Bucindolol hydrochloride (BioDeep_00000839654)
代谢物信息卡片
Bucindolol hydrochloride
化学式: C22H26ClN3O2 (399.17134460000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(CC1=CNC2=CC=CC=C21)NCC(COC3=CC=CC=C3C#N)O.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinyu Tong, Lijuan Shen, Xiaomin Zhou, Yudan Wang, Sheng Chang, Shu Lu. Comparative Efficacy of Different Drugs for the Treatment of Dilated Cardiomyopathy: A Systematic Review and Network Meta-analysis.
Drugs in R&D.
2023 Aug; ?(?):. doi:
10.1007/s40268-023-00435-5. [PMID: 37556093] - Bruna Gazzi de Lima-Seolin, Matheus Mittmann Hennemann, Rafael Oliveira Fernandes, Rafael Colombo, Jéssica Hellen Poletto Bonetto, Rayane Brinck Teixeira, Neelam Khaper, Alessandra Eifler Guerra Godoy, Isnard Elman Litvin, Alex Sander da Rosa Araujo, Paulo Cavalheiro Schenkel, Adriane Belló-Klein. Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Mar; 99(?):704-714. doi:
10.1016/j.biopha.2018.01.127. [PMID: 29710468] - Robert P Frantz, Brian D Lowes, Paul A Grayburn, Michel White, Heidi Krause-Steinrauf, Vaishali Krishnan, Lauren Uyeda, John C Burnett. Baseline and serial neurohormones in patients with congestive heart failure treated with and without bucindolol: results of the neurohumoral substudy of the Beta-Blocker Evaluation of Survival Study (BEST).
Journal of cardiac failure.
2007 Aug; 13(6):437-44. doi:
10.1016/j.cardfail.2007.03.007. [PMID: 17675057] - Krishna Lalukota, John G F Cleland, Lee Ingle, Andrew L Clark, Alison P Coletta. Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD.
European journal of heart failure.
2004 Dec; 6(7):953-5. doi:
10.1016/j.ejheart.2004.10.003. [PMID: 15556058] - Eric J Eichhorn, Paul A Grayburn, Susan A Mayer, Martin St John Sutton, Christopher Appleton, Jonathan Plehn, Jae Oh, Barry Greenberg, Anthony DeMaria, Robert Frantz, Heidi Krause-Steinrauf. Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST).
Circulation.
2003 Nov; 108(19):2336-41. doi:
10.1161/01.cir.0000097111.00170.7b. [PMID: 14597587] - Jeffrey L Anderson, Heidi Krause-Steinrauf, Steven Goldman, Barry S Clemson, Michael J Domanski, W David Hager, David R Murray, Douglas L Mann, Barry M Massie, Dennis M McNamara, Ron Oren, William J Rogers. Failure of benefit and early hazard of bucindolol for Class IV heart failure.
Journal of cardiac failure.
2003 Aug; 9(4):266-77. doi:
10.1054/jcaf.2003.42. [PMID: 13680547] - E J Eichhorn. Effects of bucindolol in heart failure.
The American journal of cardiology.
1993 Mar; 71(9):65C-70C. doi:
10.1016/0002-9149(93)90089-u. [PMID: 8096677] - E J Eichhorn, A L McGhie, J B Bedotto, J R Corbett, C R Malloy, B A Hatfield, D Deitchman, J E Willard, P A Grayburn. Effects of bucindolol on neurohormonal activation in congestive heart failure.
The American journal of cardiology.
1991 Jan; 67(1):67-73. doi:
10.1016/0002-9149(91)90102-q. [PMID: 1670902] - E M Gilbert, J L Anderson, D Deitchman, F G Yanowitz, J B O'Connell, D G Renlund, M Bartholomew, P C Mealey, P Larrabee, M R Bristow. Long-term beta-blocker vasodilator therapy improves cardiac function in idiopathic dilated cardiomyopathy: a double-blind, randomized study of bucindolol versus placebo.
The American journal of medicine.
1990 Mar; 88(3):223-9. doi:
10.1016/0002-9343(90)90146-5. [PMID: 1968710] - S Kimura, V DeQuattro, W A Edmiston, R Loo, S Thien, K Rigonan, D Deitchman, A Foti. Efficacy of bucindolol in systemic hypertension.
The American journal of cardiology.
1987 Nov; 60(13):1083-6. doi:
10.1016/0002-9149(87)90357-2. [PMID: 2890292] - A Lehtonen, A Tanskanen, J Temmerman. Effect of bucindolol on plasma HDL cholesterol subfractions and other plasma lipids in essential hypertensive patients.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Aug; 25(8):448-51. doi:
NULL. [PMID: 2888737] - M J Bartek, E H Kerns, R E Gammans, D G Gallo. Determination of bucindolol and its major metabolites in plasma by capillary gas chromatography-mass spectrometry.
Journal of chromatography.
1986 Apr; 377(?):183-94. doi:
10.1016/s0378-4347(00)80773-2. [PMID: 3711207] - P C O'Connor, M J Finch, D W Harron, P A Meredith, D G McDevitt, R G Shanks. Comparison of the haemodynamic effects of bucindolol, propranolol and pindolol in healthy volunteers.
British journal of clinical pharmacology.
1985 Dec; 20(6):659-67. doi:
10.1111/j.1365-2125.1985.tb05125.x. [PMID: 2868744] - J Webster, J C Petrie, O J Robb, M Jamieson, J Verschueren. A comparison of single doses of bucindolol and oxprenolol in hypertensive patients.
British journal of clinical pharmacology.
1985 Oct; 20(4):393-400. doi:
10.1111/j.1365-2125.1985.tb05083.x. [PMID: 2866786] - J L Reid, J Curzio, J Vincent. Bucindolol in essential hypertension.
International journal of clinical pharmacology research.
1985; 5(5):293-301. doi:
NULL. [PMID: 2866166] - M Maury, A Berdeaux, A Kher, P Duhaze, J F Giudicelli. Comparative beta-adrenoceptor blocking effect and pharmacokinetics of bucindolol and propranolol in man.
European journal of clinical pharmacology.
1985; 27(6):649-56. doi:
10.1007/bf00547043. [PMID: 2859199] - J D Fitzgerald. The possible role of the ancillary properties of beta adrenoceptor antagonists in the management of angina pectoris.
Acta medica Scandinavica. Supplementum.
1985; 694(?):120-41. doi:
10.1111/j.0954-6820.1985.tb08809.x. [PMID: 2860771] - H H Rotmensch, M L Rocci, P H Vlasses, B N Swanson, I L Fedder, L Soyka, R K Ferguson. Bucindolol, a beta-adrenoceptor blocker with vasodilatory action: its effect in systemic hypertension.
The American journal of cardiology.
1984 Aug; 54(3):353-6. doi:
10.1016/0002-9149(84)90196-6. [PMID: 6147080] - J S Gill, D G Beevers. Bucindolol: effects on blood pressure, airways resistance and serum creatine phosphokinase.
European journal of clinical pharmacology.
1984; 27(3):265-8. doi:
10.1007/bf00542157. [PMID: 6150855] - D Deitchman, J E Byrne, R W Snyder. Cardiovascular effects of bucindolol (MJ 13105) in conscious dogs.
Archives internationales de pharmacodynamie et de therapie.
1980 Sep; 247(1):76-88. doi:
NULL. [PMID: 6108746]