Atorvastatin calcium (BioDeep_00000839602)
代谢物信息卡片
Fast green FCF calcium salt
化学式: C66H68CaF2N4O10 (1154.4529)
中文名称: 阿托伐他汀钙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.[Ca+2]
InChI: /q
描述信息
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
FDA permitted colourant for food and food contact paper or board [DFC]
Food colorant [CCD]
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:50686
- KEGGdrug: D00887
- PubChem: 60822
- ChEMBL: CHEMBL393220
- MeSH: Atorvastatin
- foodb: FDB018756
- foodb: FDB018626
- CAS: 1316891-47-0
- CAS: 134523-03-8
- CAS: 363599-71-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yue Zhang, Di Wu, Qishun Sun, Zhen Luo, Yuhao Zhang, Bowei Wang, Wenting Chen. Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway.
Free radical biology & medicine.
2024 Aug; 220(?):179-191. doi:
10.1016/j.freeradbiomed.2024.05.006. [PMID: 38704053] - Mei-Jie Chen, Yi-Tong Xu, Lu Sun, Zhi-Hua Wang, Peter J Little, Li Wang, Xun-de Xian, Jian-Ping Weng, Suo-Wen Xu. A novel mouse model of familial combined hyperlipidemia and atherosclerosis.
Acta pharmacologica Sinica.
2024 Jun; 45(6):1316-1320. doi:
10.1038/s41401-024-01241-8. [PMID: 38459255] - Yufei Zhao, Yimeng Wang, Jinzhi Ren, Weibo Gong, Xiangping Nie, Ying Peng, Jianjun Li, Chunni Duan. Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes.
Aquatic toxicology (Amsterdam, Netherlands).
2024 Jun; 271(?):106909. doi:
10.1016/j.aquatox.2024.106909. [PMID: 38593744] - Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park. Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice.
Respiratory research.
2024 May; 25(1):213. doi:
10.1186/s12931-024-02842-x. [PMID: 38762465] - Pui Ying Yew, Matt Loth, Terrence J Adam, Julian Wolfson, Yue Liang, Peter J Tonellato, Chih-Lin Chi. Potential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis.
BMC cardiovascular disorders.
2024 May; 24(1):245. doi:
10.1186/s12872-024-03921-z. [PMID: 38730371] - Anna Braszak-Cymerman, Marta K Walczak, Mary-Tiffany Oduah, Aleksandra Ludziejewska, Wiesław Bryl. Comparison of the pleiotropic effect of atorvastatin and rosuvastatin on postmenopausal changes in bone turnover: A randomized comparative study.
Medicine.
2024 May; 103(19):e38122. doi:
10.1097/md.0000000000038122. [PMID: 38728464] - Antoine Fayol, François Schiele, Jean Ferrières, Etienne Puymirat, Vincent Bataille, Victoria Tea, Chekrallah Chamandi, Franck Albert, Gilles Lemesle, Guillaume Cayla, Orianne Weizman, Tabassome Simon, Nicolas Danchin. Association of Use and Dose of Lipid-Lowering Therapy Post Acute Myocardial Infarction With 5-Year Survival in Older Adults.
Circulation. Cardiovascular quality and outcomes.
2024 May; 17(5):e010685. doi:
10.1161/circoutcomes.123.010685. [PMID: 38682335] - Xuxian Lv, Xudong Liu, Yanfang Peng, Wenbin Li, Jianing Wang, Xiaofeng Chen, Junjie Lei, Chaogang Tang, Shijian Luo, Weihua Mai, Yiming Cai, Qian Fan, Chenhao Liu, Lei Zhang. Medium-intensity statin with ezetimibe versus high-intensity statin in acute ischemic cerebrovascular disease (MESIA): A randomized clinical trial.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2024 May; 33(5):107647. doi:
10.1016/j.jstrokecerebrovasdis.2024.107647. [PMID: 38431112] - Mardhiah Maslizan, Muhammad Salahuddin Haris, Mokrish Ajat, Siti Nurul Ain Md Jamil, Shah Christirani Azhar, N Idayu Zahid, Intan Diana Mat Azmi. Non-lamellar lyotropic liquid crystalline nanoparticles as nanocarriers for enhanced drug encapsulation of atorvastatin calcium and proanthocyanidins.
Chemistry and physics of lipids.
2024 May; 260(?):105377. doi:
10.1016/j.chemphyslip.2024.105377. [PMID: 38325712] - Dan Li, Jiajin Chen, Fei Zhou, Wenhe Zhang, Hongyu Chen. Aldo-keto reductase-7A2 protects against atorvastatin-induced hepatotoxicity via Nrf2 activation.
Chemico-biological interactions.
2024 Apr; 393(?):110956. doi:
10.1016/j.cbi.2024.110956. [PMID: 38484826] - Minghua Zhang, Xianxian Yao, Jian Xu, Jiaying Song, Shuting Mai, Weichu Zhu, Yichen Zhang, Liangliang Zhu, Wuli Yang. Biodegradable zwitterionic polymer-cloaked defective metal-organic frameworks for ferroptosis-inducing cancer therapy.
International journal of pharmaceutics.
2024 Apr; 655(?):124032. doi:
10.1016/j.ijpharm.2024.124032. [PMID: 38521374] - Hong-Liang Zhao, Yang You, Yan Tian, Luyan Wang, Yongqiang An, Guoqiang Zhang, Chang Shu, Mingxin Yu, Yihua Zhu, Qian Li, Yanwei Zhang, Ningling Sun, Songnian Hu, Gang Liu. Impact of LDLR polymorphisms on lipid levels and atorvastatin's efficacy in a northern Chinese adult Han cohort with dyslipidemia.
