Artemether and lumefantrine (BioDeep_00000839679)
代谢物信息卡片
Artemether and lumefantrine
化学式: C46H58Cl3NO6 (825.3329498)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN(CCCC)CC(C1=CC(=CC2=C1C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O.CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C
InChI: /t
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BF - Artemisinin and derivatives, combinations
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
4 个数据库交叉引用编号
- KEGGdrug: D02484
- PubChem: 6450800
- MeSH: Artemether, Lumefantrine Drug Combination
- CAS: 141204-94-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Paul N Newton, Lesley A Chesson, Mayfong Mayxay, Arjen Dondorp, Patricia Tabernero, John D Howa, Thure E Cerling. Forensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation.
Scientific reports.
2024 02; 14(1):3995. doi:
10.1038/s41598-024-54168-9. [PMID: 38369604] - Tobiloba Christiana Elebiyo, Olarewaju Michael Oluba, Oluyomi Stephen Adeyemi. Anti-malarial and haematological evaluation of the ethanolic, ethyl acetate and aqueous fractions of Chromolaena odorata.
BMC complementary medicine and therapies.
2023 Nov; 23(1):402. doi:
10.1186/s12906-023-04200-8. [PMID: 37946127] - Ikponmwosa Owen Evbuomwan, Omokolade Oluwaseyi Alejolowo, Tobiloba Christiana Elebiyo, Charles Obiora Nwonuma, Oluwafemi Adeleke Ojo, Evelyn Uwa Edosomwan, Joy Ifeyinwa Chikwendu, Nwanneka Victoria Elosiuba, Justina Chimezie Akulue, Festus Ayorinde Dogunro, Damilare Emmanuel Rotimi, Omorefosa Osarenkhoe Osemwegie, Adebola Busola Ojo, Olusegun George Ademowo, Oluyomi Stephen Adeyemi, Olarewaju Michael Oluba. In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy.
Journal of biomolecular structure & dynamics.
2023 Mar; ?(?):1-18. doi:
10.1080/07391102.2023.2192799. [PMID: 36974933] - Isaac A Adedara, Solomon E Owumi. Neurobehavioral and biochemical responses to artemisinin-based drug and aflatoxin B1 co-exposure in rats.
Mycotoxin research.
2023 Jan; ?(?):. doi:
10.1007/s12550-023-00474-6. [PMID: 36701108] - Solomon E Owumi, Moses T Otunla, Oyindamola O Elerewe, Uche O Arunsi. Co-exposure to aflatoxin B1 and therapeutic coartem worsens hepatic and renal function through enhanced oxido-inflammatory responses and apoptosis in rats.
Toxicon : official journal of the International Society on Toxinology.
2023 Jan; 222(?):106988. doi:
10.1016/j.toxicon.2022.106988. [PMID: 36473514] - Dancan M Wakoli, Bartholomew N Ondigo, Douglas O Ochora, Joseph G Amwoma, Winnie Okore, Edwin W Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H Opot, Agnes C Cheruiyot, Dennis Juma, Amanda Roth, Benhards R Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M Akala. Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs.
BMC medicine.
2022 11; 20(1):448. doi:
10.1186/s12916-022-02652-2. [PMID: 36397090] - Joyce Hernandez Maldonado, Oliver Grundmann. Drug-Drug Interactions of Artemisinin-Based Combination Therapies in Malaria Treatment: A Narrative Review of the Literature.
Journal of clinical pharmacology.
2022 10; 62(10):1197-1205. doi:
10.1002/jcph.2073. [PMID: 35543380] - Sri Riyati Sugiarto, Balbir Singh, Madhu Page-Sharp, Wendy A Davis, Sam Salman, King Ching Hii, Timothy M E Davis. The pharmacokinetic properties of artemether and lumefantrine in Malaysian patients with Plasmodium knowlesi malaria.
British journal of clinical pharmacology.
2022 02; 88(2):691-701. doi:
10.1111/bcp.15001. [PMID: 34296469] - Ella M E Forgie, Hannah M Brooks, Michelle Barton, Michael T Hawkes. Pediatric Malaria: Global and North American Perspectives.
Pediatric clinics of North America.
2022 02; 69(1):47-64. doi:
10.1016/j.pcl.2021.08.008. [PMID: 34794676] - M Farouk Chughlay, Karen I Barnes, Myriam El Gaaloul, Nada Abla, Jörg J Möhrle, Paul Griffin, Paul van Giersbergen, Stephanie E Reuter, Hayley B Schultz, Anita Kress, Peter Tapley, Rebecca A Webster, Timothy Wells, James S McCarthy, Bridget E Barber, Louise Marquart, Michelle J Boyle, Christian R Engwerda, Stephan Chalon. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0158421. doi:
10.1128/aac.01584-21. [PMID: 34694880] - Sri Riyati Sugiarto, Madhu Page-Sharp, Jocelyn J Drinkwater, Wendy A Davis, Sam Salman, Timothy M E Davis. Pharmacokinetic properties of the antimalarial combination therapy artemether-lumefantrine in normal-weight, overweight and obese healthy male adults.
