Tomopenem (BioDeep_00000839763)
代谢物信息卡片
化学式: C23H35N7O6S (537.236941)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(C(=O)N2C(=C1SC3CC(N(C3)C)C(=O)N4CCC(C4)NC(=O)CN=C(N)N)C(=O)O)C(C)O
InChI: InChI=1S/C23H35N7O6S/c1-10-17-16(11(2)31)21(34)30(17)18(22(35)36)19(10)37-13-6-14(28(3)9-13)20(33)29-5-4-12(8-29)27-15(32)7-26-23(24)25/h10-14,16-17,31H,4-9H2,1-3H3,(H,27,32)(H,35,36)(H4,24,25,26)/t10-,11-,12+,13+,14+,16-,17-/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Kiyoshi Sugihara, Chika Sugihara, Yoko Matsushita, Naotoshi Yamamura, Mitsutoshi Uemori, Akane Tokumitsu, Harumi Inoue, Masayo Kakuta, Eiko Namba, Hatsumi Nasu, Tetsufumi Koga. In vivo pharmacodynamic activity of tomopenem (formerly CS-023) against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus in a murine thigh infection model.
Antimicrobial agents and chemotherapy.
2010 Dec; 54(12):5298-302. doi:
10.1128/aac.00267-10
. [PMID: 20921311] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j
. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479
. [PMID: 18426954] - Navita L Mallalieu, Siân Lennon, Mei Liu, Christopher Kirkpatrick, Richard Robson, Eric Luedin, Brian E Davies. Effect of impaired renal function on the pharmacokinetics of tomopenem (RO4908463/CS-023), a novel carbapenem.
Antimicrobial agents and chemotherapy.
2008 Jul; 52(7):2360-6. doi:
10.1128/aac.01249-07
. [PMID: 18443123] - Takahiro Shibayama, Daisuke Sugiyama, Emi Kamiyama, Taro Tokui, Takashi Hirota, Toshihiko Ikeda. Characterization of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem as substrates of human renal transporters.
Drug metabolism and pharmacokinetics.
2007 Feb; 22(1):41-7. doi:
10.2133/dmpk.22.41
. [PMID: 17329910] - Takahiro Shibayama, Yoko Matsushita, Kenji Kawai, Takashi Hirota, Toshihiko Ikeda, Shogo Kuwahara. Pharmacokinetics and disposition of CS-023 (RO4908463), a novel parenteral carbapenem, in animals.
Antimicrobial agents and chemotherapy.
2007 Jan; 51(1):257-63. doi:
10.1128/aac.00459-06
. [PMID: 17074792] - T Shibayama, Y Matsushita, A Kurihara, T Hirota, T Ikeda. Prediction of pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, in humans using animal data.
Xenobiotica; the fate of foreign compounds in biological systems.
2007 Jan; 37(1):91-102. doi:
10.1080/00498250601047889
. [PMID: 17178636] - T Shibayama, N Yamamura, Y Matsushita, T Tokui, T Hirota, T Ikeda. Renal handling of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, in rabbits in comparison with meropenem.
Xenobiotica; the fate of foreign compounds in biological systems.
2006 Dec; 36(12):1273-87. doi:
10.1080/00498250600944326
. [PMID: 17162472] - Takahiro Shibayama, Yoko Matsushita, Takashi Hirota, Toshihiko Ikeda, Shogo Kuwahara. Pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem, in healthy male Caucasian volunteers.
Antimicrobial agents and chemotherapy.
2006 Dec; 50(12):4186-8. doi:
10.1128/aac.00494-06
. [PMID: 17043123]