Lipids in health and disease.
2024 Apr; 23(1):106. doi:
10.1186/s12944-024-02101-4. [PMID: 38616260] - Kaiqin Chen, He Li, Yongtai Chen, Hesen Huang, Liangfeng Wei. Association between Lipid-Lowering Drugs and Traumatic Subdural Hemorrhage: A Mendelian Randomization Study.
Journal of integrative neuroscience.
2024 Apr; 23(4):76. doi:
10.31083/j.jin2304076. [PMID: 38682216] - Zhaonian Hao, Jiejun Wang, Yifan Lv, Weiqi Wu, Shaodong Zhang, Shuyu Hao, Junsheng Chu, Hong Wan, Jie Feng, Nan Ji. Identification of MGMT promoter methylation as a specific lipid metabolism biomarker, reveals the feasibility of atorvastatin application in glioblastoma.
Metabolism: clinical and experimental.
2024 Apr; 153(?):155794. doi:
10.1016/j.metabol.2024.155794. [PMID: 38301843] - Junjie Peng, Pierre Dönnes, Stacy P Ardoin, Laura E Schanberg, Laura Lewandowski, George Robinson, Elizabeth C Jury, Coziana Ciurtin. Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile-Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature.
Arthritis & rheumatology (Hoboken, N.J.).
2024 Mar; 76(3):455-468. doi:
10.1002/art.42722. [PMID: 37786302] - Yaowei Bai, Kequan Chen, Jiacheng Liu, Yingliang Wang, Chaoyang Wang, Shuguang Ju, Chen Zhou, Wei Yao, Bin Xiong, Chuansheng Zheng. Activation of AMPK pathway by low‑dose donafenib and atorvastatin combination improves high‑fat diet‑induced metabolic dysfunction‑associated steatotic liver disease.
Molecular medicine reports.
2024 Mar; 29(3):. doi:
10.3892/mmr.2024.13175. [PMID: 38299233] - Jianqing She, Gulinigaer Tuerhongjiang, Manyun Guo, Junhui Liu, Xiang Hao, Liangan Guo, Nairong Liu, Wen Xi, Tao Zheng, Bin Du, Bowen Lou, Xiyu Gao, Xiao Yuan, Yue Yu, Yi Zhang, Fan Gao, Xiaozhen Zhuo, Ying Xiong, Xiang Zhang, Jun Yu, Zuyi Yuan, Yue Wu. Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner.
Cell metabolism.
2024 02; 36(2):408-421.e5. doi:
10.1016/j.cmet.2023.12.027. [PMID: 38325336] - Xian Qin, Qian Wang, Dongmei Xu, Yixuan Sun, Wandong Xu, Bo Wang, Zhu Yang, Lijuan Hao. Atorvastatin exerts dual effects of lesion regression and ovarian protection in the prevention and treatment of endometriosis.
European journal of pharmacology.
2024 Feb; 964(?):176261. doi:
10.1016/j.ejphar.2023.176261. [PMID: 38141938] - Chang Fengjin, Zhou Peng, L I Guoying, Zhang Weizhi, Zhang Yanyan, Peng Daiyin, Chen Guangliang. Taohong Siwu decoction ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor-κB signal pathway.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Feb; 44(1):103-112. doi:
10.19852/j.cnki.jtcm.20231215.003. [PMID: 38213245] - Yufei Zhao, Chunni Duan, Huiyu Zhang, Weibo Gong, Yimeng Wang, Jinzhi Ren, Xiangping Nie, Jianjun Li. Response of lipid metabolism, energy supply, and cell fate in yellowstripe goby (Mugilogobius chulae) exposed to environmentally relevant concentrations atorvastatin.
Environmental pollution (Barking, Essex : 1987).
2024 Jan; 341(?):122991. doi:
10.1016/j.envpol.2023.122991. [PMID: 37995957] - Huanfen Lu, Zhenglan Ban, Kai Xiao, Madi Sun, Yongbo Liu, Fangman Chen, Tongfei Shi, Li Chen, Dan Shao, Ming Zhang, Wei Li. Hepatic-Accumulated Obeticholic Acid and Atorvastatin Self-Assembled Nanocrystals Potentiate Ameliorative Effects in Treatment of Metabolic-Associated Fatty Liver Disease.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2024 Jan; ?(?):e2308866. doi:
10.1002/advs.202308866. [PMID: 38196299] - Paolo Raggi, Farzin M Takyar, Varuna Gadiyaram, Chao Zhang, Arthur E Stillman, Amir H Davarpanah. Differential effect of atorvastatin and pravastatin on thoracic spine attenuation: A sub-analysis of a randomized clinical trial.
Atherosclerosis.
2024 Jan; 388(?):117425. doi:
10.1016/j.atherosclerosis.2023.117425. [PMID: 38109819] - Deepkumar Bagasariya, Kondasingh Charankumar, Saurabh Shah, Paras Famta, Valencia Fernandes, Syed Shahrukh, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava. Quality by design endorsed atorvastatin-loaded nanostructured lipid carriers embedded in pH-responsive gel for melanoma.
Journal of microencapsulation.
