Talazoparib Tosylate (BioDeep_00000839647)
代谢物信息卡片
化学式: C26H22F2N6O4S (552.1391236000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
InChI: /m1./s1
描述信息
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C62554 - Poly (ADP-Ribose) Polymerase Inhibitor
C471 - Enzyme Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Gamze Guney Eskiler, Gulsah Cecener, Unal Egeli, Berrin Tunca. Talazoparib nanoparticles for overcoming multidrug resistance in triple-negative breast cancer.
Journal of cellular physiology.
2020 09; 235(9):6230-6245. doi:
10.1002/jcp.29552
. [PMID: 32017076] - Yan Jia, Huanhuan Jin, Liyuan Gao, Xiang Yang, Feixia Wang, Hai Ding, Anping Chen, Shanzhong Tan, Feng Zhang, Jiangjuan Shao, Shijun Wang, Shizhong Zheng. A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
Journal of cellular and molecular medicine.
2020 05; 24(9):5304-5316. doi:
10.1111/jcmm.15186
. [PMID: 32243714] - Gamze Guney Eskiler, Gulsah Cecener, Gokhan Dikmen, Unal Egeli, Berrin Tunca. Talazoparib Loaded Solid Lipid Nanoparticles: Preparation, Characterization and Evaluation of the Therapeutic Efficacy In vitro.
Current drug delivery.
2019; 16(6):511-529. doi:
10.2174/1567201816666190515105532
. [PMID: 31113350] - Gamze Guney Eskiler, Gulsah Cecener, Unal Egeli, Berrin Tunca. Synthetically Lethal BMN 673 (Talazoparib) Loaded Solid Lipid Nanoparticles for BRCA1 Mutant Triple Negative Breast Cancer.
Pharmaceutical research.
2018 Sep; 35(11):218. doi:
10.1007/s11095-018-2502-6
. [PMID: 30255456] - Yunhua Liu, Hanchen Xu, Kevin Van der Jeught, Yujing Li, Sheng Liu, Lu Zhang, Yuanzhang Fang, Xinna Zhang, Milan Radovich, Bryan P Schneider, Xiaoming He, Cheng Huang, Chi Zhang, Jun Wan, Guang Ji, Xiongbin Lu. Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.
The Journal of clinical investigation.
2018 07; 128(7):2951-2965. doi:
10.1172/jci98727
. [PMID: 29649003]