Glycyl-prolyl-glutamic acid (BioDeep_00000838717)

   


代谢物信息卡片


Glycyl-prolyl-glutamic acid

化学式: C12H19N3O6 (301.1273794)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(N(C1)C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1

描述信息

Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection [1][2].

同义名列表

2 个代谢物同义名

Glycyl-prolyl-glutamic acid; Gly-Pro-Glu



数据库引用编号

6 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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文献列表

  • Lisa Marinelli, Erika Fornasari, Antonio Di Stefano, Hasan Turkez, Salvatore Genovese, Francesco Epifano, Giuseppe Di Biase, Erica Costantini, Chiara D'Angelo, Marcella Reale, Ivana Cacciatore. Synthesis and biological evaluation of novel analogues of Gly-l-Pro-l-Glu (GPE) as neuroprotective agents. Bioorganic & medicinal chemistry letters. 2019 01; 29(2):194-198. doi: 10.1016/j.bmcl.2018.11.057. [PMID: 30522955]
  • Jian Guan, Peter D Gluckman. IGF-1 derived small neuropeptides and analogues: a novel strategy for the development of pharmaceuticals for neurological conditions. British journal of pharmacology. 2009 Jul; 157(6):881-91. doi: 10.1111/j.1476-5381.2009.00256.x. [PMID: 19438508]
  • Jian Guan. Insulin-like growth factor-1 and its derivatives: potential pharmaceutical application for ischemic brain injury. Recent patents on CNS drug discovery. 2008 Jun; 3(2):112-27. doi: 10.2174/157488908784534630. [PMID: 18537771]
  • A M Baker, D C Batchelor, G B Thomas, J Y Wen, M Rafiee, H Lin, J Guan. Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat. Neuropeptides. 2005 Apr; 39(2):81-7. doi: 10.1016/j.npep.2004.11.001. [PMID: 15752541]
  • D C Batchelor, H Lin, J-Y Wen, C Keven, P L Van Zijl, B H Breier, P D Gluckman, G B Thomas. Pharmacokinetics of glycine-proline-glutamate, the N-terminal tripeptide of insulin-like growth factor-1, in rats. Analytical biochemistry. 2003 Dec; 323(2):156-63. doi: 10.1016/j.ab.2003.08.032. [PMID: 14656520]