Ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate (BioDeep_00000838448)
代谢物信息卡片
Ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate
化学式: C20H24ClN3O4S (437.1175974000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)N1CCC(C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]
InChI: InChI=1S/C20H24ClN3O4S/c1-2-28-20(25)23-10-9-16(13-23)12-22(11-15-3-5-17(21)6-4-15)14-18-7-8-19(29-18)24(26)27/h3-8,16H,2,9-14H2,1H3
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nuria Saiz, Lisbeth Herrera-Castillo, Esther Isorna, María Jesús Delgado, Marta Conde-Sieira, José Luis Soengas, Nuria de Pedro. REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23062921. [PMID: 35328345] - Charlotte Cutler, Daniel Leigh White, Marjaana Viljanto. In vitro metabolism of the REV-ERB agonist SR-9009 and subsequent detection of metabolites in associated routine equine plasma and urine doping control samples.
Drug testing and analysis.
2022 Jan; 14(1):169-174. doi:
10.1002/dta.3124. [PMID: 34224639] - Mio Iijima, Shota Takemi, Sayaka Aizawa, Takafumi Sakai, Ichiro Sakata. The suppressive effect of REVERBs on ghrelin and GOAT transcription in gastric ghrelin-producing cells.
Neuropeptides.
2021 Dec; 90(?):102187. doi:
10.1016/j.npep.2021.102187. [PMID: 34450431] - Fangjun Yu, Zhigang Wang, Tianpeng Zhang, Xun Chen, Haiman Xu, Fei Wang, Lianxia Guo, Min Chen, Kaisheng Liu, Baojian Wu. Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Nature communications.
2021 09; 12(1):5323. doi:
10.1038/s41467-021-25674-5. [PMID: 34493722] - Zhihong Yang, Rana V Smalling, Yi Huang, Yanchao Jiang, Praveen Kusumanchi, Will Bogaert, Li Wang, Don A Delker, Nicholas J Skill, Sen Han, Ting Zhang, Jing Ma, Nazmul Huda, Suthat Liangpunsakul. The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease.
JCI insight.
2021 08; 6(16):. doi:
10.1172/jci.insight.140687. [PMID: 34423788] - Yinhua Ni, Yufeng Zhao, Lingyan Ma, Zhe Wang, Liyang Ni, Luting Hu, Zhengwei Fu. Pharmacological activation of REV-ERBα improves nonalcoholic steatohepatitis by regulating intestinal permeability.
Metabolism: clinical and experimental.
2021 01; 114(?):154409. doi:
10.1016/j.metabol.2020.154409. [PMID: 33096076] - Yanke Lin, Luomin Lin, Lu Gao, Shuai Wang, Baojian Wu. Rev-erbα regulates hepatic ischemia-reperfusion injury in mice.
Biochemical and biophysical research communications.
2020 09; 529(4):916-921. doi:
10.1016/j.bbrc.2020.06.152. [PMID: 32819599] - Joan Chang, Richa Garva, Adam Pickard, Ching-Yan Chloé Yeung, Venkatesh Mallikarjun, Joe Swift, David F Holmes, Ben Calverley, Yinhui Lu, Antony Adamson, Helena Raymond-Hayling, Oliver Jensen, Tom Shearer, Qing Jun Meng, Karl E Kadler. Circadian control of the secretory pathway maintains collagen homeostasis.
Nature cell biology.
2020 01; 22(1):74-86. doi:
10.1038/s41556-019-0441-z. [PMID: 31907414] - Xue Yuan, Dong Dong, Zhijie Li, Baojian Wu. Rev-erbα activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice.
Pharmacological research.
2019 03; 141(?):310-318. doi:
10.1016/j.phrs.2019.01.010. [PMID: 30639375] - Monica Mazzarino, Nikla Rizzato, Carlotta Stacchini, Xavier de la Torre, Francesco Botrè. A further insight into the metabolic profile of the nuclear receptor Rev-erb agonist, SR9009.
Drug testing and analysis.
2018 Nov; 10(11-12):1670-1681. doi:
10.1002/dta.2538. [PMID: 30395700] - Chao Song, Peng Tan, Zheng Zhang, Wei Wu, Yonghui Dong, Liming Zhao, Huiyong Liu, Hanfeng Guan, Feng Li. REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 06; 32(6):3215-3228. doi:
10.1096/fj.201600825rrr. [PMID: 29401617] - Benoit Pourcet, Mathilde Zecchin, Lise Ferri, Justine Beauchamp, Sadicha Sitaula, Cyrielle Billon, Stéphane Delhaye, Jonathan Vanhoutte, Alicia Mayeuf-Louchart, Quentin Thorel, Joel T Haas, Jérome Eeckhoute, David Dombrowicz, Christian Duhem, Alexis Boulinguiez, Steve Lancel, Yasmine Sebti, Thomas P Burris, Bart Staels, Hélène M Duez. Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.
Gastroenterology.
2018 04; 154(5):1449-1464.e20. doi:
10.1053/j.gastro.2017.12.019. [PMID: 29277561] - Endin Nokik Stujanna, Nobuyuki Murakoshi, Kazuko Tajiri, DongZhu Xu, Taizo Kimura, Rujie Qin, Duo Feng, Saori Yonebayashi, Yukino Ogura, Fumi Yamagami, Akira Sato, Akihiko Nogami, Kazutaka Aonuma. Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism.
PloS one.
2017; 12(12):e0189330. doi:
10.1371/journal.pone.0189330. [PMID: 29232411] - Lore Geldof, Koen Deventer, Kris Roels, Eva Tudela, Peter Van Eeno. In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011.
International journal of molecular sciences.
2016 Oct; 17(10):. doi:
10.3390/ijms17101676. [PMID: 27706103] - Joseph Bass. Drug discovery: Time in a bottle.
Nature.
2012 May; 485(7396):45-6. doi:
10.1038/485045a. [PMID: 22552089]