L-Valine, glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl- (BioDeep_00000838792)
代谢物信息卡片
化学式: C62H98N16O22 (1418.7041248)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(C(C)C)C(=O)O)NC(=O)CNC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C2CCCN2C(=O)C3CCCN3C(=O)C4CCCN4C(=O)C(CCC(=O)O)NC(=O)CN
InChI: InChI=1S/C62H98N16O22/c1-31(2)25-37(55(92)74-50(32(3)4)62(99)100)71-46(81)29-65-51(88)33(5)67-53(90)38(26-48(84)85)73-54(91)39(27-49(86)87)72-52(89)34(6)68-57(94)41-15-10-21-75(41)58(95)35(13-7-8-20-63)70-45(80)30-66-56(93)40-14-9-22-76(40)60(97)43-17-12-24-78(43)61(98)42-16-11-23-77(42)59(96)36(18-19-47(82)83)69-44(79)28-64/h31-43,50H,7-30,63-64H2,1-6H3,(H,65,88)(H,66,93)(H,67,90)(H,68,94)(H,69,79)(H,70,80)(H,71,81)(H,72,89)(H,73,91)(H,74,92)(H,82,83)(H,84,85)(H,86,87)(H,99,100)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,50-/m0/s1
描述信息
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
BPC 157 is a stable gastric pentadecapeptide and a partial sequence of the human gastric juice protein BPC. BPC 157 is an anti-ulcer peptidergic agent with no reported toxicity. BPC 157 links inflammatory bowel disease and multiple sclerosis[1][2].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 9941957
- DrugBank: DB11882
- ChEMBL: CHEMBL4297358
- CAS: 137525-51-0
- medchemexpress: HY-105174
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Bing-Shen Huang, Shih-Chiang Huang, Fang-Hsin Chen, Yu Chang, Hsiu-Fu Mei, Hsiu-Yun Huang, Wan-Yu Chen, Jong-Hwei Su Pang. Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro.
Life sciences.
2022 Dec; 310(?):121072. doi:
10.1016/j.lfs.2022.121072
. [PMID: 36228773] - Jakša Vukojević, Marko Siroglavić, Katarina Kašnik, Tamara Kralj, Duje Stanćić, Antonio Kokot, Darko Kolarić, Domagoj Drmić, Anita Zenko Sever, Ivan Barišić, Jelena Šuran, Davor Bojić, Masa Hrelec Patrlj, Ivica Sjekavica, Katarina Horvat Pavlov, Tinka Vidović, Josipa Vlainić, Mirjana Stupnišek, Sven Seiwerth, Predrag Sikirić. Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157.
Vascular pharmacology.
2018 07; 106(?):54-66. doi:
10.1016/j.vph.2018.02.010
. [PMID: 29510201] - Holly D Cox, Geoff D Miller, Daniel Eichner. Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H.
Drug testing and analysis.
2017 Oct; 9(10):1490-1498. doi:
10.1002/dta.2152
. [PMID: 28035768] - Domagoj Drmic, Danijela Kolenc, Spomenko Ilic, Lara Bauk, Marko Sever, Anita Zenko Sever, Kresimir Luetic, Jelena Suran, Sven Seiwerth, Predrag Sikiric. Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME.
World journal of gastroenterology.
2017 Aug; 23(29):5304-5312. doi:
10.3748/wjg.v23.i29.5304
. [PMID: 28839430] - Maria Medvidovic-Grubisic, Vasilije Stambolija, Danijela Kolenc, Jadranka Katancic, Tamara Murselovic, Ivna Plestina-Borjan, Sanja Strbe, Domagoj Drmic, Ivan Barisic, Aleksandra Sindic, Sven Seiwerth, Predrag Sikiric. Hypermagnesemia disturbances in rats, NO-related: pentadecapeptide BPC 157 abrogates, L-NAME and L-arginine worsen.
Inflammopharmacology.