2024 Jan; 41(1):27-44. doi:
10.1080/02652048.2023.2282971. [PMID: 37982590] - Gerard M Walls, Mihaela Ghita, Brian Herron, Kevin S Edgar, Refik Kuburas, Chris J Watson, David J Grieve, Aidan J Cole, Suneil Jain, Karl T Butterworth. A multimodality assessment of the protective capacity of statin therapy in a mouse model of radiation cardiotoxicity.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
2024 Jan; 190(?):110004. doi:
10.1016/j.radonc.2023.110004. [PMID: 37972738] - Wei Song, Zhong-Yi Zhang, Kai Wang, Hai-Rong Qiu, Xiao-Bo Zhang, Tao Shen. [Zhuyu Pills promote polarization of macrophages toward M2 phenotype to prevent atherosclerosis via PPARγ/NF-κB signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Jan; 49(1):243-250. doi:
10.19540/j.cnki.cjcmm.20230823.501. [PMID: 38403357] - Abolfazl Akbari, Mahya Razmi, Mahdi Rafiee, Gerald F Watts, Amirhossein Sahebkar. The Effect of Statin Therapy on Serum Uric Acid Levels: A Systematic Review and Meta-analysis.
Current medicinal chemistry.
2024; 31(13):1726-1739. doi:
10.2174/0929867330666230207124516. [PMID: 36748810] - Jie Zeng, Qiao Wu, Shiqiang Xiong, Cong Lu, Zheng Zhang, Hui Huang, Yan Xiong, Tiantian Luo. Inhibition of EphA2 protects against atherosclerosis by synergizing with statins to mitigate macrophage inflammation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 169(?):115885. doi:
10.1016/j.biopha.2023.115885. [PMID: 37984301] - Konrad Stępień, Marek Żółciński, Michał Ząbczyk, Jarosław Zalewski, Anetta Undas. Effect of three-day atorvastatin administration on coagulation factors in patients with prior venous thromboembolism and healthy subjects. A preliminary study.
Journal of cardiovascular pharmacology.
2023 Dec; ?(?):. doi:
10.1097/fjc.0000000000001529. [PMID: 38117119] - Bojana Petek, Henrike Häbel, Hong Xu, Marta Villa-Lopez, Irena Kalar, Minh Tuan Hoang, Silvia Maioli, Joana B Pereira, Shayan Mostafaei, Bengt Winblad, Milica Gregoric Kramberger, Maria Eriksdotter, Sara Garcia-Ptacek. Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study.
Alzheimer's research & therapy.
2023 12; 15(1):220. doi:
10.1186/s13195-023-01360-0. [PMID: 38115091] - Zeinab R Hassan, Samar El-Sayed, Kareman M Zekry, Samah Gouda Ahmed, Asmaa Hassan Abd-Elhamid, Doaa E A Salama, Azza Kamal Taha, Nihal A Mahmoud, Shaymaa Fathy Mohammed, Mona M Amin, Rasha Elsayed Mohamed, Ayat M S Eraque, Shimaa A Mohamed, Ranya M Abdelgalil, Shimaa Attia Atta, Nermeen Talaat Fahmy, Mohamed S Badr. Impact of atorvastatin and mesenchymal stem cells combined with ivermectin on murine trichinellosis.
Parasitology research.
2023 Dec; 123(1):57. doi:
10.1007/s00436-023-08077-x. [PMID: 38105357] - Niloufar Saber-Moghaddam, Mohammad Moeini Nodeh, Vahid Ghavami, Hossein Rahimi, Sajjad Ataei Azimi, Mohsen Seddigh-Shamsi, Mostafa Kamandi, Abolghasem Allahyari, Somayeh Sadat Shariatmaghani, Sepideh Elyasi, Omid Arasteh. The evaluation of atorvastatin as an adjunct to fluconazole for the anti-fungal prophylaxis in acute myeloid leukemia: a multicenter, triple-blinded, randomized clinical trial.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Dec; ?(?):. doi:
10.1007/s00210-023-02892-w. [PMID: 38095652] - Kübra Öztürk, Turan Emre Kuzu, Semih Ayrıkçil, Cem Abdulkadir Gürgan, Gözde Özge Önder, Arzu Yay. Effect of systemic atorvastatin on bone regeneration in critical-sized defects in hyperlipidemia: an experimental study.
International journal of implant dentistry.
2023 Dec; 9(1):50. doi:
10.1186/s40729-023-00508-9. [PMID: 38097856] - GuoTong Sun, XiuWen Liang. Comparison of the efficacy and safety of Shanhuang Jiangzhi tablets and atorvastatin in the treatment of patients with hyperlipidaemia.
Journal of health, population, and nutrition.
2023 Dec; 42(1):143. doi:
10.1186/s41043-023-00482-3. [PMID: 38098069] - Zhibo Zhao, Xinyi Liu, Yue Xiang, Zhengping Hou, Kun He, Guochao Zhong, Jiejun Hu, Dong Cai, Yan Liu, Jihua Ren, Jianping Gong, Lei Zhao. Inhibiting cholesterol de novo synthesis promotes hepatocellular carcinoma progression by upregulating prostaglandin E synthase 2-mediated arachidonic acid metabolism under high fatty acid conditions.
Cancer science.
2023 Dec; ?(?):. doi:
10.1111/cas.16035. [PMID: 38081591] - Shuangxi Sun, Qi Wang, Hongxia Chen, Ruihuan Pan. Huatanmaitong tablet alleviate cerebral ischemic reperfusion injury with hyperlipidaemia in rats by regulating OATPs/VEGF axis.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Dec; 69(13):235-240. doi:
10.14715/cmb/2023.69.13.35. [PMID: 38158660] - Fan Wu, Mingyu Cui, Siwen Wang, Chao Yu, Weihong Yin, Jiao Li, Xueying Yan. Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2023 Dec; 53(12):644-652. doi:
10.1080/00498254.2023.2290648. [PMID: 38054840] - Mohammed M Jalal, Claire S Whyte, Fraser P Coxon, Nicola J Mutch. Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure.
