Brompheniramine Maleate (BioDeep_00000839603)
代谢物信息卡片
Brompheniramine Maleate
化学式: C20H23BrN2O4 (434.0841098)
中文名称: 马来酸溴苯那敏
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
InChI: 2-1-
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research[1][2][3][4].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:3184
- KEGGdrug: D00663
- PubChem: 5281067
- ChEMBL: CHEMBL1200961
- MeSH: Brompheniramine
- CAS: 2664-17-7
- CAS: 980-71-2
- medchemexpress: HY-B0480
分类词条
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0 个相关的代谢反应过程信息。
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- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Joseph W Lowdon, Kasper Eersels, Rocio Arreguin-Campos, Manlio Caldara, Benjamin Heidt, Renato Rogosic, Kathia L Jimenez-Monroy, Thomas J Cleij, Hanne Diliën, Bart van Grinsven. A Molecularly Imprinted Polymer-based Dye Displacement Assay for the Rapid Visual Detection of Amphetamine in Urine.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225222. [PMID: 33182534] - Yaqi Yao, Yu Zhao, Xue Zhang, Jia Yu, Xingjie Guo. Determination of brompheniramine enantiomers in rat plasma by cation-selective exhaustive injection and sweeping cyclodextrin modified electrokinetic chromatography method.
Electrophoresis.
2018 08; 39(16):2099-2106. doi:
10.1002/elps.201800138. [PMID: 29756294] - Sudam Pathirana, Shyamalie Jayawardena, Suzanne Meeves, Gary A Thompson. Brompheniramine and Chlorpheniramine Pharmacokinetics Following Single-Dose Oral Administration in Children Aged 2 to 17 Years.
Journal of clinical pharmacology.
2018 04; 58(4):494-503. doi:
10.1002/jcph.1037. [PMID: 29136286] - Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism.
Journal of separation science.
2016 May; 39(9):1766-75. doi:
10.1002/jssc.201501026. [PMID: 26935589] - Silvia Tardioli, Ivonne Lammers, Jan-Hein Hooijschuur, Freek Ariese, Gert van der Zwan, Cees Gooijer. Complementary fluorescence and phosphorescence study of the interaction of brompheniramine with human serum albumin.
The journal of physical chemistry. B.
2012 Jun; 116(24):7033-9. doi:
10.1021/jp300055c. [PMID: 22612655] - Silvia Tardioli, Joost Buijs, Cees Gooijer, Gert van der Zwan. pH-dependent complexation of histamine H1 receptor antagonists and human serum albumin studied by UV resonance Raman spectroscopy.
The journal of physical chemistry. B.
2012 Mar; 116(12):3808-15. doi:
10.1021/jp206409d. [PMID: 22372713] - Warren C Rodrigues, Catherine Castro, Philip Catbagan, Christine Moore, Guohong Wang. Immunoassay screening of diphenhydramine (Benadryl®) in urine and blood using a newly developed assay.
Journal of analytical toxicology.
2012 Mar; 36(2):123-9. doi:
10.1093/jat/bkr015. [PMID: 22337782] - Peter Mikus, Katarína Maráková, Jozef Marák, Dusan Kaniansky, Iva Valásková, Emil Havránek. Possibilities of column coupling electrophoresis provided with a fiber-based diode array detection in enantioselective analysis of drugs in pharmaceutical and clinical samples.
Journal of chromatography. A.
2008 Jan; 1179(1):9-16. doi:
10.1016/j.chroma.2007.09.012. [PMID: 17905259] - María Amparo Martínez-Gómez, Rosa M Villanueva-Camañas, Salvador Sagrado, María José Medina-Hernández. Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE.
Electrophoresis.
2007 Aug; 28(15):2635-43. doi:
10.1002/elps.200600742. [PMID: 17605150] - László Gagyi, Arpád Gyéresi, Ferenc Kilár. Role of chemical structure in stereoselective recognition of beta-blockers and H1-antihistamines by human serum transferrin in capillary zone electrophoresis.
