Metoclopramide dihydrochloride monohydrate (BioDeep_00000839752)

   


代谢物信息卡片


Metoclopramide dihydrochloride monohydrate

化学式: C14H26Cl3N3O3 (389.10396560000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.O.Cl.Cl
InChI: 1H2

描述信息

D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents

同义名列表

1 个代谢物同义名

Metoclopramide dihydrochloride monohydrate



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Flavia Storelli, Olena Anoshchenko, Jashvant D Unadkat. Successful Prediction of Human Steady-State Unbound Brain-to-Plasma Concentration Ratio of P-gp Substrates Using the Proteomics-Informed Relative Expression Factor Approach. Clinical pharmacology and therapeutics. 2021 08; 110(2):432-442. doi: 10.1002/cpt.2227. [PMID: 33675056]
  • Yifan Chen, Min Zhang, Xinghao Ji, Jinjin Zhao, Shuang Qin, Yinghua Ji, Ruijuan Fan, Yanting Liu, Ping Lu. The anti-cancer effect of metoclopramide on triple-negative breast cancer cells. Die Pharmazie. 2021 04; 76(4):172-174. doi: 10.1691/ph.2021.0977. [PMID: 33849703]
  • Martin Bauer, Sandra Barna, Matthias Blaickner, Konstantin Prosenz, Karsten Bamminger, Verena Pichler, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Georgios Karanikas, Oliver Langer. Human Biodistribution and Radiation Dosimetry of the P-Glycoprotein Radiotracer [11C]Metoclopramide. Molecular imaging and biology. 2021 04; 23(2):180-185. doi: 10.1007/s11307-021-01582-4. [PMID: 33481175]
  • Akbar Dorgalaleh, Ali Dabbagh, Shadi Tabibian, Mehran Bahraini, Hassan Rafieemehr. Persistent hiccups in a patient with mild congenital factor V deficiency and COVID-19; clinical and laboratory finding of a rare bleeding disorder. International journal of laboratory hematology. 2021 04; 43(2):e87-e88. doi: 10.1111/ijlh.13385. [PMID: 33174336]
  • Martin Bauer, Karsten Bamminger, Verena Pichler, Maria Weber, Simon Binder, Alexandra Maier-Salamon, Ammar Tahir, Walter Jäger, Helmuth Haslacher, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Oliver Langer. Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects. Clinical pharmacology and therapeutics. 2021 03; 109(3):754-761. doi: 10.1002/cpt.2052. [PMID: 32966590]
  • Irene Hernández-Lozano, Severin Mairinger, Michael Sauberer, Johann Stanek, Thomas Filip, Thomas Wanek, Giuliano Ciarimboli, Nicolas Tournier, Oliver Langer. Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice. Pharmaceutical research. 2021 Jan; 38(1):127-140. doi: 10.1007/s11095-021-03002-2. [PMID: 33559045]
  • Jung-Woo Bae, Kyung-Yul Oh, So-Jung Yoon, Hyo-Bin Shin, Eui Hyun Jung, Chang-Keun Cho, Chang Woo Lim, Pureum Kang, Chang-Ik Choi, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee. Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide. Archives of pharmacal research. 2020 Nov; 43(11):1207-1213. doi: 10.1007/s12272-020-01293-4. [PMID: 33247397]
  • Shufan Ge, Susan R Mendley, Jacqueline G Gerhart, Chiara Melloni, Christoph P Hornik, Janice E Sullivan, Andrew Atz, Paula Delmore, Adriana Tremoulet, Barrie Harper, Elizabeth Payne, Susan Lin, Jinson Erinjeri, Michael Cohen-Wolkowiez, Daniel Gonzalez. Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. Clinical and translational science. 2020 11; 13(6):1189-1198. doi: 10.1111/cts.12803. [PMID: 32324313]
  • Iram Kaukab, Syed Nisar Hussain Shah, Zelal Jaber Kharaba, Manal Ali Buabeid, Yaseen Abd Alfoteih, Ghulam Murtaza. Effect of clarithromycin pre-treatment on the pharmacokinetics of metoclopramide after their simultaneous oral intake. Expert opinion on drug metabolism & toxicology. 2020 Aug; 16(8):735-740. doi: 10.1080/17425255.2020.1779699. [PMID: 32524862]
  • Viktoria Zoufal, Severin Mairinger, Mirjam Brackhan, Markus Krohn, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Wanek, Nicolas Tournier, Martin Bauer, Jens Pahnke, Oliver Langer. Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2020 07; 61(7):1050-1057. doi: 10.2967/jnumed.119.237198. [PMID: 31806767]
