Acetylcysteine zinc (BioDeep_00000838824)
代谢物信息卡片
Acetylcysteine zinc
化学式: C10H16N2O6S2Zn (387.9741206)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC(CS)C(=O)[O-].CC(=O)NC(CS)C(=O)[O-].[Zn+2]
InChI: /q
描述信息
D019141 - Respiratory System Agents > D005100 - Expectorants
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000975 - Antioxidants > D016166 - Free Radical Scavengers
D020011 - Protective Agents > D000975 - Antioxidants
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alondra Vargas-Barona, Johanna Bernáldez-Sarabia, Ana B Castro-Ceseña. Lipid-polymer hybrid nanoparticles loaded with N-acetylcysteine for the modulation of neuroinflammatory biomarkers in human iPSC-derived PSEN2 (N141I) astrocytes as a model of Alzheimer's disease.
Journal of materials chemistry. B.
2024 May; 12(21):5085-5097. doi:
10.1039/d4tb00521j. [PMID: 38713059] - Jia-Jia Liu, Xue Zhang, Bang-Lan Cai, Man-Man Qi, Yong-Bin Chi, Bin Peng, Deng-Hai Zhang. Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells.
Journal of integrative medicine.
2024 May; 22(3):286-294. doi:
10.1016/j.joim.2024.03.007. [PMID: 38565435] - Narjesse E L Mabrouk, Maha Mastouri, Gérard Lizard, Mahjoub Aouni, Hedi Harizi. In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2024 May; 97(?):105812. doi:
10.1016/j.tiv.2024.105812. [PMID: 38522494] - Bruna Fernandes Andrade, Angélica Souza Guimarães, Lorrany Ramos do Carmo, Marcelo Stefanini Tanaka, Paulo Rogério Fontes, Alcinéia de Lemos Souza Ramos, Eduardo Mendes Ramos. S-nitrosothiols as nitrite alternatives: Effects on residual nitrite, lipid oxidation, volatile profile, and cured color of restructured cooked ham.
Meat science.
2024 Mar; 209(?):109397. doi:
10.1016/j.meatsci.2023.109397. [PMID: 38043329] - Lin Liao, Pengyu Tao, Qiming Xu, Wenhao Chen, Jie Chen, Weiwei Liu, Wenrui Liu, Jing Hu, Jianrao Lu. TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein.
Frontiers in bioscience (Landmark edition).
2024 Feb; 29(2):58. doi:
10.31083/j.fbl2902058. [PMID: 38420829] - Bendong Shi, Zhuoqi Zhang, Jiao Xing, Qiaohan Liu, Jingzeng Cai, Ziwei Zhang. Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte.
Aquatic toxicology (Amsterdam, Netherlands).
2024 Feb; 267(?):106839. doi:
10.1016/j.aquatox.2024.106839. [PMID: 38228041] - Merve Yuce, Ertan Yildirim, Melek Ekinci, Metin Turan, Emre Ilhan, Murat Aydin, Guleray Agar, Sumeyra Ucar. N-acetyl-cysteine mitigates arsenic stress in lettuce: Molecular, biochemical, and physiological perspective.
Plant physiology and biochemistry : PPB.
2024 Feb; 207(?):108390. doi:
10.1016/j.plaphy.2024.108390. [PMID: 38373369] - Hengyou Zhang, Yinghua Huang. Genome-wide identification and characterization of greenbug-inducible NAC transcription factors in sorghum.
Molecular biology reports.
2024 Jan; 51(1):207. doi:
10.1007/s11033-023-09158-x. [PMID: 38270755] - Amir Nili-Ahmadabadi, Saeb Abdpour, Navid Omidifar, Seyyed Alireza Hashemi, Seyyed Mojtaba Mousavi, Maryam Nili Ahmadabadi. Therapeutic potentials of N-acetylcysteine immobilized polyrhodanine nanoparticles toward acetaminophen-induced acute hepatotoxicity in rat.
Chemical biology & drug design.
2024 Jan; 103(1):e14430. doi:
10.1111/cbdd.14430. [PMID: 38230777] - Rui Zhu, Guo-Jun Shang, Bao-Yuan Zhang, Hao-Tong Wang, Liang Li, Xiao-Fang Wei, Deng-Lai Li, Zhi-Yong Yang, Zi-Hui Qu, Ya-Nan Quan, Si-Ying Liu, Yin-Tao Wang, Si-Tong Meng, Li-Fang Wu, Gui-Xin Qin. Unlocking the potential of N-acetylcysteine: Improving hepatopancreas inflammation, antioxidant capacity and health in common carp (Cyprinus carpio) via the MAPK/NF-κB/Nrf2 signalling pathway.
Fish & shellfish immunology.
2024 Jan; 144(?):109294. doi:
10.1016/j.fsi.2023.109294. [PMID: 38092096] - Manoj Choudhary, Jorge Pereira, Edwin B Davidson, James Colee, Swadeshmukul Santra, Jeffrey B Jones, Mathews L Paret. Improved Persistence of Bacteriophage Formulation with Nano N-Acetylcysteine-Zinc Sulfide and Tomato Bacterial Spot Disease Control.
Plant disease.
