Antineoplaston A10 (BioDeep_00000838430)
PANOMIX_OTCML-2023
代谢物信息卡片
Antineoplaston A10
化学式: C13H14N2O3 (246.1004)
中文名称:
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 93.24%
分子结构信息
SMILES: C1CC(=O)NC(=O)C1NC(=O)CC2=CC=CC=C2
InChI: InChI=1S/C13H14N2O3/c16-11-7-6-10(13(18)15-11)14-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,14,17)(H,15,16,18)/t10-/m0/s1
描述信息
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer[1].
Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer[1].
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 56260
- DrugBank: DB11702
- ChEMBL: CHEMBL1980825
- CAS: 91531-30-5
- medchemexpress: HY-128553
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Li Yang, Hongjun Li, Han Wu, Shunyun Liu, Zhifei He. Staphylococcus inoculation enhances the sensorial attributes of Chinese bacon by coordinating the composition of flavor compounds through amino acid metabolism.
Food research international (Ottawa, Ont.).
2024 Feb; 178(?):113936. doi:
10.1016/j.foodres.2024.113936. [PMID: 38309865] - Seung-Ah Lee, Soon Jun Hong, Jung-Hoon Sung, Kyung-Soo Kim, Seong Hwan Kim, Jin Man Cho, Sung Wan Chun, Sang Rok Lee, Chul Sik Kim, Tae Nyun Kim, Dae Hyeok Kim, Hwan-Cheol Park, Byung Jin Kim, Hyun-Sook Kim, Ji-Yong Choi, Young Joon Hong, Joong Wha Chung, Seong Bo Yoon, Sang-Hak Lee, Cheol Whan Lee. Effectiveness of low-intensity atorvastatin 5 mg and ezetimibe 10 mg combination therapy compared with moderate-intensity atorvastatin 10 mg monotherapy: A randomized, double-blinded, multi-center, phase III study.
Medicine.
2023 Nov; 102(47):e36122. doi:
10.1097/md.0000000000036122. [PMID: 38013289] - Lichun Chang, Jianli Liang, Li Zhang, Zhicheng Zhang, Xu Cai, Jian Wu, Xiaowu Wang. A complex locus regulates highly lobed-leaf formation in Brassica juncea.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.
2023 Oct; 136(11):224. doi:
10.1007/s00122-023-04473-0. [PMID: 37845510] - Xin Liu, Hanyu Zhu, Mei Wang, Ning Zhang, Jing Wang, Wenbian Tan, Guochuan Wu, Pei Yu, Hongbo Liu, Qiliang Liu. An enterovirus A71 virus-like particle with replaced loops confers partial cross-protection in mice.
Virus research.
2023 Oct; 337(?):199235. doi:
10.1016/j.virusres.2023.199235. [PMID: 37788720] - C T Nihranz, I A Guzchenko, C L Casteel. Silencing ZmPP2C-A10 with a foxtail mosaic virus (FoMV) derived vector benefits maize growth and development following water limitation.
Plant biology (Stuttgart, Germany).
2023 Oct; 25(6):956-964. doi:
10.1111/plb.13568. [PMID: 37658795] - Yu Shi, Lan-Tu Xiong, Hui Li, Wen-Long Li, Dylan O'Neill Rothenberg, Li-Sheng Liao, Xin Deng, Gao-Peng Song, Zi-Ning Cui. Derivative of cinnamic acid inhibits T3SS of Xanthomonas oryzae pv. oryzae through the HrpG-HrpX regulatory cascade.
Bioorganic chemistry.
2023 Sep; 141(?):106871. doi:
10.1016/j.bioorg.2023.106871. [PMID: 37734193] - Yu Cao, Florian Kümmel, Elke Logemann, Jan M Gebauer, Aaron W Lawson, Dongli Yu, Matthias Uthoff, Beat Keller, Jan Jirschitzka, Ulrich Baumann, Kenichi Tsuda, Jijie Chai, Paul Schulze-Lefert. Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors.
