Fosdevirine (BioDeep_00000838956)
代谢物信息卡片
化学式: C20H17ClN3O3P (413.0696012)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=CC(=C1)P(=O)(C2=C(NC3=C2C=C(C=C3)Cl)C(=O)N)OC)C=CC#N
InChI: InChI=1S/C20H17ClN3O3P/c1-12-8-13(4-3-7-22)10-15(9-12)28(26,27-2)19-16-11-14(21)5-6-17(16)24-18(19)20(23)25/h3-6,8-11,24H,1-2H3,(H2,23,25)/b4-3+
描述信息
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- KEGGdrug: D09906
- PubChem: 23583058
- PubChem: 44232529
- PubChem: 44224276
- DrugBank: DB06166
- ChEMBL: CHEMBL2104968
- ChEMBL: CHEMBL1652111
- ChEMBL: CHEMBL3781845
- CAS: 1097733-15-7
- CAS: 1018450-26-4
- CAS: 881924-31-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- David A Margolis, Joseph J Eron, Edwin DeJesus, Scott White, Paul Wannamaker, Britt Stancil, Mark Johnson. Unexpected finding of delayed-onset seizures in HIV-positive, treatment-experienced subjects in the Phase IIb evaluation of fosdevirine (GSK2248761).
Antiviral therapy.
2014; 19(1):69-78. doi:
10.3851/imp2689
. [PMID: 24158593] - Steve Piscitelli, Joseph Kim, Elizabeth Gould, Yu Lou, Scott White, Mark de Serres, Mark Johnson, Xiao-Jian Zhou, Keith Pietropaolo, Douglas Mayers. Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.
British journal of clinical pharmacology.
2012 Aug; 74(2):336-45. doi:
10.1111/j.1365-2125.2012.04194.x
. [PMID: 22288567] - Carlos Zala, Marty St Clair, Kathleen Dudas, Joseph Kim, Yu Lou, Scott White, Steve Piscitelli, Etienne Dumont, Keith Pietropaolo, Xiao-Jian Zhou, Douglas Mayers. Safety and efficacy of GSK2248761, a next-generation nonnucleoside reverse transcriptase inhibitor, in treatment-naive HIV-1-infected subjects.
Antimicrobial agents and chemotherapy.
2012 May; 56(5):2570-5. doi:
10.1128/aac.05597-11
. [PMID: 22314532] - Xiao-Jian Zhou, R Colin Garner, Sheila Nicholson, C James Kissling, Douglas Mayers. Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in healthy male subjects.
Journal of clinical pharmacology.
2009 Dec; 49(12):1408-16. doi:
10.1177/0091270009343698
. [PMID: 19776293] - Xiao-Jian Zhou, Keith Pietropaolo, David Damphousse, Bruce Belanger, Jie Chen, John Sullivan-Bólyai, Douglas Mayers. Single-dose escalation and multiple-dose safety, tolerability, and pharmacokinetics of IDX899, a candidate human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor, in healthy subjects.
Antimicrobial agents and chemotherapy.
2009 May; 53(5):1739-46. doi:
10.1128/aac.01479-08
. [PMID: 19223643]