2023 Dec; 107(12):3933-3942. doi:
10.1094/pdis-02-23-0255-re. [PMID: 37368450] - Israel Pérez-Torres, Alfredo Aisa-Álvarez, Sergio Casarez-Alvarado, Gabriela Borrayo, Ricardo Márquez-Velasco, Verónica Guarner-Lans, Linaloe Manzano-Pech, Randall Cruz-Soto, Omar Gonzalez-Marcos, Giovanny Fuentevilla-Álvarez, Ricardo Gamboa, Huitizilihuitl Saucedo-Orozco, Juvenal Franco-Granillo, María Elena Soto. Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects.
International journal of molecular sciences.
2023 Nov; 24(23):. doi:
10.3390/ijms242316610. [PMID: 38068931] - Wenhao Wang, Jingxuan Zeng, Peili Luo, Jiayi Fang, Qingao Pei, Jinwu Yan, Chune Zhu, Wei Chen, Yanyun Liu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan. Engineered lipid liquid crystalline nanoparticles as an inhaled nanoplatform for mucus penetration enhancement.
Drug delivery and translational research.
2023 11; 13(11):2834-2846. doi:
10.1007/s13346-023-01351-6. [PMID: 37155080] - Farzaneh Motafeghi, Parham Mortazavi, Amir Hossein Salman Mahiny, Mohammad Mehdi Abtahi, Mohammad Shokrzadeh. The role of ginger's extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder.
Drug and chemical toxicology.
2023 Nov; 46(4):617-624. doi:
10.1080/01480545.2022.2075377. [PMID: 35575100] - Kai Nieschalke, Nick Bergau, Sönke Jessel, Albrecht Seidel, Susanne Baldermann, Monika Schreiner, Klaus Abraham, Alfonso Lampen, Bernhard H Monien, Burkhard Kleuser, Hansruedi Glatt, Fabian Schumacher. Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans.
Chemical research in toxicology.
2023 Oct; ?(?):. doi:
10.1021/acs.chemrestox.3c00212. [PMID: 37875262] - Elizabeth Smith Khoury, Ruchit V Patel, Caroline O'Ferrall, Amanda Fowler, Nirnath Sah, Anjali Sharma, Siddharth Gupta, Susanna Scafidi, Joshua S Kurtz, Sarah J Olmstead, Sapna R Kudchadkar, Rangaramanujam M Kannan, Mary E Blue, Sujatha Kannan. Dendrimer nanotherapy targeting of glial dysfunction improves inflammation and neurobehavioral phenotype in adult female Mecp2-heterozygous mouse model of Rett syndrome.
Journal of neurochemistry.
2023 Sep; ?(?):. doi:
10.1111/jnc.15960. [PMID: 37777475] - Siqin Liu, Yuanlin Guan, Yuhao Weng, Bojun Liao, Lu Tong, Zhaodong Hao, Jinhui Chen, Jisen Shi, Tielong Cheng. Genome-wide identification of the NAC gene family and its functional analysis in Liriodendron.
BMC plant biology.
2023 Sep; 23(1):415. doi:
10.1186/s12870-023-04415-4. [PMID: 37684590] - Domenico Lapenna. Glutathione and Glutathione-dependent Enzymes: From Biochemistry to Gerontology and Successful Aging.
Ageing research reviews.
2023 Sep; ?(?):102066. doi:
10.1016/j.arr.2023.102066. [PMID: 37683986] - Chi Feng, Hongxia Bai, Xu Chang, Zhixuan Wu, Wu Dong, Qianqian Ma, Jingfeng Yang. Aflatoxin B1-induced early developmental hepatotoxicity in larvae zebrafish.
Chemosphere.
2023 Aug; ?(?):139940. doi:
10.1016/j.chemosphere.2023.139940. [PMID: 37634582] - Germán Muñoz-Sánchez, Lucila A Godínez-Méndez, Mary Fafutis-Morris, Vidal Delgado-Rizo. Effect of Antioxidant Supplementation on NET Formation Induced by LPS In Vitro; the Roles of Vitamins E and C, Glutathione, and N-acetyl Cysteine.
International journal of molecular sciences.
2023 Aug; 24(17):. doi:
10.3390/ijms241713162. [PMID: 37685966] - Wen-Yu Chen, Yan-Peng Fu, Hui Tu, Wen Zhong, Liang Zhou. The association between exposure to volatile organic compounds and serum lipids in the US adult population.
Lipids in health and disease.
2023 Aug; 22(1):129. doi:
10.1186/s12944-023-01895-z. [PMID: 37568143] - Xinxin Sun, Yaru Sun, Sumin Cao, Xueli Liu. Effects of N-acetyl-L-cysteine polysulfides on periodontitis in a mouse model.
Immunity, inflammation and disease.
2023 08; 11(8):e959. doi:
10.1002/iid3.959. [PMID: 37647428] - Yasemin Korkmaz, Hüseyin Gungor, Ahmet Demirbas, Burak Dik. Pomegranate peel extract, N-Acetylcysteine and their combination with Ornipural alleviate Cadmium-induced toxicity in rats.
The Journal of veterinary medical science.
2023 Jul; ?(?):. doi:
10.1292/jvms.22-0375. [PMID: 37495528] - Golsa Khalatbari Mohseni, Seyed Ahmad Hosseini, Nastaran Majdinasab, Bahman Cheraghian. Effects of N-acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis.
Neuropsychopharmacology reports.
