Ethacrynate sodium (BioDeep_00000839656)
代谢物信息卡片
Ethacrynate sodium
化学式: C13H11Cl2NaO4 (323.9932)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)[O-])Cl)Cl.[Na+]
InChI: /q
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49184 - Loop Diuretic
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D04079
- PubChem: 23668825
- ChEMBL: CHEMBL1200487
- MeSH: Ethacrynic Acid
- CAS: 6500-81-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Srabani Kar, Kayla Vu, Madhusoodanan Mottamal, Rami A Al-Horani. Ethacrynic acid is an inhibitor of human factor XIIIa.
BMC pharmacology & toxicology.
2022 06; 23(1):35. doi:
10.1186/s40360-022-00575-5. [PMID: 35642005] - Dawn Parsell, Jun Shao, Robert Guttendorf, Vandana Mathur, Elizabeth Li, Yick Sen Wu, Li Tsao, Scott Tabakman, Yuri Stasiv, Angela Lee, Kalpesh Biyani, Gerrit Klaerner. Assessment of the Potential for Veverimer Drug-Drug Interactions.
Drug metabolism and disposition: the biological fate of chemicals.
2021 07; 49(7):490-500. doi:
10.1124/dmd.121.000366. [PMID: 34031138] - Zhaomeng Cui, Yang Liu, Wei Wan, Yuyan Xu, Yehui Hu, Meng Ding, Xin Dou, Ruina Wang, Hailing Li, Yongmei Meng, Wei Li, Wei Jiang, Zengxia Li, Yiming Li, Minjia Tan, Dengke K Ma, Yu Ding, Jun O Liu, Cheng Luo, Biao Yu, Qiqun Tang, Yongjun Dang. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes.
Protein & cell.
2021 06; 12(6):493-501. doi:
10.1007/s13238-020-00717-7. [PMID: 32399897] - Xiao-Xue Zhao, Wei-Wei Chen, Yuan-Yuan Chen, Meng-Su Liu, Meng-Yue Li, Lei Cao, Qing-Hua Liu. [Ethacrynic acid inhibits airway smooth muscle contraction in mice].
Sheng li xue bao : [Acta physiologica Sinica].
2019 Dec; 71(6):863-873. doi:
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Molecular pharmaceutics.
2018 06; 15(6):2413-2422. doi:
10.1021/acs.molpharmaceut.8b00250. [PMID: 29763317] - Wei Dou, Jing-Jing Wu, Shi-Chun Chen, Dan-Dan Wei, Jin-Jun Wang. Effects of Ethacrynic Acid Addition to Diet on Fitness and Development in the Psocid Liposcelis bostrychophila Badonnel.
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2003 Dec; 16(12):1642-51. doi:
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10.1097/01.smj.0000082004.40613.d7. [PMID: 14632366] - Dalian Ding, Sandra L McFadden, Richard W Browne, Richard J Salvi. Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells.
Hearing research.
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1994 Sep; 270(3):1186-91. doi:
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1994 Jun; 47(11):2011-5. doi:
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1994 Mar; 641(1):121-6. doi:
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1994 Mar; 18(2):95-100. doi:
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1992 Sep; 62(2-3):241-5. doi:
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1992 Feb; 293(1):130-9. doi:
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1992 Feb; 260(2):768-72. doi:
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