Electrophoresis.
2006 Apr; 27(8):1510-6. doi:
10.1002/elps.200500787. [PMID: 16609932] - F E Simons, J R Roberts, X Gu, S Kapur, K J Simons. The clinical pharmacology of brompheniramine in children.
The Journal of allergy and clinical immunology.
1999 Feb; 103(2 Pt 1):223-6. doi:
10.1016/s0091-6749(99)70494-x. [PMID: 9949311] - J A Holeman, N D Danielson. Liquid chromatography of antihistamines using post-column tris(2,2'-bipyridine) ruthenium(III) chemiluminescence detection.
Journal of chromatography. A.
1994 Sep; 679(2):277-84. doi:
10.1016/0021-9673(94)80570-9. [PMID: 7951995] - K M Olsen, M Gulliksen, A S Christophersen. Metabolites of chlorpromazine and brompheniramine may cause false-positive urine amphetamine results with monoclonal EMIT d.a.u. immunoassay.
Clinical chemistry.
1992 Apr; 38(4):611-2. doi:
10.1093/clinchem/38.4.611. [PMID: 1568344] - F E Simons, K J Simons, M Chung, J Yeh. The comparative pharmacokinetics of H1-receptor antagonists.
Annals of allergy.
1987 Dec; 59(6 Pt 2):20-4. doi:
. [PMID: 2892445] - D M Paton, D R Webster. Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines).
Clinical pharmacokinetics.
1985 Nov; 10(6):477-97. doi:
10.2165/00003088-198510060-00002. [PMID: 2866055] - H Friedman, D J Greenblatt. The pharmacokinetics of doxylamine: use of automated gas chromatography with nitrogen-phosphorus detection.
Journal of clinical pharmacology.
1985 Sep; 25(6):448-51. doi:
10.1002/j.1552-4604.1985.tb02875.x. [PMID: 4056080] - C C Lin, H K Kim, J Lim, C Digiore, S Symchowicz, R Gural. Steady-state bioavailability of dexbrompheniramine and pseudoephedrine from a repeat-action combination tablet.
Journal of pharmaceutical sciences.
1985 Jan; 74(1):25-8. doi:
10.1002/jps.2600740107. [PMID: 3981411] - M Linnoila, F Karoum, W Z Potter. Effects of antidepressant treatments on dopamine turnover in depressed patients.
Archives of general psychiatry.
1983 Sep; 40(9):1015-7. doi:
10.1001/archpsyc.1983.01790080097012. [PMID: 6225405] - O Lingjaerde, O Bratfos, T Bratlid, J O Haug. A double-blind comparison of zimelidine and desipramine in endogenous depression.
Acta psychiatrica Scandinavica.
1983 Jul; 68(1):22-30. doi:
10.1111/j.1600-0447.1983.tb06977.x. [PMID: 6225313] - M Linnoila, F Karoum, N Rosenthal, W Z Potter. Electroconvulsive treatment and lithium carbonate. Their effects on norepinephrine metabolism in patients with primary, major depressions.
Archives of general psychiatry.
1983 Jun; 40(6):677-80. doi:
10.1001/archpsyc.1983.04390010087011. [PMID: 6221709] - S B Ross, A Aberg-Wistedt. Inhibitors of serotonin and noradrenaline uptake in human plasma after withdrawal of zimelidine and clomipramine treatment.
Psychopharmacology.
1983; 79(4):298-303. doi:
10.1007/bf00433405. [PMID: 6222388] - F Holsboer, O A Müller, K Winter, H G Doerr, W G Sippell. Effect of serotonin uptake inhibition by zimelidine on hypothalamic-pituitary-adrenal activity.
Psychopharmacology.
