Carfentanil, C-11 (BioDeep_00000838294)
代谢物信息卡片
Carfentanil, C-11
化学式: C24H30N2O3 (394.225631)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CC=C3)C(=O)OC
InChI: InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3/i2-1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Neeraj Chhabra, Lum Rizvanolli, Arkady Rasin, Granger Marsden, Keiki Hinami, Steven E Aks. A cross-sectional analysis of fentanyl analog exposures among living patients.
The American journal of drug and alcohol abuse.
2021 05; 47(3):344-349. doi:
10.1080/00952990.2021.1891420. [PMID: 33798014] - Jean Jung, Allan Kolodziej, Elise Pape, Michael Bisch, Lucie Javot, Valérie Gibaja, Jean-Yves Jouzeau, Julien Scala-Bertola, Nicolas Gambier. Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.
Forensic science international.
2020 Dec; 317(?):110437. doi:
10.1016/j.forsciint.2020.110437. [PMID: 33007729] - Joseph D Stanton, Penn Whitley, Leah LaRue, William L Bundy, Eric Dawson, Angela Huskey. Fentanyl analog positivity among near-real-time urine drug test results in patients seeking health care.
Drug and alcohol dependence.
2020 12; 217(?):108264. doi:
10.1016/j.drugalcdep.2020.108264. [PMID: 32980789] - Rodell C Barrientos, Eric W Bow, Connor Whalen, Oscar B Torres, Agnieszka Sulima, Zoltan Beck, Arthur E Jacobson, Kenner C Rice, Gary R Matyas. Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues.
Molecular pharmaceutics.
2020 09; 17(9):3447-3460. doi:
10.1021/acs.molpharmaceut.0c00497. [PMID: 32787282] - Tom Tuzel, Stephanie Marina Bollini, James P Antara, J Fred Banks, Gregory A Hobbs. Carfentanil Use in a Patient Undergoing Treatment for Substance Use Disorder.
Journal of analytical toxicology.
2020 Jul; 44(6):618-622. doi:
10.1093/jat/bkaa011. [PMID: 32020184] - Anna M Gutridge, Meridith T Robins, Robert J Cassell, Rajendra Uprety, Kendall L Mores, Mee Jung Ko, Gavril W Pasternak, Susruta Majumdar, Richard M van Rijn. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder.
British journal of pharmacology.
2020 04; 177(7):1497-1513. doi:
10.1111/bph.14913. [PMID: 31705528] - C N Chatterton, R P Handy, G K Shoemaker, M Scott-Ham. The distribution and redistribution of carfentanil in post mortem samples.
Forensic science international.
2020 Apr; 309(?):110215. doi:
10.1016/j.forsciint.2020.110215. [PMID: 32113175] - Peter J H Scott, Robert A Koeppe, Xia Shao, Melissa E Rodnick, Alexandra R Sowa, Bradford D Henderson, Jenelle Stauff, Phillip S Sherman, Janna Arteaga, Dennis J Carlo, Ronald B Moss. The Effects of Intramuscular Naloxone Dose on Mu Receptor Displacement of Carfentanil in Rhesus Monkeys.
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061360. [PMID: 32192089] - Marianne Skov-Skov Bergh, Inger Lise Bogen, Nancy Garibay, Michael H Baumann. Evidence for nonlinear accumulation of the ultrapotent fentanyl analog, carfentanil, after systemic administration to male rats.
Neuropharmacology.
2019 11; 158(?):107596. doi:
10.1016/j.neuropharm.2019.04.002. [PMID: 30965021] - Raminta Daniulaityte, Robert R Carlson, Matthew P Juhascik, Kraig E Strayer, Ioana E Sizemore. Street fentanyl use: Experiences, preferences, and concordance between self-reports and urine toxicology.
The International journal on drug policy.
