S Cotecchia, A Gomez, S Garattini. Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors.
Naunyn-Schmiedeberg's archives of pharmacology.
1982 Nov; 321(2):112-5. doi:
10.1007/bf00518477. [PMID: 6296700] - E Tomori, G Horváth, I Elekes, T Láng, J Körösi. Investigation of the metabolites of tofizopam in man and animals by gas-liquid chromatography-mass spectrometry.
Journal of chromatography.
1982 May; 241(1):89-99. doi:
10.1016/s0021-9673(00)82392-4. [PMID: 6809776] - A Bond, M Lader. A comparison of the psychotropic profiles of tofisopam and diazepam.
European journal of clinical pharmacology.
1982; 22(2):137-42. doi:
10.1007/bf00542458. [PMID: 6124424] - M Sajgó, A Gesztesi, T Sidó. Determination of tofisopam in serum by high-performance liquid chromatography.
Journal of chromatography.
1981 Feb; 222(2):303-7. doi:
10.1016/s0378-4347(00)81065-8. [PMID: 6114105]