alpha-L-Idopyranosyluronic acid (BioDeep_00000839348)
代谢物信息卡片
化学式: C6H10O7 (194.042651)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(C(C(OC(C1O)O)C(=O)O)O)O
InChI: InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4+,6+/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Barbara Bartolini, Martin A Thelin, Uwe Rauch, Ricardo Feinstein, Ake Oldberg, Anders Malmström, Marco Maccarana. Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition.
Glycobiology.
2012 Jul; 22(7):1007-16. doi:
10.1093/glycob/cws065
. [PMID: 22496542] - Giovanni V Coppa, Dania Buzzega, Lucia Zampini, Francesca Maccari, Tiziana Galeazzi, Francesca Pederzoli, Orazio Gabrielli, Nicola Volpi. Effect of 6 years of enzyme replacement therapy on plasma and urine glycosaminoglycans in attenuated MPS I patients.
Glycobiology.
2010 Oct; 20(10):1259-73. doi:
10.1093/glycob/cwq088
. [PMID: 20538645] - Osama A Hamad, Per H Nilsson, Maria Lasaosa, Daniel Ricklin, John D Lambris, Bo Nilsson, Kristina Nilsson Ekdahl. Contribution of chondroitin sulfate A to the binding of complement proteins to activated platelets.
PloS one.
2010 Sep; 5(9):e12889. doi:
10.1371/journal.pone.0012889
. [PMID: 20886107] - Jin-ping Li. Glucuronyl C5-epimerase an enzyme converting glucuronic acid to iduronic acid in heparan sulfate/heparin biosynthesis.
Progress in molecular biology and translational science.
2010; 93(?):59-78. doi:
10.1016/s1877-1173(10)93004-4
. [PMID: 20807641] - Juan Jia, Marco Maccarana, Xiao Zhang, Maxim Bespalov, Ulf Lindahl, Jin-Ping Li. Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.
The Journal of biological chemistry.
2009 Jun; 284(23):15942-50. doi:
10.1074/jbc.m809577200
. [PMID: 19336402] - Laercio Pol-Fachin, Hugo Verli. Depiction of the forces participating in the 2-O-sulfo-alpha-L-iduronic acid conformational preference in heparin sequences in aqueous solutions.
Carbohydrate research.
2008 Jul; 343(9):1435-45. doi:
10.1016/j.carres.2008.04.016
. [PMID: 18452898] - Sudarsanareddy Lokireddy, Sarojamma Vemula, Ramakrishna Vadde. Connective tissue metabolism in chikungunya patients.
Virology journal.
2008 Feb; 5(?):31. doi:
10.1186/1743-422x-5-31
. [PMID: 18302795] - Charles R Holst, Hani Bou-Reslan, Bryan B Gore, Karen Wong, Deanna Grant, Sreedevi Chalasani, Richard A Carano, Gretchen D Frantz, Marc Tessier-Lavigne, Brad Bolon, Dorothy M French, Avi Ashkenazi. Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival.
PloS one.
2007 Jun; 2(6):e575. doi:
10.1371/journal.pone.0000575
. [PMID: 17593974] - Sietze Reitsma, Dick W Slaaf, Hans Vink, Marc A M J van Zandvoort, Mirjam G A oude Egbrink. The endothelial glycocalyx: composition, functions, and visualization.
Pflugers Archiv : European journal of physiology.
2007 Jun; 454(3):345-59. doi:
10.1007/s00424-007-0212-8
. [PMID: 17256154] - Marc Lahaye, Audrey Robic. Structure and functional properties of ulvan, a polysaccharide from green seaweeds.
Biomacromolecules.
2007 Jun; 8(6):1765-74. doi:
10.1021/bm061185q
. [PMID: 17458931] - Wei-min Zhang, Hui-ping Shi, Bei-te Li, Shi-min Zhao, Qing-wei Qi, Nian-hu Sun, Shang-zhi Huang. [Postnatal and prenatal diagnosis of mucopolysaccharidosis type II (Hunter syndrome)].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2006 Sep; 44(9):644-7. doi:
NULL
. [PMID: 17217652] - Anh-Tri Do, Emanuel Smeds, Dorothe Spillmann, Marion Kusche-Gullberg. Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.