International journal of antimicrobial agents.
2022 Jan; 59(1):106482. doi:
10.1016/j.ijantimicag.2021.106482. [PMID: 34818520] - Ogechi Chinelo Ekoh, Uchechukwu Okoro, David Ugwu, Rafat Ali, Sunday Okafor, Daniel Ugwuja, Solomon Attah. Novel Dipeptides Bearing Sulfonamide as Antimalarial and Antitrypanosomal Agents: Synthesis and Molecular Docking.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2022; 18(3):394-405. doi:
10.2174/1573406417666210604101201. [PMID: 34097595] - Carolyne M Kifude, Ashleigh Roberds, Janet Oyieko, Stephen Ocholla, Solomon Otieno, John N Waitumbi, Jack Hutter, Hunter Smith, Nathanial K Copeland, Shirley Luckhart, V Ann Stewart. Initiation of anti-retroviral/Trimethoprim-Sulfamethoxazole therapy in a longitudinal cohort of HIV-1 positive individuals in Western Kenya rapidly decreases asymptomatic malarial parasitemia.
Frontiers in cellular and infection microbiology.
2022; 12(?):1025944. doi:
10.3389/fcimb.2022.1025944. [PMID: 36506016] - Ashleigh Roberds, Carolyne Kifude, Janet Oyieko, Stephen Ocholla, James Mutunga, David Oullo, Charles Waga, Zhaozhang Li, Shirley Luckhart, V Ann Stewart. Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes.
Frontiers in cellular and infection microbiology.
2022; 12(?):934641. doi:
10.3389/fcimb.2022.934641. [PMID: 36189366] - Catherine Nuwagira, Emanuel L Peter, Clement Olusoji Ajayi, John Adriko, Grace-Rugunda Kagoro, Eunice Apio Olet, Patrick Engeu Ogwang, Casim Umba Tolo. Developmental stages influence in vivo antimalarial activity of aerial part extracts of Schkuhria pinnata.
Journal of ethnopharmacology.
2021 Oct; 279(?):114341. doi:
10.1016/j.jep.2021.114341. [PMID: 34144195] - Fabiana Volpe-Zanutto, Bruno Fonseca-Santos, Peter E McKenna, Alejandro J Paredes, José Luis Dávila, Maelíosa T C McCrudden, Marcelo Marucci Pereira Tangerina, Mariana Ceccheto Figueiredo, Wagner Vilegas, Andi Brisibe, Marcos Akira D'Ávila, Ryan F Donnelly, Marlus Chorilli, Mary Ann Foglio. Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine.
Biomedical materials (Bristol, England).
2021 10; 16(6):. doi:
10.1088/1748-605x/ac2885. [PMID: 34544052] - Sikiru Olatunji Usman, Ibrahim Adekunle Oreagba, Michael Rotimi Kadri, Ololade Oluwatosin Adewumi, Akinwumi Akinyede, Esther Oluwatoyin Agbaje, Ganiyu Abideen, AbdulWasiu Adeniyi Busari, Olayinka Olaiwola Hassan, Moshood Olusola Akinleye, Alani Sulaimon Akanmu. Evaluation of the effects of atazanavir-ritonavir on the pharmacokinetics of lumefantrine in patients living with HIV in Lagos University Teaching Hospital, South-Western Nigeria.
European journal of clinical pharmacology.
2021 Sep; 77(9):1341-1348. doi:
10.1007/s00228-021-03116-x. [PMID: 33755736] - Aida N Kawuma, Stephen I Walimbwa, Goonaseelan Colin Pillai, Saye Khoo, Mohammed Lamorde, Roeland E Wasmann, Paolo Denti. Dolutegravir pharmacokinetics during co-administration with either artemether/lumefantrine or artesunate/amodiaquine.
The Journal of antimicrobial chemotherapy.
2021 04; 76(5):1269-1272. doi:
10.1093/jac/dkab022. [PMID: 33550391] - Paul Achile Akpa, Joseph Abuchi Ugwuoke, Anthony Amaechi Attama, Chinenye Nnenna Ugwu, Ezinwanne Nneoma Ezeibe, Mumuni Audu Momoh, Adaeze Chidiebere Echezona, Franklin Chimaobi Kenechukwu. Improved antimalarial activity of caprol-based nanostructured lipid carriers encapsulating artemether-lumefantrine for oral administration.