2019 09; 71(?):3-9. doi:
10.1016/j.drugpo.2019.05.020. [PMID: 31146200] - Jarkko Johansson, Jussi Hirvonen, Zsófia Lovró, Laura Ekblad, Valtteri Kaasinen, Olli Rajasilta, Semi Helin, Jouni Tuisku, Saija Sirén, Mirka Pennanen, Arvind Agrawal, Roger Crystal, Petri J Vainio, Hannu Alho, Mika Scheinin. Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2019 08; 44(9):1667-1673. doi:
10.1038/s41386-019-0368-x. [PMID: 30867551] - Lisa Franzén, Olof Beck, Anders Helander. An analytically confirmed non-fatal intoxication by carfentanil in Sweden.
Clinical toxicology (Philadelphia, Pa.).
2019 05; 57(5):372-374. doi:
10.1080/15563650.2018.1520999. [PMID: 30484713] - Elizabeth S Dhummakupt, Gabrielle M Rizzo, Michael Feasel, Phillip M Mach, Bao Q Tran, Daniel O Carmany, Paul S Demond, Ethan M McBride, Michele Maughan, Jennifer W Sekowski, Trevor Glaros. Proteomic and Metabolomic Profiling Identify Plasma Biomarkers for Exposure to Ultra-low Levels of Carfentanil.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 02; 167(2):524-535. doi:
10.1093/toxsci/kfy259. [PMID: 30321427] - Dmitrij Fomin, Vilma Baranauskaite, Emilija Usaviciene, Alina Sumkovskaja, Sigitas Laima, Algimantas Jasulaitis, Zita Nijole Minkuviene, Sigitas Chmieliauskas, Jurgita Stasiuniene. Human deaths from drug overdoses with carfentanyl involvement-new rising problem in forensic medicine: A STROBE-compliant retrospective study.
Medicine.
2018 Nov; 97(48):e13449. doi:
10.1097/md.0000000000013449. [PMID: 30508965] - Uvaraj Uddayasankar, Colin Lee, Curtis Oleschuk, Gregg Eschun, Robert E Ariano. The Pharmacokinetics and Pharmacodynamics of Carfentanil After Recreational Exposure: A Case Report.
Pharmacotherapy.
2018 06; 38(6):e41-e45. doi:
10.1002/phar.2117. [PMID: 29679387] - Dina M Swanson, Laura S Hair, Selly R Strauch Rivers, Brianna C Smyth, Sara C Brogan, Alexis D Ventoso, Samantha L Vaccaro, Julia M Pearson. Fatalities Involving Carfentanil and Furanyl Fentanyl: Two Case Reports.
Journal of analytical toxicology.
2017 Jul; 41(6):498-502. doi:
10.1093/jat/bkx037. [PMID: 28575422] - Alan R Prossin, Steven S Zalcman, Mary M Heitzeg, Alisa E Koch, Phillip L Campbell, K Luan Phan, Christian S Stohler, Jon-Kar Zubieta. Dynamic interactions between plasma IL-1 family cytokines and central endogenous opioid neurotransmitter function in humans.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Feb; 40(3):554-65. doi:
10.1038/npp.2014.202. [PMID: 25139063] - Kimberly L Rainwater, Marc T Valitutto, Penny Kalk, Robert P Moore, John M Sykes. Comparison of two injectable immobilization combinations in Himalayan tahr (Hemitragus jemlahicus): medetomidine, ketamine, and atipamezole versus carfentanil, xylazine, naltrexone, and atipamezole.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2013 Sep; 44(3):596-604. doi:
10.1638/2012-0140r1.1. [PMID: 24063087] - James R Riches, Robert W Read, Robin M Black, Nicholas J Cooper, Christopher M Timperley. Analysis of clothing and urine from Moscow theatre siege casualties reveals carfentanil and remifentanil use.
Journal of analytical toxicology.
2012 Nov; 36(9):647-56. doi:
10.1093/jat/bks078. [PMID: 23002178] - E A Rabiner, J Beaver, A Makwana, G Searle, C Long, P J Nathan, R D Newbould, J Howard, S R Miller, M A Bush, S Hill, R Reiley, J Passchier, R N Gunn, P M Matthews, E T Bullmore. Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans.
Molecular psychiatry.
