Tafamidis meglumine (BioDeep_00000839618)
代谢物信息卡片
化学式: C21H24Cl2N2O8 (502.09096439999996)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNCC(C(C(C(CO)O)O)O)O.C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
InChI: 4-13H,2-3H2,1H3/t
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:79345
- KEGGdrug: D09674
- PubChem: 24970412
- ChEMBL: CHEMBL2105675
- CAS: 951395-08-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yuri Ochi, Toru Kubo, Yuichi Baba, Kenta Sugiura, Kazuya Miyagawa, Tatsuya Noguchi, Takayoshi Hirota, Tomoyuki Hamada, Naohito Yamasaki, Hiroaki Kitaoka. Early Experience of Tafamidis Treatment in Japanese Patients With Wild-Type Transthyretin Cardiac Amyloidosis From the Kochi Amyloidosis Cohort.
Circulation journal : official journal of the Japanese Circulation Society.
2022 Jun; 86(7):1121-1128. doi:
10.1253/circj.cj-21-0965
. [PMID: 35599003] - Yeamin Huh, Steve Riley, Lutz Harnisch, Timothy Nicholas. Population pharmacokinetic modelling and simulation of tafamidis in healthy subjects and patients with transthyretin amyloidosis.
British journal of clinical pharmacology.
2021 09; 87(9):3574-3587. doi:
10.1111/bcp.14773
. [PMID: 33586186] - Lily K Stern, Michelle M Kittleson. Updates in Cardiac Amyloidosis Diagnosis and Treatment.
Current oncology reports.
2021 03; 23(4):47. doi:
10.1007/s11912-021-01028-8
. [PMID: 33725199] - Luke T Nelson, Ryan J Paxman, Jin Xu, Bill Webb, Evan T Powers, Jeffery W Kelly. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2021 Mar; 28(1):24-29. doi:
10.1080/13506129.2020.1808783
. [PMID: 32811187] - David Adams, Michel Slama. Hereditary transthyretin amyloidosis: current treatment.
Current opinion in neurology.
2020 10; 33(5):553-561. doi:
10.1097/wco.0000000000000852
. [PMID: 32796279] - Morie A Gertz, Angela Dispenzieri. Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review.
JAMA.
2020 07; 324(1):79-89. doi:
10.1001/jama.2020.5493
. [PMID: 32633805] - Terry J McGenity, Amare Gessesse, John E Hallsworth, Esther Garcia Cela, Carol Verheecke-Vaessen, Fengping Wang, Max Chavarría, Max M Haggblom, Søren Molin, Antoine Danchin, Eddy J Smid, Cédric Lood, Charles S Cockell, Corinne Whitby, Shuang-Jiang Liu, Nancy P Keller, Lisa Y Stein, Seth R Bordenstein, Rup Lal, Olga C Nunes, Lone Gram, Brajesh K Singh, Nicole S Webster, Cindy Morris, Sharon Sivinski, Saskia Bindschedler, Pilar Junier, André Antunes, Bonnie K Baxter, Paola Scavone, Kenneth Timmis. Visualizing the invisible: class excursions to ignite children's enthusiasm for microbes.
Microbial biotechnology.
2020 07; 13(4):844-887. doi:
10.1111/1751-7915.13576
. [PMID: 32406115] - D M Paton. Tafamidis: a selective transthyretin stabilizer to treat wild-type ATTR amyloidosis and hereditary ATTR amyloidosis with cardiomyopathy.
Drugs of today (Barcelona, Spain : 1998).
2019 Dec; 55(12):727-734. doi:
10.1358/dot.2019.55.12.3078389
. [PMID: 31942875] - Cecília Monteiro, Jaleh S Mesgazardeh, João Anselmo, Joana Fernandes, Marta Novais, Carla Rodrigues, Gabriel J Brighty, David L Powers, Evan T Powers, Teresa Coelho, Jeffery W Kelly. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy.
JCI insight.
2019 06; 4(12):. doi:
10.1172/jci.insight.126526
. [PMID: 31217346] - Joel N Buxbaum. Treatment of hereditary and acquired forms of transthyretin amyloidosis in the era of personalized medicine: the role of randomized controlled trials.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2019 Jun; 26(2):55-65. doi:
10.1080/13506129.2019.1575201
. [PMID: 30907141] - Asuncion Ferrer-Nadal, Tomas Ripoll, Mercedes Uson, Antoni Figuerola, Hernan Andreu, Ines Losada, Juan Gonzalez, Eugenia Cisneros-Barroso, Juan Buades. Significant reduction in proteinuria after treatment with tafamidis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2019 ; 26(sup1):67-68. doi:
10.1080/13506129.2019.1583186
. [PMID: 31343359] - Hiroyuki Yamamoto, Toru Hashimoto, Shunji Kawamura, Michiaki Hiroe, Taro Yamashita, Yukio Ando, Tomoki Yokochi. Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report.
Journal of medical case reports.
2018 Dec; 12(1):370. doi:
10.1186/s13256-018-1931-5
. [PMID: 30553273] - Kyeong-Ryoon Lee, Jong-Woo Jeong, Hun-Chan Hyun, Eunseo Jang, Sunjoo Ahn, Sungwook Choi, Sang Hoon Joo, Sungsub Kim, Tae-Sung Koo. Pharmacokinetics of tafamidis, a transthyretin amyloidosis drug, in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 Aug; 48(8):831-838. doi:
10.1080/00498254.2017.1366575
. [PMID: 28803538] - Joseph D Schonhoft, Cecilia Monteiro, Lars Plate, Yvonne S Eisele, John M Kelly, Daniel Boland, Christopher G Parker, Benjamin F Cravatt, Sergio Teruya, Stephen Helmke, Mathew Maurer, John Berk, Yoshiki Sekijima, Marta Novais, Teresa Coelho, Evan T Powers, Jeffery W Kelly. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.
