Lubeluzole (BioDeep_00000839683)
代谢物信息卡片
化学式: C22H25F2N3O2S (433.1635)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C1CCN(CC1)CC(COC2=CC(=C(C=C2)F)F)O)C3=NC4=CC=CC=C4S3
InChI: InChI=1S/C22H25F2N3O2S/c1-26(22-25-20-4-2-3-5-21(20)30-22)15-8-10-27(11-9-15)13-16(28)14-29-17-6-7-18(23)19(24)12-17/h2-7,12,15-16,28H,8-11,13-14H2,1H3/t16-/m0/s1
描述信息
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C26170 - Protective Agent > C1509 - Neuroprotective Agent
D002317 - Cardiovascular Agents
D020011 - Protective Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:135703
- KEGGdrug: D04789
- PubChem: 65998
- ChEMBL: CHEMBL281724
- CAS: 144665-07-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Maria Maddalena Cavalluzzi, Maurizio Viale, Claudio Bruno, Alessia Carocci, Alessia Catalano, Antonio Carrieri, Carlo Franchini, Giovanni Lentini. A convenient synthesis of lubeluzole and its enantiomer: evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells.
Bioorganic & medicinal chemistry letters.
2013 Sep; 23(17):4820-3. doi:
10.1016/j.bmcl.2013.06.077. [PMID: 23886686] - Jean-François Desaphy, Roberta Carbonara, Teresa Costanza, Giovanni Lentini, Maria Maddalena Cavalluzzi, Claudio Bruno, Carlo Franchini, Diana Conte Camerino. Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials.
Molecular pharmacology.
2013 Feb; 83(2):406-15. doi:
10.1124/mol.112.080804. [PMID: 23175529] - Maarten Uyttenboogaart, Marcus W Koch, Roy E Stewart, Patrick C Vroomen, Gert-Jan Luijckx, Jacques De Keyser. Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke.
Brain : a journal of neurology.
2007 Jun; 130(Pt 6):1626-30. doi:
10.1093/brain/awm087. [PMID: 17525141] - M Shimojo, K Takasugi, I Yamamoto, H Funato, H Mochizuki, S Kohsaka. Neuroprotective action of a novel compound--M50463--in primary cultured neurons.
Brain research.
1999 Jan; 815(1):131-9. doi:
10.1016/s0006-8993(98)01157-3. [PMID: 9974133] - V Van de Velde, R Crabbe, A Van Peer, R Woestenborghs, N Van Osselaer, L Hantson, J Heykants. Pharmacokinetics of lubeluzole (Prosynap) after single intravenous doses in healthy subjects.
International journal of clinical pharmacology and therapeutics.
1998 Sep; 36(9):490-3. doi:
NULL. [PMID: 9760010] - J Herron, P Lee, L Pesco-Koplowitz, D Gajjar, Y W Soo, R Woestenborghs. Determination of the dose proportionality of single intravenous doses (5, 10, and 15 mg) of lubeluzole in healthy volunteers.
Clinical therapeutics.
1998 Jul; 20(4):682-90. doi:
10.1016/s0149-2918(98)80131-8. [PMID: 9737828] - J De Keyser, V Van de Velde, R L Schellens, L Hantson, L Tritsmans, J Gheuens, A Van Peer, R Woestenborghs, C L Franke, J van Gorp. Safety and pharmacokinetics of the neuroprotective drug lubeluzole in patients with ischemic stroke.
Clinical therapeutics.
1997 Nov; 19(6):1340-51. doi:
10.1016/s0149-2918(97)80009-4. [PMID: 9444444] - A Sugiyama, C Ni, J Arita, K Eto, Y X Xue, K Hashimoto. Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording.
Toxicology and applied pharmacology.
1996 Jul; 139(1):109-14. doi:
10.1006/taap.1996.0148. [PMID: 8685892] - L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate.
The Journal of urology.
1979 May; 121(5):630-4. doi:
10.1016/s0022-5347(17)56913-x. [PMID: 439260]
