Pamapimod (BioDeep_00000839756)
代谢物信息卡片
化学式: C19H20F2N4O4 (406.14525440000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC(CCO)CCO
InChI: InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24)
描述信息
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2149 - Mitogen-Activated Protein Kinase Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:90685
- KEGGdrug: D08963
- PubChem: 16220188
- ChEMBL: CHEMBL1090089
- CAS: 449811-01-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Christian Setz, Maximilian Große, Janina Auth, Maria Fröba, Pia Rauch, Alexander Bausch, Matthew Wright, Ulrich Schubert. Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern.
International journal of molecular sciences.
2022 Jun; 23(12):. doi:
10.3390/ijms23126830. [PMID: 35743273] - X Zhang, S Fettner, E Winter, M Masjedizadeh, G Hisoire. Metabolism and excretion of a novel p38 MAP kinase inhibitor pamapimod in healthy male subjects.
International journal of clinical pharmacology and therapeutics.
2011 Jun; 49(6):345-52. doi:
10.5414/cp201530. [PMID: 21612741] - Xiaoping Zhang, Yue Huang, Mercidita T Navarro, Grace Hisoire, John P Caulfield. A proof-of-concept and drug-drug interaction study of pamapimod, a novel p38 MAP kinase inhibitor, with methotrexate in patients with rheumatoid arthritis.
Journal of clinical pharmacology.
2010 Sep; 50(9):1031-8. doi:
10.1177/0091270009357433. [PMID: 20100913] - Stanley Cohen, Roy Fleischmann. Kinase inhibitors: a new approach to rheumatoid arthritis treatment.
Current opinion in rheumatology.
2010 May; 22(3):330-5. doi:
10.1097/bor.0b013e3283378e6f. [PMID: 20164774] - Jeffrey D Peterson, Timothy P Labranche, Kristine O Vasquez, Sylvie Kossodo, Michele Melton, Randall Rader, John T Listello, Mark A Abrams, Thomas P Misko. Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis.
Arthritis research & therapy.
2010; 12(3):R105. doi:
10.1186/ar3038. [PMID: 20509880] - Ronald J Hill, Karim Dabbagh, Deborah Phippard, Ching Li, Rebecca T Suttmann, Mary Welch, Eva Papp, Kyung W Song, Kung-Ching Chang, David Leaffer, Yong-Nam Kim, Richard T Roberts, Tanja S Zabka, Dee Aud, Joseph Dal Porto, Anthony M Manning, Stanford L Peng, David M Goldstein, Brian R Wong. Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity.
The Journal of pharmacology and experimental therapeutics.
2008 Dec; 327(3):610-9. doi:
10.1124/jpet.108.139006. [PMID: 18776065] - S Y Shenouda, G M Pigott. Electron paramagnetic resonance studies of actin-lipid interaction in aqueous media.
Journal of agricultural and food chemistry.
1976 Jan; 24(1):11-5. doi:
10.1021/jf60203a023. [PMID: 1428]