African health sciences.
2020 Dec; 20(4):1679-1697. doi:
10.4314/ahs.v20i4.20. [PMID: 34394228] - Adebanjo J Adegbola, Julius O Soyinka, Oluseye O Bolaji. Effect of CYP3A5*3 genotypes on lumefantrine plasma concentrations among malaria-HIV-infected women.
Pharmacogenomics.
2020 12; 21(18):1289-1297. doi:
10.2217/pgs-2020-0081. [PMID: 33243092] - J Raman, K I Barnes, L Baker, M Blaylock, L Blumberg, J Frean, E Misiani, I S Ukpe. Maintaining focus on administering effective malaria treatment during the COVID-19 pandemic.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
2020 11; 111(1):13-16. doi:
10.7196/samj.2020.v111i11.15289. [PMID: 33403998] - Monday Tola, Olumide Ajibola, Emmanuel Taiwo Idowu, Olusesan Omidiji, Samson Taiwo Awolola, Alfred Amambua-Ngwa. Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria.
BMC research notes.
2020 Oct; 13(1):497. doi:
10.1186/s13104-020-05334-5. [PMID: 33109270] - Mathieu Gendrot, Isabelle Duflot, Manon Boxberger, Océane Delandre, Priscilla Jardot, Marion Le Bideau, Julien Andreani, Isabelle Fonta, Joel Mosnier, Clara Rolland, Sébastien Hutter, Bernard La Scola, Bruno Pradines. Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Oct; 99(?):437-440. doi:
10.1016/j.ijid.2020.08.032. [PMID: 32805422] - Adebanjo Jonathan Adegbola, Abutaima Rana, Babatunde Ayodeji Adeagbo, Rahman A Bolarinwa, Adeniyi Ebenezer Olagunju, Marco Siccardi, Andrew Owen, Oluseye Oladotun Bolaji. Influence of selected polymorphisms in disposition genes on lumefantrine pharmacokinetics when coadministered with efavirenz.
Pharmacogenetics and genomics.
2020 07; 30(5):96-106. doi:
10.1097/fpc.0000000000000401. [PMID: 32209837] - Sa'ad T Abdullahi, Julius O Soyinka, Adeniyi Olagunju, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Markus Winterberg, Joel Tarning, Andrew Owen, Saye Khoo. CYP2B6*6 Genotype Specific Differences in Artemether-Lumefantrine Disposition in Healthy Volunteers.
Journal of clinical pharmacology.
2020 03; 60(3):351-360. doi:
10.1002/jcph.1527. [PMID: 31549442] - Sa'ad T Abdullahi, Julius O Soyinka, Adeniyi Olagunju, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Markus Winterberg, Joel Tarning, Andrew Owen, Saye Khoo. Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.00947-19. [PMID: 31871092] - Marie A Onyamboko, Richard M Hoglund, Sue J Lee, Charlie Kabedi, Daddy Kayembe, Benjamin B Badjanga, Gareth D H Turner, Nikky V Jackson, Joel Tarning, Rose McGready, Francois Nosten, Nicholas J White, Nicholas P J Day, Caterina Fanello. A Randomized Controlled Trial of Three- versus Five-Day Artemether-Lumefantrine Regimens for Treatment of Uncomplicated Plasmodium falciparum Malaria in Pregnancy in Africa.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.01140-19. [PMID: 31818818] - Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Vito Baraka, Philip Sasi, Eleni Aklillu, Appolinary Kamuhabwa. Usefulness of day 7 lumefantrine plasma concentration as a predictor of malaria treatment outcome in under-fives children treated with artemether-lumefantrine in Tanzania.
Malaria journal.
2020 Feb; 19(1):66. doi:
10.1186/s12936-020-3150-y. [PMID: 32046718] - Kelvin M Shija, Ramadhani S O Nondo, Doreen Mloka, Raphael Z Sangeda, George M Bwire. Effects of lemon decoction on malaria parasite clearance and selected hematological parameters in Plasmodium berghei ANKA infected mice.
BMC complementary medicine and therapies.
2020 Jan; 20(1):24. doi:
10.1186/s12906-020-2820-1. [PMID: 32020885] - E I Ekhoye, C P Aloamaka, E K Nwangwa. Alterations in Gonadal Oxidative Stress Markers and Reproductive Function of Balb/C Mice Infected with Plasmodium Berghei.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2019 Dec; 34(2):131-139. doi:
. [PMID: 32343264] - Ritah F Mutagonda, Omary M S Minzi, Siriel N Massawe, Muhammad Asghar, Anna Färnert, Appolinary A R Kamuhabwa, Eleni Aklillu. Pregnancy and CYP3A5 Genotype Affect Day 7 Plasma Lumefantrine Concentrations.
