Cinaciguat (BioDeep_00000839681)
代谢物信息卡片
Cinaciguat
化学式: C36H39NO5 (565.2828084)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CCC2=CC=C(C=C2)COC3=CC=CC=C3CCN(CCCCC(=O)O)CC4=CC=C(C=C4)C(=O)O
InChI: InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41)
描述信息
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:142433
- KEGGdrug: D94958
- KEGGdrug: D07577
- PubChem: 9808022
- ChEMBL: CHEMBL1236936
- CAS: 329773-35-5
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
18 个相关的代谢反应过程信息。
Reactome(18)
- Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
Ca2+ + Inactive Myosin Actin Contractile Complex ⟶ Calcium Bound Myosin Actin Complex - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
ATP + Smooth Muscle Myosin Light Chain ⟶ ADP + Phosphorylated Smooth Muscle Myosin Light Chain - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
ATP ⟶ ADP - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
ATP + Calcium Bound Myosin Actin Complex ⟶ ATP:Calcium Bound Myosin Actin Complex - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
ATP + Smooth Muscle Myosin Light Chain ⟶ ADP + Phosphorylated Smooth Muscle Myosin Light Chain - Muscle contraction:
Guanylate cyclase, soluble + NO ⟶ Guanylate cyclase:NO - Smooth Muscle Contraction:
Guanylate cyclase, soluble + NO ⟶ Guanylate cyclase:NO - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
ATP + Smooth Muscle Myosin Light Chain ⟶ ADP + Phosphorylated Smooth Muscle Myosin Light Chain - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
ATP + Smooth Muscle Myosin Light Chain ⟶ ADP + Phosphorylated Smooth Muscle Myosin Light Chain - Muscle contraction:
AHCYL1:NAD+ + ITPR:I(1,4,5)P3 tetramer ⟶ AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer - Smooth Muscle Contraction:
Ca2+ + Inactive Myosin Actin Contractile Complex ⟶ Calcium Bound Myosin Actin Complex
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Manuela Harloff, Sally Prüschenk, Roland Seifert, Jens Schlossmann. Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice.
British journal of pharmacology.
2022 06; 179(11):2460-2475. doi:
10.1111/bph.15425. [PMID: 33651375] - Daniel Fleischmann, Manuela Harloff, Sara Maslanka Figueroa, Jens Schlossmann, Achim Goepferich. Targeted Delivery of Soluble Guanylate Cyclase (sGC) Activator Cinaciguat to Renal Mesangial Cells via Virus-Mimetic Nanoparticles Potentiates Anti-Fibrotic Effects by cGMP-Mediated Suppression of the TGF-β Pathway.
International journal of molecular sciences.
2021 Mar; 22(5):. doi:
10.3390/ijms22052557. [PMID: 33806499] - Jeffrey A Kline, Michael A Puskarich, Jonathan W Pike, John Zagorski, Nathan J Alves. Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism.
Nitric oxide : biology and chemistry.
2020 03; 96(?):20-28. doi:
10.1016/j.niox.2020.01.004. [PMID: 31940502] - Tingting Jia, Ya-Nan Wang, Jiajia Zhang, Xinyu Hao, Dongjiao Zhang, Xin Xu. Cinaciguat in combination with insulin induces a favorable effect on implant osseointegration in type 2 diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109216. doi:
10.1016/j.biopha.2019.109216. [PMID: 31319371] - Toshihiro Sawabe, Toshiki Chiba, Akihiro Kobayashi, Kosuke Nagasaka, Kazuyuki Aihara, Akiyuki Takaya. A novel soluble guanylate cyclase activator with reduced risk of hypotension by short-acting vasodilation.
Pharmacology research & perspectives.
2019 04; 7(2):e00463. doi:
10.1002/prp2.463. [PMID: 30873284] - Sandra Frankenreiter, Piotr Bednarczyk, Angelina Kniess, Nadja I Bork, Julia Straubinger, Piotr Koprowski, Antoni Wrzosek, Eva Mohr, Angela Logan, Michael P Murphy, Meinrad Gawaz, Thomas Krieg, Adam Szewczyk, Viacheslav O Nikolaev, Peter Ruth, Robert Lukowski. cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels.
Circulation.
2017 Dec; 136(24):2337-2355. doi:
10.1161/circulationaha.117.028723. [PMID: 29051185] - Szabina Czirok, Lilla Fang, Tamás Radovits, Gábor Szabó, Gábor Szénási, László Rosivall, Béla Merkely, Gábor Kökény. Cinaciguat ameliorates glomerular damage by reducing ERK1/2 activity and TGF-ß expression in type-1 diabetic rats.
Scientific reports.
2017 09; 7(1):11218. doi:
10.1038/s41598-017-10125-3. [PMID: 28894114] - Stefanie Breitenstein, Lothar Roessig, Peter Sandner, Kelly S Lewis. Novel sGC Stimulators and sGC Activators for the Treatment of Heart Failure.
