Acriflavine neutral (BioDeep_00000839594)

   


代谢物信息卡片


Acriflavine neutral

化学式: C27H25ClN6 (468.182912)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[N+]1=C2C=C(C=CC2=CC3=C1C=C(C=C3)N)N.C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.[Cl-]
InChI: 1H

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D007364 - Intercalating Agents
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
D000890 - Anti-Infective Agents

同义名列表

1 个代谢物同义名

Acriflavine neutral



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Liang, Mengzhu Zheng, Wei Xu, Yongkang Chen, Piyu Tang, Guoyi Wu, Peng Zou, Hua Li, Lixia Chen. Acriflavine and proflavine hemisulfate as potential antivirals by targeting Mpro. Bioorganic chemistry. 2022 Dec; 129(?):106185. doi: 10.1016/j.bioorg.2022.106185. [PMID: 36240541]
  • Przemysław J Jodłowski, Klaudia Dymek, Grzegorz Kurowski, Jolanta Jaśkowska, Wojciech Bury, Marzena Pander, Sylwia Wnorowska, Katarzyna Targowska-Duda, Witold Piskorz, Artur Wnorowski, Anna Boguszewska-Czubara. Zirconium-Based Metal-Organic Frameworks as Acriflavine Cargos in the Battle against Coronaviruses─A Theoretical and Experimental Approach. ACS applied materials & interfaces. 2022 Jun; 14(25):28615-28627. doi: 10.1021/acsami.2c06420. [PMID: 35700479]
  • Valeria Napolitano, Agnieszka Dabrowska, Kenji Schorpp, André Mourão, Emilia Barreto-Duran, Malgorzata Benedyk, Pawel Botwina, Stefanie Brandner, Mark Bostock, Yuliya Chykunova, Anna Czarna, Grzegorz Dubin, Tony Fröhlich, Michael Hölscher, Malwina Jedrysik, Alex Matsuda, Katarzyna Owczarek, Magdalena Pachota, Oliver Plettenburg, Jan Potempa, Ina Rothenaigner, Florian Schlauderer, Klaudia Slysz, Artur Szczepanski, Kristin Greve-Isdahl Mohn, Bjorn Blomberg, Michael Sattler, Kamyar Hadian, Grzegorz Maria Popowicz, Krzysztof Pyrc. Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell chemical biology. 2022 May; 29(5):774-784.e8. doi: 10.1016/j.chembiol.2021.11.006. [PMID: 35021060]
  • Somayeh Vandghanooni, Forough Rasoulian, Masoud Eskandani, Sattar Akbari Nakhjavani, Morteza Eskandani. Acriflavine-loaded solid lipid nanoparticles: preparation, physicochemical characterization, and anti-proliferative properties. Pharmaceutical development and technology. 2021 Nov; 26(9):934-942. doi: 10.1080/10837450.2021.1963276. [PMID: 34338582]
  • Thibaut Fourniols, Estelle Bastien, Alizée Canevat, Olivier Feron, Véronique Préat. Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel. International journal of pharmaceutics. 2020 Jun; 584(?):119337. doi: 10.1016/j.ijpharm.2020.119337. [PMID: 32371002]
  • Yoann Montigaud, Bernard Ucakar, Balaji Krishnamachary, Zaver M Bhujwalla, Olivier Feron, Véronique Préat, Fabienne Danhier, Bernard Gallez, Pierre Danhier. Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer. International journal of pharmaceutics. 2018 Nov; 551(1-2):322-328. doi: 10.1016/j.ijpharm.2018.09.034. [PMID: 30236645]
  • Chao-Tsai Liao, Hsueh-Hsia Lo, Weng-Ting Peng, Wan-Ling Song, Shin-Chiao Du, Yi-Min Hsiao. XCC2366, A Gene Encoding A Putative TetR Family Transcriptional Regulator, is Required for Acriflavin Resistance and Virulence of Xanthomonas campestris pv. campestris. Current microbiology. 2017 Dec; 74(12):1373-1381. doi: 10.1007/s00284-017-1328-5. [PMID: 28821943]
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  • Mako Kawai, Sakuo Yamada, Ai Ishidoshiro, Yoshihiro Oyamada, Hideaki Ito, Jun-Ichi Yamagishi. Cell-wall thickness: possible mechanism of acriflavine resistance in meticillin-resistant Staphylococcus aureus. Journal of medical microbiology. 2009 Mar; 58(Pt 3):331-336. doi: 10.1099/jmm.0.004184-0. [PMID: 19208883]
  • Dae Hwan Shin, Kyu Seok Choi, Byung Suk Cho, Sukgil Song, Dong-Cheul Moon, Jin Tae Hong, Chong-Kil Lee, Youn Bok Chung. Pharmacokinetics of guanosine in rats following intravenous or intramuscular administration of a 1:1 mixture of guanosine and acriflavine, a potential antitumor agent. Archives of pharmacal research. 2008 Oct; 31(10):1347-53. doi: 10.1007/s12272-001-2116-z. [PMID: 18958427]
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  • Pung Sok Lee, Dae Hwan Shin, Kyoung Mi Lee, Sukgil Song, Hwan-Soo Yoo, Dong-Cheul Moon, Jin Tae Hong, Youn Bok Chung. Effects of guanosine on the pharmacokinetics of acriflavine in rats following the administration of a 1:1 mixture of acriflavine and guanosine, a potential antitumor agent. Archives of pharmacal research. 2007 Mar; 30(3):372-80. doi: 10.1007/bf02977621. [PMID: 17424946]
  • S Song, O S Kwon, Y B Chung. Pharmacokinetics and metabolism of acriflavine in rats following intravenous or intramuscular administration of AG60, a mixture of acriflavine and guanosine, a potential antitumour agent. Xenobiotica; the fate of foreign compounds in biological systems. 2005 Jul; 35(7):755-73. doi: 10.1080/00498250500188073. [PMID: 16323364]
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  • R Nakaune, K Adachi, O Nawata, M Tomiyama, K Akutsu, T Hibi. A novel ATP-binding cassette transporter involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum. Applied and environmental microbiology. 1998 Oct; 64(10):3983-8. doi: 10.1128/aem.64.10.3983-3988.1998. [PMID: 9758830]
  • S M Plakas, K R el Said, F A Bencsath, S M Musser, W L Hayton. Pharmacokinetics, tissue distribution and metabolism of acriflavine and proflavine in the channel catfish (Ictalurus punctatus). Xenobiotica; the fate of foreign compounds in biological systems. 1998 Jun; 28(6):605-16. doi: 10.1080/004982598239353. [PMID: 9667083]
  • S G Kim, C W Kim, E T Ahn, K Y Lee, E K Hong, B I Yoo, Y B Han. Enhanced anti-tumour effects of acriflavine in combination with guanosine in mice. The Journal of pharmacy and pharmacology. 1997 Feb; 49(2):216-22. doi: 10.1111/j.2042-7158.1997.tb06783.x. [PMID: 9055199]
  • G Mathé, P Pontiggia, C Bourut, E Chenu, S Orbach-Arbouys. In vivo eradication of Friend virus as an experimental HIV-model, by combination of zidovudine, acriflavine and an ellipticine analogue. Possible application to the treatment of human pre-AIDS?. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 1994; 48(2):51-3. doi: 10.1016/0753-3322(94)90075-2. [PMID: 7919105]
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