2017 Aug; 25(4):439-449. doi:
10.1007/s10787-017-0323-6
. [PMID: 28210905] - Sven Seiwerth, Luka Brcic, Lovorka Batelja Vuletic, Danijela Kolenc, Gorana Aralica, Marija Misic, Anita Zenko, Domagoj Drmic, Rudolf Rucman, Predrag Sikiric. BPC 157 and blood vessels.
Current pharmaceutical design.
2014; 20(7):1121-5. doi:
10.2174/13816128113199990421
. [PMID: 23782145] - Spomenko Ilic, Domagoj Drmic, Sandra Franjic, Danijela Kolenc, Marijana Coric, Luka Brcic, Robert Klicek, Bozo Radic, Marko Sever, Viktor Djuzel, Marinko Filipovic, Zeljko Djakovic, Vasilije Stambolija, Alenka Boban Blagaic, Ivan Zoricic, Miroslav Gjurasin, Mirjana Stupnisek, Zeljko Romic, Kamelija Zarkovic, Senka Dzidic, Sven Seiwerth, Predrag Sikiric. Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions.
Life sciences.
2011 Mar; 88(11-12):535-42. doi:
10.1016/j.lfs.2011.01.015
. [PMID: 21295044] - S Ilic, D Drmic, K Zarkovic, D Kolenc, M Coric, L Brcic, R Klicek, B Radic, M Sever, V Djuzel, M Ivica, A Boban Blagaic, Z Zoricic, T Anic, I Zoricic, S Djidic, Z Romic, S Seiwerth, P Sikiric. High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2010 Apr; 61(2):241-50. doi:
NULL
. [PMID: 20436226] - B Keremi, Z Lohinai, P Komora, S Duhaj, K Borsi, G Jobbagy-Ovari, K Kallo, A D Szekely, A Fazekas, C Dobo-Nagy, P Sikiric, G Varga. Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2009 Dec; 60 Suppl 7(?):115-22. doi:
NULL
. [PMID: 20388954] - S Ilic, I Brcic, M Mester, M Filipovic, M Sever, R Klicek, I Barisic, B Radic, Z Zoricic, V Bilic, L Berkopic, L Brcic, D Kolenc, Z Romic, L Pazanin, S Seiwerth, P Sikiric. Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2009 Dec; 60 Suppl 7(?):107-14. doi:
NULL
. [PMID: 20388953] - Martina Lovric-Bencic, Predrag Sikiric, Jadranka S Hanzevacki, Sven Seiwerth, Dunja Rogic, Vesna Kusec, Gorana Aralica, Pasko Konjevoda, Lovorka Batelja, Alenka B Blagaic. Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse.
Journal of pharmacological sciences.
2004 May; 95(1):19-26. doi:
10.1254/jphs.95.19
. [PMID: 15153646] - M Staresinic, B Sebecic, L Patrlj, S Jadrijevic, S Suknaic, D Perovic, G Aralica, N Zarkovic, S Borovic, M Srdjak, K Hajdarevic, M Kopljar, L Batelja, A Boban-Blagaic, I Turcic, T Anic, S Seiwerth, P Sikiric. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2003 Nov; 21(6):976-83. doi:
10.1016/s0736-0266(03)00110-4
. [PMID: 14554208] - P Sikirić, S Seiwerth, Z Grabarević, R Rucman, M Petek, V Jagić, B Turković, I Rotkvić, S Mise, I Zoricić, L Jurina, P Konjevoda, M Hanzevacki, D Ljubanović, J Separović, M Gjurasin, M Bratulić, B Artuković, N Jelovac, G Buljat. Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats.
Digestive diseases and sciences.
1996 Jul; 41(7):1518-26. doi:
10.1007/bf02088582
. [PMID: 8689934] - P Sikiric, M Petek, R Rucman, S Seiwerth, Z Grabarević, I Rotkvić, V Jagić, B Turković, B Mildner, M Duvnjak. The significance of the gastroprotective effect of body protection compound (BPC): modulation by different procedures.
Acta physiologica Hungarica.
1992; 80(1-4):89-98. doi:
NULL
. [PMID: 1345210]