Platelets.
2023 Dec; 34(1):2206921. doi:
10.1080/09537104.2023.2206921. [PMID: 37139869] - Seung-Ah Lee, Soon Jun Hong, Jung-Hoon Sung, Kyung-Soo Kim, Seong Hwan Kim, Jin Man Cho, Sung Wan Chun, Sang Rok Lee, Chul Sik Kim, Tae Nyun Kim, Dae Hyeok Kim, Hwan-Cheol Park, Byung Jin Kim, Hyun-Sook Kim, Ji-Yong Choi, Young Joon Hong, Joong Wha Chung, Seong Bo Yoon, Sang-Hak Lee, Cheol Whan Lee. Effectiveness of low-intensity atorvastatin 5 mg and ezetimibe 10 mg combination therapy compared with moderate-intensity atorvastatin 10 mg monotherapy: A randomized, double-blinded, multi-center, phase III study.
Medicine.
2023 Nov; 102(47):e36122. doi:
10.1097/md.0000000000036122. [PMID: 38013289] - Fengchao Gong, Qian Shi, Xiaojie Mou, Kang Wang, Qianqian Wang, Haitao Wang. Atorvastatin mitigates memory deficits and brain monocyte infiltration in chronic hypercholesterolemia.
Aging.
2023 Nov; 15(23):13669-13679. doi:
10.18632/aging.205217. [PMID: 38048213] - Isabela Bruna Pires Borges, Sueli Mieko Oba-Shinjo, Antonio Marcondes Lerario, Suely Kazue Nagahashi Marie, Samuel Katsuyuki Shinjo. Effect of atorvastatin on muscle tissues of dermatomyositis and antisynthetase syndrome patients with dyslipidemia.
International journal of rheumatic diseases.
2023 Nov; ?(?):. doi:
10.1111/1756-185x.14965. [PMID: 37933530] - Guiyi Gong, Hiotong Kam, Yubin Bai, Wai San Cheang, Shuilong Wu, Xiaoning Cheng, John P Giesy, Simon Ming-Yuen Lee. 6-benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin-induced cerebral hemorrhage in zebrafish.
Environmental toxicology.
2023 Nov; ?(?):. doi:
10.1002/tox.24012. [PMID: 37929299] - Hugues Beaufrère, Trinita Barboza, Alysha Burnett, Ken D Stark, R Darren Wood. Effects of Atorvastatin and Rosuvastatin on Blood Lipids in Quaker Parrots (Myiopsitta monachus).
Journal of avian medicine and surgery.
2023 Nov; 37(3):199-208. doi:
10.1647/22-00014. [PMID: 37962313] - Song-Li Hao, Chun-Lan Zhang, Xiao-Yu Meng. Comparison of different drug for reducing testosterone levels in women with polycystic ovary syndrome: A systematic review and network meta-analysis.
Medicine.
2023 Oct; 102(41):e35152. doi:
10.1097/md.0000000000035152. [PMID: 37832133] - Fei Xiang Liu, Dao Pei Zhang, Yan Min Ma, Huai Liang Zhang, Xiang Zhe Liu, Zhen Qiang Zhang, Rui Qin Sun, Yun Ke Zhang, Jin Xin Miao, Zhao Xin Wu, Ya Li Liu, Yan Chen Feng. Effect of Jiawei Tongqiao Huoxue decoction in basilar artery dolichoectasia mice through yes-associated protein/transcriptional co-activator with PDZ-binding motif pathway.
Journal of ethnopharmacology.
2023 Oct; 314(?):116599. doi:
10.1016/j.jep.2023.116599. [PMID: 37149070] - Wen Yuan, Hongjun Fan, Haibing Yang, Liang Tang, Zhiming Liu, Fan Ouyang, Wei Luo, Yong Yan. Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway.
Diagnostic pathology.
2023 Sep; 18(1):108. doi:
10.1186/s13000-023-01393-x. [PMID: 37759223] - Joanna Lewek, Jacek Niedziela, Piotr Desperak, Krzysztof Dyrbuś, Tadeusz Osadnik, Piotr Jankowski, Adam Witkowski, Agata Bielecka-Dąbrowa, Dariusz Dudek, Marek Gierlotka, Mariusz Gąsior, Maciej Banach. Intensive Statin Therapy Versus Upfront Combination Therapy of Statin and Ezetimibe in Patients With Acute Coronary Syndrome: A Propensity Score Matching Analysis Based on the PL-ACS Data.
Journal of the American Heart Association.
2023 09; 12(18):e030414. doi:
10.1161/jaha.123.030414. [PMID: 37671618] - Stephen P Adams, Nima Alaeiilkhchi, Sara Tasnim, James M Wright. Pravastatin for lowering lipids.
The Cochrane database of systematic reviews.
2023 09; 9(?):CD013673. doi:
10.1002/14651858.cd013673.pub2. [PMID: 37721222] - Rituparna Maiti, Rashmi Ranjan Mohanty, Anupam Dey, Shampa Maji, Milan Padhan, Archana Mishra. Effect of Virgin Coconut Oil (VCO) on Cardiometabolic Parameters in Patients with Dyslipidemia: A Randomized, Add-on Placebo-Controlled Clinical Trial.