Drug metabolism and disposition: the biological fate of chemicals.
2019 12; 47(12):1415-1424. doi:
10.1124/dmd.119.088062. [PMID: 31744845] - Palang Chotsiri, Lise Denoeud-Ndam, Elisabeth Baudin, Ousmane Guindo, Halimatou Diawara, Oumar Attaher, Michiel Smit, Philippe J Guerin, Ogobara K Doumbo, Lubbe Wiesner, Karen I Barnes, Richard M Hoglund, Alassane Dicko, Jean-Francois Etard, Joel Tarning. Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria.
Clinical pharmacology and therapeutics.
2019 12; 106(6):1299-1309. doi:
10.1002/cpt.1531. [PMID: 31152555] - Helmi Pett, John Bradley, Joseph Okebe, Alassane Dicko, Alfred B Tiono, Bronner P Gonçalves, Will Stone, Ingrid Chen, Kjerstin Lanke, Mikko Neuvonen, Anna-Liina Mustaniemi, Alice C Eziefula, Roly Gosling, Umberto D'Alessandro, Chris Drakeley, Mikko Niemi, Teun Bousema. CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00538-19. [PMID: 31383656] - Rabindra K Mandal, Rosie J Crane, James A Berkley, Wilson Gumbi, Juliana Wambua, Joyce Mwongeli Ngoi, Francis M Ndungu, Nathan W Schmidt. Longitudinal Analysis of Infant Stool Bacteria Communities Before and After Acute Febrile Malaria and Artemether-Lumefantrine Treatment.
The Journal of infectious diseases.
2019 07; 220(4):687-698. doi:
10.1093/infdis/jiy740. [PMID: 30590681] - Geoffrey Odhiambo, Elke Bergmann-Leitner, Moureen Maraka, Christine N L Wanjala, Elizabeth Duncan, John Waitumbi, Ben Andagalu, Walter G Z O Jura, Sheetij Dutta, Evelina Angov, Bernhards R Ogutu, Edwin Kamau, Daniel Ochiel. Correlation Between Malaria-Specific Antibody Profiles and Responses to Artemisinin Combination Therapy for Treatment of Uncomplicated Malaria in Western Kenya.
The Journal of infectious diseases.
2019 05; 219(12):1969-1979. doi:
10.1093/infdis/jiz027. [PMID: 30649381] - Sa'ad T Abdullahi, Adeniyi Olagunju, Julius O Soyinka, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Andrew Owen, Saye Khoo. Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?.
British journal of clinical pharmacology.
2019 03; 85(3):540-550. doi:
10.1111/bcp.13821. [PMID: 30471138] - Jean Claude Dejon-Agobé, Jeannot Fréjus Zinsou, Yabo Josiane Honkpehedji, Ulysse Ateba-Ngoa, Jean-Ronald Edoa, Bayodé Roméo Adegbite, Ghyslain Mombo-Ngoma, Selidji Todagbe Agnandji, Michael Ramharter, Peter Gottfried Kremsner, Bertrand Lell, Martin Peter Grobusch, Ayôla Akim Adegnika. Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon.
PLoS neglected tropical diseases.
2018 08; 12(8):e0006663. doi:
10.1371/journal.pntd.0006663. [PMID: 30080853] - Frank Kloprogge, Lesley Workman, Steffen Borrmann, Mamadou Tékété, Gilbert Lefèvre, Kamal Hamed, Patrice Piola, Johan Ursing, Poul Erik Kofoed, Andreas Mårtensson, Billy Ngasala, Anders Björkman, Michael Ashton, Sofia Friberg Hietala, Francesca Aweeka, Sunil Parikh, Leah Mwai, Timothy M E Davis, Harin Karunajeewa, Sam Salman, Francesco Checchi, Carole Fogg, Paul N Newton, Mayfong Mayxay, Philippe Deloron, Jean François Faucher, François Nosten, Elizabeth A Ashley, Rose McGready, Michele van Vugt, Stephane Proux, Ric N Price, Juntra Karbwang, Farkad Ezzet, Rajesh Bakshi, Kasia Stepniewska, Nicholas J White, Philippe J Guerin, Karen I Barnes, Joel Tarning. Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis.
PLoS medicine.