Handbook of experimental pharmacology.
2017; 243(?):225-247. doi:
10.1007/164_2016_100. [PMID: 27900610] - Mariana G de Oliveira, Fabiano B Calmasini, Eduardo C Alexandre, Gilberto De Nucci, Fabíola Z Mónica, Edson Antunes. Activation of soluble guanylyl cyclase by BAY 58-2667 improves bladder function in cyclophosphamide-induced cystitis in mice.
American journal of physiology. Renal physiology.
2016 07; 311(1):F85-93. doi:
10.1152/ajprenal.00041.2016. [PMID: 27122537] - Irene Lou, David F Schneider, Glen Leverson, David Foley, Rebecca Sippel, Herbert Chen. Parathyroidectomy is underused in patients with tertiary hyperparathyroidism after renal transplantation.
Surgery.
2016 Jan; 159(1):172-9. doi:
10.1016/j.surg.2015.08.039. [PMID: 26603850] - Robrecht Thoonen, Anje Cauwels, Kelly Decaluwe, Sandra Geschka, Robert E Tainsh, Joris Delanghe, Tino Hochepied, Lode De Cauwer, Elke Rogge, Sofie Voet, Patrick Sips, Richard H Karas, Kenneth D Bloch, Marnik Vuylsteke, Johannes-Peter Stasch, Johan Van de Voorde, Emmanuel S Buys, Peter Brouckaert. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
Nature communications.
2015 Oct; 6(?):8482. doi:
10.1038/ncomms9482. [PMID: 26442659] - Marcel Dautzenberg, Antje Kahnert, Johannes-Peter Stasch, Armin Just. Role of soluble guanylate cyclase in renal hemodynamics and autoregulation in the rat.
American journal of physiology. Renal physiology.
2014 Nov; 307(9):F1003-12. doi:
10.1152/ajprenal.00229.2014. [PMID: 25209860] - K Hirschberg, V Tarcea, Sz Páli, E Barnucz, P N Gwanmesia, S Korkmaz, T Radovits, S Loganathan, B Merkely, M Karck, G Szabó. Cinaciguat prevents neointima formation after arterial injury by decreasing vascular smooth muscle cell migration and proliferation.
International journal of cardiology.
2013 Jul; 167(2):470-7. doi:
10.1016/j.ijcard.2012.01.032. [PMID: 22357420] - Reiner Frey, Christian Scheerans, Martin Blunck, Wolfgang Mück, Mark Jean Gnoth, Sigrun Unger, Anja Schmidt, Georg Wensing. Pharmacokinetics of the soluble guanylate cyclase activator cinaciguat in individuals with hepatic impairment.
Journal of clinical pharmacology.
2012 Nov; 52(11):1714-24. doi:
10.1177/0091270011426143. [PMID: 22162535] - John T Lettieri, Christian Scheerans, Martin Blunck, Arthur L Mazzu, Reiner Frey, Wolfgang Mück, Pavur R Sundaresan. Assessment of the effects of renal impairment on the pharmacokinetics of the soluble guanylate cyclase activator cinaciguat after a single intravenous dose.
Journal of clinical pharmacology.
2012 Aug; 52(8):1240-7. doi:
10.1177/0091270011410567. [PMID: 21868716] - Wolfgang Mueck, Reiner Frey. Population pharmacokinetics and pharmacodynamics of cinaciguat, a soluble guanylate cyclase activator, in patients with acute decompensated heart failure.
Clinical pharmacokinetics.
2010; 49(2):119-29. doi:
10.2165/11317590-000000000-00000. [PMID: 20067336] - Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann, Georg Wensing. Pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in healthy male volunteers.
Journal of clinical pharmacology.
2008 Dec; 48(12):1400-10. doi:
10.1177/0091270008322906. [PMID: 18779378] - Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Harald Lapp, Johannes-Peter Stasch, John C Burnett. Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure.
Hypertension (Dallas, Tex. : 1979).
2007 May; 49(5):1128-33. doi:
10.1161/hypertensionaha.106.083832. [PMID: 17325237] - Thomas Münzel, Sabine Genth-Zotz, Ulrich Hink. Targeting heme-oxidized soluble guanylate cyclase: solution for all cardiorenal problems in heart failure?.
Hypertension (Dallas, Tex. : 1979).
2007 May; 49(5):974-6. doi:
10.1161/hypertensionaha.106.085456. [PMID: 17325236] - Philipp Kalk, Michael Godes, Katharina Relle, Christiane Rothkegel, Andreas Hucke, Johannes-Peter Stasch, Berthold Hocher. NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy.
British journal of pharmacology.
2006 Jul; 148(6):853-9. doi:
10.1038/sj.bjp.0706792. [PMID: 16770325]