2023 Jun; ?(?):. doi:
10.1002/npr2.12360. [PMID: 37386885] - Shumaila Iqbal Siddiqui, Chetan Malik, Subhendu Ghosh. Voltage dependent anion channel and its interaction with N-acetyl-L-Cysteine (NAC) under oxidative stress on planar lipid bilayer.
Biochimie.
2023 Jun; 209(?):150-160. doi:
10.1016/j.biochi.2023.02.005. [PMID: 36780980] - Hong Yang, Xiangyu Li, Han Jin, Hasan Turkez, Gurkan Ozturk, Hamdi Levent Doganay, Cheng Zhang, Jens Nielsen, Mathias Uhlén, Jan Borén, Adil Mardinoglu. Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators.
Free radical biology & medicine.
2023 May; ?(?):. doi:
10.1016/j.freeradbiomed.2023.05.013. [PMID: 37245532] - Elena Cecilia Marcano-Gómez, Ana Beatriz Farias de Souza, Pedro Alves Machado-Junior, Andrea Jazel Rodríguez-Herrera, Thalles de Freitas Castro, Sirlaine Pio Gomes da Silva, Ramony Gonzaga Vieira, André Talvani, Katiane de Oliveira Pinto Coelho Nogueira, Laser Antônio Machado de Oliveira, Frank Silva Bezerra. N-acetylcysteine modulates redox imbalance and inflammation in macrophages and mice exposed to formaldehyde.
Free radical research.
2023 May; 57(6-12):444-459. doi:
10.1080/10715762.2023.2284636. [PMID: 37987619] - Min-Yu Lee, Jun-Ping Shiau, Jen-Yang Tang, Ming-Feng Hou, Phoebe Sussana Primus, Chai-Lin Kao, Yeun-Mun Choo, Hsueh-Wei Chang. Boesenbergia stenophylla-Derived Stenophyllol B Exerts Antiproliferative and Oxidative Stress Responses in Triple-Negative Breast Cancer Cells with Few Side Effects in Normal Cells.
International journal of molecular sciences.
2023 Apr; 24(9):. doi:
10.3390/ijms24097751. [PMID: 37175458] - Meilin Wei, Solairaj Dhanasekaran, Qihao Ji, Qiya Yang, Hongyin Zhang. Sustainable and efficient method utilizing N-acetyl-L-cysteine for complete and enhanced ochratoxin A clearance by antagonistic yeast.
Journal of hazardous materials.
2023 04; 448(?):130975. doi:
10.1016/j.jhazmat.2023.130975. [PMID: 36860082] - Rachel Tan, Matthew Black, Joseph Home, Jamie Blackwell, Ida Clark, Lee Wylie, Anni Vanhatalo, Andrew M Jones. Physiological and performance effects of dietary nitrate and N-acetylcysteine supplementation during prolonged heavy-intensity cycling.
Journal of sports sciences.
2023 Feb; ?(?):1-10. doi:
10.1080/02640414.2023.2176052. [PMID: 36759944] - Rasha S Albeltagy, Shauq M Dawood, Farah Mumtaz, Ahmed E Abdel Moneim, Ola H El-Habit. Antioxidant capacity of N-acetylcysteine against the molecular and cytotoxic implications of cadmium chloride leading to hepatotoxicity and vital progression.
Environmental science and pollution research international.
2023 Feb; 30(9):23237-23247. doi:
10.1007/s11356-022-23823-x. [PMID: 36322347] - Ashkan Karbasi, Anahita Abbasifard, Farzin Firouzian, Sara Soleimani Asl, Zahra Azizi, Akram Ranjbar. Is nanoparaquat safer than bulk paraquat? An in vitro and in vivo evaluation.
Toxicology.
2023 01; 484(?):153398. doi:
10.1016/j.tox.2022.153398. [PMID: 36535436] - Yanliang Wu, Yongrong Yao, Hangjia Bai, Kuniyoshi Shimizu, Renshi Li, Chaofeng Zhang. Investigation of pulmonary toxicity evaluation on mice exposed to polystyrene nanoplastics: The potential protective role of the antioxidant N-acetylcysteine.
The Science of the total environment.
2023 Jan; 855(?):158851. doi:
10.1016/j.scitotenv.2022.158851. [PMID: 36155047] - Xin Cao, Guohu Di, Ying Bai, Kaier Zhang, Yihui Wang, Hui Zhao, Dianqiang Wang, Peng Chen. Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands.
Investigative ophthalmology & visual science.
2023 01; 64(1):4. doi:
10.1167/iovs.64.1.4. [PMID: 36626177] - Holger Hoffmann, Susanne Baldermann, Melanie Wiesner-Reinhold, Manuela M Bergmann, Tilman Grune, Franziska S Hanschen. Metabolism and Recovery of Epithionitriles from Glucosinolates-A Human Intervention Study.
Molecular nutrition & food research.
2023 01; 67(1):e2200619. doi:
10.1002/mnfr.202200619. [PMID: 36373491] - Amylly Sanuelly da Paz Martins, Kívia Queiroz de Andrade, Orlando Roberto Pimentel de Araújo, Glenn Côsallin Melquiades da Conceição, Amanda da Silva Gomes, Marília Oliveira Fonseca Goulart, Fabiana Andréa Moura. Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney.
Oxidative medicine and cellular longevity.