Science translational medicine.
2017 Sep; 9(407):. doi:
10.1126/scitranslmed.aam7621
. [PMID: 28904227] - Hun-Chan Hyun, Jong-Woo Jeong, Hye-Rim Kim, Ji-Hoon Oh, Jong-Hwa Lee, Sungwook Choi, Yeon-Soo Kim, Tae-Sung Koo. Development and validation of a liquid chromatography-tandem mass spectrometry method for the assay of tafamidis in rat plasma: Application to a pharmacokinetic study in rats.
Journal of pharmaceutical and biomedical analysis.
2017 Apr; 137(?):90-95. doi:
10.1016/j.jpba.2017.01.020
. [PMID: 28107689] - Haruki Koike, Shohei Ikeda, Mie Takahashi, Yuichi Kawagashira, Masahiro Iijima, Yohei Misumi, Yukio Ando, Shu-Ichi Ikeda, Masahisa Katsuno, Gen Sobue. Disruption of blood-nerve barriers in hereditary transthyretin (ATTR) amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2017 Mar; 24(sup1):89-90. doi:
10.1080/13506129.2017.1278691
. [PMID: 28434331] - Ana Rocha, Ana Silva, Márcio Cardoso, Idalina Beirão, Cristina Alves, Paulo Teles, Teresa Coelho, Luísa Lobato. Transthyretin (ATTR) amyloidosis nephropathy: lessons from a TTR stabilizer molecule.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2017 03; 24(sup1):81-82. doi:
10.1080/13506129.2016.1277697
. [PMID: 28434370] - Irina Iakovleva, Afshan Begum, Kristoffer Brännström, Alexandra Wijsekera, Lina Nilsson, Jin Zhang, Patrik L Andersson, A Elisabeth Sauer-Eriksson, Anders Olofsson. Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer.
PloS one.
2016; 11(4):e0153529. doi:
10.1371/journal.pone.0153529
. [PMID: 27093678] - Simon Dubrey, Elizabeth Ackermann, Julian Gillmore. The transthyretin amyloidoses: advances in therapy.
Postgraduate medical journal.
2015 Aug; 91(1078):439-48. doi:
10.1136/postgradmedj-2014-133224
. [PMID: 26048914] - Younhee Cho, Aleksandra Baranczak, Stephen Helmke, Sergio Teruya, Evelyn M Horn, Mathew S Maurer, Jeffery W Kelly. Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy).
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2015; 22(3):175-80. doi:
10.3109/13506129.2015.1063485
. [PMID: 26193961] - Irit Rappley, Cecília Monteiro, Marta Novais, Aleksandra Baranczak, Gregory Solis, R Luke Wiseman, Stephen Helmke, Mathew S Maurer, Teresa Coelho, Evan T Powers, Jeffery W Kelly. Quantification of transthyretin kinetic stability in human plasma using subunit exchange.
Biochemistry.
2014 Apr; 53(12):1993-2006. doi:
10.1021/bi500171j
. [PMID: 24661308] - Teresa Coelho, Luis F Maia, Ana Martins da Silva, Márcia W Cruz, Violaine Planté-Bordeneuve, Ole B Suhr, Isabel Conceiçao, Hartmut H-J Schmidt, Pedro Trigo, Jeffery W Kelly, Richard Labaudinière, Jason Chan, Jeff Packman, Donna R Grogan. Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy.
Journal of neurology.
2013 11; 260(11):2802-14. doi:
10.1007/s00415-013-7051-7
. [PMID: 23974642] - Sravan C Penchala, Stephen Connelly, Yu Wang, Miki S Park, Lei Zhao, Aleksandra Baranczak, Irit Rappley, Hannes Vogel, Michaela Liedtke, Ronald M Witteles, Evan T Powers, Natàlia Reixach, William K Chan, Ian A Wilson, Jeffery W Kelly, Isabella A Graef, Mamoun M Alhamadsheh. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proceedings of the National Academy of Sciences of the United States of America.
2013 Jun; 110(24):9992-7. doi:
10.1073/pnas.1300761110
. [PMID: 23716704] - David Adams, Cécile Cauquil, Marie Théaudin. [Familial amyloid polyneuropathies: therapeutic issues].
Bulletin de l'Academie nationale de medecine.
2012 Oct; 196(7):1333-45; discussion 1345. doi:
NULL
. [PMID: 23815018] - David Adams, Didier Samuel, Michel Slama. [Treatment of familial amyloid polyneuropathy].
Presse medicale (Paris, France : 1983).
2012 Sep; 41(9 Pt 1):793-806. doi:
10.1016/j.lpm.2011.11.027
. [PMID: 22341949] - James P Solomon, Lesley J Page, William E Balch, Jeffery W Kelly. Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention.
Critical reviews in biochemistry and molecular biology.
2012 May; 47(3):282-96. doi:
10.3109/10409238.2012.661401
. [PMID: 22360545] - J de Lartigue. Tafamidis for transthyretin amyloidosis.
Drugs of today (Barcelona, Spain : 1998).
2012 May; 48(5):331-7. doi:
10.1358/dot.2012.48.5.1808486
. [PMID: 22645721]