Elamipretide (BioDeep_00000838388)
代谢物信息卡片
Elamipretide
化学式: C32H49N9O5 (639.3856463999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=CC(=C1CC(C(=O)NC(CCCCN)C(=O)NC(CC2=CC=CC=C2)C(=O)N)NC(=O)C(CCCN=C(N)N)N)C)O
InChI: InChI=1S/C32H49N9O5/c1-19-15-22(42)16-20(2)23(19)18-27(41-29(44)24(34)11-8-14-38-32(36)37)31(46)39-25(12-6-7-13-33)30(45)40-26(28(35)43)17-21-9-4-3-5-10-21/h3-5,9-10,15-16,24-27,42H,6-8,11-14,17-18,33-34H2,1-2H3,(H2,35,43)(H,39,46)(H,40,45)(H,41,44)(H4,36,37,38)/t24-,25+,26+,27+/m1/s1
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D10925
- KEGGdrug: D78262
- PubChem: 11764719
- DrugBank: DB11981
- ChEMBL: CHEMBL3833370
- CAS: 736992-21-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Silvia Russo, Domenico De Rasmo, Anna Signorile, Angela Corcelli, Simona Lobasso. Beneficial effects of SS-31 peptide on cardiac mitochondrial dysfunction in tafazzin knockdown mice.
Scientific reports.
2022 11; 12(1):19847. doi:
10.1038/s41598-022-24231-4. [PMID: 36400945] - Nastaran Daneshgar, Peir-In Liang, Renny S Lan, McKenna M Horstmann, Lindsay Pack, Gourav Bhardwaj, Christie M Penniman, Brian T O'Neill, Dao-Fu Dai. Elamipretide treatment during pregnancy ameliorates the progression of polycystic kidney disease in maternal and neonatal mice with PKD1 mutations.
Kidney international.
2022 05; 101(5):906-911. doi:
10.1016/j.kint.2021.12.006. [PMID: 34953771] - Stuart J Shankland, Yuliang Wang, Andrey S Shaw, Joshua C Vaughan, Jeffrey W Pippin, Oliver Wessely. Podocyte Aging: Why and How Getting Old Matters.
Journal of the American Society of Nephrology : JASN.
2021 11; 32(11):2697-2713. doi:
10.1681/asn.2021050614. [PMID: 34716239] - Jasvinder Singh Bhatti, Kavya Tamarai, Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Bhagavathi Ramasubramanian, Neha Sawant, Jangampalli Adi Pradeepkiran, Murali Vijayan, Subodh Kumar, P Hemachandra Reddy. Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice.
Mitochondrion.
2021 05; 58(?):49-58. doi:
10.1016/j.mito.2021.02.007. [PMID: 33639273] - Jasvinder Singh Bhatti, Kavya Thamarai, Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Subodh Kumar, Murali Vijayan, P Hemachandra Reddy. Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice.
Molecular neurobiology.
2021 Feb; 58(2):795-808. doi:
10.1007/s12035-020-02142-7. [PMID: 33025510] - Shi-Kun Yang, Ya-Chun Han, Jin-Rong He, Ming Yang, Wei Zhang, Ming Zhan, Ai-Mei Li, Liu Li, Na-Song, Yu-Ting Liu, Xue-Qin Wu, Qin Zhang, Jian-Wen Wang, Hao Zhang. Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110521. doi:
10.1016/j.biopha.2020.110521. [PMID: 32717631] - Hongwei Bai, Yingchun Zhang, Shan Tian, Rui Hu, Yu Liang, Jiangang Gao, Yunshan Wang, Bin Wu. Elamipretide as a potential candidate for relieving cryodamage to human spermatozoa during cryopreservation.
Cryobiology.
2020 08; 95(?):138-142. doi:
10.1016/j.cryobiol.2020.03.011. [PMID: 32240641] - Satoshi Miyamoto, Guanshi Zhang, David Hall, Peter J Oates, Soumya Maity, Muniswamy Madesh, Xianlin Han, Kumar Sharma. Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease.
The Journal of biological chemistry.
2020 05; 295(21):7249-7260. doi:
10.1074/jbc.ra119.011110. [PMID: 32277051] - Wayne Mitchell, Emily A Ng, Jeffrey D Tamucci, Kevin J Boyd, Murugappan Sathappa, Adrian Coscia, Meixia Pan, Xianlin Han, Nicholas A Eddy, Eric R May, Hazel H Szeto, Nathan N Alder. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action.
The Journal of biological chemistry.
