Imipramine pamoate (BioDeep_00000839650)
代谢物信息卡片
Imipramine pamoate
化学式: C61H64N4O6 (948.4826)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
InChI: 2*3-6,8-11H,7,12-15H2,1-2H3
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D08071
- PubChem: 24904
- ChEMBL: CHEMBL3989845
- MeSH: Imipramine
- CAS: 22540-17-6
- CAS: 10075-24-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Biomolecules.
2023 12; 13(12):. doi:
10.3390/biom13121732. [PMID: 38136603] - Zakaria Zitoune, Luc Kugener, Joop Jonckheer, Katrien Lanckmans, Philippe Hantson, Jacques Devriendt, Patrick M Honore. Effective Treatment of Acute Tricyclic Antidepressant Poisoning with Cardiogenic Shock and Severe Rhabdomyolysis Using ECMO and CytoSorb® Adsorber.
The American journal of case reports.
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Metabolic brain disease.
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Acupuncture in medicine : journal of the British Medical Acupuncture Society.
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Acta neuropsychiatrica.
2019 Oct; 31(5):258-265. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
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Iranian journal of kidney diseases.
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Behavioural brain research.
2019 05; 364(?):274-280. doi:
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Journal of clinical psychopharmacology.
2019 May; 39(3):254-257. doi:
10.1097/jcp.0000000000001024. [PMID: 30925498] - Reyhaneh Sobhani, Behzad Rezaei, Marzieh Shahshahanipour, Ali A Ensafi, Gholamhossein Mohammadnezhad. Simple and green synthesis of carbon dots (CDs) from valerian root and application of modified mesoporous boehmite (AlOOH) with CDs as a fluorescence probe for determination of imipramine.
Analytical and bioanalytical chemistry.
2019 May; 411(14):3115-3124. doi:
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Journal of virology.
2019 03; 93(5):. doi:
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PloS one.
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Acta psychiatrica Scandinavica.
2017 07; 136(1):118-128. doi:
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Neuroscience letters.
2017 04; 647(?):147-152. doi:
10.1016/j.neulet.2017.03.034. [PMID: 28336340] - Sachie Sasaki-Hamada, Azusa Suzuki, Yudai Ueda, Kinzo Matsumoto, Jun-Ichiro Oka. Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice.
Journal of pharmacological sciences.
2017 Feb; 133(2):110-113. doi:
10.1016/j.jphs.2017.01.002. [PMID: 28233634] - Tomoyuki Tashiro, Yuki Murakami, Akihiro Mouri, Yukio Imamura, Toshitaka Nabeshima, Yasuko Yamamoto, Kuniaki Saito. Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions.
Behavioural brain research.
2017 01; 317(?):279-285. doi:
10.1016/j.bbr.2016.09.050. [PMID: 27693848] - Kazunari Iwao, Rushiana Tokie Kawai, Masako Oda, Hiroshi Saitoh. Investigation on the Interactions between Various Drugs and Aojiru (Green Juice) Using a Simple Centrifugation Method.
Biological & pharmaceutical bulletin.
2017; 40(9):1566-1571. doi:
10.1248/bpb.b17-00149. [PMID: 28867740] - Jessica M Carpenter, Mary K Jourdan, Emily M Fountain, Zulfiqar Ali, Naohito Abe, Ikhlas A Khan, Kenneth J Sufka. The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model.
Journal of ethnopharmacology.
2016 Dec; 193(?):329-332. doi:
10.1016/j.jep.2016.08.019. [PMID: 27553978] - Yong Wang, Xingwen Li, Liyuan Sun, Baihuan Feng, Wenjun Sun. Acid sphingomyelinase mediates 50-Hz magnetic field-induced EGF receptor clustering on lipid raft.
Journal of receptor and signal transduction research.
2016 Dec; 36(6):593-600. doi:
10.3109/10799893.2016.1147583. [PMID: 26915736] - Yun-Ui Bae, Jae-Wan Huh, Bieong-Kil Kim, Hyeon Young Park, Young-Bae Seu, Kyung-Oh Doh. Enhancement of liposome mediated gene transfer by adding cholesterol and cholesterol modulating drugs.
Biochimica et biophysica acta.
2016 12; 1858(12):3017-3023. doi:
10.1016/j.bbamem.2016.09.013. [PMID: 27664498] - Karol Ramirez, John F Sheridan. Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors.
Brain, behavior, and immunity.
2016 Oct; 57(?):293-303. doi:
10.1016/j.bbi.2016.05.008. [PMID: 27223094] - Hoa Q Nguyen, Ernesto Callegari, R Scott Obach. The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.
Drug metabolism and disposition: the biological fate of chemicals.
2016 10; 44(10):1569-78. doi:
10.1124/dmd.116.071639. [PMID: 27440861] - Kartik T Nakhate, Sadanand U Yedke, Ashish P Bharne, Nishikant K Subhedar, Dadasaheb M Kokare. Evidence for the involvement of neuropeptide Y in the antidepressant effect of imipramine in type 2 diabetes.
Brain research.
