Apstatin (BioDeep_00000838785)
代谢物信息卡片
化学式: C23H33N5O5 (459.24815680000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)N)NC(=O)C1CCCN1C(=O)C2CCCN2C(=O)C(C(CC3=CC=CC=C3)N)O
InChI: InChI=1S/C23H33N5O5/c1-14(20(25)30)26-21(31)17-9-5-11-27(17)22(32)18-10-6-12-28(18)23(33)19(29)16(24)13-15-7-3-2-4-8-15/h2-4,7-8,14,16-19,29H,5-6,9-13,24H2,1H3,(H2,25,30)(H,26,31)/t14-,16+,17-,18-,19-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Rahul Singh, Sahayog N Jamdar, Venuka Durani Goyal, Ashwani Kumar, Biplab Ghosh, Ravindra D Makde. Structure of the human aminopeptidase XPNPEP3 and comparison of its in vitro activity with Icp55 orthologs: Insights into diverse cellular processes.
The Journal of biological chemistry.
2017 06; 292(24):10035-10047. doi:
10.1074/jbc.m117.783357
. [PMID: 28476889] - Karim Abid, Bertrand Rochat, Paul-Gerhard Lassahn, Reto Stöcklin, Sophie Michalet, Noureddine Brakch, Jean-Francois Aubert, Bilgin Vatansever, Patricia Tella, Ingrid De Meester, Eric Grouzmann. Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35: a new peptide generated by plasma kallikrein.
The Journal of biological chemistry.
2009 Sep; 284(37):24715-24. doi:
10.1074/jbc.m109.035253
. [PMID: 19620246] - Anthony C Sulpizio, Mark A Pullen, Richard M Edwards, James B Louttit, Rob West, David P Brooks. Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406.
The Journal of pharmacology and experimental therapeutics.
2005 Dec; 315(3):1306-13. doi:
10.1124/jpet.105.084749
. [PMID: 16144980] - K K Veeravalli, A Akula. Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction.
Pharmacological research.
2004 Jan; 49(1):23-9. doi:
10.1016/j.phrs.2003.07.010
. [PMID: 14597148] - K K Veeravalli, A Akula, K V Routhu, M K Kota. Infarct size limiting effect of apstatin alone and in combination with enalapril, lisinopril and ramipril in rats with experimental myocardial infarction.
Pharmacological research.
2003 Dec; 48(6):557-63. doi:
10.1016/s1043-6618(03)00222-6
. [PMID: 14527819] - Rory E Morty, Jennifer Morehead. Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species.
The Journal of biological chemistry.
2002 Jul; 277(29):26057-65. doi:
10.1074/jbc.m202779200
. [PMID: 12006595] - V Laurent, D R Brooks, D Coates, R E Isaac. Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans.
European journal of biochemistry.
2001 Oct; 268(20):5430-8. doi:
10.1046/j.0014-2956.2001.02483.x
. [PMID: 11606206] - L L Maggiora, A T Orawski, W H Simmons. Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme.
Journal of medicinal chemistry.
1999 Jul; 42(13):2394-402. doi:
10.1021/jm9805642
. [PMID: 10395480] - S Kitamura, L A Carbini, W H Simmons, A G Scicli. Effects of aminopeptidase P inhibition on kinin-mediated vasodepressor responses.
The American journal of physiology.
1999 05; 276(5):H1664-71. doi:
10.1152/ajpheart.1999.276.5.h1664
. [PMID: 10330252] - R J Hyde, N M Hooper, A J Turner. Molecular cloning and expression in COS-1 cells of pig kidney aminopeptidase P.
The Biochemical journal.
1996 Oct; 319 ( Pt 1)(?):197-201. doi:
10.1042/bj3190197
. [PMID: 8870669] - M C Chung, H J Lee, H K Chun, C H Lee, S I Kim, Y H Kho. Bestatin analogue from Streptomyces neyagawaensis SL-387.
Bioscience, biotechnology, and biochemistry.
1996 May; 60(5):898-900. doi:
10.1271/bbb.60.898
. [PMID: 8704320] - J Lim, A J Turner. Chemical modification of porcine kidney aminopeptidase P indicates the involvement of two critical histidine residues.
FEBS letters.
1996 Mar; 381(3):188-90. doi:
10.1016/0014-5793(96)00124-x
. [PMID: 8601452]