Journal of the American Nutrition Association.
2023 Sep; ?(?):1-8. doi:
10.1080/27697061.2023.2256816. [PMID: 37708389] - Priyanka Shridharan, Radhika Nair, Sankar P Gorthi, K Prakashini, Aparajita Chatterjee. Effects of Serum Cholesterol on Severity of Stroke and Dosage of Statins on Functional Outcome in Acute Ischemic Stroke.
Neurology India.
2023 Sep; 71(5):923-927. doi:
10.4103/0028-3886.388115. [PMID: 37929428] - Umidakhon Makhmudova, Beasat Samadifar, Aurel Maloku, Pellumb Haxhikadrija, Jens-Arndt Geiling, Robert Römer, Bernward Lauer, Sven Möbius-Winkler, Sylvia Otto, P Christian Schulze, Oliver Weingärtner. Intensive lipid-lowering therapy for early achievement of guideline-recommended LDL-cholesterol levels in patients with ST-elevation myocardial infarction ('Jena auf Ziel').
Clinical research in cardiology : official journal of the German Cardiac Society.
2023 Sep; 112(9):1212-1219. doi:
10.1007/s00392-022-02147-3. [PMID: 36602598] - Amna Sarfraz, Muhammad Imran Hussain, Ramisha Ibtisam, Annum Maha, Saher Asghar, Khizra Zubair, Khurram Sarfraz. Synergistic effect of Moringa oleifera and Allium sativum on BMI and lipid profile: A randomized controlled trial.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5(Special)):1591-1595. doi:
". [PMID: 38008957] - Siyu Zhu, Tehasi Wang, Qingyi Wang, Mengyu Du. Application of Atorvastatin Combined with Ezetimibe in Elderly Patients with Hypertension Combined with T2DM and Analysis of Significance of Changes in Serum Bilirubin Levels During Treatment.
Alternative therapies in health and medicine.
2023 Aug; ?(?):. doi:
. [PMID: 37632947] - Shengnan Liu, Yingyin Zhao, Hanming Yao, Lizhen Zhang, Cui Chen, Zhinan Zheng, Sanqing Jin. DRP1 knockdown and atorvastatin alleviate ox-LDL-induced vascular endothelial cells injury: DRP1 is a potential target for preventing atherosclerosis.
Experimental cell research.
2023 08; 429(2):113688. doi:
10.1016/j.yexcr.2023.113688. [PMID: 37315759] - Zeyu Yin, Shilong You, Shu Zhang, Linlin Zhang, Boquan Wu, Xinyue Huang, Saien Lu, Liu Cao, Ying Zhang, Da Li, Xingang Zhang, Jingwei Liu, Yingxian Sun, Naijin Zhang. Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Aug; 166(?):115228. doi:
10.1016/j.biopha.2023.115228. [PMID: 37557013] - Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis.
The Cochrane database of systematic reviews.
2023 Aug; 8(?):CD013573. doi:
10.1002/14651858.cd013573.pub2. [PMID: 37565307] - Aiai Zhang, Kaijing Liu, Xiaoyu Liang, Huiyang Li, Xue Fu, Ni Zhu, Fangjiang Li, Jing Yang. Metal-phenolic capsules with ROS scavenging reshape the oxidative microenvironment of atherosclerosis.
Nanomedicine : nanotechnology, biology, and medicine.
2023 Aug; ?(?):102700. doi:
10.1016/j.nano.2023.102700. [PMID: 37544347] - Robert Krysiak, Karolina Kowalcze, Bogusław Okopień. The Impact of Atorvastatin on Cardiometabolic Risk Factors in Sisters of Women with Polycystic Ovary Syndrome.
Pharmacology.
2023 Aug; ?(?):1-9. doi:
10.1159/000531321. [PMID: 37536301] - Punitha Lakxmi Ramesh, Priyanka Khandelwal, R Lakshmy, Aditi Sinha, Arvind Bagga, Pankaj Hari. Short-term safety and efficacy of escalating doses of atorvastatin for dyslipidemia in children with predialysis chronic kidney disease stage 2-5.
Pediatric nephrology (Berlin, Germany).
2023 08; 38(8):2763-2770. doi:
10.1007/s00467-023-05887-0. [PMID: 36780007] - Oğuzhan Birdal, Mehmet Saygı, Remziye Doğan, Ozan Tezen, Ali Karagöz, İbrahim Halil Tanboğa. Risk of Venous Thromboembolism with Statins: Evidence Gathered via a Network Meta-analysis.
Balkan medical journal.
2023 07; ?(?):. doi:
10.4274/balkanmedj.galenos.2023.2023-5-26. [PMID: 37519020] - Sahar Y Al-Okbi, Ola Ali, A S Aly, D Refaat, Reham S H Esmail, Hagar F H Elbakry. Management of metabolic syndrome by nutraceuticals prepared from chitosan and ferulic acid with or without beta-sitosterol and their nanoforms.
Scientific reports.
2023 07; 13(1):12176. doi:
10.1038/s41598-023-38837-9. [PMID: 37500657] - Joy Temiloluwa Folahan, Olufunke Esan Olorundare, Abayomi Mayowa Ajayi, Adeoye Oyetunji Oyewopo, Sunday Sokunle Soyemi, Adejuwon Adewale Adeneye, Ikechukwu Innocent Okoye, Saheed Olanrewaju Afolabi, Anoka Ayembe Njan. Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo.
Lipids in health and disease.