2023; 2023(?):8811463. doi:
10.1155/2023/8811463. [PMID: 37577725] - Zahra Mokhtari, Mahdieh Raeeszadeh, Loghman Akradi. Comparative Effect of the Active Substance of Thyme with N-Acetyl Cysteine on Hematological Parameters and Histopathological Changes of Bone Marrow and Liver in Rat Models of Acetaminophen Toxicity.
Analytical cellular pathology (Amsterdam).
2023; 2023(?):1714884. doi:
10.1155/2023/1714884. [PMID: 37056637] - Bianca R Silva, José R V Silva. Mechanisms of action of non-enzymatic antioxidants to control oxidative stress during in vitro follicle growth, oocyte maturation, and embryo development.
Animal reproduction science.
2022 Dec; 249(?):107186. doi:
10.1016/j.anireprosci.2022.107186. [PMID: 36638648] - Ashwag H Alwadani, Soheir A Almasri, Amal A Aloud, Nawal A Albadr, Ghedeir M Alshammari, Mohammed Abdo Yahya. The Synergistic Protective Effect of γ-Oryzanol (OZ) and N-Acetylcysteine (NAC) against Experimentally Induced NAFLD in Rats Entails Hypoglycemic, Antioxidant, and PPARα Stimulatory Effects.
Nutrients.
2022 Dec; 15(1):. doi:
10.3390/nu15010106. [PMID: 36615764] - Yu Jiang, Nan Geng, Mingyong Wang, Wen Wu, Ninghan Feng, Xian Zhang. 5-HMF affects cardiovascular development in zebrafish larvae via reactive oxygen species and Wnt signaling pathways.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2022 Dec; 262(?):109452. doi:
10.1016/j.cbpc.2022.109452. [PMID: 36067963] - Rasha M Hussein, Mohamed A Kandeil, Norhan A Mohammed, Rasha A Khallaf. Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity: Role of inducible nitric oxide synthase.
Journal of liposome research.
2022 Dec; 32(4):365-375. doi:
10.1080/08982104.2022.2032737. [PMID: 35132919] - Asghar Beigi Harchegani, Sareh Rostami, Zhaleh Mohsenifar, Alireza Beheshti Dafchahi, Fatemeh Mozaffari Moghadam, Mohammad Jaafarzadeh, Saman Seyfizadeh Saraabestan, Najmeh Ranji. Anti-apoptotic properties of N-Acetyl cysteine and its effects on of Liver X receptor and Sirtuin 1 expression in the liver of rats exposed to Lead.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2022 Dec; 74(?):127070. doi:
10.1016/j.jtemb.2022.127070. [PMID: 36155419] - Yi Su, Xin Yin, Xin Huang, Qianqian Guo, Mingyuan Ma, Liheng Guo. The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells.
Pharmaceutical biology.
2022 Dec; 60(1):1812-1818. doi:
10.1080/13880209.2022.2101668. [PMID: 36121248] - Katie B Hillmann, Madeline E Goethel, Natalie A Erickson, Thomas D Niehaus. Identification of a S-(2-succino)cysteine breakdown pathway that uses a novel S-(2-succino) lyase.
The Journal of biological chemistry.
2022 12; 298(12):102639. doi:
10.1016/j.jbc.2022.102639. [PMID: 36309089] - Bohao Liu, Cong Ding, Wenbin Tang, Chen Zhang, Yiying Gu, Zhiqiang Wang, Tingzi Yu, Zhuan Li. Hepatic ROS Mediated Macrophage Activation Is Responsible for Irinotecan Induced Liver Injury.
Cells.
2022 Nov; 11(23):. doi:
10.3390/cells11233791. [PMID: 36497051] - Xinrun Li, Haitong Wu, Haihua Huo, Feiyang Ma, Menglong Zhao, Qingyue Han, Lianmei Hu, Ying Li, Hui Zhang, Jiaqiang Pan, Zhaoxin Tang, Jianying Guo. N-acetylcysteine combined with insulin alleviates the oxidative damage of cerebrum via regulating redox homeostasis in type 1 diabetic mellitus canine.
Life sciences.
2022 Nov; 308(?):120958. doi:
10.1016/j.lfs.2022.120958. [PMID: 36108767] - Jiahui Wu, Zhitian Peng, Qiyun Wu, Roy Wai Lun Tang, Tingxia Dong, Huaiyou Wang, Karl Wah Keung Tsim. The water extract of Aloe vera prevents fluoxetine-induced multiple-drug resistance of E. coli by inhibiting reactive oxygen species formation and membrane permeability.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154421. doi:
10.1016/j.phymed.2022.154421. [PMID: 36054995] - Jin Vivian Lee, Connor Engel, Shirli Tay, Gayan DeSilva, Kshitij Desai, John Cashin, Clay F Semenkovich, Mohamed A Zayed. Impact of N-Acetyl-Cysteine on Ischemic Stumps Following Major Lower Extremity Amputation: A Pilot Randomized Clinical Trial.
Annals of surgery.
2022 11; 276(5):e302-e310. doi:
10.1097/sla.0000000000005389. [PMID: 35129469] - Karima Rjiba-Touati, Imen Ayed-Boussema, Hiba Hamdi, Awatef Azzebi, Salwa Abid. Bromuconazole fungicide induces cell cycle arrest and apoptotic cell death in cultured human colon carcinoma cells (HCT116) via oxidative stress process.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2022 Nov; 27(7):659-670. doi:
10.1080/1354750x.2022.2098378. [PMID: 35968645] - Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang, Yi Ding. NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
BMC medicine.