The Journal of biological chemistry.
2006 Mar; 281(9):5348-56. doi:
10.1074/jbc.m509584200
. [PMID: 16326709] - Anna Kloska, Jerzy Bohdanowicz, Grazyna Konopa, Anna Tylki-Szymńska, Joanna Jakóbkiewicz-Banecka, Barbara Czartoryska, Anna Liberek, Alicja Wegrzyn, Grzegorz Wegrzyn. Changes in hair morphology of mucopolysaccharidosis I patients treated with recombinant human alpha-L-iduronidase (laronidase, Aldurazyme).
American journal of medical genetics. Part A.
2005 Dec; 139(3):199-203. doi:
10.1002/ajmg.a.31021
. [PMID: 16283671] - Zhengliang L Wu, Miroslaw Lech. Characterizing the non-reducing end structure of heparan sulfate.
The Journal of biological chemistry.
2005 Oct; 280(40):33749-55. doi:
10.1074/jbc.m505677200
. [PMID: 16079142] - Gerdy B ten Dam, Els M A van de Westerlo, Toon F C M Smetsers, Marieke Willemse, Goos N P van Muijen, Catherine L R Merry, John T Gallagher, Yeong S Kim, Toin H van Kuppevelt. Detection of 2-O-sulfated iduronate and N-acetylglucosamine units in heparan sulfate by an antibody selected against acharan sulfate (IdoA2S-GlcNAc)n.
The Journal of biological chemistry.
2004 Sep; 279(37):38346-52. doi:
10.1074/jbc.m404166200
. [PMID: 15247295] - Maria Fuller, Peter J Meikle, John J Hopwood. Glycosaminoglycan degradation fragments in mucopolysaccharidosis I.
Glycobiology.
2004 May; 14(5):443-50. doi:
10.1093/glycob/cwh049
. [PMID: 14718373] - Asa Hagner-McWhirter, Jin-Ping Li, Stefan Oscarson, Ulf Lindahl. Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate.
The Journal of biological chemistry.
2004 Apr; 279(15):14631-8. doi:
10.1074/jbc.m313760200
. [PMID: 14718527] - Jin-Ping Li, Feng Gong, Asa Hagner-McWhirter, Erik Forsberg, Magnus Abrink, Robert Kisilevsky, Xiao Zhang, Ulf Lindahl. Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.
The Journal of biological chemistry.
2003 Aug; 278(31):28363-6. doi:
10.1074/jbc.c300219200
. [PMID: 12788935] - L Kjellén. Glucosaminyl N-deacetylase/N-sulphotransferases in heparan sulphate biosynthesis and biology.
Biochemical Society transactions.
2003 Apr; 31(2):340-2. doi:
10.1042/bst0310340
. [PMID: 12653633] - Ichiro Koshiishi, Takashi Hasegawa, Toshio Imanari. Quantitative and qualitative alterations of chondroitin/dermatan sulfates accompanied with development of tubulointerstitial nephritis.
Archives of biochemistry and biophysics.
2002 May; 401(1):38-43. doi:
10.1016/s0003-9861(02)00032-2
. [PMID: 12054485] - H Baumann. The role of regioselectively sulfated and acetylated polysaccharide coatings of biomaterials for reducing platelet and plasma protein adhesion.
Seminars in thrombosis and hemostasis.
2001 Oct; 27(5):445-63. doi:
10.1055/s-2001-17955
. [PMID: 11668414] - J Rong, H Habuchi, K Kimata, U Lindahl, M Kusche-Gullberg. Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferase.
Biochemistry.
2001 May; 40(18):5548-55. doi:
10.1021/bi002926p
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