Siponimod fumarate (BioDeep_00000839677)

   


代谢物信息卡片


Siponimod fumarate

化学式: C62H74F6N4O10 (1148.5308856)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=C(C=CC(=C1)C(=NOCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)C)CN4CC(C4)C(=O)O.CCC1=C(C=CC(=C1)C(=NOCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)C)CN4CC(C4)C(=O)O.C(=CC(=O)O)C(=O)O
InChI: 2-1+

描述信息

D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D000081243 - Sphingosine 1 Phosphate Receptor Modulators
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C308 - Immunotherapeutic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

1 个代谢物同义名

Siponimod fumarate



数据库引用编号

4 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Thomas Hach, Kasra Shakeri-Nejad, Marc Bigaud, Frank Dahlke, Massimiliano de Micco, Olivier Petricoul, Gordon Graham, Daniela Piani-Meier, Renato Turrini, Volker Brinkmann, Ferdinando Nicoletti. Rationale for Use of Sphingosine-1-Phosphate Receptor Modulators in COVID-19 Patients: Overview of Scientific Evidence. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2022 Nov; ?(?):. doi: 10.1089/jir.2022.0078. [PMID: 36454249]
  • Shian Liu, Navid Paknejad, Lan Zhu, Yasuyuki Kihara, Manisha Ray, Jerold Chun, Wei Liu, Richard K Hite, Xin-Yun Huang. Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nature communications. 2022 02; 13(1):731. doi: 10.1038/s41467-022-28417-2. [PMID: 35136060]
  • Yuan Yuan, Guowen Jia, Chao Wu, Wei Wang, Lin Cheng, Qian Li, Ziyan Li, Kaidong Luo, Shengyong Yang, Wei Yan, Zhaoming Su, Zhenhua Shao. Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell research. 2021 12; 31(12):1263-1274. doi: 10.1038/s41422-021-00566-x. [PMID: 34526663]
  • Jerold Chun, Gavin Giovannoni, Samuel F Hunter. Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects. Drugs. 2021 Feb; 81(2):207-231. doi: 10.1007/s40265-020-01431-8. [PMID: 33289881]
  • Catherine O'Sullivan, Anna Schubart, Anis K Mir, Kumlesh K Dev. The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. Journal of neuroinflammation. 2016 Feb; 13(?):31. doi: 10.1186/s12974-016-0494-x. [PMID: 26856814]