2022 10; 20(1):365. doi:
10.1186/s12916-022-02554-3. [PMID: 36258210] - Soon Su Shin, Eun Hye Yang, Hyo Choon Lee, Seong Ho Moon, Jae-Hong Ryoo. Association of metabolites of benzene and toluene with lipid profiles in Korean adults: Korean National Environmental Health Survey (2015-2017).
BMC public health.
2022 10; 22(1):1917. doi:
10.1186/s12889-022-14319-x. [PMID: 36242012] - Yong-Ming He, Xing-Ling Shen, Yan-Na Guo, Shao-Shan Liang, Kang-Ning Ding, Meng-Han Lu, Lu-Ping Tang. Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling.
Ecotoxicology and environmental safety.
2022 Oct; 244(?):114073. doi:
10.1016/j.ecoenv.2022.114073. [PMID: 36115150] - Morteza Mamashli, Saeed Nasseri, Yaser Mohammadi, Sahar Ayati, Asghar Zarban. Anti-inflammatory effects of N-Acetylcysteine and Elaeagnus angustifolia extract on acute lung injury induced by λ-carrageenan in rat.
Inflammopharmacology.
2022 Oct; 30(5):1759-1768. doi:
10.1007/s10787-022-01003-0. [PMID: 35723848] - Yuehan Zhang, Sushan Yang, Zhenhua Qiu, Li Huang, Linyan Huang, Yueyun Liang, Xuanyu Liu, Maosheng Wang, Beixian Zhou. Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.
Free radical biology & medicine.
2022 10; 191(?):66-81. doi:
10.1016/j.freeradbiomed.2022.08.030. [PMID: 36028178] - Bin Liu, Ming Tang, Hui Chen. Activation of the ROS/CncC Signaling Pathway Regulates Cytochrome P450 CYP4BQ1 Responsible for (+)-α-Pinene Tolerance in Dendroctonus armandi.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911578. [PMID: 36232876] - Yong-Seok Song, Andrew J Annalora, Craig B Marcus, Colin R Jefcoate, Christine M Sorenson, Nader Sheibani. Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress.
Cells.
2022 09; 11(19):. doi:
10.3390/cells11192930. [PMID: 36230892] - Marta Wołosowicz, Patrycja Dajnowicz-Brzezik, Bartłomiej Łukaszuk, Ewa Żebrowska, Mateusz Maciejczyk, Anna Zalewska, Irena Kasacka, Adrian Chabowski. Diverse impact of N-acetylcysteine or alpha-lipoic acid supplementation during high-fat diet regime on fatty acid transporters in visceral and subcutaneous adipose tissue.
Advances in medical sciences.
2022 Sep; 67(2):216-228. doi:
10.1016/j.advms.2022.05.001. [PMID: 35594763] - Twinkle Dhillon, Amit Kumar, Vijay Kumar. Neuroprotective Effect of N-acetylcysteine Against Monocrotophos-Induced Oxidative Stress in Different Brain Regions of Rats.
Applied biochemistry and biotechnology.
2022 Sep; 194(9):4049-4065. doi:
10.1007/s12010-022-03967-9. [PMID: 35587328] - Dimitrios Tsikas, Marie Mikuteit. N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
Amino acids.
2022 Sep; 54(9):1251-1260. doi:
10.1007/s00726-022-03185-x. [PMID: 35829920] - Meng Tang, Zhihui Yang, Jing Liu, Xiangfei Zhang, Lan Guan, Xinming Liu, Ming Zeng. Combined intervention with N-acetylcysteine and desipramine alleviated silicosis development by regulating the Nrf2/HO-1 and ASMase/ceramide signaling pathways.
Ecotoxicology and environmental safety.
2022 Sep; 242(?):113914. doi:
10.1016/j.ecoenv.2022.113914. [PMID: 35878501] - Yi Zhang, Bo Hu, Xiaolan Qian, Guangtao Xu, Xin Jin, Deqing Chen, Jie Tang, Long Xu. Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells.
Ecotoxicology and environmental safety.
2022 Aug; 241(?):113790. doi:
10.1016/j.ecoenv.2022.113790. [PMID: 35753275] - Bernhard H Monien, Klaus Abraham. Levels of 2,3-dihydroxypropyl mercapturic acid (DHPMA) in human urine do not reflect the exposure to 3-chloro-1,2-propanediol (3-MCPD) or glycidol.
Environmental research.
2022 08; 211(?):112977. doi:
10.1016/j.envres.2022.112977. [PMID: 35248561] - Francesca Julià, Antonia Costa-Bauza, Francisco Berga, Felix Grases. Effect of theobromine on dissolution of uric acid kidney stones.
World journal of urology.
2022 Aug; 40(8):2105-2111. doi:
10.1007/s00345-022-04059-3. [PMID: 35689678] - Chen Yang, Xiaofang Zhang, Xilin Ge, Chunmei He, Suhuan Liu, Shuyu Yang, Caoxin Huang. N-Acetylcysteine protects against cobalt chloride-induced endothelial dysfunction by enhancing glucose-6-phosphate dehydrogenase activity.
FEBS open bio.