2018 06; 15(6):e1002579. doi:
10.1371/journal.pmed.1002579. [PMID: 29894518] - Paul John Huggan, Chin Hin Ng, Jennifer Ho, Raymond Tzer Pin Valentine Lin, Jean-Marc Chavatte. A case of blackwater fever with persistent Plasmodium falciparum parasitaemia detected by PCR after artemether-lumefantrine treatment.
Malaria journal.
2018 Jan; 17(1):35. doi:
10.1186/s12936-018-2180-1. [PMID: 29338726] - Sameer Bhandari, Vikram Bhandari, Jatin Sood, Sunil Jaswal, Vikas Rana, Neena Bedi, Rakesh Sehgal, Ashok K Tiwary. Improved pharmacokinetic and pharmacodynamic attributes of artemether-lumefantrine-loaded solid SMEDDS for oral administration.
The Journal of pharmacy and pharmacology.
2017 Nov; 69(11):1437-1446. doi:
10.1111/jphp.12795. [PMID: 28809448] - Nsengiyumva Bati Daddy, Luc Malemo Kalisya, Pascal Gisenya Bagire, Robert L Watt, Melissa J Towler, Pamela J Weathers. Artemisia annua dried leaf tablets treated malaria resistant to ACT and i.v. artesunate: Case reports.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2017 Aug; 32(?):37-40. doi:
10.1016/j.phymed.2017.04.006. [PMID: 28732806] - Bronner P Gonçalves, Helmi Pett, Alfred B Tiono, Daryl Murry, Sodiomon B Sirima, Mikko Niemi, Teun Bousema, Chris Drakeley, Rob Ter Heine. Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children.
Antimicrobial agents and chemotherapy.
2017 05; 61(5):. doi:
10.1128/aac.02590-16. [PMID: 28289025] - Priyanka Prabhu, Shital Suryavanshi, Sulabha Pathak, Aditya Patra, Shobhona Sharma, Vandana Patravale. Nanostructured lipid carriers of artemether-lumefantrine combination for intravenous therapy of cerebral malaria.
International journal of pharmaceutics.
2016 Nov; 513(1-2):504-517. doi:
10.1016/j.ijpharm.2016.09.008. [PMID: 27596113] - Isaac Julius Asiedu-Gyekye, Mahmood Abdulai Seidu, Banga Benoit N'guessan, Samuel Frimpong-Manso, Joseph Edusei Sarkodie, Samuel Adjei, Schevadnazy Kutu, Joseph Osei-Little, Alexander Kwadwo Nyarko, Philip Debrah. A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity.
BMC complementary and alternative medicine.
2016 Sep; 16(?):348. doi:
10.1186/s12906-016-1334-3. [PMID: 27599802] - Ritah F Mutagonda, Appolinary A R Kamuhabwa, Omary M S Minzi, Siriel N Massawe, Betty A Maganda, Eleni Aklillu. Malaria prevalence, severity and treatment outcome in relation to day 7 lumefantrine plasma concentration in pregnant women.
Malaria journal.
2016 05; 15(1):278. doi:
10.1186/s12936-016-1327-1. [PMID: 27177586] - Breanna Barger-Kamate, Michael Forman, Cheik Oumar Sangare, Aboubecrin Sedhigh A Haidara, Hamma Maiga, Dhananjay Vaidya, Abdoulaye Djimde, Ravit Arav-Boger. Effect of artemether-lumefantrine (Coartem) on cytomegalovirus urine viral load during and following treatment for malaria in children.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2016 Apr; 77(?):40-5. doi:
10.1016/j.jcv.2016.02.006. [PMID: 26895228] - Lawrence G Febir, Kwaku Poku Asante, Samuel Afari-Asiedu, Livesy N Abokyi, Anthony Kwarteng, Bernhards Ogutu, Margaret Gyapong, Seth Owusu-Agyei. Seeking treatment for uncomplicated malaria: experiences from the Kintampo districts of Ghana.
Malaria journal.
2016 Feb; 15(?):108. doi:
10.1186/s12936-016-1151-7. [PMID: 26896962] - Petra Obioma Nnamani, Agatha Adaora Ugwu, Emmanuel Chinedu Ibezim, Franklin Chimaobi Kenechukwu, Paul Achile Akpa, John-Dike Nwabueze Ogbonna, Nicholas Chinedu Obitte, Amelia Ngozi Odo, Maike Windbergs, Claus-Michael Lehr, Anthony Amaechi Attama. Sustained-release liquisolid compact tablets containing artemether-lumefantrine as alternate-day regimen for malaria treatment to improve patient compliance.
International journal of nanomedicine.