2020 05; 295(21):7452-7469. doi:
10.1074/jbc.ra119.012094. [PMID: 32273339] - Marcus Hortmann, Samuel Robinson, Moritz Mohr, Maximillian Mauler, Daniela Stallmann, Jochen Reinöhl, Daniel Duerschmied, Karlheinz Peter, James Carr, C Michael Gibson, Christoph Bode, Ingo Ahrens. The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction.
European heart journal. Acute cardiovascular care.
2019 Dec; 8(8):695-702. doi:
10.1177/2048872617710789. [PMID: 28534645] - Di Liu, Feiyang Jin, Gaofeng Shu, Xiaoling Xu, Jing Qi, Xuqi Kang, Hui Yu, Kongjun Lu, Saiping Jiang, Feng Han, Jian You, Yongzhong Du, Jiansong Ji. Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes.
Biomaterials.
2019 08; 211(?):57-67. doi:
10.1016/j.biomaterials.2019.04.034. [PMID: 31085359] - Li-Hong Zhang, Xiang-Yang Zhu, Alfonso Eirin, Arash Aghajani Nargesi, John R Woollard, Adrian Santelli, In O Sun, Stephen C Textor, Lilach O Lerman. Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria.
American journal of physiology. Renal physiology.
2019 07; 317(7):F12-F22. doi:
10.1152/ajprenal.00399.2018. [PMID: 31042059] - Shi-Kun Yang, Ai-Mei Li, Ya-Chun Han, Can-Hui Peng, Na Song, Ming Yang, Ming Zhan, Ling-Feng Zeng, Pan-Ai Song, Wei Zhang, Shi-Qi Tang, Hao Zhang. Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice.
Oxidative medicine and cellular longevity.
2019; 2019(?):2346580. doi:
10.1155/2019/2346580. [PMID: 31281569] - Seo Rin Kim, Alfonso Eirin, Xin Zhang, Amir Lerman, Lilach O Lerman. Mitochondrial Protection Partly Mitigates Kidney Cellular Senescence in Swine Atherosclerotic Renal Artery Stenosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 52(3):617-632. doi:
10.33594/000000044. [PMID: 30907989] - Alfonso Eirin, Ahmad F Hedayat, Christopher M Ferguson, Stephen C Textor, Amir Lerman, Lilach O Lerman. Mitoprotection preserves the renal vasculature in porcine metabolic syndrome.
Experimental physiology.
2018 07; 103(7):1020-1029. doi:
10.1113/ep086988. [PMID: 29714040] - Zong-Rui Liu, Si-Qi Chen, Yao-Wei Zou, Xiao-Yu Wu, Hong-Ying Li, Xiao-Qiao Wang, Yue Shi, Hong-Xin Niu. Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides.
Free radical research.
2018 May; 52(5):616-628. doi:
10.1080/10715762.2018.1457789. [PMID: 29781318] - Amel Karaa, Richard Haas, Amy Goldstein, Jerry Vockley, W Douglas Weaver, Bruce H Cohen. Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy.
Neurology.
2018 04; 90(14):e1212-e1221. doi:
10.1212/wnl.0000000000005255. [PMID: 29500292] - P Hemachandra Reddy, Maria Manczak, XiangLing Yin, Arubala P Reddy. Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2018; 62(4):1549-1565. doi:
10.3233/jad-170988. [PMID: 29400667] - Melissa A Daubert, Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S Douglas, Christopher O'Connor, Sidney Goldstein, James E Udelson, Hani N Sabbah. Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.
Circulation. Heart failure.
2017 Dec; 10(12):. doi:
10.1161/circheartfailure.117.004389. [PMID: 29217757] - Hazel H Szeto. Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD.
Journal of the American Society of Nephrology : JASN.
2017 Oct; 28(10):2856-2865. doi:
10.1681/asn.2017030247. [PMID: 28778860] - Ahmed Saad, Sandra M S Herrmann, Alfonso Eirin, Christopher M Ferguson, James F Glockner, Haraldur Bjarnason, Michael A McKusick, Sanjay Misra, Lilach O Lerman, Stephen C Textor. Phase 2a Clinical Trial of Mitochondrial Protection (Elamipretide) During Stent Revascularization in Patients With Atherosclerotic Renal Artery Stenosis.
Circulation. Cardiovascular interventions.
