Aramchol (BioDeep_00000838386)

   


代谢物信息卡片


Aramchol

化学式: C44H79NO5 (701.5957923999999)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCCC(=O)NC1CCC2(C(C1)CC(C3C2CC(C4(C3CCC4C(C)CCC(=O)O)C)O)O)C
InChI: InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1

描述信息

D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
C78276 - Agent Affecting Digestive System or Metabolism
Icomidocholic acid (Aramchol) is a conjugate of cholic acid and arachidic acid that could inhibit stearoyl coenzyme A desaturase 1 (SCD1) activity. Icomidocholic acid has potential use in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) treatment[1].

同义名列表

3 个代谢物同义名

Aramchol; C20-FABAC; Icomidocholic acid



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • David Fernández-Ramos, Fernando Lopitz-Otsoa, Laura Delacruz-Villar, Jon Bilbao, Martina Pagano, Laura Mosca, Maider Bizkarguenaga, Marina Serrano-Macia, Mikel Azkargorta, Marta Iruarrizaga-Lejarreta, Jesús Sot, Darya Tsvirkun, Sebastiaan Martijn van Liempd, Felix M Goni, Cristina Alonso, María Luz Martínez-Chantar, Felix Elortza, Liat Hayardeny, Shelly C Lu, José M Mato. Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation. World journal of gastroenterology. 2020 Sep; 26(34):5101-5117. doi: 10.3748/wjg.v26.i34.5101. [PMID: 32982112]
  • Alicia Leikin-Frenkel, Ayelet Gonen, Aviv Shaish, Ilana Goldiner, Diana Leikin-Gobbi, Fred M Konikoff, Dror Harats, Tuvia Gilat. Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic. Archives of medical research. 2010 Aug; 41(6):397-404. doi: 10.1016/j.arcmed.2010.09.001. [PMID: 21044742]
  • Alicia Leikin-Frenkel, Ilana Goldiner, Diana Leikin-Gobbi, Ruth Rosenberg, Hamutal Bonen, Alex Litvak, Joelle Bernheim, Fred M Konikoff, Tuvia Gilat. Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents. European journal of gastroenterology & hepatology. 2008 Dec; 20(12):1205-13. doi: 10.1097/meg.0b013e3282fc9743. [PMID: 18989145]
  • Alicia Leikin-Frenkel, Paolo Parini, Fred M Konikoff, Lisbet Benthin, Diana Leikin-Gobbi, Ilana Goldiner, Curt Einarsson, Tuvia Gilat. Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice. Archives of biochemistry and biophysics. 2008 Mar; 471(1):63-71. doi: 10.1016/j.abb.2007.12.005. [PMID: 18167305]
  • Ilana Goldiner, Astrid E van der Velde, Kristin E Vandenberghe, Michel A van Wijland, Zamir Halpern, Tuvia Gilat, Fred M Konikoff, Robert Jan Veldman, Albert K Groen. ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid-bile acid conjugates (FABACs). The Biochemical journal. 2006 Jun; 396(3):529-36. doi: 10.1042/bj20051694. [PMID: 16522192]
  • A Leikin-Frenkel, A A Weinbroum, D Leikin-Gobbi, L Krupitzky, I Goldiner, L Shafat, T Gilat, F M Konikoff. Faecal sterol output is increased by arachidyl amido cholanoic acid (Aramchol) in rats. Biochemical Society transactions. 2004 Feb; 32(Pt 1):131-3. doi: 10.1042/bst0320131. [PMID: 14748731]
  • Tuvia Gilat, Alicia Leikin-Frenkel, Ilana Goldiner, Christine Juhel, Huguette Lafont, Diana Gobbi, Fred M Konikoff. Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC). Hepatology (Baltimore, Md.). 2003 Aug; 38(2):436-42. doi: 10.1053/jhep.2003.50348. [PMID: 12883488]