2023 Jul; 22(1):107. doi:
10.1186/s12944-023-01818-y. [PMID: 37495992] - Mohammad Taghi Gorji, Fariba Alaei-Shahmiri, Gisoo Darban Hosseini Amirkhiz, Seyed Hashem Sezavar, Mojtaba Malek, Mohammad E Khamseh. Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial.
Archives of Iranian medicine.
2023 Jun; 26(6):290-299. doi:
10.34172/aim.2023.45. [PMID: 38310429] - Gloria Stoyanova, Sidra Jabeen, Joselyn Landazuri Vinueza, Sounak Ghosh Roy, Richard A Lockshin, Zahra Zakeri. Zika virus triggers autophagy to exploit host lipid metabolism and drive viral replication.
Cell communication and signaling : CCS.
2023 05; 21(1):114. doi:
10.1186/s12964-022-01026-8. [PMID: 37208782] - Rasmita Dash, Madhulika Yadav, Jyotirmaya Biswal, Anshuman Chandra, Vijay Kumar Goel, Tripti Sharma, Shakti Ketan Prusty, Sujata Mohapatra. Modeling of Chitosan modified PLGA atorvastatin-curcumin conjugate (AT-CU) nanoparticles, overcoming the barriers associated with PLGA: an approach for better management of atherosclerosis.
International journal of pharmaceutics.
2023 May; ?(?):123009. doi:
10.1016/j.ijpharm.2023.123009. [PMID: 37142139] - Ali Saud, Nabeel Ali, Fadhil Gali, Heider Qassam, Najah Rayish Hadi. The effect of evolocumab alone and in combination with atorvastatin on atherosclerosis progression and TLRs expression.
Journal of medicine and life.
2023 May; 16(5):759-765. doi:
10.25122/jml-2021-0210. [PMID: 37520489] - Megan M Sperry, Tomiko T Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E Carlson, Ronald J Wong, Idit Kosti, Brian L Le, James Logue, Holly Hammond, Matthew Frieman, David K Stevenson, Donald E Ingber, Marina Sirota, Richard Novak. Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.
PLoS computational biology.
2023 05; 19(5):e1011050. doi:
10.1371/journal.pcbi.1011050. [PMID: 37146076] - Karen Claesen, Yani Sim, Shahir Basir, Simon De Belder, Tinne van den Keybus, Glenn Van Edom, Hilde Stoffelen, Gilles W De Keulenaer, Johan Bosmans, Tijs Bringmans, Ingrid De Meester, Dirk Hendriks. Atorvastatin downregulates plasma procarboxypeptidase U concentrations and improves fibrinolytic potential dose-dependently in hyperlipidemic individuals.
Journal of thrombosis and haemostasis : JTH.
2023 05; 21(5):1266-1273. doi:
10.1016/j.jtha.2023.01.029. [PMID: 36740042] - Jennifer D Kusovschi, Anna A Ivanova, Michael S Gardner, Robert W McGarrah, William E Kraus, Zsuzsanna Kuklenyik, James L Pirkle, John R Barr. Confirmation of Statin and Fibrate Use from Small-Volume Archived Plasma Samples by High-Throughput LC-MS/MS Method.
International journal of molecular sciences.
2023 Apr; 24(9):. doi:
10.3390/ijms24097931. [PMID: 37175638] - Routong Yang, Junhui Wu, Huan Yu, Siyue Wang, Hongbo Chen, Mengying Wang, Xueying Qin, Tao Wu, Yiqun Wu, Yonghua Hu. Is statin therapy after ischaemic stroke associated with increased intracerebral hemorrhage? The association may be dependent on intensity of statin therapy.
International journal of stroke : official journal of the International Stroke Society.
2023 Apr; ?(?):17474930231172623. doi:
10.1177/17474930231172623. [PMID: 37070670] - Qingqing Wang, Zihou Liu, Rui Wang, Run Li, Xiaoru Lian, Yanquan Yang, Jiao Yan, Zhiqi Yin, Guangji Wang, Jianguo Sun, Ying Peng. Effect of Ginkgo biloba extract on pharmacology and pharmacokinetics of atorvastatin in rats with hyperlipidaemia.
Food & function.
2023 Apr; 14(7):3051-3066. doi:
10.1039/d2fo03238d. [PMID: 36916480] - M A Abdelaziz, O M Ahmed, M Abdel-Gabbar, M R Mohammad, S R Ibrahim, M H Abdelzaher, A P Mohideen, S A Moawd, A I Geddawy. The preventive effects of Ulva lactuca aqueous extract, ulvan polysaccharides and atorvastatin on ethylene glycol-induced hyperoxaluria.
European review for medical and pharmacological sciences.
2023 Apr; 27(8):3699-3713. doi:
10.26355/eurrev_202304_32169. [PMID: 37140319] - Wei Li, Honglin Liu, Jiyi Liang, Tao Wang, Jia Liu, Xiaofeng Pi, Wenjun Zou, Liping Qu. Effects of Atorvastatin on Bile Acid Metabolism in High-Fat Diet-Fed ApoE-/- Mice.
Journal of cardiovascular pharmacology.
2023 Mar; ?(?):. doi:
10.1097/fjc.0000000000001425. [PMID: 36995080] - Huiqin Liu, Ronghong Jiao, Lingling Wang, Fei Feng, Xiaohui Zhao, Juan Yang. Machine-learning-based analysis of the sensitivity and specificity on lipid-lowering effect of one-month-administered statins.
Medicine.
