Tas-108 (BioDeep_00000838324)
代谢物信息卡片
化学式: C39H55NO10 (697.382577)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CC1=CC(=C(C=C1)OCCC2CCC3C2(CCC4C3C(CC5=C4C=CC(=C5)O)C)C)OC.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI: /m1./s1
描述信息
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
C1892 - Chemopreventive Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hideo Inaji, Hiroji Iwata, Takahiro Nakayama, Naohito Yamamoto, Yasuyuki Sato, Yutaka Tokuda, Kenjiro Aogi, Shigehira Saji, Kenichi Watanabe, Tsuyoshi Saito, Masayuki Yoshida, Nobuaki Sato, Toshiaki Saeki, Yuichi Takatsuka, Masaru Kuranami, Hiroko Yamashita, Atsushi Kikuchi, Toshio Tabei, Tadashi Ikeda, Shinzaburo Noguchi. Randomized phase II study of three doses of oral TAS-108 in postmenopausal patients with metastatic breast cancer.
Cancer science.
2012 Sep; 103(9):1708-13. doi:
10.1111/j.1349-7006.2012.02354.x. [PMID: 22676245] - T Saeki, S Noguchi, K Aogi, H Inaji, T Tabei, T Ikeda. Evaluation of the safety and tolerability of oral TAS-108 in postmenopausal patients with metastatic breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology.
2009 May; 20(5):868-73. doi:
10.1093/annonc/mdn714. [PMID: 19150935] - Yuji Kumagai, Tomoe Fujita, Machiko Ozaki, Shin-ichi Yokota, Mika Maeda, Mizue Shida, Yoshio Otani, Hidetoshi Yamaya, Hideo Tsuruta. Safety, tolerability and pharmacokinetics of TAS-108, a novel anti-oestrogen, in healthy post-menopausal Japanese women: a phase I single oral dose study.
Basic & clinical pharmacology & toxicology.
2009 May; 104(5):352-9. doi:
10.1111/j.1742-7843.2008.00373.x. [PMID: 19175362] - Hidetoshi Yamaya, Mayuko Saeki, Ken-ichiro Yoshida, Jiro Shibata, Shingo Yano, Yoshiaki Sato, Atsushi Takao, Takashi Shindo, Aman U Buzdar, Sekio Nagayama. Distribution of (7alpha)-21-[4-[(diethylamino) methyl]-2-methoxyphenoxy]-7-methyl-19-norpregna-1,3,5(10)-trien-3-ol-20-[14C]2-hydroxy-1,2,3-propanetricarboxylate ([14C]TAS-108) and its metabolites after single oral administration to rats bearing 7,12-dimethylbenz(alpha)anthracene-induced mammary tumor.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Feb; 34(2):331-8. doi:
10.1124/dmd.105.005504. [PMID: 16299166] - H Yamaya, K Yoshida, J Kuritani, J Yonezawa, J-I Yonezawa, M Tsuda, T Shindo, S Nagayama, A U Buzdar. Safety, tolerability, and pharmacokinetics of TAS-108 in normal healthy post-menopausal female subjects: a phase I study on single oral dose.
Journal of clinical pharmacy and therapeutics.
2005 Oct; 30(5):459-70. doi:
10.1111/j.1365-2710.2005.00673.x. [PMID: 16164493] - Yasuji Yamamoto, Osamu Wada, Ichiro Takada, Yoshiko Yogiashi, Jiro Shibata, Junn Yanagisawa, Kenji Kitazato, Shigeaki Kato. Both N- and C-terminal transactivation functions of DNA-bound ERalpha are blocked by a novel synthetic estrogen ligand.
Biochemical and biophysical research communications.
2003 Dec; 312(3):656-62. doi:
10.1016/j.bbrc.2003.10.178. [PMID: 14680815]