2022 08; 12(8):1475-1488. doi:
10.1002/2211-5463.13449. [PMID: 35666067] - Karlee M Quinn, Llion Roberts, Amanda J Cox, David N Borg, Evan N Pennell, Daniel R McKeating, Joshua J Fisher, Anthony V Perkins, Clare Minahan. Blood oxidative stress biomarkers in women: influence of oral contraception, exercise, and N-acetylcysteine.
European journal of applied physiology.
2022 Aug; 122(8):1949-1964. doi:
10.1007/s00421-022-04964-w. [PMID: 35674828] - Heather Walker, Greg D Guthrie, Emilie Lambourg, Philippa Traill, Ian Zealley, Andrew Plumb, Samira Bell. Systematic review and meta-analysis of prophylaxis use with intravenous contrast exposure to prevent contrast-induced nephropathy.
European journal of radiology.
2022 Aug; 153(?):110368. doi:
10.1016/j.ejrad.2022.110368. [PMID: 35636024] - Guangbin Chen, Hongzhou Lu. Oral high-dose acetylcysteine: Effective against the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)?.
Drug discoveries & therapeutics.
2022 Jul; 16(3):139-141. doi:
10.5582/ddt.2022.01032. [PMID: 35527020] - Tatiane G Hammerschmidt, Bruna Donida, Jéssica L Faverzani, Alana P Moura, Bianca G Dos Reis, Andryele Z Machado, Rejane G Kessler, Fernanda M Sebastião, Luiza S Reinhardt, Dinara J Moura, Carmen R Vargas. Cytokine profile and cholesterol levels in patients with Niemann-Pick type C disease presenting neurological symptoms: in vivo effect of miglustat and in vitro effect of N-acetylcysteine and coenzyme Q10.
Experimental cell research.
2022 07; 416(2):113175. doi:
10.1016/j.yexcr.2022.113175. [PMID: 35487270] - Muhammad Asif Tahir, Hamayun Shaheen, Bala Rathinasabapathi. Health risk associated with heavy metal contamination of vegetables grown in agricultural soil of Siran valley, Mansehra, Pakistan-a case study.
Environmental monitoring and assessment.
2022 Jul; 194(8):551. doi:
10.1007/s10661-022-10210-9. [PMID: 35778622] - Shih-Lung Chen, Chia-Ying Ho, Shy-Chyi Chin. Effects of oral N-acetylcysteine combined with oral prednisolone on idiopathic sudden sensorineural hearing loss.
Medicine.
2022 Jul; 101(26):e29792. doi:
10.1097/md.0000000000029792. [PMID: 35777063] - Ahmed Ghallab, Reham Hassan, Ute Hofmann, Adrian Friebel, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Maiju Myllys, Joerg Reinders, Nina Overbeck, Selahaddin Sezgin, Sebastian Zühlke, Abdel-Latif Seddek, Walaa Murad, Tim Brecklinghaus, Franziska Kappenberg, Jörg Rahnenführer, Daniela González, Christopher Goldring, Ian M Copple, Rosemarie Marchan, Thomas Longerich, Mihael Vucur, Tom Luedde, Stephan Urban, Ali Canbay, Thomas Schreiter, Michael Trauner, Jephte Y Akakpo, Mojtaba Olyaee, Steven C Curry, Jan-Peter Sowa, Hartmut Jaeschke, Stefan Hoehme, Jan G Hengstler. Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
Journal of hepatology.
2022 07; 77(1):71-83. doi:
10.1016/j.jhep.2022.01.020. [PMID: 35131407] - Kate Magner, Julius Vladimir Ilin, Edward G Clark, Jennifer W Y Kong, Alexandra Davis, Swapnil Hiremath. Meta-analytic Techniques to Assess the Association Between N-acetylcysteine and Acute Kidney Injury After Contrast Administration: A Systematic Review and Meta-analysis.
JAMA network open.
2022 Jul; 5(7):e2220671. doi:
10.1001/jamanetworkopen.2022.20671. [PMID: 35788669] - Yixin Xu, Haoran Bu, Yufan Jiang, Xiaoqing Zhuo, Ke Hu, Zhihua Si, Yong Chen, Qiwei Liu, Xianwei Gong, Haihui Sun, Qingyi Zhu, Lianqun Cui, Xiaochun Ma, Yuqi Cui. N‑acetyl cysteine prevents ambient fine particulate matter‑potentiated atherosclerosis via inhibition of reactive oxygen species‑induced oxidized low density lipoprotein elevation and decreased circulating endothelial progenitor cell.
Molecular medicine reports.
2022 Jul; 26(1):. doi:
10.3892/mmr.2022.12752. [PMID: 35621139] - Fethi Ahmet Atilgan, Metin Atescelik, Mustafa Yilmaz, Ahmet Turk, Mehtap Gurger, Mehmet Cagri Goktekin, Tuncay Kuloglu. Effects of N-acetyl cysteine on TRPM2 expression in kidney and liver tissues following malathion intoxication.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2022 Jul; 97(5):340-346. doi:
10.1080/10520295.2021.1986639. [PMID: 34652265] - Xiaonan Li, Gang Xing, Xinxin Guo, Yang Wang, Zixia Hu, Maosheng Cheng, Ying Peng, Jiang Zheng. Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity.
Chemical research in toxicology.