  • Julien Wils, Céline Duparc, Anne-Françoise Cailleux, Antoine-Guy Lopez, Caroline Guiheneuf, Isabelle Boutelet, Hadrien-Gaël Boyer, Christophe Dubessy, Saloua Cherifi, Bruno Cauliez, Françoise Gobet, Guillaume Defortescu, Jean-François Ménard, Estelle Louiset, Hervé Lefebvre. The neuropeptide substance P regulates aldosterone secretion in human adrenals. Nature communications. 2020 05; 11(1):2673. doi: 10.1038/s41467-020-16470-8. [PMID: 32471973]
  • Siew Cheng Foong, May Loong Tan, Wai Cheng Foong, Lisa A Marasco, Jacqueline J Ho, Joo Howe Ong. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. The Cochrane database of systematic reviews. 2020 05; 5(?):CD011505. doi: 10.1002/14651858.cd011505.pub2. [PMID: 32421208]
  • Beata Irena Cejko, Sławomir Krejszeff, Sylwia Judycka, Katarzyna Targońska, Dariusz Kucharczyk. Effect of different treatment agents and post-treatment latency times on spermiation stimulation of northern pike (Esox lucius) under controlled conditions. Theriogenology. 2020 Jan; 142(?):260-267. doi: 10.1016/j.theriogenology.2019.10.035. [PMID: 31711700]
  • Cecilia Nwadiuto Amadi, Wisdom Izuchukwu Nwachukwu. The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits. BMC pharmacology & toxicology. 2020 01; 21(1):4. doi: 10.1186/s40360-019-0379-6. [PMID: 31907041]
  • Mustafa Bilici, M Utku Badak, Adem Zengin, Zekiye Suludere, Nahit Aktas. Synthesis of magnetic halloysite nanotube-based molecularly imprinted polymers for sensitive spectrophotometric detection of metoclopramide in urine samples. Materials science & engineering. C, Materials for biological applications. 2020 Jan; 106(?):110223. doi: 10.1016/j.msec.2019.110223. [PMID: 31753383]
  • Iram Kaukab, Syed Nisar Hussain Shah, Muhammad Asad Abrar, Naveed Anwer, Ghulam Murtaza. Influence of Rifampicin Pre-treatment on the In vivo Pharmacokinetics of Metoclopramide in Pakistani Healthy Volunteers Following Concurrent Oral Administration. Current drug metabolism. 2020; 21(4):301-306. doi: 10.2174/1389200221666200514132654. [PMID: 32407272]
  • Ahmad Al-Saffar, Hans Lennernäs, Per M Hellström. Gastroparesis, metoclopramide, and tardive dyskinesia: Risk revisited. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2019 11; 31(11):e13617. doi: 10.1111/nmo.13617. [PMID: 31050085]
  • Nicolas Tournier, Martin Bauer, Verena Pichler, Lukas Nics, Eva-Maria Klebermass, Karsten Bamminger, Peter Matzneller, Maria Weber, Rudolf Karch, Fabien Caillé, Sylvain Auvity, Solène Marie, Walter Jäger, Wolfgang Wadsak, Marcus Hacker, Markus Zeitlinger, Oliver Langer. Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019 07; 60(7):985-991. doi: 10.2967/jnumed.118.219972. [PMID: 30630940]
  • Shirin Osouli Tabrizi, Mojgan Mirghafourvand, Abdollah Jannat Dost, Sakineh Mohammad-Alizadeh-Charandabi, Yousef Javadzadeh, Robabe Seyedi. Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: a randomized, controlled, clinical trial. World journal of pediatrics : WJP. 2019 Apr; 15(2):135-142. doi: 10.1007/s12519-018-0217-8. [PMID: 30519818]
  • Noura H Abd Ellah, Esraa A Ahmed, Rasha B Abd-Ellatief, Marwa F Ali, Asmaa M Zahran, Helal F Hetta. Metoclopramide nanoparticles modulate immune response in a diabetic rat model: association with regulatory T cells and proinflammatory cytokines. International journal of nanomedicine. 2019; 14(?):2383-2395. doi: 10.2147/ijn.s196842. [PMID: 31040663]
  • Iram Kaukab, Syed Nisar Hussain Shah, Zelal Kharaba, Ghulam Murtaza, Abubaker Ali Saad, Shakeel Ahmad. Evaluation of Pharmacokinetic Interaction of Cilostazol with Metoclopramide after Oral Administration in Human. Current drug metabolism. 2019; 20(11):924-928. doi: 10.2174/1389200220666191105115805. [PMID: 31702486]
  • Joanna Sikora, Piotr Niezgoda, Malwina Barańska, Katarzyna Buszko, Natalia Skibińska, Wiktor Sroka, Krzysztof Pstrągowski, Jolanta Siller-Matula, Jilma Bernd, Diana Gorog, Eliano Pio Navarese, Michał Piotr Marszałł, Jacek Kubica. METoclopramide Administration as a Strategy to Overcome MORPHine-ticagrelOr Interaction in PatientS with Unstable Angina PectorIS-The METAMORPHOSIS Trial. Thrombosis and haemostasis. 2018 Dec; 118(12):2126-2133. doi: 10.1055/s-0038-1675605. [PMID: 30453344]