2017 Sep; 10(9):. doi:
10.1161/circinterventions.117.005487. [PMID: 28916603] - Hao Zhao, Yan-Jun Liu, Zong-Rui Liu, Dong-Dong Tang, Xiao-Wen Chen, Yi-Hua Chen, Ru-Ning Zhou, Si-Qi Chen, Hong-Xin Niu. Role of mitochondrial dysfunction in renal fibrosis promoted by hypochlorite-modified albumin in a remnant kidney model and protective effects of antioxidant peptide SS-31.
European journal of pharmacology.
2017 Jun; 804(?):57-67. doi:
10.1016/j.ejphar.2017.03.037. [PMID: 28322835] - Alfonso Eirin, John R Woollard, Christopher M Ferguson, Kyra L Jordan, Hui Tang, Stephen C Textor, Amir Lerman, Lilach O Lerman. The metabolic syndrome induces early changes in the swine renal medullary mitochondria.
Translational research : the journal of laboratory and clinical medicine.
2017 06; 184(?):45-56.e9. doi:
10.1016/j.trsl.2017.03.002. [PMID: 28363084] - Mariya T Sweetwyne, Jeffrey W Pippin, Diana G Eng, Kelly L Hudkins, Ying Ann Chiao, Matthew D Campbell, David J Marcinek, Charles E Alpers, Hazel H Szeto, Peter S Rabinovitch, Stuart J Shankland. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.
Kidney international.
2017 05; 91(5):1126-1145. doi:
10.1016/j.kint.2016.10.036. [PMID: 28063595] - Hazel H Szeto, Shaoyi Liu, Yi Soong, Surya V Seshan, Leona Cohen-Gould, Viacheslav Manichev, Leonard C Feldman, Torgny Gustafsson. Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD.
Journal of the American Society of Nephrology : JASN.
2017 May; 28(5):1437-1449. doi:
10.1681/asn.2016070761. [PMID: 27881606] - P Hemachandra Reddy, Maria Manczak, Ramesh Kandimalla. Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.
Human molecular genetics.
2017 04; 26(8):1483-1496. doi:
10.1093/hmg/ddx052. [PMID: 28186562] - Meng Zhang, Hongting Zhao, Jing Cai, Huihui Li, Qi Wu, Tong Qiao, Kuanyu Li. Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet.
PloS one.
2017; 12(9):e0185688. doi:
10.1371/journal.pone.0185688. [PMID: 28961281] - Hazel H Szeto, Shaoyi Liu, Yi Soong, Nazia Alam, Glen T Prusky, Surya V Seshan. Protection of mitochondria prevents high-fat diet-induced glomerulopathy and proximal tubular injury.
Kidney international.
2016 11; 90(5):997-1011. doi:
10.1016/j.kint.2016.06.013. [PMID: 27519664] - Leonie G M Wijermars, Alexander F Schaapherder, Dorottya K de Vries, Lars Verschuren, Rob C I Wüst, Sarantos Kostidis, Oleg A Mayboroda, Frans Prins, Jan Ringers, Jörgen Bierau, Jaap A Bakker, Teake Kooistra, Jan H N Lindeman. Defective postreperfusion metabolic recovery directly associates with incident delayed graft function.
Kidney international.
2016 07; 90(1):181-91. doi:
10.1016/j.kint.2016.02.034. [PMID: 27188504] - Yanjuan Hou, Shuangcheng Li, Ming Wu, Jinying Wei, Yunzhuo Ren, Chunyang Du, Haijiang Wu, Caili Han, Huijun Duan, Yonghong Shi. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.
American journal of physiology. Renal physiology.
2016 Mar; 310(6):F547-59. doi:
10.1152/ajprenal.00574.2014. [PMID: 26719366] - Hani N Sabbah, Ramesh C Gupta, Smita Kohli, Mengjun Wang, Souheila Hachem, Kefei Zhang. Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure.
Circulation. Heart failure.
2016 Feb; 9(2):e002206. doi:
10.1161/circheartfailure.115.002206. [PMID: 26839394] - Guoming Li, Jing Wu, Renqi Li, Dong Yuan, Yunxia Fan, Jianjun Yang, Muhuo Ji, Sihai Zhu. Protective Effects of Antioxidant Peptide SS-31 Against Multiple Organ Dysfunctions During Endotoxemia.
Inflammation.
2016 Feb; 39(1):54-64. doi:
10.1007/s10753-015-0222-1. [PMID: 26231114] - Dong Sun, Alfonso Eirin, Xiang-Yang Zhu, Xin Zhang, John A Crane, John R Woollard, Amir Lerman, Lilach O Lerman. Experimental coronary artery stenosis accelerates kidney damage in renovascular hypertensive swine.