2016 ; 11(?):6365-6378. doi:
10.2147/ijn.s92755. [PMID: 27932882] - André Lin Ouédraogo, Guido J H Bastiaens, Alfred B Tiono, Wamdaogo M Guelbéogo, Kevin C Kobylinski, Alphonse Ouédraogo, Aïssata Barry, Edith C Bougouma, Issa Nebie, Maurice San Ouattara, Kjerstin H W Lanke, Lawrence Fleckenstein, Robert W Sauerwein, Hannah C Slater, Thomas S Churcher, Sodiomon B Sirima, Chris Drakeley, Teun Bousema. Efficacy and safety of the mosquitocidal drug ivermectin to prevent malaria transmission after treatment: a double-blind, randomized, clinical trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2015 Feb; 60(3):357-65. doi:
10.1093/cid/ciu797. [PMID: 25414262] - M A Onyamboko, C I Fanello, K Wongsaen, J Tarning, P Y Cheah, K A Tshefu, A M Dondorp, F Nosten, N J White, N P J Day. Randomized comparison of the efficacies and tolerabilities of three artemisinin-based combination treatments for children with acute Plasmodium falciparum malaria in the Democratic Republic of the Congo.
Antimicrobial agents and chemotherapy.
2014 Sep; 58(9):5528-36. doi:
10.1128/aac.02682-14. [PMID: 25001306] - Dominic Mosha, Monia Guidi, Felista Mwingira, Salim Abdulla, Thomas Mercier, Laurent Arthur Decosterd, Chantal Csajka, Blaise Genton. Population pharmacokinetics and clinical response for artemether-lumefantrine in pregnant and nonpregnant women with uncomplicated Plasmodium falciparum malaria in Tanzania.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4583-92. doi:
10.1128/aac.02595-14. [PMID: 24867986] - Omary Minzi, Sylivester Maige, Philip Sasi, Billy Ngasala. Adherence to artemether-lumefantrine drug combination: a rural community experience six years after change of malaria treatment policy in Tanzania.
Malaria journal.
2014 Jul; 13(?):267. doi:
10.1186/1475-2875-13-267. [PMID: 25011682] - Betty A Maganda, Omary M S Minzi, Appolinary A R Kamuhabwa, Billy Ngasala, Philip G Sasi. Outcome of artemether-lumefantrine treatment for uncomplicated malaria in HIV-infected adult patients on anti-retroviral therapy.
Malaria journal.
2014 May; 13(?):205. doi:
10.1186/1475-2875-13-205. [PMID: 24885714] - Gilbert Lefèvre, Prafulla Bhad, Jay Prakash Jain, Sampath Kalluri, Yi Cheng, Hardik Dave, Daniel S Stein. Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem) for bioequivalence in a randomized, open-label, two-period study.
Malaria journal.
2013 Sep; 12(?):312. doi:
10.1186/1475-2875-12-312. [PMID: 24010572] - Eva Maria Staehli Hodel, Monia Guidi, Boris Zanolari, Thomas Mercier, Socheat Duong, Abdunoor M Kabanywanyi, Frédéric Ariey, Thierry Buclin, Hans-Peter Beck, Laurent A Decosterd, Piero Olliaro, Blaise Genton, Chantal Csajka. Population pharmacokinetics of mefloquine, piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients.
Malaria journal.
2013 Jul; 12(?):235. doi:
10.1186/1475-2875-12-235. [PMID: 23841950] - Norah Mwebaza, Markus Jerling, Lars L Gustafsson, Celestino Obua, Paul Waako, Margarita Mahindi, Muhammad Ntale, Olof Beck, Urban Hellgren. Comparable lumefantrine oral bioavailability when co-administered with oil-fortified maize porridge or milk in healthy volunteers.
Basic & clinical pharmacology & toxicology.
2013 Jul; 113(1):66-72. doi:
10.1111/bcpt.12065. [PMID: 23480875] - Solomon M Abay, Mulugeta Tilahun, Nigus Fikrie, Abiy Habtewold. Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients.
Journal of infection in developing countries.
2013 Jun; 7(6):468-74. doi:
10.3855/jidc.2658. [PMID: 23771290] - Deokary Joseph, Abdunoor M Kabanywanyi, Ruth Hulser, Zulfiqarali Premji, Omary Ms Minzi, Kefas Mugittu. Exploration of in vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in under fives in Tabora region, Tanzania.
Malaria journal.
2013 Feb; 12(?):60. doi:
10.1186/1475-2875-12-60. [PMID: 23399782] - George O Adjei, Collins Oduro-Boatey, Onike P Rodrigues, Lotte C Hoegberg, Michael Alifrangis, Jorgen A Kurtzhals, Bamenla Q Goka. Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine.
Malaria journal.