2023 Mar; 102(9):e33139. doi:
10.1097/md.0000000000033139. [PMID: 36862920] - Rui-Xin Li, Ling-Yun Chen, Samwel M Limbu, Bing Yao, Yi-Fan Qian, Wen-Hao Zhou, Li-Qiao Chen, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du, Yuan Luo. Atorvastatin remodels lipid distribution between liver and adipose tissues through blocking lipoprotein efflux in fish.
American journal of physiology. Regulatory, integrative and comparative physiology.
2023 03; 324(3):R281-R292. doi:
10.1152/ajpregu.00222.2022. [PMID: 36572553] - Bahar Arican Tarim, Francesco Fici, Istemihan Tengiz, Saadet Avunduk, Yurdaer Ozcan, Gokhan Faikoglu, Elif Ari, Nicolás Roberto Robles, Guido Grassi. Do Statins Counteract the Effect of Antidiabetic Drugs? Results of the SCEAD Study.
Yonsei medical journal.
2023 Mar; 64(3):175-180. doi:
10.3349/ymj.2022.0287. [PMID: 36825343] - Shiyu Wang, Anna I Neel, Kristen L Adams, Haiguo Sun, Sara R Jones, Allyn C Howlett, Rong Chen. Atorvastatin differentially regulates the interactions of cocaine and amphetamine with dopamine transporters.
Neuropharmacology.
2023 03; 225(?):109387. doi:
10.1016/j.neuropharm.2022.109387. [PMID: 36567004] - Miao Liu, Tingchao Gao, Lei Jiang, Shunqi Li, Bolun Shi, Fangxu Li. Enhancing the biopharmaceutical attributes of atorvastatin calcium using polymeric and lipid-polymer hybrid nanoparticles: An approach for atherosclerosis treatment.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Mar; 159(?):114261. doi:
10.1016/j.biopha.2023.114261. [PMID: 36689837] - A V Susekov. [Lipid-lowering Eeficacy and Safety of High Doses of Atorvastatin and Rosuvastatin].
Kardiologiia.
2023 Feb; 63(2):59-67. doi:
10.18087/cardio.2023.2.n2407. [PMID: 36880145] - S Y Cai, X Gu, P J Liu, R S Li, J J Jiang, S P Zhao, W Yao, Y N Jiang, Y H Yin, B Yu, Z Y Yuan, J A Wang. [Efficacy and safety of various doses of hybutimibe monotherapy or in combination with atorvastatin for primary hypercholesterolemia: a multicenter, randomized, double-blind, double-dummy, parallel-controlled phase Ⅲ clinical trial].
Zhonghua xin xue guan bing za zhi.
2023 Feb; 51(2):180-187. doi:
10.3760/cma.j.cn112148-20230105-00009. [PMID: 36789598] - Castillo Ta, Scribano Parada Mp, Rossi Mm, Signorini F, Fonseca I, Baez Mdc. Pharmacological action of atorvastatin and metformin on Non-alcoholic fatty liver disease on an experimental model of metabolic syndrome.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2023 Feb; ?(?):. doi:
10.2174/1871523022666230223090714. [PMID: 36815659] - Yan-Zhao Wu, Ke-Xin Wang, Xin-di Ma, Chu-Chu Wang, Nan-Nan Chen, Chen Xiong, Jun-Xia Li, Su-Wen Su. Therapeutic effects of atorvastatin on doxorubicin-induced hepatotoxicity in rats via antioxidative damage, anti-inflammatory, and anti-lipotoxicity.
Journal of biochemical and molecular toxicology.
2023 Feb; ?(?):e23329. doi:
10.1002/jbt.23329. [PMID: 36808658] - Esmaeil Karami, Zahra Goodarzi, Ali Ghanbari, Alireza Dehdashti, Ahmad Reza Bandegi, Sedighe Yosefi. Atorvastatin prevents cadmium-induced renal toxicity in a rat model.
Toxicology and industrial health.
2023 Feb; ?(?):7482337231157150. doi:
10.1177/07482337231157150. [PMID: 36802990] - Junling Ren, Heng Fang, Le Yang, Hui Sun, Hongwei Song, Guangli Yan, Ying Han, Xijun Wang. Fecal metabolomics analysis for deciphering the lipid-lowering effect of Qizhi capsule on high-fat feed induced hyperlipidemia.
Journal of ethnopharmacology.
2023 Feb; 308(?):116270. doi:
10.1016/j.jep.2023.116270. [PMID: 36806341] - Qi Liu, Shuai Dong, Xue Zhou, Yubo Zhao, Bin Dong, Jing Shen, Kang Yang, Linsen Li, Dan Zhu. Effects of Long-Term Intervention with Losartan, Aspirin and Atorvastatin on Vascular Remodeling in Juvenile Spontaneously Hypertensive Rats.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041844. [PMID: 36838830] - Jianmin Xiao, Qiong Sun, Lang Ran, Yinfeng Wang, Xia Qin, Xiaotong Xu, Chuhua Tang, Lu Liu, Guilong Zhang. pH-Responsive Selenium Nanoplatform for Highly Efficient Cancer Starvation Therapy by Atorvastatin Delivery.
ACS biomaterials science & engineering.
2023 02; 9(2):809-820. doi:
10.1021/acsbiomaterials.2c01500. [PMID: 36622161] - Gülay Çiftci, Alper Çiftci, Burcu Onuk, Metin Çenesiz, Sadık Savaşan, Sena Çenesiz. Investigation of the effects of atorvastatin and Lactobacillus acidophilus on some hormones and oxidative stress in experimental hypercholesterolemia.