Proceedings of the National Academy of Sciences of the United States of America.
2023 08; 120(32):e2307604120. doi:
10.1073/pnas.2307604120. [PMID: 37523523] - Yaiza Gara Padilla, Ramón Gisbert-Mullor, Eduardo Bueso, Leilei Zhang, Javier Forment, Luigi Lucini, Salvador López-Galarza, Ángeles Calatayud. New insights into short-term water stress tolerance through transcriptomic and metabolomic analyses on pepper roots.
Plant science : an international journal of experimental plant biology.
2023 May; 333(?):111731. doi:
10.1016/j.plantsci.2023.111731. [PMID: 37196901] - Hao Niu, Meng Kuang, Longyu Huang, Haihong Shang, Youlu Yuan, Qun Ge. Lint percentage and boll weight QTLs in three excellent upland cotton (Gossypium hirsutum): ZR014121, CCRI60, and EZ60.
BMC plant biology.
2023 Apr; 23(1):179. doi:
10.1186/s12870-023-04147-5. [PMID: 37020180] - Sombir Rao, Apoorva Gupta, Chandni Bansal, Celine Sorin, Martin Crespi, Saloni Mathur. A conserved HSF:miR169:NF-YA loop involved in tomato and Arabidopsis heat stress tolerance.
The Plant journal : for cell and molecular biology.
2022 10; 112(1):7-26. doi:
10.1111/tpj.15963. [PMID: 36050841] - Mariem Samet, Imen Ghazala, Fatma Karray, Cyrine Abid, Nour Chiab, Oumèma Nouri-Ellouz, Sami Sayadi, Radhia Gargouri-Bouzid. Isolation of bacterial strains from compost teas and screening of their PGPR properties on potato plants.
Environmental science and pollution research international.
2022 Oct; 29(50):75365-75379. doi:
10.1007/s11356-022-21046-8. [PMID: 35653020] - Shun Feng, Pan Dong, Liang Jin, Zhengguo Li. Complete Genome Sequence Data of a Newly Isolated Streptomyces violascens Strain A10, a Potential Biological Control Agent for Fungal and Oomycete Diseases.
Plant disease.
2022 09; 106(9):2498-2501. doi:
10.1094/pdis-11-21-2561-a. [PMID: 35895328] - Hong Zhao, Ting Yang, Lei Yue, Hua Li, Tianhong Xie, Hong Xiang, Jie Wang, Xingchen Wei, Yuhao Zhang, Zhongping Xie. Comparative analysis of the biological characteristics of three CV-A10 clones adaptively cultured on Vero cells.
Journal of medical virology.
2022 Aug; 94(8):3820-3828. doi:
10.1002/jmv.27796. [PMID: 35437759] - Yaqian Huo, Jinghuan Yang, Pei Liu, Bopei Cui, Chenfei Wang, Siyuan Liu, Fangyu Dong, Xujia Yan, Lianlian Bian, Fan Gao, Xing Wu, Jiuyue Zhou, Tong Cheng, Xiuling Li, Qunying Mao, Zhenglun Liang. Evaluation of the cross-neutralization activities elicited by Coxsackievirus A10 vaccine strains.
Human vaccines & immunotherapeutics.
2021 12; 17(12):5334-5347. doi:
10.1080/21645515.2021.1978792. [PMID: 34756160] - Shuai Yin, Ming Wan, Chaocheng Guo, Bo Wang, Haitao Li, Ge Li, Yanyong Tian, Xianhong Ge, Graham J King, Kede Liu, Zaiyun Li, Jing Wang. Transposon insertions within alleles of BnaFLC.A10 and BnaFLC.A2 are associated with seasonal crop type in rapeseed.
Journal of experimental botany.
2020 08; 71(16):4729-4741. doi:
10.1093/jxb/eraa237. [PMID: 32417916] - Hidemichi Kihara, David M Kim, Masazumi Nagai, Toshiki Nojiri, Shigemi Nagai, Chia-Yu Chen, Cliff Lee, Wataru Hatakeyama, Hisatomo Kondo, John Da Silva. Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface.