Kidney international.
2015 Apr; 87(4):719-27. doi:
10.1038/ki.2014.343. [PMID: 25337776] - Alfonso Eirin, Behzad Ebrahimi, Xin Zhang, Xiang-Yang Zhu, John R Woollard, Quan He, Stephen C Textor, Amir Lerman, Lilach O Lerman. Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease.
Cardiovascular research.
2014 Sep; 103(4):461-72. doi:
10.1093/cvr/cvu157. [PMID: 24947415] - Shaoyi Liu, Yi Soong, Surya V Seshan, Hazel H Szeto. Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis.
American journal of physiology. Renal physiology.
2014 May; 306(9):F970-80. doi:
10.1152/ajprenal.00697.2013. [PMID: 24553434] - Hazel H Szeto. First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics.
British journal of pharmacology.
2014 Apr; 171(8):2029-50. doi:
10.1111/bph.12461. [PMID: 24117165] - Shao-Bin Duan, Shi-Kun Yang, Qiao-Yan Zhou, Peng Pan, Hui Zhang, Fang Liu, Xiang-Qing Xu. Mitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia.
Renal failure.
2013 Sep; 35(8):1124-9. doi:
10.3109/0886022x.2013.815107. [PMID: 23879473] - Alexander V Birk, Shaoyi Liu, Yi Soong, William Mills, Pradeep Singh, J David Warren, Surya V Seshan, Joel D Pardee, Hazel H Szeto. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin.
Journal of the American Society of Nephrology : JASN.
2013 Jul; 24(8):1250-61. doi:
10.1681/asn.2012121216. [PMID: 23813215] - Wen-Yu Zhao, Shu Han, Lei Zhang, You-Hua Zhu, Li-Ming Wang, Li Zeng. Mitochondria-targeted antioxidant peptide SS31 prevents hypoxia/reoxygenation-induced apoptosis by down-regulating p66Shc in renal tubular epithelial cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 32(3):591-600. doi:
10.1159/000354463. [PMID: 24021885] - Alfonso Eirin, Zilun Li, Xin Zhang, James D Krier, John R Woollard, Xiang-Yang Zhu, Hui Tang, Sandra M Herrmann, Amir Lerman, Stephen C Textor, Lilach O Lerman. A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis.
Hypertension (Dallas, Tex. : 1979).
2012 Nov; 60(5):1242-9. doi:
10.1161/hypertensionaha.112.199919. [PMID: 23045468] - Edward A Carter, Ali A Bonab, Jeremy Goverman, Kasie Paul, John Yerxa, Ronald G Tompkins, Alan J Fischman. Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.
International journal of molecular medicine.
2011 Oct; 28(4):589-94. doi:
10.3892/ijmm.2011.752. [PMID: 21805045] - Hazel H Szeto, Shaoyi Liu, Yi Soong, Dunli Wu, Shaun F Darrah, Feng-Ying Cheng, Zhihong Zhao, Michael Ganger, Clara Y Tow, Surya V Seshan. Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury.
Journal of the American Society of Nephrology : JASN.
2011 Jun; 22(6):1041-52. doi:
10.1681/asn.2010080808. [PMID: 21546574] - Andrew M Hall. Pores for thought: new strategies to re-energize stressed mitochondria in acute kidney injury.
Journal of the American Society of Nephrology : JASN.
2011 Jun; 22(6):986-9. doi:
10.1681/asn.2011030309. [PMID: 21566050] - Yasunori Mizuguchi, Jie Chen, Surya V Seshan, Dix P Poppas, Hazel H Szeto, Diane Felsen. A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.
American journal of physiology. Renal physiology.
2008 Nov; 295(5):F1545-53. doi:
10.1152/ajprenal.00395.2007. [PMID: 18784263] - Janghyun Cho, Kyungheon Won, DunLi Wu, Yi Soong, Shaoyi Liu, Hazel H Szeto, Mun K Hong. Potent mitochondria-targeted peptides reduce myocardial infarction in rats.
Coronary artery disease.
2007 May; 18(3):215-20. doi:
10.1097/01.mca.0000236285.71683.b6. [PMID: 17429296] - Kesheng Zhao, Guoxiong Luo, Serena Giannelli, Hazel H Szeto. Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.
Biochemical pharmacology.
2005 Dec; 70(12):1796-806. doi:
10.1016/j.bcp.2005.08.022. [PMID: 16216225]