2011 Aug; 16(8):826-35, 785. doi:
10.1038/mp.2011.29. [PMID: 21502953] - Udi E Ghitza, Kenzie L Preston, David H Epstein, Hiroto Kuwabara, Christopher J Endres, Badreddine Bencherif, Susan J Boyd, Marc L Copersino, J James Frost, David A Gorelick. Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients.
Biological psychiatry.
2010 Oct; 68(8):697-703. doi:
10.1016/j.biopsych.2010.05.003. [PMID: 20579973] - Jussi Hirvonen, Sargo Aalto, Nora Hagelberg, Anu Maksimow, Kimmo Ingman, Vesa Oikonen, Jussi Virkkala, Kjell Någren, Harry Scheinin. Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects.
European journal of nuclear medicine and molecular imaging.
2009 Feb; 36(2):275-86. doi:
10.1007/s00259-008-0935-6. [PMID: 18779961] - David A Gorelick, Yu Kyeong Kim, Badreddine Bencherif, Susan J Boyd, Richard Nelson, Marc L Copersino, Robert F Dannals, J James Frost. Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence.
Psychopharmacology.
2008 Nov; 200(4):475-86. doi:
10.1007/s00213-008-1225-5. [PMID: 18762918] - Elise M Weerts, Yu Kyeong Kim, Gary S Wand, Robert F Dannals, Jae Sung Lee, J James Frost, Mary E McCaul. Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2008 Feb; 33(3):653-65. doi:
10.1038/sj.npp.1301440. [PMID: 17487229] - Mark Greenwald, Chris-Ellyn Johanson, Joshua Bueller, Yan Chang, David E Moody, Michael Kilbourn, Robert Koeppe, Jon-Kar Zubieta. Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices.
Biological psychiatry.
2007 Jan; 61(1):101-10. doi:
10.1016/j.biopsych.2006.04.043. [PMID: 16950210] - Susan E Kennedy, Robert A Koeppe, Elizabeth A Young, Jon-Kar Zubieta. Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women.
Archives of general psychiatry.
2006 Nov; 63(11):1199-208. doi:
10.1001/archpsyc.63.11.1199. [PMID: 17088500] - Alexander Cole, Adrian Mutlow, Ramiro Isaza, James W Carpenter, David E Koch, Robert P Hunter, Betsy L Dresser. Pharmacokinetics and pharmacodynamics of carfentanil and naltrexone in female common eland (Taurotragus oryx).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2006 Sep; 37(3):318-26. doi:
10.1638/05-070.1. [PMID: 17319131] - Kimmo Ingman, Nora Hagelberg, Sargo Aalto, Kjell Någren, Auni Juhakoski, Sakari Karhuvaara, Antero Kallio, Vesa Oikonen, Jarmo Hietala, Harry Scheinin. Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2005 Dec; 30(12):2245-53. doi:
10.1038/sj.npp.1300790. [PMID: 15956985] - David A Gorelick, Yu Kyeong Kim, Badreddine Bencherif, Susan J Boyd, Richard Nelson, Marc Copersino, Christopher J Endres, Robert F Dannals, J James Frost. Imaging brain mu-opioid receptors in abstinent cocaine users: time course and relation to cocaine craving.
Biological psychiatry.