International journal of oral science.
2018 07; 10(3):21. doi:
10.1038/s41368-018-0022-1. [PMID: 29961761] - Yutaka Ogata, Keiko Matono, Hideaki Tsuda, Masataka Ushijima, Shinji Uchida, Yoshito Akagi, Kazuo Shirouzu. Randomized phase II study of 5-fluorouracil hepatic arterial infusion with or without antineoplastons as an adjuvant therapy after hepatectomy for liver metastases from colorectal cancer.
PloS one.
2015; 10(3):e0120064. doi:
10.1371/journal.pone.0120064. [PMID: 25790229] - A Ra Kim, Seung Won Shin, Seung-Woo Cho, Joo Young Lee, Dong-Ik Kim, Soong Ho Um. A light-driven anti-cancer dual-therapeutic cassette enhances solid tumour regression.
Advanced healthcare materials.
2013 Sep; 2(9):1252-8. doi:
10.1002/adhm.201200471. [PMID: 23495231] - F Badria, M Mabed, M El-Awadi, L Abou-Zeid, E Al-Nashar, S Hawas. Immune modulatory potentials of antineoplaston A-10 in breast cancer patients.
Cancer letters.
2000 Aug; 157(1):57-63. doi:
10.1016/s0304-3835(00)00472-9. [PMID: 10893443] - F Badria, M Mabed, W Khafagy, L Abou-Zeid. Potential utility of antineoplaston A-10 levels in breast cancer.
Cancer letters.
2000 Jul; 155(1):67-70. doi:
10.1016/s0304-3835(00)00408-0. [PMID: 10814881] - J C Buckner, M G Malkin, E Reed, T L Cascino, J M Reid, M M Ames, W P Tong, S Lim, W D Figg. Phase II study of antineoplastons A10 (NSC 648539) and AS2-1 (NSC 620261) in patients with recurrent glioma.
Mayo Clinic proceedings.
1999 Feb; 74(2):137-45. doi:
10.4065/74.2.137. [PMID: 10069350] - W Xu, H Wang, Y Yuan. Pharmacokinetic study of radioactive antineoplaston A10 in rats and mice.
Drugs under experimental and clinical research.
1990; 16(7):351-5. doi:
NULL. [PMID: 2092961] - L B Hendry, T G Muldoon. Actions of an endogenous antitumorigenic agent on mammary tumor development and modeling analysis of its capacity for interacting with DNA.
Journal of steroid biochemistry.
1988; 30(1-6):325-8. doi:
10.1016/0022-4731(88)90116-1. [PMID: 3133525] - M C Liau, M Szopa, B Burzynski, S R Burzynski. Chemo-surveillance: a novel concept of the natural defence mechanism against cancer.
Drugs under experimental and clinical research.
1987; 13 Suppl 1(?):71-6. doi:
NULL. [PMID: 3569019] - A Q Ashraf, M C Liau, B N Kampalath, S R Burzynski. Pharmacokinetic study of radioactive antineoplaston A10 following oral administration in rats.
Drugs under experimental and clinical research.
1987; 13 Suppl 1(?):45-50. doi:
NULL. [PMID: 3569015] - B N Kampalath, M C Liau, B Burzynski, S R Burzynski. Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia.
Drugs under experimental and clinical research.
1987; 13 Suppl 1(?):51-5. doi:
NULL. [PMID: 3569016] - L B Hendry, T G Muldoon, S R Burzynski, J A Copland, A F Lehner. Stereochemical modelling studies of the interaction of antineoplaston A10 with DNA.
Drugs under experimental and clinical research.
1987; 13 Suppl 1(?):77-81. doi:
NULL. [PMID: 3569020] - M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.
Cancer treatment reports.
1979 Sep; 63(9-10):1663-7. doi:
. [PMID: 91435]