2022 Jun; 35(6):1059-1069. doi:
10.1021/acs.chemrestox.2c00052. [PMID: 35575346] - Bin Wang, Xing Wang, Linling Yu, Wei Liu, Jiahao Song, Lieyang Fan, Min Zhou, Meng Yang, Jixuan Ma, Man Cheng, Weihong Qiu, Ruyi Liang, Dongming Wang, Yanjun Guo, Weihong Chen. Acrylamide exposure increases cardiovascular risk of general adult population probably by inducing oxidative stress, inflammation, and TGF-β1: A prospective cohort study.
Environment international.
2022 06; 164(?):107261. doi:
10.1016/j.envint.2022.107261. [PMID: 35486963] - Lijie Fan, Fengli Guan, Yucong Ma, Yu Zhang, Li Li, Ying Sun, Can Cao, Huilan Du, Ming He. N-Acetylcysteine improves oocyte quality through modulating the Nrf2 signaling pathway to ameliorate oxidative stress caused by repeated controlled ovarian hyperstimulation.
Reproduction, fertility, and development.
2022 Jun; 34(10):736-750. doi:
10.1071/rd22020. [PMID: 35513370] - Sivan Arber Raviv, Mohammed Alyan, Egor Egorov, Agam Zano, Moshit Yaskin Harush, Calvin Pieters, Hila Korach-Rechtman, Adi Saadya, Galoz Kaneti, Igor Nudelman, Shai Farkash, Ofri Doppelt Flikshtain, Lucy N Mekies, Lilach Koren, Yoav Gal, Ella Dor, Janna Shainsky, Jeny Shklover, Yochai Adir, Avi Schroeder. Lung targeted liposomes for treating ARDS.
Journal of controlled release : official journal of the Controlled Release Society.
2022 Jun; 346(?):421-433. doi:
10.1016/j.jconrel.2022.03.028. [PMID: 35358610] - Euan A Sandilands, Jessica M B Rees, Khuram Raja, Neeraj Dhaun, Emma E Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P Thompson, Neil R Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J Webb, D Nicholas Bateman, John Norrie, Ian L Megson, Michael Eddleston. Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy: A Failure of Academic Clinical Science.
Clinical pharmacology and therapeutics.
2022 06; 111(6):1222-1238. doi:
10.1002/cpt.2541. [PMID: 35098531] - Xiaoqing Xu, Xiaohui Wang, Yaqin Yang, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, María-Rosa Martínez-Larrañaga, Xu Wang, Arturo Anadón, María-Aránzazu Martinez. Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage.
Archives of toxicology.
2022 06; 96(6):1493-1520. doi:
10.1007/s00204-022-03267-5. [PMID: 35344072] - María Codinach-Martín, Juan Ortega-Pérez, Maria Àngels Gispert-Ametller, Emilio Salgado-García, Amelia Rodríguez-Mariblanca, Santiago Nogué-Xarau, Jordi Puiguriguer-Ferrando. N-acetylcysteine as an antidote for paracetamol poisoning: a multicenter study.
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.
2022 Jun; 34(3):190-195. doi:
NULL. [PMID: 35736523] - Brandon M Kenwood, Wanzhe Zhu, Luyu Zhang, Deepak Bhandari, Benjamin C Blount. Cigarette smoking is associated with acrylamide exposure among the U.S. population: NHANES 2011-2016.
Environmental research.
2022 06; 209(?):112774. doi:
10.1016/j.envres.2022.112774. [PMID: 35074357] - Kalliopi Papavasileiou, Apostolia Tsiasioti, Paraskevas D Tzanavaras, Constantinos K Zacharis. HPLC Determination of Colistin in Human Urine Using Alkaline Mobile Phase Combined with Post-Column Derivatization: Validation Using Accuracy Profiles.
Molecules (Basel, Switzerland).
2022 May; 27(11):. doi:
10.3390/molecules27113489. [PMID: 35684427] - Jiaru Li, Junzu Shi, Chenyang Jia, Wei Li, Ying Peng, Jiang Zheng. Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6.
Chemical research in toxicology.
2022 05; 35(5):829-839. doi:
10.1021/acs.chemrestox.2c00013. [PMID: 35442037] - Margaux Berthou, Arnaud Pallotta, Jordan Beurton, Thomas Chaigneau, Athanassia Athanassiou, Christophe Marcic, Eric Marchioni, Ariane Boudier, Igor Clarot. Gold nanostructured membranes to concentrate low molecular weight thiols, a proof of concept study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 May; 1198(?):123244. doi:
10.1016/j.jchromb.2022.123244. [PMID: 35429732] - Himanshu Aggarwal, Surbhi Gupta, Poonam Sharma, B M Sharma, Bhupesh Sharma. Neurobehavioral and neurobiochemical effect of atomoxetine and N-acetylcysteine in streptozotocin diabetes induced endothelial dysfunction and related dementia.
Physiology & behavior.
2022 05; 249(?):113767. doi:
10.1016/j.physbeh.2022.113767. [PMID: 35245527] - Huseyin Gungor, Mehmet Ekici, Mehmet Burak Ates. Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice.
Drug and chemical toxicology.
2022 May; ?(?):1-9. doi:
10.1080/01480545.2022.2069256. [PMID: 35502492] - Pratim Sengupta, Sumanta Biswas, Tapas Roy. Comparative Study to Evaluate the Effect of Low-Protein Diet Supplementation with Taurine and N-Acetylcysteine, N-Acetylcysteine and Pyridoxamine Dihydrochloride in Preventing the Progression of Chronic Renal Failure in Patients with Non-Diabetic Kidney Disease.
