L-Eflornithine (BioDeep_00000838742)

   


代谢物信息卡片


L-Eflornithine

化学式: C6H12F2N2O2 (182.0867)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(C(F)F)(C(=O)O)N)CN
InChI: InChI=1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)/t6-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

L-Eflornithine



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yi He, Xian Zhang, Xing Zeng, Yu Huang, Jian-An Wei, Ling Han, Cai-Xia Li, Guo-Wei Zhang. HuR-mediated posttranscriptional regulation of p21 is involved in the effect of Glycyrrhiza uralensis licorice aqueous extract on polyamine-depleted intestinal crypt cells proliferation. The Journal of nutritional biochemistry. 2012 Oct; 23(10):1285-93. doi: 10.1016/j.jnutbio.2011.07.009. [PMID: 22217517]
  • Ikumi Ishii, Yoshihiko Ikeguchi, Hiroshi Mano, Masahiro Wada, Anthony E Pegg, Akira Shirahata. Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino acids. 2012 Feb; 42(2-3):619-26. doi: 10.1007/s00726-011-1037-5. [PMID: 21809076]
  • Kuniyasu Soda. The mechanisms by which polyamines accelerate tumor spread. Journal of experimental & clinical cancer research : CR. 2011 Oct; 30(?):95. doi: 10.1186/1756-9966-30-95. [PMID: 21988863]
  • Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS neglected tropical diseases. 2011 Jun; 5(6):e1151. doi: 10.1371/journal.pntd.0001151. [PMID: 21738803]
  • Can Hu, Ru-Liu Li, Wen-Biao Lu, Yan-Qun Yang, Jing Wang, Wei-Wen Chen. Studies on cell migration model in intestinal epithelial restitution for pharmacological research. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 May; 34(5):738-46. doi: NULL. [PMID: 21954562]
  • Theunis T Cloete, Carl C Johansson, David D N'Da, Suman Kumar Vodnala, Martin E Rottenberg, Jaco C Breytenbach, Michael Ashton. Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma. Arzneimittel-Forschung. 2011; 61(5):317-25. doi: 10.1055/s-0031-1296205. [PMID: 21755816]
  • Uriel Bachrach. The early history of polyamine research. Plant physiology and biochemistry : PPB. 2010 Jul; 48(7):490-5. doi: 10.1016/j.plaphy.2010.02.003. [PMID: 20219382]
  • Susanna Vuohelainen, Eija Pirinen, Marc Cerrada-Gimenez, Tuomo A Keinänen, Anne Uimari, Marko Pietilä, Alex R Khomutov, Juhani Jänne, Leena Alhonen. Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. Journal of cellular and molecular medicine. 2010 Jun; 14(6B):1683-92. doi: 10.1111/j.1582-4934.2009.00808.x. [PMID: 19538475]
  • Patrick Y K Yue, Emily P Y Leung, N K Mak, Ricky N S Wong. A simplified method for quantifying cell migration/wound healing in 96-well plates. Journal of biomolecular screening. 2010 Apr; 15(4):427-33. doi: 10.1177/1087057110361772. [PMID: 20208035]
  • Ying Wang, Jian-Ping Luo, Hu-Qi Wu, Hong Jin. Conversion of protocorm-like bodies of Dendrobium huoshanense to shoots: the role of polyamines in relation to the ratio of total cytokinins and indole-3-acetic acid. Journal of plant physiology. 2009 Dec; 166(18):2013-22. doi: 10.1016/j.jplph.2009.06.008. [PMID: 19625103]
  • Xiao-Ba Wu, Jing Wang, Ji-Hong Liu, Xiu-Xin Deng. Involvement of polyamine biosynthesis in somatic embryogenesis of Valencia sweet orange (Citrus sinensis) induced by glycerol. Journal of plant physiology. 2009 Jan; 166(1):52-62. doi: 10.1016/j.jplph.2008.02.005. [PMID: 18448195]
  • K Oikonomopoulou, L Li, Y Zheng, I Simon, R L Wolfert, D Valik, M Nekulova, M Simickova, T Frgala, E P Diamandis. Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel. British journal of cancer. 2008 Oct; 99(7):1103-13. doi: 10.1038/sj.bjc.6604630. [PMID: 18766180]
  • Carlos López-García, Andrés Joaquín López-Contreras, Asunción Cremades, Maria Teresa Castells, Faustino Marín, Fernanda Schreiber, Rafael Peñafiel. Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. Endocrinology. 2008 Oct; 149(10):5012-23. doi: 10.1210/en.2008-0084. [PMID: 18583422]
  • R Jansson, M Malm, C Roth, M Ashton. Enantioselective and nonlinear intestinal absorption of eflornithine in the rat. Antimicrobial agents and chemotherapy. 2008 Aug; 52(8):2842-8. doi: 10.1128/aac.00050-08. [PMID: 18519728]
  • Andrés Gárriz, María E Gonzalez, María Marina, Oscar A Ruiz, Fernando L Pieckenstain. Polyamine metabolism during sclerotial development of Sclerotinia sclerotiorum. Mycological research. 2008 Mar; 112(Pt 3):414-22. doi: 10.1016/j.mycres.2007.10.016. [PMID: 18308526]
