(2r)-N-Hydroxy-3-Naphthalen-2-Yl-2-[(Naphthalen-2-Ylsulfonyl)amino]propanamide (BioDeep_00000838974)
代谢物信息卡片
化学式: C23H20N2O4S (420.1144)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C=C(C=CC2=C1)CC(C(=O)NO)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
InChI: InChI=1S/C23H20N2O4S/c26-23(24-27)22(14-16-9-10-17-5-1-3-7-19(17)13-16)25-30(28,29)21-12-11-18-6-2-4-8-20(18)15-21/h1-13,15,22,25,27H,14H2,(H,24,26)/t22-/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yousuke Yamada, Hajime Takashima, David Lee Walmsley, Fumihito Ushiyama, Yohei Matsuda, Harumi Kanazawa, Toru Yamaguchi-Sasaki, Nozomi Tanaka-Yamamoto, Junya Yamagishi, Risa Kurimoto-Tsuruta, Yuya Ogata, Norikazu Ohtake, Hayley Angove, Lisa Baker, Richard Harris, Alba Macias, Alan Robertson, Allan Surgenor, Hayato Watanabe, Koichiro Nakano, Masashi Mima, Kunihiko Iwamoto, Atsushi Okada, Iichiro Takata, Kosuke Hitaka, Akihiro Tanaka, Kiyoko Fujita, Hiroyuki Sugiyama, Roderick E Hubbard. Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity.
Journal of medicinal chemistry.
2020 12; 63(23):14805-14820. doi:
10.1021/acs.jmedchem.0c01215. [PMID: 33210531] - Chul-Jin Lee, Xiaofei Liang, Ramesh Gopalaswamy, Javaria Najeeb, Eugene D Ark, Eric J Toone, Pei Zhou. Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.
ACS chemical biology.
2014 Jan; 9(1):237-46. doi:
10.1021/cb400067g. [PMID: 24117400] - Dibyabhaba Pradhan, Vani Priyadarshini, Manne Munikumar, Sandeep Swargam, Amineni Umamaheswari, Aparna Bitla. Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC of Leptospira spp.: homology modeling, docking, and molecular dynamics study.
Journal of biomolecular structure & dynamics.
2014; 32(2):171-85. doi:
10.1080/07391102.2012.758056. [PMID: 23383626] - Joseph S Warmus, Cheryl L Quinn, Clarke Taylor, Sean T Murphy, Timothy A Johnson, Chris Limberakis, Daniel Ortwine, Joel Bronstein, Paul Pagano, John D Knafels, Sandra Lightle, Igor Mochalkin, Roger Brideau, Terry Podoll. Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
Bioorganic & medicinal chemistry letters.
2012 Apr; 22(7):2536-43. doi:
10.1016/j.bmcl.2012.01.140. [PMID: 22401863] - Igor Mochalkin, John D Knafels, Sandra Lightle. Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.
Protein science : a publication of the Protein Society.
2008 Mar; 17(3):450-7. doi:
10.1110/ps.073324108. [PMID: 18287278] - Adam W Barb, Ling Jiang, Christian R H Raetz, Pei Zhou. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.
Proceedings of the National Academy of Sciences of the United States of America.
2007 Nov; 104(47):18433-8. doi:
10.1073/pnas.0709412104. [PMID: 18025458] - John M Clements, Fanny Coignard, Ian Johnson, Stephen Chandler, Shilpa Palan, Andrew Waller, Jac Wijkmans, Michael G Hunter. Antibacterial activities and characterization of novel inhibitors of LpxC.
Antimicrobial agents and chemotherapy.
2002 Jun; 46(6):1793-9. doi:
10.1128/aac.46.6.1793-1799.2002. [PMID: 12019092]
