1alpha,24S-Dihydroxyvitamin D2 (BioDeep_00000838353)
代谢物信息卡片
化学式: C28H44O3 (428.3290274)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C)(C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C)O
InChI: InChI=1S/C28H44O3/c1-18(2)28(6,31)15-13-19(3)24-11-12-25-21(8-7-14-27(24,25)5)9-10-22-16-23(29)17-26(30)20(22)4/h9-10,13,15,18-19,23-26,29-31H,4,7-8,11-12,14,16-17H2,1-3,5-6H3/b15-13+,21-9+,22-10-/t19-,23-,24-,25+,26+,27-,28-/m1/s1
描述信息
D018977 - Micronutrients > D014815 - Vitamins > D004872 - Ergocalciferols
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- R St-Arnaud, A Arabian, V W C Yu, O Akhouayri, J C Knutson, S A Strugnell. 1α,24(S)(OH)2D2 normalizes bone morphology and serum parathyroid hormone without hypercalcemia in 25-hydroxyvitamin D-1-hydroxylase (CYP27B1)-deficient mice, an animal model of vitamin D deficiency with secondary hyperparathyroidism.
Journal of endocrinological investigation.
2008 Aug; 31(8):711-7. doi:
10.1007/bf03346420. [PMID: 18852532] - Glendon M Zinser, Emily Tribble, Meggan Valrance, Colleen M Urben, Joyce C Knutson, Richard B Mazess, Stephen A Strugnell, Joellen Welsh. 1,24(S)-dihydroxyvitamin D2, an endogenous vitamin D2 metabolite, inhibits growth of breast cancer cells and tumors.
Anticancer research.
2005 Jan; 25(1A):235-41. doi:
. [PMID: 15816543] - Alex J Brown, Cynthia S Ritter, L Shannon Holliday, Joyce C Knutson, Stephen A Strugnell. Tissue distribution and activity studies of 1,24-dihydroxyvitamin D2, a metabolite of vitamin D2 with low calcemic activity in vivo.
Biochemical pharmacology.
2004 Oct; 68(7):1289-96. doi:
10.1016/j.bcp.2004.06.015. [PMID: 15345318] - Joost G J Hoenderop, Annemiete W C M van der Kemp, Colleen M Urben, Stephen A Strugnell, René J M Bindels. Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice.
Kidney international.
2004 Sep; 66(3):1082-9. doi:
10.1111/j.1523-1755.2004.00858.x. [PMID: 15327402] - R Horst, S Prapong, T Reinhardt, N Koszewski, J Knutson, C Bishop. Comparison of the relative effects of 1,24-dihydroxyvitamin D(2) [1, 24-(OH)(2)D(2)], 1,24-dihydroxyvitamin D(3) [1,24-(OH)(2)D(3)], and 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] on selected vitamin D-regulated events in the rat.
Biochemical pharmacology.
2000 Sep; 60(5):701-8. doi:
10.1016/s0006-2952(00)00378-6. [PMID: 10927029] - E B Mawer, G Jones, M Davies, P E Still, V Byford, N J Schroeder, H L Makin, C W Bishop, J C Knutson. Unique 24-hydroxylated metabolites represent a significant pathway of metabolism of vitamin D2 in humans: 24-hydroxyvitamin D2 and 1,24-dihydroxyvitamin D2 detectable in human serum.
The Journal of clinical endocrinology and metabolism.
1998 Jun; 83(6):2156-66. doi:
10.1210/jcem.83.6.4841. [PMID: 9626155] - J C Knutson, L W LeVan, C R Valliere, C W Bishop. Pharmacokinetics and systemic effect on calcium homeostasis of 1 alpha,24-dihydroxyvitamin D2 in rats. Comparison with 1 alpha,25-dihydroxyvitamin D2, calcitriol, and calcipotriol.
Biochemical pharmacology.
1997 Mar; 53(6):829-37. doi:
10.1016/s0006-2952(97)00004-x. [PMID: 9113104]