  • Laura J Henze, Brendan T Griffin, Martin Christiansen, Christoffer Bundgaard, Peter Langguth, René Holm. Exploring gastric emptying rate in minipigs: Effect of food type and pre-dosing of metoclopramide. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Jun; 118(?):183-190. doi: 10.1016/j.ejps.2018.03.017. [PMID: 29559403]
  • James B Leonard, Kashif M Munir, Hong K Kim. Metoclopramide induced pheochromocytoma crisis. The American journal of emergency medicine. 2018 Jun; 36(6):1124.e1-1124.e2. doi: 10.1016/j.ajem.2018.03.009. [PMID: 29534916]
  • Ying Li, Xianpeng Fan, Wanqing Li, Peng Yang, Hui Zhang, Daoquan Tang, Xiaoxin Yin, Jianxu Sun, Aiping Zheng. Metoclopramide nasal spray in vitro evaluation and in vivo pharmacokinetic studies in dogs. Pharmaceutical development and technology. 2018 Mar; 23(3):275-281. doi: 10.1080/10837450.2017.1316734. [PMID: 28379057]
  • Gina Della Togna, Brian Gratwicke, Matthew Evans, Lauren Augustine, Han Chia, Ed Bronikowski, James B Murphy, Pierre Comizzoli. Influence of extracellular environment on the motility and structural properties of spermatozoa collected from hormonally stimulated Panamanian Golden Frog (Atelopus zeteki). Theriogenology. 2018 Mar; 108(?):153-160. doi: 10.1016/j.theriogenology.2017.11.032. [PMID: 29216539]
  • Stefanie R Keller, Zsolt Abonyi-Tóth, Norbert Sprenger, Sean C Austin, Brigitta A C Wichert, Annette Liesegang, Christine H Y Oei, Orsolya Balogh, Iris M Reichler. Effect of metoclopramide treatment of bitches during the first week of lactation on serum prolactin concentration, milk composition, and milk yield and on weight gain of their puppies. American journal of veterinary research. 2018 Feb; 79(2):233-241. doi: 10.2460/ajvr.79.2.233. [PMID: 29359978]
  • Fabien Caillé, Sébastien Goutal, Solène Marie, Sylvain Auvity, Salvatore Cisternino, Bertrand Kuhnast, Géraldine Pottier, Nicolas Tournier. Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide. Contrast media & molecular imaging. 2018; 2018(?):7310146. doi: 10.1155/2018/7310146. [PMID: 29853808]
  • Suxian Luan, Meiling Mu, Liangzhi Sun. The mechanism of selfheal extract in treating hyperprolactinemia. Cancer biomarkers : section A of Disease markers. 2017 Dec; 20(4):575-580. doi: 10.3233/cbm-170454. [PMID: 28946556]
  • Hannah Kenward, Jonathan Elliott, Terry Lee, Ludovic Pelligand. Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study. BMC veterinary research. 2017 Aug; 13(1):244. doi: 10.1186/s12917-017-1156-7. [PMID: 28814338]
  • Emilie Zingler, Angélica Amorim Amato, Alysson Zanatta, Maria de Fátima Brito Vogt, Miriam da Silva Wanderley, Coríntio Mariani Neto, Alberto Moreno Zaconeta. Lactation Induction in a Commissioned Mother by Surrogacy: Effects on Prolactin Levels, Milk Secretion and Mother Satisfaction. Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia. 2017 Feb; 39(2):86-89. doi: 10.1055/s-0037-1598641. [PMID: 28257588]
  • Carsten Stoetzer, Marc Voelker, Thorben Doll, Joerg Heineke, Florian Wegner, Andreas Leffler. Cardiotoxic Antiemetics Metoclopramide and Domperidone Block Cardiac Voltage-Gated Na+ Channels. Anesthesia and analgesia. 2017 01; 124(1):52-60. doi: 10.1213/ane.0000000000001673. [PMID: 27861438]
  • Ahmad Khan, Jallat Khan, Muhammad Irfan, Syed Baqir Shyum Naqvi, Gul Majid Khan, Muhammad Harris Shoaib, Rabia Ismail Yousaf, Amjad Khan. Validation and application of high performance liquid chromatographic method for the estimation of metoclopramide hydrochloride in plasma. Pakistan journal of pharmaceutical sciences. 2017 Jan; 30(1):143-147. doi: NULL. [PMID: 28603124]