The Journal of the Association of Physicians of India.
2022 May; 70(5):11-12. doi:
. [PMID: 35598122] - Sasha K Kaiser, Richard C Dart. The Roles of Antidotes in Emergency Situations.
Emergency medicine clinics of North America.
2022 May; 40(2):381-394. doi:
10.1016/j.emc.2022.01.008. [PMID: 35461629] - Jana Vanova, David Malinak, Rudolf Andrys, Miroslav Kubat, Tomas Mikysek, Erika Rousarova, Kamil Musilek, Tomas Rousar, Petr Cesla. Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model.
Journal of chromatography. A.
2022 Apr; 1669(?):462956. doi:
10.1016/j.chroma.2022.462956. [PMID: 35306469] - Ying Kiat Tan, HaiDong Luo, Giap Swee Kang, Kristine Lk Teoh, Theo Kofidis. N-Acetylcysteine's Renoprotective Effect in Cardiac Surgery: A Systematic Review and Meta-Analysis.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia.
2022 Apr; 28(2):138-145. doi:
10.5761/atcs.oa.21-00132. [PMID: 34732600] - Kai-Wei Liao, Fang-Chi Chang, Chia-Huang Chang, Yu-Fang Huang, Wen-Harn Pan, Mei-Lien Chen. Associating acrylamide internal exposure with dietary pattern and health risk in the general population of Taiwan.
Food chemistry.
2022 Apr; 374(?):131653. doi:
10.1016/j.foodchem.2021.131653. [PMID: 34906800] - Jitender K Bhardwaj, Vijay Kumar, Priyanka Saraf, Harish Panchal, Vishavjeet Rathee, Som N Sachdeva. Efficacy of N-acetyl- l-cysteine against glyphosate induced oxidative stress and apoptosis in testicular germ cells preventing infertility.
Journal of biochemical and molecular toxicology.
2022 Apr; 36(4):e22979. doi:
10.1002/jbt.22979. [PMID: 34964212] - Jordana Grazziela A Coelho Dos Reis, Geovane Marques Ferreira, Alice Aparecida Lourenço, Ágata Lopes Ribeiro, Camila Pacheco da Silveira Martins da Mata, Patrícia de Melo Oliveira, Daisymara Priscila de Almeida Marques, Linziane Lopes Ferreira, Felipe Alves Clarindo, Murillo Ferreira da Silva, Heitor Portella Póvoas Filho, Nilson Roberto Ribeiro Oliveira, Maisah Meyhr D'Carmo Sodré, Sandra Rocha Gadelha, George Rego Albuquerque, Bianca Mendes Maciel, Ana Paula Melo Mariano, Mylene de Melo Silva, Renato Fontana, Lauro Juliano Marin, Renata Santiago Alberto Carlos, Amanda Teixeira Sampaio Lopes, Fabrício Barbosa Ferreira, Uener Ribeiro Dos Santos, Íris Terezinha Santos de Santana, Hllytchaikra Ferraz Fehlberg, Rachel Passos Rezende, João Carlos T Dias, Eduardo Gross, Gisele Assis Castro Goulart, Marie Gabriele Santiago, Ana Paula Motta Lavigne de Lemos, Aline O da Conceição, Carla Cristina Romano, Luciana Debortoli de Carvalho, Olindo Assis Martins Filho, Claudio Almeida Quadros, David L Morris, Sarah J Valle. Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 04; 148(?):112753. doi:
10.1016/j.biopha.2022.112753. [PMID: 35272139] - Ai Luo, Xuemei Liu, Qiongqiong Hu, Mei Yang, Hongli Jiang, Wei Liu. Efficacy of N-acetylcysteine on idiopathic or postinfective non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis protocol.
BMJ open.
2022 03; 12(3):e053625. doi:
10.1136/bmjopen-2021-053625. [PMID: 35361640] - Deepak Bhandari, Luyu Zhang, Wanzhe Zhu, Víctor R De Jesús, Benjamin C Blount. Optimal Cutoff Concentration of Urinary Cyanoethyl Mercapturic Acid for Differentiating Cigarette Smokers From Nonsmokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
2022 03; 24(5):761-767. doi:
10.1093/ntr/ntab224. [PMID: 34718769] - Zifang Ding, Xu Wang, Ning Zhang, Chen Sun, Guode Zhao, Ying Peng, Jiang Zheng. Metabolic Activation of Perampanel Mediated by CYP1A2.
Chemical research in toxicology.
2022 03; 35(3):490-498. doi:
10.1021/acs.chemrestox.1c00396. [PMID: 35200000] - Yen-Chuan Ou, Jian-Ri Li, Chih-Cheng Wu, Tung-Min Yu, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Yu-Fan Chen, Chun-Jung Chen. Cadmium induces the expression of Interleukin-6 through Heme Oxygenase-1 in HK-2 cells and Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Mar; 161(?):112846. doi:
10.1016/j.fct.2022.112846. [PMID: 35122928] - Christina Gade, Søren Bøgevig, Alaa Daoud, Pernille R Mathiesen, Mikkel B Chrstensen, Kim P Dalhoff, Tonny S Petersen. Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0-6 years.
Acta paediatrica (Oslo, Norway : 1992).
2022 Mar; 111(3):667-674. doi:
10.1111/apa.16185. [PMID: 34773285]