2012 Dec; 11(?):420. doi:
10.1186/1475-2875-11-420. [PMID: 23244570] - Pauline Byakika-Kibwika, Mohammed Lamorde, Jonathan Mayito, Lillian Nabukeera, Rhoda Namakula, Harriet Mayanja-Kizza, Elly Katabira, Muhammad Ntale, Nadine Pakker, Mairin Ryan, Warunee Hanpithakpong, Joel Tarning, Niklas Lindegardh, Peter J de Vries, Saye Khoo, David Back, Concepta Merry. Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults.
The Journal of antimicrobial chemotherapy.
2012 Sep; 67(9):2213-21. doi:
10.1093/jac/dks207. [PMID: 22687893] - Sophie Zaloumis, Andrew Humberstone, Susan A Charman, Ric N Price, Joerg Moehrle, Javier Gamo-Benito, James McCaw, Kris M Jamsen, Katherine Smith, Julie A Simpson. Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development.
Malaria journal.
2012 Aug; 11(?):303. doi:
10.1186/1475-2875-11-303. [PMID: 22931058] - God'swill Nduka Anyasor, Isaac Olayinka Oyewole, Kayode Olushola Ogunwenmo, Adegoke Ayowole. Coartemether induced oxidative and hepatic damage in Plasmodium berghei strain Anka infected mice.
Bulletin of environmental contamination and toxicology.
2012 Jan; 88(1):108-11. doi:
10.1007/s00128-011-0460-3. [PMID: 22057281] - Quique Bassat. The use of artemether-lumefantrine for the treatment of uncomplicated Plasmodium vivax malaria.
PLoS neglected tropical diseases.
2011 Dec; 5(12):e1325. doi:
10.1371/journal.pntd.0001325. [PMID: 22216359] - T Kredo, K Mauff, J S Van der Walt, L Wiesner, G Maartens, K Cohen, P Smith, K I Barnes. Interaction between artemether-lumefantrine and nevirapine-based antiretroviral therapy in HIV-1-infected patients.
Antimicrobial agents and chemotherapy.
2011 Dec; 55(12):5616-23. doi:
10.1128/aac.05265-11. [PMID: 21947399] - Jacobien Veenemans, Paul Milligan, Andrew M Prentice, Laura R A Schouten, Nienke Inja, Aafke C van der Heijden, Linsey C C de Boer, Esther J S Jansen, Anna E Koopmans, Wendy T M Enthoven, Rob J Kraaijenhagen, Ayse Y Demir, Donald R A Uges, Erasto V Mbugi, Huub F J Savelkoul, Hans Verhoef. Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: a randomised trial.
PLoS medicine.
2011 Nov; 8(11):e1001125. doi:
10.1371/journal.pmed.1001125. [PMID: 22131908] - Geoffrey S Dow, Montip Gettayacamin, Pranee Hansukjariya, Rawiwan Imerbsin, Srawuth Komcharoen, Jetsumon Sattabongkot, Dennis Kyle, Wilbur Milhous, Simon Cozens, David Kenworthy, Anne Miller, Jim Veazey, Colin Ohrt. Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).
Malaria journal.
2011 Jul; 10(?):212. doi:
10.1186/1475-2875-10-212. [PMID: 21801400] - Shabana Ali, Muzammil H Najmi, Joel Tarning, Niklas Lindegardh. Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine.
Malaria journal.
2010 Oct; 9(?):275. doi:
10.1186/1475-2875-9-275. [PMID: 20932349] - Salim Abdulla, Baraka Amuri, Abdunoor M Kabanywanyi, David Ubben, Christine Reynolds, Steve Pascoe, Serge Fitoussi, Ching-Ming Yeh, Marja Nuortti, Romain Séchaud, Günther Kaiser, Gilbert Lefèvre. Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.
Malaria journal.
2010 Sep; 9(?):253. doi:
10.1186/1475-2875-9-253. [PMID: 20815879] - Steffen Borrmann, William M Sallas, Sonia Machevo, Raquel González, Anders Björkman, Andreas Mårtensson, Mary Hamel, Elizabeth Juma, Judy Peshu, Bernhards Ogutu, Abdoulaye Djimdé, Umberto D'Alessandro, Anne-Claire Marrast, Gilbert Lefèvre, Steven E Kern. The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.
Tropical medicine & international health : TM & IH.
2010 Apr; 15(4):434-41. doi:
10.1111/j.1365-3156.2010.02477.x. [PMID: 20180933] - Zulfiqarali G Premji. Coartem: the journey to the clinic.
Malaria journal.