  • Giacomo Rossitto, Diego Miotto, Michele Battistel, Giulio Barbiero, Giuseppe Maiolino, Valeria Bisogni, Viola Sanga, Gian Paolo Rossi. Metoclopramide unmasks potentially misleading contralateral suppression in patients undergoing adrenal vein sampling for primary aldosteronism. Journal of hypertension. 2016 11; 34(11):2258-65. doi: 10.1097/hjh.0000000000001082. [PMID: 27512976]
  • Venkateswaran Shekar, Abhi Shah, Mohammad Shadid, Jing-Tao Wu, Jayaprakasam Bolleddula, Swapan Chowdhury. An accelerated background subtraction algorithm for processing high-resolution MS data and its application to metabolite identification. Bioanalysis. 2016 Aug; 8(16):1693-707. doi: 10.4155/bio-2016-0101. [PMID: 27460980]
  • Jennyfer Cázares-Delgadillo, Adriana Ganem-Rondero, Virginia Merino, Yogeshvar N Kalia. Controlled transdermal iontophoresis for poly-pharmacotherapy: Simultaneous delivery of granisetron, metoclopramide and dexamethasone sodium phosphate in vitro and in vivo. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Mar; 85(?):31-8. doi: 10.1016/j.ejps.2016.01.027. [PMID: 26826281]
  • Géraldine Pottier, Solène Marie, Sébastien Goutal, Sylvain Auvity, Marie-Anne Peyronneau, Simon Stute, Raphaël Boisgard, Frédéric Dollé, Irène Buvat, Fabien Caillé, Nicolas Tournier. Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 Feb; 57(2):309-14. doi: 10.2967/jnumed.115.164350. [PMID: 26585058]
  • Di Wang, Wei Wang, Yulin Zhou, Juan Wang, Dongxu Jia, Hei Kiu Wong, Zhang-Jin Zhang. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neuroscience letters. 2015 Oct; 606(?):60-5. doi: 10.1016/j.neulet.2015.08.024. [PMID: 26297122]
  • Sonia Goineau, Philippe Guillaume, Vincent Castagné. Comparison of the effects of clonidine, loperamide and metoclopramide in two models of gastric emptying in the rat. Fundamental & clinical pharmacology. 2015 Feb; 29(1):86-94. doi: 10.1111/fcp.12086. [PMID: 24920467]
  • Mariko Takayasu, Kouko Hamamoto, Hiroshi Satoh, Toshihiro Ichijo, Toru Takahashi, Kazuhisa Furuhama. Pharmacokinetics of metoclopramide in calves with renal dysfunction. The Journal of veterinary medical science. 2015 Feb; 77(2):261-3. doi: 10.1292/jvms.14-0301. [PMID: 25373879]
  • Scott G Blair, Andrew C Bright, Ryan O Kennedy, John M Allen, Mohammad Amin Frotan, Sidney B Brevard, Richard P Gonzalez, Jon D Simmons. Green urine in the intensive care unit: is this clinically relevant?. The American surgeon. 2015 Jan; 81(1):E32-3. doi: 10.1177/000313481508100122. [PMID: 25569058]
  • Anouar Jarraya, Sahar Elleuch, Jawhar Zouari, Khaled Trigui, Abidi Sofiene, Mohamed Smaoui, Kamel Kolsi. [Hyperemesis gravidarum with severe electrolyte disorders: report of a case]. The Pan African medical journal. 2015; 20(?):264. doi: 10.11604/pamj.2015.20.264.6298. [PMID: 26161187]
  • Liliane Spazzapam Lima, Patrícia Los Weinert, Leonardo Pezza, Helena Redigolo Pezza. Sensitive flow-injection spectrophotometric analysis of bromopride. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2014 Dec; 133(?):597-604. doi: 10.1016/j.saa.2014.06.027. [PMID: 24992919]
  • D F do Nascimento, A L A e Silva Leite, R A de Moraes, G C Camarão, F A F Bezerra, M O de Moraes, M E A de Moraes. Effect of dimeticone and pepsin on the bioavailability of metoclopramide in healthy volunteers. Drug research. 2014 Oct; 64(10):537-40. doi: 10.1055/s-0033-1363250. [PMID: 24504688]
  • Tomasz Urbanowicz, Magdalena Pawłowska, Piotr Buczkowski, Bartłomiej Perek, Hanna Baszyńska-Wachowiak, Ewa Straburzyńska-Migaj, Marek Jemielity. Seizures after heart transplantation--two cases of non-immunosuppressant drug interactions in young patients. Annals of transplantation. 2014 Aug; 19(?):417-20. doi: 10.12659/aot.890743. [PMID: 25152323]
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  • Di Wang, Hei Kiu Wong, Li Zhang, Grainne M McAlonan, Xiao-Min Wang, Stephen Cho Wing Sze, Yi-Bin Feng, Zhang-Jin Zhang. Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Progress in neuro-psychopharmacology & biological psychiatry. 2012 Dec; 39(2):332-8. doi: 10.1016/j.pnpbp.2012.07.005. [PMID: 22796279]
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