ORG-25935 free base (BioDeep_00000838368)
代谢物信息卡片
ORG-25935 free base
化学式: C21H25NO3 (339.1834)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CC1CCC2=C(C1C3=CC=CC=C3)C=CC(=C2)OC)CC(=O)O
InChI: InChI=1S/C21H25NO3/c1-22(14-20(23)24)13-17-9-8-16-12-18(25-2)10-11-19(16)21(17)15-6-4-3-5-7-15/h3-7,10-12,17,21H,8-9,13-14H2,1-2H3,(H,23,24)/t17-,21+/m1/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Helga Höifödt Lidö, Susanne Jonsson, Petri Hyytiä, Mia Ericson, Bo Söderpalm. Further characterization of the GlyT-1 inhibitor Org25935: anti-alcohol, neurobehavioral, and gene expression effects.
Journal of neural transmission (Vienna, Austria : 1996).
2017 05; 124(5):607-619. doi:
10.1007/s00702-017-1685-z. [PMID: 28161754] - S A Castner, N V Murthy, K Ridler, H Herdon, B M Roberts, D P Weinzimmer, Y Huang, M Q Zheng, E A Rabiner, R N Gunn, R E Carson, G V Williams, M Laruelle. Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primates.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2014 Nov; 39(12):2742-9. doi:
10.1038/npp.2014.4. [PMID: 24487737] - Andrea de Bejczy, Kari R Nations, Armin Szegedi, Joep Schoemaker, Frank Ruwe, Bo Söderpalm. Efficacy and safety of the glycine transporter-1 inhibitor org 25935 for the prevention of relapse in alcohol-dependent patients: a randomized, double-blind, placebo-controlled trial.
Alcoholism, clinical and experimental research.
2014 Sep; 38(9):2427-35. doi:
10.1111/acer.12501. [PMID: 25257291] - Joep H Schoemaker, Wim T Jansen, Jacques Schipper, Armin Szegedi. The selective glycine uptake inhibitor org 25935 as an adjunctive treatment to atypical antipsychotics in predominant persistent negative symptoms of schizophrenia: results from the GIANT trial.
Journal of clinical psychopharmacology.
2014 Apr; 34(2):190-8. doi:
10.1097/jcp.0000000000000073. [PMID: 24525661] - Donnie Eddins, Terence G Hamill, Vanita Puri, Christopher E Cannon, Jeffrey A Vivian, Sandra M Sanabria-Bohórquez, Jacquelynn J Cook, John A Morrow, Fiona Thomson, Jason M Uslaner. The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey.
Psychopharmacology.
2014 Feb; 231(3):511-9. doi:
10.1007/s00213-013-3260-0. [PMID: 24051602] - Andrea Balla, Samantha Schneider, Henry Sershen, Daniel C Javitt. Effects of novel, high affinity glycine transport inhibitors on frontostriatal dopamine release in a rodent model of schizophrenia.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2012 Dec; 22(12):902-10. doi:
10.1016/j.euroneuro.2012.03.006. [PMID: 22561005] - Kent Jardemark, Monica M Marcus, Anna Malmerfelt, Mohammed Shahid, Torgny H Svensson. Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission.
Psychopharmacology.
2012 May; 221(1):115-31. doi:
10.1007/s00213-011-2554-3. [PMID: 22068461] - Kari R Nations, Jasper A J Smits, David F Tolin, Barbara O Rothbaum, Stefan G Hofmann, Candyce D Tart, Allen Lee, Jacques Schipper, Magnus Sjogren, Dixi Xue, Armin Szegedi, Michael W Otto. Evaluation of the glycine transporter inhibitor Org 25935 as augmentation to cognitive-behavioral therapy for panic disorder: a multicenter, randomized, double-blind, placebo-controlled trial.
The Journal of clinical psychiatry.
2012 May; 73(5):647-53. doi:
10.4088/jcp.11m07081. [PMID: 22394471] - Deepak Cyril D'Souza, Nagendra Singh, Jacqueline Elander, Michelle Carbuto, Brian Pittman, Joanna Udo de Haes, Magnus Sjogren, Pierre Peeters, Mohini Ranganathan, Jacques Schipper. Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2012 Mar; 37(4):1036-46. doi:
10.1038/npp.2011.295. [PMID: 22113087] - Veronica Musante, Maria Summa, Rodrigo A Cunha, Maurizio Raiteri, Anna Pittaluga. Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Journal of neurochemistry.
2011 May; 117(3):516-27. doi:
10.1111/j.1471-4159.2011.07223.x. [PMID: 21348870] - Valentina Vengeliene, Fernando Leonardi-Essmann, Wolfgang H Sommer, Hugh M Marston, Rainer Spanagel. Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats.
Biological psychiatry.
2010 Oct; 68(8):704-11. doi:
10.1016/j.biopsych.2010.05.029. [PMID: 20655511] - Helga Höifödt Lidö, Rosita Stomberg, Anne Fagerberg, Mia Ericson, Bo Söderpalm. The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens.
Alcoholism, clinical and experimental research.
2009 Jul; 33(7):1151-7. doi:
10.1111/j.1530-0277.2009.00938.x. [PMID: 19389199] - Katsuya Morita, Naoyo Motoyama, Tomoya Kitayama, Norimitsu Morioka, Toshihiro Dohi. Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2007 12; 130(6):458-63. doi:
10.1254/fpj.130.458. [PMID: 18079595] - Anna Molander, Helga Höifödt Lidö, Elin Löf, Mia Ericson, Bo Söderpalm. The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats.
Alcohol and alcoholism (Oxford, Oxfordshire).
2007 Jan; 42(1):11-8. doi:
10.1093/alcalc/agl085. [PMID: 17098748]