2009 Oct; 8 Suppl 1(?):S3. doi:
10.1186/1475-2875-8-s1-s3. [PMID: 19818170] - David J Bell, Dan Wootton, Mavuto Mukaka, Jacqui Montgomery, Noel Kayange, Phillips Chimpeni, Dyfrig A Hughes, Malcolm E Molyneux, Steve A Ward, Peter A Winstanley, David G Lalloo. Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.
Malaria journal.
2009 Aug; 8(?):204. doi:
10.1186/1475-2875-8-204. [PMID: 19709418] - Neena Valecha, Prakriti Srivastava, Suman S Mohanty, Pooja Mittra, Surya K Sharma, Prajesh K Tyagi, Khageswar Pradhan, Vas Dev, Ruchi Singh, Aditya P Dash, Yagya D Sharma. Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India.
Malaria journal.
2009 May; 8(?):107. doi:
10.1186/1475-2875-8-107. [PMID: 19454000] - Yasutaka Mizuno, Yasuyuki Kato, Koichiro Kudo, Shigeyuki Kano. First case of treatment failure of artemether-lumefantrine in a Japanese traveler with imported falciparum malaria.
Japanese journal of infectious diseases.
2009 Mar; 62(2):139-41. doi:
NULL. [PMID: 19305055] - Oluwatosin A Adaramoye, Dorcas O Osaimoje, Adewale M Akinsanya, Chiaka M Nneji, Michael A Fafunso, Olusegun G Ademowo. Changes in antioxidant status and biochemical indices after acute administration of artemether, artemether-lumefantrine and halofantrine in rats.
Basic & clinical pharmacology & toxicology.
2008 Apr; 102(4):412-8. doi:
10.1111/j.1742-7843.2008.00211.x. [PMID: 18282195] - Thomas Kuhn, Ying Wang. Artemisinin--an innovative cornerstone for anti-malaria therapy.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.
2008; 66(?):383, 385-422. doi:
10.1007/978-3-7643-8595-8_9. [PMID: 18416312] - I Adam, O A Elhardello, M O Elhadi, E Abdalla, K A Elmardi, F H Jansen. The antischistosomal efficacies of artesunate-sulfamethoxypyrazine-pyrimethamine and artemether-lumefantrine administered as treatment for uncomplicated, Plasmodium falciparum malaria.
Annals of tropical medicine and parasitology.
2008 Jan; 102(1):39-44. doi:
10.1179/136485908x252214. [PMID: 18186976] - Elizabeth A Ashley, Kasia Stepniewska, Niklas Lindegårdh, Rose McGready, Anna Annerberg, Robert Hutagalung, Thida Singtoroj, Gilvary Hla, Al Brockman, Stephane Proux, Jahser Wilahphaingern, Pratap Singhasivanon, Nicholas J White, François Nosten. Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria.
Tropical medicine & international health : TM & IH.
2007 Feb; 12(2):201-8. doi:
10.1111/j.1365-3156.2006.01785.x. [PMID: 17300626] - Elizabeth A Ashley, Kasia Stepniewska, Niklas Lindegårdh, Anna Annerberg, Am Kham, Al Brockman, Pratap Singhasivanon, Nicholas J White, François Nosten. How much fat is necessary to optimize lumefantrine oral bioavailability?.
Tropical medicine & international health : TM & IH.
2007 Feb; 12(2):195-200. doi:
10.1111/j.1365-3156.2006.01784.x. [PMID: 17300625] - Mey Bouth Denis, Reiko Tsuyuoka, Pharath Lim, Niklas Lindegardh, Poravuth Yi, Sophoan Narann Top, Duong Socheat, Thierry Fandeur, Anna Annerberg, Eva Maria Christophel, Pascal Ringwald. Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.
Tropical medicine & international health : TM & IH.
2006 Dec; 11(12):1800-7. doi:
10.1111/j.1365-3156.2006.01739.x. [PMID: 17176344] - Margaretha Bindschedler, Gilbert Lefèvre, Peter Degen, Antoine Sioufi. Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants.
The American journal of tropical medicine and hygiene.
2002 Mar; 66(3):293-8. doi:
10.4269/ajtmh.2002.66.293. [PMID: 12139223] - M Bindschedler, G Lefèvre, F Ezzet, N Schaeffer, I Meyer, M S Thomsen. Cardiac effects of co-artemether (artemether/lumefantrine) and mefloquine given alone or in combination to healthy volunteers.
European journal of clinical pharmacology.
2000 Aug; 56(5):375-81. doi:
10.1007/s002280000155. [PMID: 11009045] - K Na-Bangchang, J Karbwang, U Tasanor, A Thanavibul, E Farkad, R Mull. Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria.
International journal of clinical pharmacology research.
1999; 19(2):41-6. doi:
NULL. [PMID: 10669897]