1983; 80(1):85-7. doi:
10.1007/bf00427502. [PMID: 6306711] - J Claghorn, S Gershon, B J Goldstein, S Behrnetz, D F Bush, B Huitfeldt. A double-blind evaluation of zimelidine in comparison to placebo and amitriptyline in patients with major depressive disorder.
Progress in neuro-psychopharmacology & biological psychiatry.
1983; 7(2-3):367-82. doi:
10.1016/0278-5846(83)90125-2. [PMID: 6225150] - F E Simons, E M Frith, K J Simons. The pharmacokinetics and antihistaminic effects of brompheniramine.
The Journal of allergy and clinical immunology.
1982 Dec; 70(6):458-64. doi:
10.1016/0091-6749(82)90009-4. [PMID: 6128358] - D Kupfer. Interaction of EEG sleep, antidepressants, and affective disease.
The Journal of clinical psychiatry.
1982 Nov; 43(11 Pt 2):30-6. doi:
NULL. [PMID: 6217197] - M Linnoila, F Karoum, H M Calil, I J Kopin, W Z Potter. Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients.
Archives of general psychiatry.
1982 Sep; 39(9):1025-8. doi:
10.1001/archpsyc.1982.04290090027006. [PMID: 6214234] - A Aberg-Wistedt. Comparison between zimelidine and desipramine in endogenous depression. A cross-over study.
Acta psychiatrica Scandinavica.
1982 Aug; 66(2):129-38. doi:
10.1111/j.1600-0447.1982.tb00921.x. [PMID: 6215831] - A Aberg-Wistedt. A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. I. Clinical findings.
Acta psychiatrica Scandinavica.
1982 Jul; 66(1):50-65. doi:
10.1111/j.1600-0447.1982.tb00914.x. [PMID: 6214925] - A Aberg-Wistedt, S B Ross, K G Jostell, B Sjöquist. A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. II. Biochemical findings.
Acta psychiatrica Scandinavica.
1982 Jul; 66(1):66-82. doi:
10.1111/j.1600-0447.1982.tb00915.x. [PMID: 6181652] - H M Calil, K G Jostell, R W Cowdry, W Z Potter. Zimelidine and norzimelidine protein binding measured by equilibrium dialysis and cerebrospinal fluid.
Clinical pharmacology and therapeutics.
1982 Apr; 31(4):522-7. doi:
10.1038/clpt.1982.70. [PMID: 6460587] - Z W Brown, Z Amit, A Sutherland, G Rockman, N Selvaggi, S O Ogren. An examination of possible interactions between zimelidine, a serotonin uptake inhibitor, and ethanol ingested conjointly in human subjects.
Neuroscience letters.
1981 Dec; 27(3):351-5. doi:
10.1016/0304-3940(81)90456-0. [PMID: 6460207] - W Z Potter, H M Calil, I Extein, P W Gold, T A Wehr, F K Goodwin. Specific norepinephrine and serotonin uptake inhibitors in man: a crossover study with pharmacokinetic, biochemical, neuroendocrine and behavioral parameters.
Acta psychiatrica Scandinavica. Supplementum.
1981; 290(?):152-65. doi:
10.1111/j.1600-0447.1981.tb00716.x. [PMID: 6452790] - A Aberg. Controlled cross-over study of a 5-HT uptake inhibiting and an NA uptake inhibiting antidepressant.
Acta psychiatrica Scandinavica. Supplementum.
1981; 290(?):244-55. doi:
NULL. [PMID: 6452794] - B L Love, R G Moore, J Thomas, S Chaturvedi. Pharmacokinetics of zimelidine in humans--plasma levels and urinary excretion of zimelidine and norzimelidine after intravenous and oral administration of zimelidine.
European journal of clinical pharmacology.
1981; 20(2):135-9. doi:
10.1007/bf00607150. [PMID: 6455297] - J B Loudon, B Tiplady, G W Ashcroft, J L Waddell. Zimelidine and amitriptyline in the treatment of depressive illness in general practice.
Acta psychiatrica Scandinavica. Supplementum.
