N-Hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride (BioDeep_00000838988)

   


代谢物信息卡片


N-Hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride

化学式: C18H23N3O5S (393.13583480000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NO)N(CC1=CN=CC=C1)S(=O)(=O)C2=CC=C(C=C2)OC
InChI: InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D061965 - Matrix Metalloproteinase Inhibitors

同义名列表

1 个代谢物同义名

N-Hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Chun-Gu Wang, Wei-Na Yao, Bin Zhang, Jing Hua, Dong Liang, Heng-Shan Wang. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. Bioorganic & medicinal chemistry letters. 2018 08; 28(14):2413-2417. doi: 10.1016/j.bmcl.2018.06.024. [PMID: 29921475]
  • Tapan K Majumdar, Sunanda Vedananda, Francis L S Tse. Rapid analysis of MMI270B, an inhibitor of matrix metalloproteases in human plasma by liquid chromatography-tandem mass spectrometry: matrix interference in patient samples. Biomedical chromatography : BMC. 2004 Mar; 18(2):77-85. doi: 10.1002/bmc.295. [PMID: 15039958]
  • Klaus Kopka, Hans-Jörg Breyholz, Stefan Wagner, Marilyn P Law, Burkhard Riemann, Sandra Schröer, Monika Trub, Benedicte Guilbert, Bodo Levkau, Otmar Schober, Michael Schäfers. Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo. Nuclear medicine and biology. 2004 Feb; 31(2):257-67. doi: 10.1016/j.nucmedbio.2003.08.003. [PMID: 15013492]
  • N C Levitt, F A Eskens, K J O'Byrne, D J Propper, L J Denis, S J Owen, L Choi, J A Foekens, S Wilner, J M Wood, M Nakajima, D C Talbot, W P Steward, A L Harris, J Verweij. Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001 Jul; 7(7):1912-22. doi: NULL. [PMID: 11448904]
  • P P Lee, J J Hwang, L Mead, M M Ip. Functional role of matrix metalloproteinases (MMPs) in mammary epithelial cell development. Journal of cellular physiology. 2001 Jul; 188(1):75-88. doi: 10.1002/jcp.1090. [PMID: 11382924]
  • W J Lane, S Dias, K Hattori, B Heissig, M Choy, S Y Rabbany, J Wood, M A Moore, S Rafii. Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood. 2000 Dec; 96(13):4152-9. doi: NULL. [PMID: 11110686]
  • K Ko, S Yazumi, K Yoshikawa, Y Konda, M Nakajima, T Chiba, R Takahashi. Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact Co-cultures. International journal of cancer. 2000 Jul; 87(2):165-71. doi: 10.1002/1097-0215(20000715)87:2<165::aid-ijc2>3.0.co;2-f. [PMID: 10861469]
  • F A Eskens, N C Levitt, A Sparreboom, L Choi, R Mather, J Verweij, A L Harris. Effect of food on the pharmacokinetics of oral MMI270B (CGS 27023A), a novel matrix metalloproteinase inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research. 2000 Feb; 6(2):431-3. doi: NULL. [PMID: 10690520]