  • Carmen M Bastida, Asunción Cremades, Maria T Castells, Andrés J López-Contreras, Carlos López-García, Jesús Sánchez-Mas, Rafael Peñafiel. Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels. American journal of physiology. Endocrinology and metabolism. 2007 Apr; 292(4):E1010-7. doi: 10.1152/ajpendo.00316.2006. [PMID: 17148758]
  • Ildikó Loikkanen, Yanfeng Lin, Antti Railo, Antti Pajunen, Seppo Vainio. Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes. Differentiation; research in biological diversity. 2005 Jul; 73(6):303-12. doi: 10.1111/j.1432-0436.2005.00036.x. [PMID: 16138831]
  • Neil Ashman, Steven M Harwood, Julius Kieswich, David A Allen, Norman B Roberts, A Claudio Mendes-Ribeiro, Muhammad M Yaqoob. Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells. Kidney international. 2005 May; 67(5):1878-89. doi: 10.1111/j.1523-1755.2005.00286.x. [PMID: 15840035]
  • Yu-Jin Hao, Hiroyasu Kitashiba, Chikako Honda, Kazuyoshi Nada, Takaya Moriguchi. Expression of arginine decarboxylase and ornithine decarboxylase genes in apple cells and stressed shoots. Journal of experimental botany. 2005 Apr; 56(414):1105-15. doi: 10.1093/jxb/eri102. [PMID: 15723827]
  • Carmen M Bastida, Asunción Cremades, Maria T Castells, Andrés J López-Contreras, Carlos López-García, Francisco Tejada, Rafael Peñafiel. Influence of ovarian ornithine decarboxylase in folliculogenesis and luteinization. Endocrinology. 2005 Feb; 146(2):666-74. doi: 10.1210/en.2004-1004. [PMID: 15514084]
  • Rosa María Reguera, Babu L Tekwani, Rafael Balaña-Fouce. Polyamine transport in parasites: a potential target for new antiparasitic drug development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2005 Feb; 140(2):151-64. doi: 10.1016/j.cca.2005.02.006. [PMID: 15907761]
  • Lan Liu, Li Li, Jaladanki N Rao, Tongtong Zou, Huifang M Zhang, Dessy Boneva, Marasa S Bernard, Jian-Ying Wang. Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation. American journal of physiology. Cell physiology. 2005 Jan; 288(1):C89-99. doi: 10.1152/ajpcell.00326.2004. [PMID: 15355849]
  • Rahul Shah, Catherine S Coleman, Kiran Mir, Jeffrey Baldwin, James L Van Etten, Nick V Grishin, Anthony E Pegg, Bruce A Stanley, Margaret A Phillips. Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases. The Journal of biological chemistry. 2004 Aug; 279(34):35760-7. doi: 10.1074/jbc.m405366200. [PMID: 15190062]
  • Analía I Sannazzaro, Cora L Alvarez, Ana B Menéndez, Fernando L Pieckenstain, Edgardo O Albertó, Oscar A Ruiz. Ornithine and arginine decarboxylase activities and effect of some polyamine biosynthesis inhibitors on Gigaspora rosea germinating spores. FEMS microbiology letters. 2004 Jan; 230(1):115-21. doi: 10.1016/s0378-1097(03)00880-2. [PMID: 14734173]
  • Hiroshi Yoda, Yube Yamaguchi, Hiroshi Sano. Induction of hypersensitive cell death by hydrogen peroxide produced through polyamine degradation in tobacco plants. Plant physiology. 2003 Aug; 132(4):1973-81. doi: 10.1104/pp.103.024737. [PMID: 12913153]
  • Mariano Fos, Karina Proaño, David Alabadí, Fernando Nuez, Juan Carbonell, José L García-Martínez. Polyamine metabolism is altered in unpollinated parthenocarpic pat-2 tomato ovaries. Plant physiology. 2003 Jan; 131(1):359-66. doi: 10.1104/pp.013037. [PMID: 12529543]
  • Yihuai Gao, Shufeng Zhou, Jianbo Wen, Min Huang, Anlong Xu. Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat. Life sciences. 2002 Dec; 72(6):731-45. doi: 10.1016/s0024-3205(02)02301-9. [PMID: 12467913]
  • Carol J Fabian, Bruce F Kimler, Deborah A Brady, Matthew S Mayo, C H Joseph Chang, John A Ferraro, Carola M Zalles, Annette L Stanton, Shahla Masood, William E Grizzle, Norman F Boyd, Dora W Arneson, Karen A Johnson. A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 Oct; 8(10):3105-17. doi: . [PMID: 12374678]
  • Carmen M Bastida, Francisco Tejada, Asunción Cremades, Rafael Peñafiel. The preovulatory rise of ovarian ornithine decarboxylase is required for progesterone secretion by the corpus luteum. Biochemical and biophysical research communications. 2002 Apr; 293(1):106-11. doi: 10.1016/s0006-291x(02)00191-2. [PMID: 12054570]
  • Zili Zhang, Weiwen Chen. Plating densities, alpha-difluoromethylornithine effects and time dependence on the proliferation of IEC-6 cells. Chinese medical journal. 2002 Apr; 115(4):518-20. doi: ". [PMID: 12133287]
  • Y N Ye, E S Liu, V Y Shin, M W Koo, Y Li, E Q Wei, H Matsui, C H Cho. A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line. Biochemical pharmacology. 2001 Jun; 61(11):1439-48. doi: 10.1016/s0006-2952(01)00625-6. [PMID: 11331080]