2005 Jun; 57(12):1573-82. doi:
10.1016/j.biopsych.2005.02.026. [PMID: 15953495] - Adrian Mutlow, Ramiro Isaza, James W Carpenter, David E Koch, Robert P Hunter. Pharmacokinetics of carfentanil and naltrexone in domestic goats (Capra hircus).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2004 Dec; 35(4):489-96. doi:
10.1638/03-074. [PMID: 15732589] - Robert P Hunter, David E Koch, Adrian Mutlow, Ramiro Isaza. Extraction and quantitation of carfentanil and naltrexone in goat plasma with liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Aug; 793(2):351-5. doi:
10.1016/s1570-0232(03)00351-9. [PMID: 12906910] - A Moresco, R S Larsen, J M Sleeman, M A Wild, J S Gaynor. Use of naloxone to reverse carfentanil citrate-induced hypoxemia and cardiopulmonary depression in Rocky Mountain wapiti (Cervus elaphus nelsoni).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2001 Mar; 32(1):81-9. doi:
10.1638/1042-7260(2001)032[0081:uontrc]2.0.co;2. [PMID: 12790400] - W B Karesh, M M Uhart, E S Dierenfeld, W E Braselton, A Torres, C House, H Puche, R A Cook. Health evaluation of free-ranging guanaco (Lama guanicoe).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
1998 Jun; 29(2):134-41. doi:
NULL. [PMID: 9732026] - S Kim, H N Wagner, V L Villemagne, P F Kao, R F Dannals, H T Ravert, T Joh, R B Dixon, A C Civelek. Longer occupancy of opioid receptors by nalmefene compared to naloxone as measured in vivo by a dual-detector system.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1997 Nov; 38(11):1726-31. doi:
NULL. [PMID: 9374341] - J M Sleeman, W Carter, T Tobin, E C Ramsay. Immobilization of domestic goats (Capra hircus) using orally administered carfentanil citrate and detomidine hydrochloride.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
1997 Jun; 28(2):158-65. doi:
NULL. [PMID: 9279404] - J Schumacher, S B Citino, R Dawson. Effects of a carfentanil-xylazine combination on cardiopulmonary function and plasma catecholamine concentrations in female bongo antelopes.
American journal of veterinary research.
1997 Feb; 58(2):157-61. doi:
NULL. [PMID: 9028481] - K He, Y Z Quan, Z Y Qiu. [The stereoselective binding of praziquantel enantiomers to plasma proteins].
Yao xue xue bao = Acta pharmaceutica Sinica.
1991; 26(7):488-92. doi:
NULL. [PMID: 1805506] - Y Cohen, M Besnard, L Merlin. Pharmacology and pharmacokinetics of stereoisomers in radiopharmacy.
Acta radiologica. Supplementum.
1990; 374(?):25-32. doi:
NULL. [PMID: 1966966] - J J Frost, K H Douglass, H S Mayberg, R F Dannals, J M Links, A A Wilson, H T Ravert, W C Crozier, H N Wagner. Multicompartmental analysis of [11C]-carfentanil binding to opiate receptors in humans measured by positron emission tomography.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1989 Jun; 9(3):398-409. doi:
10.1038/jcbfm.1989.59. [PMID: 2541148] - T J Weckman, C L Tai, W E Woods, H H Tai, J W Blake, T Tobin. Pharmacologic effects and detection methods of methylated analogs of fentanyl in horses.
American journal of veterinary research.
1989 Apr; 50(4):502-7. doi:
NULL. [PMID: 2523679] - T Tobin, S Kwiatkowski, D S Watt, H H Tai, C L Tai, W E Woods, J P Goodman, D G Taylor, T J Weckman, J M Yang. Immunoassay detection of drugs in racing horses. XI. ELISA and RIA detection of fentanyl, alfentanil, sufentanil and carfentanil in equine blood and urine.
Research communications in chemical pathology and pharmacology.
1989 Jan; 63(1):129-52. doi:
NULL. [PMID: 2521746] - T F Meert, H R Lu, H van Craenndonck, P A Janssen. Comparison between epidural fentanyl, sufentanil, carfentanil, lofentanil and alfentanil in the rat: analgesia and other in vivo effects.
European journal of anaesthesiology.
1988 Sep; 5(5):313-21. doi:
". [PMID: 2905988] - M C Lee, H N Wagner, S Tanada, J J Frost, A N Bice, R F Dannals. Duration of occupancy of opiate receptors by naltrexone.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1988 Jul; 29(7):1207-11. doi:
NULL. [PMID: 2839637] - U S Seal, S M Schmitt, R O Peterson. Carfentanil and xylazine for immobilization of moose (Alces alces) on Isle Royale.
Journal of wildlife diseases.
1985 Jan; 21(1):48-51. doi:
10.7589/0090-3558-21.1.48. [PMID: 3981744]