Pheniramine maleate (BioDeep_00000839593)
代谢物信息卡片
化学式: C20H24N2O4 (356.1735984)
中文名称: 非尼拉敏马来酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
InChI: 2-1-
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:31990
- KEGGdrug: D01174
- PubChem: 5282139
- ChEMBL: CHEMBL1653
- MeSH: Pheniramine
- CAS: 155683-11-7
- CAS: 132-20-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Raka Jain, Siddharth Sarkar, Nizamuddin Saifi, Shayani Ghosh. Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre.
Asian journal of psychiatry.
2022 May; 71(?):103080. doi:
10.1016/j.ajp.2022.103080
. [PMID: 35305452] - Joseph W Lowdon, Kasper Eersels, Rocio Arreguin-Campos, Manlio Caldara, Benjamin Heidt, Renato Rogosic, Kathia L Jimenez-Monroy, Thomas J Cleij, Hanne Diliën, Bart van Grinsven. A Molecularly Imprinted Polymer-based Dye Displacement Assay for the Rapid Visual Detection of Amphetamine in Urine.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225222
. [PMID: 33182534] - Yaqi Yao, Bo Zhang, Shuang Li, Jia Yu, Xingjie Guo. Enantioselective analysis of pheniramine in rat using large volume sample stacking or cation-selective exhaustive injection and sweeping coupled with cyclodextrin modified electrokinetic chromatography.
Talanta.
2019 Jan; 192(?):226-232. doi:
10.1016/j.talanta.2018.09.052
. [PMID: 30348382] - Ercan Yuvanc, Devrim Tuglu, Tunc Ozan, Ucler Kisa, Mahi Balci, Ertan Batislam, Erdal Yilmaz. Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion.
Acta cirurgica brasileira.
2018 Feb; 33(2):125-133. doi:
10.1590/s0102-865020180020000004
. [PMID: 29513811] - Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism.
Journal of separation science.
2016 May; 39(9):1766-75. doi:
10.1002/jssc.201501026
. [PMID: 26935589] - Juraj Piešťanský, Katarína Maráková, Marián Kovaľ, Peter Mikuš. Comparison of hydrodynamically closed isotachophoresis-capillary zone electrophoresis with hydrodynamically open capillary zone electrophoresis hyphenated with tandem mass spectrometry in drug analysis: pheniramine, its metabolite and phenylephrine in human urine.
Journal of chromatography. A.
2014 Sep; 1358(?):285-92. doi:
10.1016/j.chroma.2014.06.083
. [PMID: 25035234] - Imran Ali, Zeid A Al-Othman, Abdulrahman Al-Warthan, Syed Dilshad Alam, Javed A Farooqi. Enantiomeric separation and simulation studies of pheniramine, oxybutynin, cetirizine, and brinzolamide chiral drugs on amylose-based columns.
Chirality.
2014 Mar; 26(3):136-43. doi:
10.1002/chir.22276
. [PMID: 24464520] - Katarína Maráková, Juraj Piešt'anský, Lucia Veizerová, Jaroslav Galba, Svetlana Dokupilová, Emil Havránek, Peter Mikuš. Multidrug analysis of pharmaceutical and urine matrices by on-line coupled capillary electrophoresis and triple quadrupole mass spectrometry.
Journal of separation science.
2013 Jun; 36(11):1805-16. doi:
10.1002/jssc.201200980
. [PMID: 23494966] - Orhan Gokalp, Ismail Yurekli, Muge Kiray, Alper Bagriyanik, Ufuk Yetkin, Banu Sarer Yurekli, Serkan Gur, Murat Aksun, Ismail Safa Satoglu, Gamze Gokalp, Ali Gurbuz. Assessment of protective effects of pheniramine maleate on reperfusion injury in lung after distant organ ischemia: a rat model.
Vascular and endovascular surgery.
2013 Apr; 47(3):219-24. doi:
10.1177/1538574413475885
. [PMID: 23377174] - Rajeev B Ahuja, Gaurav K Gupta. A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus.
Burns : journal of the International Society for Burn Injuries.
2013 Feb; 39(1):24-9. doi:
10.1016/j.burns.2012.09.016
. [PMID: 23089176] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068
. [PMID: 22961681] - Wenhua Gao, Yunsheng Chen, Gaopan Chen, Jing Xi, Yaowen Chen, Jianying Yang, Ning Xu. Trace analysis of three antihistamines in human urine by on-line single drop liquid-liquid-liquid microextraction coupled to sweeping micellar electrokinetic chromatography and its application to pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Sep; 904(?):121-7. doi:
10.1016/j.jchromb.2012.07.032
. [PMID: 22902104] - Serdar Bayrak, Ismail Yurekli, Orhan Gokalp, Muge Kiray, Mehmet Senel Bademci, Barcin Ozcem, Yuksel Besir, Levent Yilik, Mert Kestelli, Ali Gurbuz. Assessment of protective effects of methylprednisolone and pheniramine maleate on reperfusion injury in kidney after distant organ ischemia: a rat model.
Annals of vascular surgery.
2012 May; 26(4):559-65. doi:
10.1016/j.avsg.2012.01.006
. [PMID: 22445244] - Tshering Lama, Biraj Karmacharya, Colin Chandler, Victor Patterson. Telephone management of severe wasp stings in rural Nepal: a case report.
Journal of telemedicine and telecare.