1981; 290(?):454-63. doi:
10.1111/j.1600-0447.1981.tb00752.x. [PMID: 6452805] - A Aberg-Wistedt, K G Jostell, S B Ross, D Westerlund. Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression.
Psychopharmacology.
1981; 74(4):297-305. doi:
10.1007/bf00432735. [PMID: 6457309] - S A Montgomery, R McAuley, S J Rani, D Roy, D B Montgomery. A double blind comparison of zimelidine and amitriptyline in endogenous depression.
Acta psychiatrica Scandinavica. Supplementum.
1981; 290(?):314-27. doi:
10.1111/j.1600-0447.1981.tb00735.x. [PMID: 6452798] - J Lundström, T Högberg, T Gosztonyi, T de Paulis. Metabolism of zimelidine in rat, dog and man. Identification and synthesis of the principal metabolites.
Arzneimittel-Forschung.
1981; 31(3):486-94. doi:
NULL. [PMID: 6452883] - O Dehlin, G Björnsson, J Lundström. Zimelidine to geriatric patients: a pharmacokinetic and clinical study.
Acta psychiatrica Scandinavica. Supplementum.
1981; 290(?):410-24. doi:
10.1111/j.1600-0447.1981.tb00747.x. [PMID: 6452803] - L Bertilsson, J R Tuck, B Siwers. Biochemical effects of zimelidine in man.
European journal of clinical pharmacology.
1980 Nov; 18(6):483-7. doi:
10.1007/bf00874660. [PMID: 6450684] - L B Hansen, I S Thomsen, P Vestergård, N E Larsen, E F Hvidberg. Plasma levels of zimelidine and norzimelidine in endogenous depression.
Psychopharmacology.
1980; 69(2):157-60. doi:
10.1007/bf00427642. [PMID: 6450427] - D Westerlund, E Erixson. Reversed-phase chromatography of zimelidine and similar dibasic amines. I. Analysis in biological material.
Journal of chromatography.
1979 Dec; 185(?):593-603. doi:
10.1016/s0021-9673(00)85633-2. [PMID: 546935] - E Syvälahti, P Eneroth, S B Ross. Acute effects of zimelidine and alaproclate, two inhibitors of serotonin uptake, on neuroendocrine function.
Psychiatry research.
1979 Oct; 1(2):111-20. doi:
10.1016/0165-1781(79)90051-9. [PMID: 121774] - C G Persson, M Ekman. Application of the method of Magnus to measure drug antihistaminic activity in blood plasma.
Acta pharmaceutica Suecica.
1972 Jun; 9(3):229-36. doi:
NULL. [PMID: 4403352] - T B Vree, J M van Rossum, D D Breimer, G A van Ginneken, J M van Kordelaar. Gas-liquid chromatography in pharmacology and toxicology. Pharmacokinetic analysis limited by the sensitivity of the analytical technique.
Clinica chimica acta; international journal of clinical chemistry.
1971 Sep; 34(2):311-9. doi:
10.1016/0009-8981(71)90185-9. [PMID: 5113568] - R B Bruce, L B Turnbull, J H Newman, J E Pitts. Metabolism of brompheniramine.
Journal of medicinal chemistry.
1968 Sep; 11(5):1031-4. doi:
10.1021/jm00311a026. [PMID: 4386938] - R B Bruce, J E Pitts, F M Pinchbeck. Determination of brompheniramine in blood and urine by gas-liquid chromatography.
Analytical chemistry.
1968 Jul; 40(8):1246-50. doi:
10.1021/ac60264a030. [PMID: 4393465] - P Kabasakalian, M Taggart, E Townley. Urinary excretion of pheniramine and its N-demthylated metabolites in man--comparison with chlorpheniramine and brompheniramine data.
Journal of pharmaceutical sciences.
1968 Apr; 57(4):621-3. doi:
10.1002/jps.2600570416. [PMID: 4385103]