Mavacoxib (BioDeep_00000839640)

   


代谢物信息卡片


Mavacoxib

化学式: C16H11F4N3O2S (385.0508)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)F
InChI: InChI=1S/C16H11F4N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor

同义名列表

1 个代谢物同义名

Mavacoxib



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Chao Wan, Jian-Yu Pang, Wei Jiang, Xiao-Wei Zhang, Xiang-Guo Hu. Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib. The Journal of organic chemistry. 2021 03; 86(6):4557-4566. doi: 10.1021/acs.joc.0c02980. [PMID: 33586981]
  • Gail L Huckins, James W Carpenter, Sara Dias, Butch KuKanich. PHARMACOKINETICS OF ORAL MAVACOXIB IN CARIBBEAN FLAMINGOS (PHOENICOPTERUS RUBER RUBER). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2020 Mar; 51(1):53-58. doi: 10.1638/2019-0161. [PMID: 32212546]
  • Elke Gasthuys, Renée Houben, Roel Haesendonck, Siegrid De Baere, Stanislas U Sys, Joachim Morrens, Gunther Antonissen. Development of an in Vivo Lipopolysaccharide Inflammation Model to Study the Pharmacodynamics of COX-2 Inhibitors Celecoxib, Mavacoxib, and Meloxicam in Cockatiels (Nymphicus hollandicus). Journal of avian medicine and surgery. 2019 Dec; 33(4):349-360. doi: 10.1647/2018-391. [PMID: 31833303]
  • Laura Dhondt, Mathias Devreese, Siska Croubels, Siegrid De Baere, Roel Haesendonck, Tess Goessens, Ronette Gehring, Patrick De Backer, Gunther Antonissen. Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus). Scientific reports. 2017 09; 7(1):12043. doi: 10.1038/s41598-017-12159-z. [PMID: 28947805]
  • P Lees, L Pelligand, J Elliott, P-L Toutain, G Michels, M Stegemann. Pharmacokinetics, pharmacodynamics, toxicology and therapeutics of mavacoxib in the dog: a review. Journal of veterinary pharmacology and therapeutics. 2015 Feb; 38(1):1-14. doi: 10.1111/jvp.12185. [PMID: 25413929]
  • Lisa Y Pang, Sally A Argyle, Ayako Kamida, Katherine O'Neill Morrison, David J Argyle. The long-acting COX-2 inhibitor mavacoxib (Trocoxil™) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro. BMC veterinary research. 2014 Sep; 10(?):184. doi: 10.1186/s12917-014-0184-9. [PMID: 25190452]
  • S R Cox, S Liao, M Payne-Johnson, R J Zielinski, M R Stegemann. Population pharmacokinetics of mavacoxib in osteoarthritic dogs. Journal of veterinary pharmacology and therapeutics. 2011 Feb; 34(1):1-11. doi: 10.1111/j.1365-2885.2010.01183.x. [PMID: 21219337]
  • S R Cox, S P Lesman, J F Boucher, M J Krautmann, B D Hummel, M Savides, S Marsh, A Fielder, M R Stegemann. The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs. Journal of veterinary pharmacology and therapeutics. 2010 Oct; 33(5):461-70. doi: 10.1111/j.1365-2885.2010.01165.x. [PMID: 20840390]
  • T D Penning, J J Talley, S R Bertenshaw, J S Carter, P W Collins, S Docter, M J Graneto, L F Lee, J W Malecha, J M Miyashiro, R S Rogers, D J Rogier, S S Yu, AndersonGD, E G Burton, J N Cogburn, S A Gregory, C M Koboldt, W E Perkins, K Seibert, A W Veenhuizen, Y Y Zhang, P C Isakson. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). Journal of medicinal chemistry. 1997 Apr; 40(9):1347-65. doi: 10.1021/jm960803q. [PMID: 9135032]