Tropifexor (BioDeep_00000839682)
代谢物信息卡片
化学式: C29H25F4N3O5S (603.1450968)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC1C2=C(C(=NO2)C3=CC=CC=C3OC(F)(F)F)COC4CC5CCC(C4)N5C6=NC7=C(C=C(C=C7S6)C(=O)O)F
InChI: InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18?
描述信息
C26170 - Protective Agent > C2081 - Hepatoprotective Agent
C78276 - Agent Affecting Digestive System or Metabolism
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11548
- PubChem: 121418176
- ChEMBL: CHEMBL4298169
- CAS: 1383816-29-2
- CAS: 1383819-10-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rowan Stringer, Jin Chen, Bharti Shah, Jessie Gu, Yiming Zhang, William Prince, Lloyd B Klickstein, Ralph Woessner. A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants.
Clinical pharmacology in drug development.
2023 02; 12(2):122-131. doi:
10.1002/cpdd.1208. [PMID: 36495282] - Chunlong Ma, Yanmei Hu, Yuyin Wang, Juliana Choza, Jun Wang. Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor.
ACS infectious diseases.
2022 05; 8(5):1022-1030. doi:
10.1021/acsinfecdis.1c00629. [PMID: 35404564] - Jin Chen, Jessie Gu, Bharti Shah, Rowan Stringer, Leonel Reis da Silva Torrao, Melissa Hackling, Prasanna Kumar Nidamarthy, William T Prince, Ralph Woessner. Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment.
Journal of clinical pharmacology.
2022 04; 62(4):520-531. doi:
10.1002/jcph.1996. [PMID: 34738233] - Lydia Wang-Lakshman, Zhuang Miao, Lai Wang, Helen Gu, Mark Kagan, Jessie Gu, Elizabeth McNamara, Markus Walles, Ralph Woessner, Gian Camenisch, Heidi J Einolf, Jin Chen. Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism.
Drug metabolism and disposition: the biological fate of chemicals.
2021 07; 49(7):548-562. doi:
10.1124/dmd.120.000349. [PMID: 33952610] - Yang Liu, Yongtao Xiao, Shanshan Chen, Xinbei Tian, Weipeng Wang, Ying Wang, Wei Cai. The Farnesoid X Receptor Agonist Tropifexor Prevents Liver Damage in Parenteral Nutrition-fed Neonatal Piglets.
Journal of pediatric gastroenterology and nutrition.
2021 07; 73(1):e11-e19. doi:
10.1097/mpg.0000000000003135. [PMID: 33783400] - Guoshun Luo, Xin Lin, Zhenbang Li, Maoxu Xiao, Xinyu Li, Dayong Zhang, Hua Xiang. Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.
European journal of medicinal chemistry.
2021 Jan; 209(?):112910. doi:
10.1016/j.ejmech.2020.112910. [PMID: 33049605] - Longying Jiang, Desheng Xiao, Yubin Li, Shuyan Dai, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Hudie Wei, Yongheng Chen. Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor.
Biochemical and biophysical research communications.
2021 01; 534(?):1047-1052. doi:
10.1016/j.bbrc.2020.10.039. [PMID: 33121679] - Michael Camilleri, Priya Vijayvargiya. The Role of Bile Acids in Chronic Diarrhea.
The American journal of gastroenterology.
2020 10; 115(10):1596-1603. doi:
10.14309/ajg.0000000000000696. [PMID: 32558690] - Michael Camilleri, Sara Linker Nord, Duane Burton, Ibironke Oduyebo, Yiming Zhang, Jin Chen, Koeun Im, Prafulla Bhad, Michael K Badman, David S Sanders, Julian R F Walters. Randomised clinical trial: significant biochemical and colonic transit effects of the farnesoid X receptor agonist tropifexor in patients with primary bile acid diarrhoea.
Alimentary pharmacology & therapeutics.
2020 09; 52(5):808-820. doi:
10.1111/apt.15967. [PMID: 32702169] - Donatella Chianelli, Paul V Rucker, Jason Roland, David C Tully, John Nelson, Xiaodong Liu, Badry Bursulaya, Eloy D Hernandez, Jane Wu, Mahavir Prashad, Thierry Schlama, Yugang Liu, Alan Chu, James Schmeits, David J Huang, Robert Hill, Dingjiu Bao, Jocelyn Zoll, Young Kim, Todd Groessl, Peter McNamara, Bo Liu, Wendy Richmond, Ignacio Sancho-Martinez, Andrew Phimister, H Martin Seidel, Michael K Badman, Sean B Joseph, Bryan Laffitte, Valentina Molteni. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
Journal of medicinal chemistry.
2020 04; 63(8):3868-3880. doi:
10.1021/acs.jmedchem.9b01621. [PMID: 31940200] - Michael K Badman, Jin Chen, Sachin Desai, Soniya Vaidya, Srikanth Neelakantham, Jie Zhang, Lu Gan, Kate Danis, Bryan Laffitte, Lloyd B Klickstein. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers.
Clinical pharmacology in drug development.
2020 04; 9(3):395-410. doi:
10.1002/cpdd.762. [PMID: 31823525]