Prostaglandins & other lipid mediators.
2023 Feb; 165(?):106716. doi:
10.1016/j.prostaglandins.2023.106716. [PMID: 36764153] - Juwon Kim, Danbee Kang, Hyejeong Park, Minwoong Kang, Ki Hong Choi, Taek Kyu Park, Joo Myung Lee, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Eliseo Guallar, Juhee Cho, Joo-Yong Hahn. Moderate-Intensity Statins Plus Ezetimibe vs. High-Intensity Statins After Coronary Revascularization: A Cohort Study.
Cardiovascular drugs and therapy.
2023 02; 37(1):141-150. doi:
10.1007/s10557-021-07256-1. [PMID: 34533691] - Lin Dong, Silu Wen, Yulei Tang, Fen Li, Yan He, Yuqin Deng, Zezhang Tao. Atorvastatin attenuates allergic inflammation by blocking prostaglandin biosynthesis in rats with allergic rhinitis.
International immunopharmacology.
2023 Feb; 115(?):109681. doi:
10.1016/j.intimp.2023.109681. [PMID: 36634416] - Yimeng Wang, Tianli Tang, Jinzhi Ren, Yufei Zhao, Yingshi Hou, Xiangping Nie. Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure.
Aquatic toxicology (Amsterdam, Netherlands).
2023 Feb; 255(?):106381. doi:
10.1016/j.aquatox.2022.106381. [PMID: 36587518] - Carlos Torrado-Salmerón, Víctor Guarnizo-Herrero, Guillermo Torrado, M Ángeles Peña, Santiago Torrado-Santiago, Paloma Marina de la Torre-Iglesias. Solid dispersions of atorvastatin with Kolliphor RH40: Enhanced supersaturation and improvement in a hyperlipidemic rat model.
International journal of pharmaceutics.
2023 Jan; 631(?):122520. doi:
10.1016/j.ijpharm.2022.122520. [PMID: 36581105] - L I Salyamova, A A Khromova, O G Kvasova, I V Avdeeva, N A Borisova, K N Korenkova, K N Polezhaeva, V E Oleynikov. [Vasoprotective effect of effective lipid-lowering therapy in patients with ST-segment elevation myocardial infarction].
Terapevticheskii arkhiv.
2023 Jan; 94(12):1355-1360. doi:
10.26442/00403660.2022.12.202007. [PMID: 37167178] - Ivanna Carolina Golfetto Miskiewicz, Hyen Chung Cho, Ji In Lee, Jihye Lee, Yenna Lee, Yun Kyung Lee, Sung Hee Choi. Effect of atorvastatin on lipoxygenase pathway-related gene expression in an in vitro model of lipid accumulation in hepatocytes.
FEBS open bio.
2023 Jan; ?(?):. doi:
10.1002/2211-5463.13552. [PMID: 36637998] - Subhadip Banerjee, Amrendra Tiwari, Amit Kar, Joydeb Chanda, Sayan Biswas, Gudrun Ulrich-Merzenich, Pulok K Mukherjee. Combining LC-MS/MS profiles with network pharmacology to predict molecular mechanisms of the hyperlipidemic activity of Lagenaria siceraria stand.
Journal of ethnopharmacology.
2023 Jan; 300(?):115633. doi:
10.1016/j.jep.2022.115633. [PMID: 36031104] - Peng Zheng, Hengfang Wu, Yilu Gu, Luo Li, Ran Hu, Wenjing Ma, Zhiping Bian, Nannan Liu, Di Yang, Xiangjian Chen. Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jan; 157(?):114024. doi:
10.1016/j.biopha.2022.114024. [PMID: 36402030] - Ewelina Woźniak, Marlena Broncel, Mateusz Niedzielski, Agnieszka Woźniak, Paulina Gorzelak-Pabiś. The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells.
PloS one.
2023; 18(2):e0280741. doi:
10.1371/journal.pone.0280741. [PMID: 36753488] - H Aldal'in, A H Al-Nadaf, A Awadallah, S Thiab, H M Bastoni. Methanolic extract of S. securidaca flowers, leaves, and seeds' antihyperlipidemic effects on high fat diet-induced hyperlipidemia in Wistar rats.
Brazilian journal of biology = Revista brasleira de biologia.
2023; 83(?):e275382. doi:
10.1590/1519-6984.275382. [PMID: 37909591] - Miao-Ping Hong, Wei-Fen Chen, Jie-Hao Wu, Tai-Shan Kang, Shun-Po He, Qing-Wei Yang. Correlation between lipid-lowering therapy and cerebral microbleeds.
Clinical hemorheology and microcirculation.
2023; 85(1):59-71. doi:
10.3233/ch-231833. [PMID: 37355888] - Hongmei Yao, Xingxing Zhao, Lili Wang, Yi Ren. Atorvastatin ameliorated PM2.5-induced atherosclerosis in rats.
Archives of environmental & occupational health.
2023; 78(5):267-272. doi:
10.1080/19338244.2023.2166892. [PMID: 36660941] - Farah Rahman, Irena Brates, Francesca Aweeka, Ronald J Bosch, Amelia Deitchman, Daniel Nixon, Judith A Aberg. Evaluating the effect of atorvastatin exposure and vitamin D levels on lipid outcomes in people with HIV-1 with suppressed HIV-1 RNA and LDL cholesterol <130 mg/dL.
HIV medicine.
2022 Dec; ?(?):. doi:
10.1111/hiv.13453. [PMID: 36549898]