2011; 17(2):105-8. doi:
10.1258/jtt.2010.100606
. [PMID: 21139015] - Peter Mikus, Katarína Maráková, Jozef Marák, Dusan Kaniansky, Iva Valásková, Emil Havránek. Possibilities of column coupling electrophoresis provided with a fiber-based diode array detection in enantioselective analysis of drugs in pharmaceutical and clinical samples.
Journal of chromatography. A.
2008 Jan; 1179(1):9-16. doi:
10.1016/j.chroma.2007.09.012
. [PMID: 17905259] - Jozef Marák, Peter Mikus, Katarína Maráková, Dusan Kaniansky, Iva Valásková, Emil Havránek. Enantioselective analysis of pheniramine in urine by charged CD-mediated CZE provided with a fiber-based DAD and an on-line sample pretreatment by capillary ITP.
Electrophoresis.
2007 Aug; 28(15):2738-47. doi:
10.1002/elps.200600748
. [PMID: 17600843] - A Sowunmi, A M Oduola, O A Ogundahunsi, L A Salako. Enhancement of the antimalarial effect of chloroquine by chloropheniramine in vivo.
Tropical medicine & international health : TM & IH.
1998 Mar; 3(3):177-83. doi:
10.1046/j.1365-3156.1998.00212.x
. [PMID: 9593355] - J Martens. Determination of loratadine and pheniramine from human serum by gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical applications.
1995 Nov; 673(2):183-8. doi:
10.1016/0378-4347(95)00267-2
. [PMID: 8611951] - J A Holeman, N D Danielson. Liquid chromatography of antihistamines using post-column tris(2,2'-bipyridine) ruthenium(III) chemiluminescence detection.
Journal of chromatography. A.
1994 Sep; 679(2):277-84. doi:
10.1016/0021-9673(94)80570-9
. [PMID: 7951995] - N Khanna, A Mathur, U C Chaturvedi. Regulation of vascular permeability by macrophage-derived chemotactic factor produced in Japanese encephalitis.
Immunology and cell biology.
1994 Jun; 72(3):200-4. doi:
10.1038/icb.1994.30
. [PMID: 8088859] - A Ray, S Puri, A K Chakravarty, P Sen. Central histaminergic involvement during stress in rats.
Indian journal of experimental biology.
1992 Aug; 30(8):724-8. doi:
NULL
. [PMID: 1360944] - S Puri, A Ray, A K Chakravarty, P Sen. Role of histaminergic mechanisms in the regulation of some stress responses in rats.
Pharmacology, biochemistry, and behavior.
1991 Aug; 39(4):847-50. doi:
10.1016/0091-3057(91)90042-z
. [PMID: 1763102] - S Ogbuihi, W Audick, G Bohn. [Sudden infant death--fatal poisoning with pheniramine].
Zeitschrift fur Rechtsmedizin. Journal of legal medicine.
1990; 103(3):221-5. doi:
10.1007/bf00207344
. [PMID: 2309532] - P U Witte, R Irmisch, P Hajdú. Pharmacokinetics of pheniramine (Avil) and metabolites in healthy subjects after oral and intravenous administration.
International journal of clinical pharmacology, therapy, and toxicology.
1985 Jan; 23(1):59-62. doi:
NULL
. [PMID: 3988394] - J Sorgenfrei, B Damerau, W Vogt. Role of histamine in the spasmogenic effect of the complement peptides C3a and C5a-desArg (classical anaphylatoxin).
Agents and actions.
1982 Apr; 12(1-2):118-21. doi:
10.1007/bf01965121
. [PMID: 6177210] - E Pöhlmann, E Schulz. [Fatal Triaminic poisoning in an infant].
Anasthesiologische und intensivmedizinische Praxis.
1977 Feb; 13(1):93-5. doi:
NULL
. [PMID: 18067] - A Bobik, A J McLean. Cardiovascular complications due to pheniramine overdosage.
Australian and New Zealand journal of medicine.
1976 Feb; 6(1):65-7. doi:
10.1111/j.1445-5994.1976.tb03293.x
. [PMID: 1065303] - L Diekmann, R Hösemann, H W Dibbern. [Pheniramine(Avil) poisoning in a young child].
Archiv fur Toxikologie.
1972; 29(4):317-24. doi:
NULL
. [PMID: 4647059] - C L Winek, W D Collom, C H Wecht. Codeine fatality from cough syrup.
Clinical toxicology.
1970 Mar; 3(1):97-100. doi:
10.3109/15563657008990104
. [PMID: 5520397] - K V Rao, K S Swami. The effects of histamine and pheniramine maleate on the activities of dehydrogenases and acetylcholinesterase in sheep kidney homogenate.
Annals of allergy.
1969 Sep; 27(9):429-33. doi:
NULL
. [PMID: 5806028] - R Kretzschmar, H Giertz, R Mitze, H J Teschendorf. [Effect of antihistaminics on the plasma histamine level in histamine and anaphylactic shock of guinea pigs].
Naunyn-Schmiedebergs Archiv fur Pharmakologie.
1969; 264(3):260-1. doi:
NULL
. [PMID: 4390698] - S S Basha, K S Swami. The effect of histamine on oxidative enzymes and acetylcholinesterase in sheep kidney homogenates.
Annals of allergy.
1968 Nov; 26(11):601-4. doi:
NULL
. [PMID: 5696195] - P Kabasakalian, M Taggart, E Townley. Urinary excretion of pheniramine and its N-demthylated metabolites in man--comparison with chlorpheniramine and brompheniramine data.
Journal of pharmaceutical sciences.
1968 Apr; 57(4):621-3. doi:
10.1002/jps.2600570416
. [PMID: 4385103]