2016 09; 1646(?):1-11. doi:
10.1016/j.brainres.2016.05.035. [PMID: 27208493] - Gayaprasad Upadhyay, Sarvesh Khoshla, Ramoji Kosuru, Sanjay Singh. Anxiolytic, antidepressant, and antistress activities of the aqueous extract of Cinnamomum tamala Nees and Eberm in rats.
Indian journal of pharmacology.
2016 Sep; 48(5):555-561. doi:
10.4103/0253-7613.190752. [PMID: 27721543] - Weronika Duda, Katarzyna Curzytek, Marta Kubera, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Anna Bilska-Wilkosz, Elżbieta Lorenc-Koci, Monika Leśkiewicz, Agnieszka Basta-Kaim, Bogusława Budziszewska, Magdalena Regulska, Joanna Ślusarczyk, Piotr Gruca, Mariusz Papp, Michael Maes, Władysław Lasoń, Lucyna Antkiewicz-Michaluk. The Effect of Chronic Mild Stress and Imipramine on the Markers of Oxidative Stress and Antioxidant System in Rat Liver.
Neurotoxicity research.
2016 08; 30(2):173-84. doi:
10.1007/s12640-016-9614-8. [PMID: 26961706] - Ahmad Nassar, Yael Sharon-Granit, Abed N Azab. Psychotropic drugs attenuate lipopolysaccharide-induced hypothermia by altering hypothalamic levels of inflammatory mediators in rats.
Neuroscience letters.
2016 07; 626(?):59-67. doi:
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Food & function.
2016 Jun; 7(6):2811-9. doi:
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Bioorganic & medicinal chemistry.
2016 06; 24(12):2725-38. doi:
10.1016/j.bmc.2016.04.039. [PMID: 27160055] - Qin Ding, Hongxia Li, Xue Tian, Zhilei Shen, Xiaoli Wang, Fengfeng Mo, Junlong Huang, Hui Shen. Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress.
Journal of affective disorders.
2016 Jun; 197(?):100-6. doi:
10.1016/j.jad.2016.03.017. [PMID: 26985741] - Nobuyuki Tanahashi, Ken Takagi, Nozomi Amagasu, Guifeng Wang, Kaito Mizuno, Jun Kawanoguchi, Guo Yi, Torao Ishida. Effect of acupuncture stimulation on rats with depression induced by water-immersion stress.
Neuroscience letters.
2016 Apr; 618(?):99-103. doi:
10.1016/j.neulet.2016.02.051. [PMID: 26940241] - Bai Li, Yangyang Hou, Ming Zhu, Hongkun Bao, Jun Nie, Grace Y Zhang, Liping Shan, Yao Yao, Kai Du, Hongju Yang, Meizhang Li, Bingrong Zheng, Xiufeng Xu, Chunjie Xiao, Jing Du. 3'-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway.
The international journal of neuropsychopharmacology.
2016 Apr; 19(4):. doi:
10.1093/ijnp/pyv112. [PMID: 26443809] - Jing Zhao, Yujin Shin, Kwang-Hoon Chun, Hye-Ran Yoon, Jeongmi Lee. A Simple, Rapid and Reliable Method to Determine Imipramine and Desipramine in Mouse Serum Using Ultra-High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry.
Journal of chromatographic science.
2016 Apr; 54(4):561-8. doi:
10.1093/chromsci/bmv187. [PMID: 26688563] - Valter Viana Andrade-Neto, Thaís Martins Pereira, Marilene do Canto-Cavalheiro, Eduardo Caio Torres-Santos. Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole.
Parasites & vectors.
2016 Mar; 9(?):183. doi:
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Bioanalysis.
2016 Feb; 8(4):297-309. doi:
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Methods in molecular biology (Clifton, N.J.).
2016; 1383(?):265-70. doi:
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International journal of urology : official journal of the Japanese Urological Association.
2016 Jan; 23(1):93-9. doi:
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Scientific reports.
2015 Nov; 5(?):16751. doi:
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Journal of neuroinflammation.
2015 Oct; 12(?):197. doi:
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Neuropharmacology.
2015 Oct; 97(?):447-56. doi:
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Pharmacological reports : PR.
2015 Oct; 67(5):1024-32. doi:
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BMC complementary and alternative medicine.
2015 Sep; 15(?):337. doi:
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The international journal of neuropsychopharmacology.
2015 Sep; 19(3):pyv103. doi:
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European journal of pharmacology.
2015 Sep; 762(?):127-35. doi:
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Neuron.
2015 Aug; 87(3):549-62. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
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Cell death & disease.
2015 Jul; 6(?):e1828. doi:
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Drug research.
2015 Jul; 65(7):337-43. doi:
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Pharmacology, biochemistry, and behavior.
2015 Jun; 133(?):83-91. doi:
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Drug testing and analysis.
2015 Jun; 7(6):457-66. doi:
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Metabolic brain disease.
2015 Apr; 30(2):519-27. doi:
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Chronobiology international.
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Talanta.
2015 Mar; 134(?):165-172. doi:
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Behavioural brain research.
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Behavioural brain research.
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